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Wearables and other connected devices have been available to help treat chronic conditions like asthma and heart disease for a while now. But thus far, the nation’s 30 million diabetics haven’t seen much to help them improve their health or reduce the daily grind of finger pricks and needle pokes.

The $2.5 billion connected-care industry may be off to a late start in diabetes, but it’s making up for lost time. A new breed of connected glucometers, insulin pumps and smartphone apps is hitting the market. They promise to make it easier for diabetics to manage the slow-progressing disease and keep them motivated with feedback and support. In as little as two years, the industry plans to take charge of the entire uncomfortable, time-consuming routine of checking and regulating blood-sugar levels with something called an artificial pancreas. Such systems mimic the functions of a healthy pancreas by blending continuous glucose monitoring, remote-controlled insulin pumps and artificial intelligence to maintain healthy blood-sugar levels automatically.

For Jeroen Tas, CEO of Philips’ Connected Care and Health Informatics unit, diabetes management is also personal: his daughter Kim is diabetic.

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New funding awarded by DARPA on new spinal implants; this should make some commercial pilots that I know happy.


Carmel, IN-based startup Nanovis is no stranger to nabbing research grants. It’s just nabbed one from the National Institutes of Health for preclinical research on the use of its porous Forticore interbody fusion devices in combination with nanotube technology. The combination is expected to result in a surface that mimics nature and encourages regeneration around an implant.

Nanovis has previously gotten 8 competitive peer-reviewed grants from the NIH and other research organizations; this is its second NIH grant. In September 2014, it got FDA clearance for its FortiCore interbody fusion devices and then last October it launched an expanded FortiCore line.

“Gaining the attention and support of the NIH for Nanovis’ technology platforms and research is gratifying,” said Nanovis CEO Matt Hedrick in a statement. “Our deeply porous FortiCore interbody fusion device are increasingly being adopted by leading surgeons and hospital networks driving accelerated company growth. As we progress forward, we continue to invest in the fundamental science at the core of our uniquely differentiated technologies. Grants from the NIH help us continue to discover potential applications to improve the future of healthcare.”

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Cool beans.


Using a bionic fingertip, an amputee for the first time has been able to feel rough and smooth textures in real-time, as though the fingertip were naturally connected to his hand.

After Luke Skywalker got his hand cut off during a duel with Darth Vader in “Star Wars,” the young Jedi received an artificial hand that helped him both grip and feel again. Scientists worldwide are seeking to make this vision from science fiction a reality with prosthetic limbs that are wired directly into the nervous systems of their recipients.

Researchers experimented with amputee Dennis Aabo Sørensen from Denmark, who damaged his left hand more than a decade ago while playing with fireworks. Doctors immediately amputated the appendage after Sørensen was brought to a hospital. [Bionic Humans: Top 10 Technologies].

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Jeff Goodell is a braver person than me. Goodell reports that the driverless car “still drives like a teenager” Personally, I would worry more about the ability to hack these cars in the middle of a major US highway going 60 to 70 mph and hackers abruptly shutting off the engine.


Self-driving cars, war outsourced to robots, surgery by autonomous machines – this is only the beginning.

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It wasn’t all that long ago that the first human genome was sequenced – a massive, globally orchestrated scientific undertaking that took years and some US$3 billion to achieve.

Since then, rapid advancements in genetic technology and techniques have seen the cost and time required for genome sequencing drop dramatically, leading to this week’s remarkable announcement: the first whole genome sequencing service for consumers that costs less than $1,000.

At just $999, myGenome, from US-based genetics startup Veritas Genetics, is being billed by its makers as the first practical and affordable way for people to access unparalleled personal data on their individual genetic code. The company claims its personalised service offers an accessible way to keep tabs on your current health, keep you abreast of any potential future issues, and even know what inherited genetics you might pass onto your children.

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I have spent the last 30 years in various aspects of the biopharmaceutical industry, which for the most part has been a very rewarding experience.

However, during this time period, having been immersed many different components of therapeutic development and commercialization, one thing has always bothered me: a wide array of promising research never makes it off the bench to see the translational light of day, and gets lost in the historical scientific archives.

bqiinclab

I always believed that scientific progress happened in a very linear narrative, with each new discovery supporting the next, resulting ultimately in an eventual stairway of scientific enlightenment.

What the reality turned out to be was much more of a fragmented, research “evolutionary tree”, with dozens of potential pathways, only very few branches of which ever resulted in scientific maturity, and not always the most fruitful ones by any means.

The premature extinction of these promising discovery pathways were the result of a variety of factors, including, but not limited to, funding priorities, competing industrial interests, “out of vogue” concepts, lack of intellectual properties, non-existent regulatory models, conflicted legislative initiatives, and even religious implications.

In 2016, as in previous years, we continue to see these “valleys of death” swallow up pathways of scientific possibility, with few popular segments attracting the majority of attention and support.

gene sequencing

The preponderance of resources focused on the somatic mutation model of carcinogenesis, despite an endless range of research highlighting that the disease is extremely heterogenic and rarely ever follows such a clonal model, is one example that continues to be inappropriately manifested in the oncology system, decades into the “war on cancer”.

On a similar plane, the jettisoning of most studies of the biophysical aspects of human genetics, despite the gross incompleteness offered by the central dogma to explain higher biological form and function, is another example that has become all too pervasive in the research community.

And then there are the areas of human consciousness, memory, and information processing / storage, where in many ways we are still operating in the dark ages, with materialists and dualists battling it out for centuries.

One topic that I have written quite a bit about is that of death, specifically that of the death of the human brain — http://www.singularityweblog.com/is-death-reversible/

brainimage

While I am a staunch supporter and advocate of the life-extension / anti-aging movement, I am equally vocal about our need to develop technologies, products, and services that can actually reverse our ultimate transition between the living and dead states, a transition that occurs annually for 60 million humans around the globe.

Death, however, is unfortunately seen by many as a natural, biological progression for human beings, and in many circles, deemed an unnecessary area of scientific research and exploration.

I beg to differ.

Far too often, death arrives too early and too unexpectedly for many of us and our loved ones. And the best modern medicine has to offer today is “Sorry. There is nothing else we can do.”

But what if there was?

There are a variety of species across the natural world that are capable of regenerating and repairing themselves from forms of severe CNS damage that bring them to the transitional grey zone between life and death. Along the evolutionary timeline however, this ability gradually disappeared hundreds of millions of years ago and does not manifest in higher species.

lizard and lady

Now, in the 21st century, with the convergence of the disciplines of regenerative biology, cognitive neuroscience, and clinical resuscitation, we may finally be poised to take back these capabilities for humans.

Over the years, clinical science has focused heavily on preventing such life and death transitions and made some initial progress with suspended animation technologies, such as therapeutic hypothermia. But once we transition through the brain death window, currently defined by the medical establishment as “irreversible” (per the 1968 Ad Hoc Committee of the Harvard Medical School definition), we are technically no longer alive.

surgeons

To add insult to injury, a human can be declared dead, even while our bodies can still circulate blood, digest food, excrete waste, balance hormones, grow, sexually mature, heal wounds, spike a fever, and gestate and deliver a baby. It is even acknowledged by thought leaders that recently brain dead humans still may have residual blood flow and electrical nests of activity in their brains, just not enough to allow for an integrated functioning of the organism as a whole.

Several prominent cases in the media over the past few years have further served to highlight the current situation, as well as the substantial anatomical and functional differences between the state known as brain death, and other severe disorders of consciousness, such as coma, and the vegetative and minimally conscious states.

It is now time to take the necessary steps to provide new possibilities of hope, in order to counter the pain, sorrow, and grief that is all too pervasive in the world when we experience a loved one’s unexpected or untimely death, due to lesions which might be potentially reversible with the application of promising neuro-regeneration and neuro-reanimation technologies and therapies.

bqaproduction

It is time to undertake the required research, based on 2016 technological knowledge, in order to bring about such transformational change.

My name is Ira S. Pastor and I am the CEO of the biotechnology company Bioquark Inc.

Welcome to the unveiling of the Reanima project.

Reanima Video

Further support for SENS strategy. Senolytics improve vascular biomarkers in mice. This is exactly the work my project MMTP is working on, we are looking at conducting robust lifespan studies for Senolytics including the two compounds used here.

The next step will be to test Senolytics with MSC stem cells to see if we can further improve on vascular aging and pathology such as atherosclerosis.

We are launching a fundraiser on lifespan.io in April to get this work done, please support us!

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“Lung cancer is one of the most commonly diagnosed cancers and the most common cause of cancer-related deaths in Manitoba”, said Dr. Sri Navaratnam, president and CEO of CancerCare Manitoba. They all are carbohydrate-containing foods with a high glycemic index (GI).

Almost two years ago, the American Lung Association launched LUNG FORCE, an initiative to defeat lung cancer and rally Americans to raise their voices in support of a cure.

Eating a lot of white bread, processed breakfast cereals, cakes and biscuits may increase your risk for lung cancer, warns a new study. Why? However, they recommend individuals to limit food items high in GI such as white bread, corn flakes, bagels and puffed rice. The study results encompass 1,905 cases and 2,413 controls.

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