Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical

Top scientists at Roche Holding AG and AstraZeneca Plc are sizing up potential allies in the fight against cancer: the trillions of bacteria that live in the human body.

“Five years ago, if you had asked me about bacteria in your gut playing an important role in your systemic immune response, I probably would have laughed it off,” Daniel Chen, head of cancer immunotherapy research at Roche’s Genentech division, said in a phone interview. “Most of us immunologists now believe that there really is an important interaction there.”

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EU Justice Ministers Claims Cyber Attackers are terrorists. I wouldn’t say all of them are terrorists. Those who attack hospitals, attack government infrastructures, threaten markets, etc, are terrorists. The next door neighbor’s 13 yr old kid hacking to use your wireless internet service; not a terrorist.

European Union justice ministers on March 11th adopted a general approach on the directive on combatting terrorism, including serious cyber crimes, informs LETA/BNS.

On Friday the council greed its negotiating position on the proposal for a directive on combatting terrorism. The proposed directive strengthens the EU’s legal framework in preventing terrorist attacks by criminalising preparatory acts such as training and travel abroad for terrorist purposes – hence addressing the issue of foreign fighters – as well as aiding and abetting, inciting or attempting such acts. It also reinforce rules on the rights for the victims of terrorism, the Ministry of Justice said.

Estonian Justice Minister Urmas Reinsalu said in a speech at the Justice and Home Affairs Council that for Estonia it is very important that justice ministers were able to agree on defining serious terrorist cyber attacks as terrorist crimes. This gives the EU additional legal tools in such situations as the cyber attacks that followed the so-called Bronze Night riots that took place in Tallinn in April 2007, he added.

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“One small step for man, one giant leap for mankind.”

When Neil Armstrong stepped onto the dusty surface of the moon on July 20, 1969, it was a victory for NASA and a victory for science.

Backed by billions and led by NASA, the Apollo project is hardly the only government-organized science initiative to change the world. Two decades earlier, the Manhattan Project produced the first atomic bomb and restructured modern warfare; three decades later, the Human Genome Project published the blueprint to our DNA, heralding the dawn of population genomics and personalized medicine.

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Another great invention by the folks from Australia.

Researchers said they developed the new thinnest lens in the world. Made from a crystal called molybdenum disulphide, the new lens is 2,000 thinner than a human hair and can revolutionize the field of nanotechnology. (Photo : Gerd Altmann | Pixabay)

A team of Australian scientists said they have developed the thinnest lens in the world. The new 6.3-nanometer lens, which is 2,000 times thinner than a human hair, can lead to novel advances in medicine and science which could revolutionize nanotechnology.

Putting that in perspective, the previous thinnest lens was 50 nanometers thick. The new world’s thinnest lens was created by a team of scientists lead by The Australian National University’s Dr. Yuerui ‘Larry’ Lu.

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Lens regeneration in monkeys after minimally invasive surgery. Slit-lamp microscopy showed regenerating lens tissue grew from the peripheral to the central lens in a circular symmetrical pattern 2–3 months after surgery, reaching the center at 5 months post-surgery; direct illumination showed that the visual axis remained translucent. (credit: Haotian Lin et al./Nature)

Researchers at University of California, San Diego School of Medicine and Shiley Eye Institute, with colleagues in China, have developed an eye lens restoration treatment that has been tested in monkeys and in a small human clinical trial. It produced much fewer surgical complications than the current standard-of-care and resulted in regenerated lenses with superior visual function in all 12 of the pediatric cataract patients who received the new surgery.

Congenital cataracts — lens clouding that occurs at birth or shortly thereafter — is a significant cause of blindness in children.

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SENS has kindly commented about MMTP and the impact our research should have on aging. We launch a fundraiser in April to test senolytics (ApoptoSENS) with a planned follow up to combine this with stem cell therapy (RepleniSENS). It is time to put the engineering approach to aging to the test!

Some drugs tested have been found to increase mouse lifespan such as Metformin and Rapamycin for example and are considered for human testing. Many more substances have never been tested and we do not know if they might extend healthy lifespan.

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CRISPR may have burst on the scene as a revolutionary gene editing tool, but it’s proving to be so much more. Tagging the targeting system with a gene silencing component could revolutionise stem cell work and enable a new level of genetic control we’ve never seen before.

A wonder tool

Efficient and accurate, CRISPR may be in the throes of a patent battle but it’s undoubtedly going down in history as a landmark in biological science. There may be other similar systems out there, but CRISPR makes things quick and comparatively cheap — which tends to revolutionise any industry.

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Innovative new project the MMTP aims to fast forward translation from lab to clinic with rapid, parallel mice testing. We caught up with Steve Hill and Elena Milova from the MMTP team to discuss the program and why being pro-actively involved with longevity advocacy is so important.

What’s the gap in the market you’re aiming to fill and the major motivation behind the MMTP?

Steve – The bridge between basic research and taking it to clinical trials. People like The SENS Foundation are spinning a lot of plates doing the high risk, nitty gritty research that isn’t profitable, but crowdfunding can get that done. We want to create a solid gold standard testing platform without the restrictions of government, where any team can come to us for parallel testing and halve development time. The problem with animal testing is there’s this disconnect; it’s not sexy science basically. A common response is let me know when it’s available in humans, but it’s not going to be! No animal data means no human testing, organizations like the FDA, NHS and EMA all insist on a battery of animal testing before human trials. Period. It’s not sexy, it’s not available in humans next week, but if MMTP or other projects don’t get things done on mice for example, it’s never going to get done. It doesn’t matter if one theory turns out to be wrong, let’s get stuck in and find out!

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