Lifeboat Foundation: Safeguarding Humanity
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Philadelphia, PA, USA / Mexico City, Mexico — Bioquark, Inc., (www.bioquark.com) a life sciences company focused on the development of novel bioproducts for complex regeneration, disease reversion, and aging, and RegenerAge SAPI de CV, (www.regenerage.clinic/en/) a clinical company focused on translational therapeutic applications of a range of regenerative and rejuvenation healthcare interventions, have announced a collaboration to focus on novel combinatorial approaches in human disease and wellness. SGR-Especializada (http://www.sgr-especializada.com/), regulatory experts in the Latin American healthcare market, assisted in the relationship.

regenerage

“We are very excited about this collaboration with RegenerAge SAPI de CV,” said Ira S. Pastor, CEO, Bioquark Inc. “The natural synergy of our cellular and biologic to applications of regenerative and rejuvenative medicine will make for novel and transformational opportunities in a range of degenerative disorders.”

As we close in on $7 trillion in total annual health care expenditures around the globe ($1 trillion spent on pharmaceutical products; $200 billion on new R&D), we are simultaneously witnessing a paradoxical rise in the prevalence of all chronic degenerative diseases responsible for human suffering and death.

With the emergence of such trends including: personalization of medicine on an “n-of-1” basis, adaptive clinical design, globalization of health care training, compassionate use legislative initiatives for experimental therapies, wider acceptance of complementary medical technologies, and the growth of international medical travel, patients and clinicians are more than ever before, exploring the ability to access the therapies of tomorrow, today.

recovering patient

The estimate of the current market size for procedural medical travel, defined by medical travelers who travel across international borders for the purpose of receiving medical care, is in the range of US $40–55 billion.

Additionally, major clinical trial gaps currently exist across all therapeutic segments that are responsible for human suffering and death. Cancer is one prime example. As a leading cause of morbidity and mortality worldwide for many decades, today there are approximately 14 million new cases diagnosed each year, with over 8 million cancer related deaths annually. It is estimated that less than 5% of these patients, take the initiative to participate in any available clinical studies.

“We look forward to working closely with Bioquark Inc. on this exciting initiative,” said Dr. Joel Osorio, Chief of Clinical Development RegenerAge SAPI de CV. “The ability to merge cellular and biologic approaches represents the next step in achieving comprehensive regeneration and disease reversion events in a range of chronic diseases responsible for human suffering and death.”

bioquarklogo

About Bioquark, Inc.
Bioquark Inc. is focused on the development of natural biologic based products, services, and technologies, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing both biological pharmaceutical candidates, as well as products for the global consumer health and wellness market segments.

About RegenerAge SAPI de CV

RegenerAge SAPI de CV is a novel clinical company focused on translational therapeutic applications, as well as expedited, experimental access for “no option” patients, to a novel range of regenerative and reparative biomedical products and services, with the goal of reducing human degeneration, suffering, and death.

Fox 29 — Good Day Philadelphia

http://www.fox29.com/140735577-video

Reanimalogo

NBC TV 10

http://www.nbcphiladelphia.com/news/local/Zombies-from-Philly_-Local-Firm-Hopes-to-Bring-People-Back-from-the-Dead_Philadelphia-378365101.html

fmri5

CNN en Espanol

http://cnnespanol.cnn.com/video/cnnee-encuentro-intvw-joel-osorio-bioquantina-muerte-cerebral/

Researcher-test

I have spent the last 30 years in various aspects of the biopharmaceutical industry, which for the most part has been a very rewarding experience.

However, during this time period, having been immersed many different components of therapeutic development and commercialization, one thing has always bothered me: a wide array of promising research never makes it off the bench to see the translational light of day, and gets lost in the historical scientific archives.

bqiinclab

I always believed that scientific progress happened in a very linear narrative, with each new discovery supporting the next, resulting ultimately in an eventual stairway of scientific enlightenment.

What the reality turned out to be was much more of a fragmented, research “evolutionary tree”, with dozens of potential pathways, only very few branches of which ever resulted in scientific maturity, and not always the most fruitful ones by any means.

The premature extinction of these promising discovery pathways were the result of a variety of factors, including, but not limited to, funding priorities, competing industrial interests, “out of vogue” concepts, lack of intellectual properties, non-existent regulatory models, conflicted legislative initiatives, and even religious implications.

In 2016, as in previous years, we continue to see these “valleys of death” swallow up pathways of scientific possibility, with few popular segments attracting the majority of attention and support.

gene sequencing

The preponderance of resources focused on the somatic mutation model of carcinogenesis, despite an endless range of research highlighting that the disease is extremely heterogenic and rarely ever follows such a clonal model, is one example that continues to be inappropriately manifested in the oncology system, decades into the “war on cancer”.

On a similar plane, the jettisoning of most studies of the biophysical aspects of human genetics, despite the gross incompleteness offered by the central dogma to explain higher biological form and function, is another example that has become all too pervasive in the research community.

And then there are the areas of human consciousness, memory, and information processing / storage, where in many ways we are still operating in the dark ages, with materialists and dualists battling it out for centuries.

One topic that I have written quite a bit about is that of death, specifically that of the death of the human brain — http://www.singularityweblog.com/is-death-reversible/

brainimage

While I am a staunch supporter and advocate of the life-extension / anti-aging movement, I am equally vocal about our need to develop technologies, products, and services that can actually reverse our ultimate transition between the living and dead states, a transition that occurs annually for 60 million humans around the globe.

Death, however, is unfortunately seen by many as a natural, biological progression for human beings, and in many circles, deemed an unnecessary area of scientific research and exploration.

I beg to differ.

Far too often, death arrives too early and too unexpectedly for many of us and our loved ones. And the best modern medicine has to offer today is “Sorry. There is nothing else we can do.”

But what if there was?

There are a variety of species across the natural world that are capable of regenerating and repairing themselves from forms of severe CNS damage that bring them to the transitional grey zone between life and death. Along the evolutionary timeline however, this ability gradually disappeared hundreds of millions of years ago and does not manifest in higher species.

lizard and lady

Now, in the 21st century, with the convergence of the disciplines of regenerative biology, cognitive neuroscience, and clinical resuscitation, we may finally be poised to take back these capabilities for humans.

Over the years, clinical science has focused heavily on preventing such life and death transitions and made some initial progress with suspended animation technologies, such as therapeutic hypothermia. But once we transition through the brain death window, currently defined by the medical establishment as “irreversible” (per the 1968 Ad Hoc Committee of the Harvard Medical School definition), we are technically no longer alive.

surgeons

To add insult to injury, a human can be declared dead, even while our bodies can still circulate blood, digest food, excrete waste, balance hormones, grow, sexually mature, heal wounds, spike a fever, and gestate and deliver a baby. It is even acknowledged by thought leaders that recently brain dead humans still may have residual blood flow and electrical nests of activity in their brains, just not enough to allow for an integrated functioning of the organism as a whole.

Several prominent cases in the media over the past few years have further served to highlight the current situation, as well as the substantial anatomical and functional differences between the state known as brain death, and other severe disorders of consciousness, such as coma, and the vegetative and minimally conscious states.

It is now time to take the necessary steps to provide new possibilities of hope, in order to counter the pain, sorrow, and grief that is all too pervasive in the world when we experience a loved one’s unexpected or untimely death, due to lesions which might be potentially reversible with the application of promising neuro-regeneration and neuro-reanimation technologies and therapies.

bqaproduction

It is time to undertake the required research, based on 2016 technological knowledge, in order to bring about such transformational change.

My name is Ira S. Pastor and I am the CEO of the biotechnology company Bioquark Inc.

Welcome to the unveiling of the Reanima project.

Reanima Video

NOT.GRANDMAS.ROBOT.NO.IS
Japanese People are Getting Old — Fast. So… Robots!
Japan is one of those great examples of how, when a society reaches a certain stage of development, population can stabilize itself based simply on quality of life (economic well-being, healthcare, community, Golden Rule morality, etc.). There is a challenge, however: population decline. In arguably one of the world’s most advanced capitalist nations, where 70% of GDP is based on the services economy and nearly all national debt is public held, a big die-off is… big problematic. Sure, the population decline will be gradual — but it’s inexorable, and Japan has to prepare now.

Make Robots, Not Babies?
A (perhaps questionable) study from the Japan Family Planning Association found that 1/3 of Japanese youth have no desire to get their groove on. They just don’t wanna hump each other. And as many of us know, it’s not just an enjoyable hobby, it’s where babies come from! Realistically, a decent number of respondents were probably lying, though. Because in Japan being fake polite and feigning ignorance to the nastiness & porno of human life is… a way of life (that’s a compliment — fake polite is far better than honest rude).

But actually, whether a large segment of the youth truly don’t want to make sweet love, or do, it doesn’t change the fact that Japan’s going to be running out of people. Factor in a rising women’s liberation, the destigmatization of birth control, and perceived economic instability — who knows what the actual equation looks like, but the answer is a birthrate of 1.39. And in case it’s not obvious, a birthrate of at least 2 is a replacement set for the parents; a population at stasis. Ain’t happening.

So, at the end of the day, replacing the lost population with robots, thereby replacing a lost labor force and augmenting the consumer economy — well, seems like a decent enough course of action.

Three States of Robot Assimilation:
Hop on over to Akihabara News to have a look at the sharing, the wearing, and the caring: Dear Assistive Robot Industry, We Need You. Sincerely, Rapidly Aging Japan.

Lastly, you kinda have to wonder: in the macro, why don’t they want sex AND robots?
Japan, sometimes you so cray.

[YOUNG JAPANESE PEOPLE NOT INTERESTED IN GETTING IT ON — HUFF POST]


LEFT: Activelink Power Loader Light — RIGHT: The Latest HAL Suit

New Japanese Exoskeleton Pushing into HAL’s (potential) Marketshare
We of the robot/technology nerd demo are well aware of the non-ironically, ironically named HAL (Hybrid Assistive Limb) exoskeletal suit developed by Professor Yoshiyuki Sankai’s also totally not meta-ironically named Cyberdyne, Inc. Since its 2004 founding in Tsukuba City, just north of the Tokyo metro area, Cyberdyne has developed and iteratively refined the force-amplifying exoskeletal suit, and through the HAL FIT venture, they’ve also created a legs-only force resistance rehabilitation & training platform.

Joining HAL and a few similar projects here in Japan (notably Toyota’s & Honda’s) is Kansai based & Panasonic-owned Activelink’s new Power Loader Light (PLL). Activelink has developed various human force amplification systems since 2003, and this latest version of the Loader looks a lot less like its big brother the walking forklift, and a lot more like the bottom half & power pack of a HAL suit. Activelink intends to connect an upper body unit, and if successful, will become HAL’s only real competition here in Japan.
And for what?

Well, along with general human force amplification and/or rehab, this:


福島第一原子力発電所事故 — Fukushima Daiichi Nuclear Disaster Site

Fukushima Cleanup & Recovery: Heavy with High-Rads
As with Cyberdyne’s latest radiation shielded self-cooling HAL suit (the metallic gray model), Activelink’s PLL was ramped up after the 2011 Tohoku earthquake, tsunami, and resulting disaster at the Fukushima Daiichi Power Plant. Cleanup at the disaster area and responding to future incidents will of course require humans in heavy radiation suits with heavy tools possibly among heavy debris.While specific details on both exoskeletons’ recent upgrades and deployment timeline and/or capability are sparse, clearly the HAL suit and the PLL are conceptually ideal for the job. One assumes both will incorporate something like 20-30KG/45-65lbs. per limb of force amplification along with fully supporting the weight of the suit itself, and like HAL, PLL will have to work in a measure of radiological shielding and design consideration. So for now, HAL is clearly in the lead here.

Exoskeleton Competition Motivation Situation
Now, the HAL suit is widely known, widely deployed, and far and away the most successful of its kind ever made. No one else in Japan — in the world — is actually manufacturing and distributing powered exoskeletons at comparable scale. And that’s awesome and all due props to Professor Sankai and his team, but in taking stock of the HAL project’s 8 years of ongoing development, objectively one doesn’t see a whole lot of fundamental advancement. Sure, lifting capacity has increased incrementally and the size of the power source & overall bulk have decreased a bit. And yeah, no one else is doing what Cyberdyne’s doing, but that just might be the very reason why HAL seems to be treading water — and until recently, e.g., Activelink’s PLL, no one’s come along to offer up any kind of alternative.

Digressively Analogizing HAL with Japan & Vice-Versa Maybe
What follows is probably anecdotal, but probably right: See, Japanese economic and industrial institutions, while immensely powerful and historically cutting-edge, are also insular, proud — and weirdly — often glacially slow to innovate or embrace new technologies. With a lot of relatively happy workers doing excellent engineering with unmatched quality control and occasional leaps of innovation, Japan’s had a healthy electronics & general tech advantage for a good long time. Okay but now, thorough and integrated globalization has monkeywrenched the J-system, and while the Japanese might be just as good as ever, the world has caught up. For example, Korea’s big two — Samsung & LG — are now selling more TVs globally than all Japanese makers combined. Okay yeah, TVs ain’t robots, but across the board competition has arrived in a big way, and Japan’s tech & electronics industries are faltering and freaking out, and it’s illustrative of a wider socioeconomic issue. Cyberdyne, can you dig the parallel here?

Back to the Robot Stuff: Get on it, HAL/Japan — or Someone Else Will
A laundry list of robot/technology outlets, including Anthrobotic & IEEE, puzzled at how the first robots able to investigate at Fukushima were the American iRobot PackBots & Warriors. It really had to sting that in robot loving, automation saturated, theretofore 30% nuclear-powered Japan, there was no domestically produced device nimble enough and durable enough to investigate the facility without getting a radiation BBQ (the battle-tested PackBots & Warriors — no problem). So… ouch?

For now, HAL & Japan lead the exoskeletal pack, but with a quick look at Andra Keay’s survey piece over at Robohub it’s clear that HAL and the PLL are in a crowded and rapidly advancing field. So, if the U.S. or France or Germany or Korea or the Kiwis or whomever are first to produce a nimble, sufficiently powered, appropriately equipped, and ready-for-market & deployment human amplification platform, Japanese energy companies and government agencies and disaster response teams just might add those to cart instead. Without rapid and inspired development and improvement, HAL & Activelink, while perhaps remaining viable for Japan’s aging society industry, will be watching emergency response and cleanup teams at home with their handsome friend Asimo and his pet Aibo, wondering whatever happened to all the awesome, innovative, and world-leading Japanese robots.

It’ll all look so real on a 80-inch Samsung flat-panel HDTV.

Activelink Power Loader — Latest Model


Cyberdyne, Inc. HAL Suit — Latest Model
http://youtu.be/xwzYjcNXlFE

SOURCES & INFO & STUFF
[HAL SUIT UPGRADE FOR FUKUSHIMA — MEDGADGET]
[HAL RADIATION CONTAMINATION SUIT DETAILS — GIZMAG]
[ACTIVELINK POWER LOADER UPDATE — DIGINFO.TV]

[TOYOTA PERSONAL MOBILITY PROJECTS & ROBOT STUFF]
[HONDA STRIDE MANAGEMENT & ASSISTIVE DEVICE]

[iROBOT SENDING iROBOTS TO FUKUSHIMA — IEEE]
[MITSUBISHI NUCLEAR INSPECTION BOT]

For Fun:
[SKELETONICS — CRAZY HUMAN-POWERED PROJECT: JAPAN]
[KURATAS — EVEN CRAZIER PROJECT: JAPAN]

Note on Multimedia:
Main images were scraped from the above Diginfo.tv & AFPBBNEWS
YouTube videos, respectively. Because there just aren’t any decent stills
out there — what else is a pseudo-journalist of questionable competency to do?

This piece originally appeared at Anthrobotic.com on January 17, 2013.