FGF21 and Chronic Kidney Disease: https://www.sciencedirect.com/science/article/pii/S002604952100038X
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466591/
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21: https://pubmed.ncbi.nlm.nih.gov/18585098/
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877690/
Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression: https://pubmed.ncbi.nlm.nih.gov/31773901/
In the myofiber-specific model, they found that adding the Yamanaka factors accelerated muscle regeneration in mice by reducing the levels of a protein called Wnt4 in the niche, which in turn activated the satellite cells.
Salk research reveals clues about molecular changes underlying muscle loss tied to aging.
One of the many effects of aging is loss of muscle mass, which contributes to disability in older people. To counter this loss, scientists at the Salk Institute are studying ways to accelerate the regeneration of muscle tissue, using a combination of molecular compounds that are commonly used in stem-cell research.
In a study published on May 25, 2021, in Nature Communications, the investigators showed that using these compounds increased the regeneration of muscle cells in mice by activating the precursors of muscle cells, called myogenic progenitors. Although more work is needed before this approach can be applied in humans, the research provides insight into the underlying mechanisms related to muscle regeneration and growth and could one day help athletes as well as aging adults regenerate tissue more effectively.
As part of preparing for an experiment aboard the International Space Station, researchers explored new ways to culture living heart cells for microgravity research. They found that cryopreservation, a process of storing cells at-80°C, makes it easier to transport these cells to the orbiting lab, providing more flexibility in launch and operations schedules. The process could benefit other biological research in space and on Earth.
The investigation, MVP Cell-03, cultured heart precursor cells on the space station to study how microgravity affects the number of cells produced and how many of them survive. These precursor cells have potential for use in disease modeling, drug development, and regenerative medicine, such as using cultured heart cells to replenish those damaged or lost due to cardiac disease.
Previous studies suggest that culturing such cells in simulated microgravity increases the efficiency of their production. But using live cell cultures in space presents some unique challenges. The MVP Cell-03 experiment, for example, must be conducted within a specific timeframe, when the cells are at just the right stage. Flight changes and crew availability could lead to delays that affect the research.
Things to note: Treating the rats until they die. They are at 31 months and the longest they have lived without treatments is 38 months. Also, a small number of people have done this and though ailments like arthritis go away they still look elderly.
We recently had an update from Professor Rodolfo Goya who is conducting a follow up experiment from the one that Dr. Katcher first did in India, showing a rejuvenation in old rats. This video goes through the update that we had and provides a short introduction to the background.
Nicolas Chernavsky recently also did an interview with Didier Coeurnelle which discussed the update, which you can find here : https://youtu.be/GMNXjvXV268
Our earlier videos on the previous experiment and interview with Dr. Katcher are in this playlist https://www.youtube.com/playlist?list=PLkfzM7KJv6vaIQZ_n3WS6FHTpBtfS2lzw.
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Summary: Simple dietary changes and adopting lifestyle alterations, including improved sleep schedules, taking probiotics, and exercising, can reduce signs of biological aging by three years in just eight weeks, a new study reports.
Source: Impact Journals
A groundbreaking clinical trial shows we can reduce biological age (as measured by the Horvath 2013 DNAmAge clock) by more than three years in only eight weeks with diet and lifestyle through balancing DNA methylation.
A first-of-its-kind, peer-reviewed study provides scientific evidence that lifestyle and diet changes can deliver immediate and rapid reduction of our biological age. Since aging is the primary driver of chronic disease, this reduction has the power to help us live better, longer.
- Designed and led the TRIIM trial; Published the first report of thymus regeneration in a normal human; Granted patents on methods for and applications of human thymus regeneration. - Fellow of the American Aging Association. (since 2005), Former Director of the American Aging Association (16 years) - Editor-in-Chief, The Future of Aging: Pathways to Human Life Extension. - Awarded the Society for Cryobiology’s Luyet Medal in 2016. - In 2009, showed indefinite survival of rabbit kidney transplanted after cooling to-130°Celsius; Led 21CM team as co-winner of Small Mammal Brain Preservation Prize, 2018 winner of Large Mammal Brain Preservation Prize.
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Foresight Institute advances technologies for the long-term future of life, focusing on molecular machine nanotechnology, biotechnology, and computer science.
A study in ‘Nature Communications’ combines data from blood analyses and information about physical exercise to identify a new measure influencing “biological age.”
Senior director, milken institute center for the future of aging, milken institute; executive director, alliance to improve dementia care.
Nora Super is the Senior Director of the Milken Institute Center for the Future of Aging (CFA) (https://milkeninstitute.org/centers/center-for-the-future-of-aging) and the Executive Director of the Milken Institute Alliance to Improve Dementia Care (https://milkeninstitute.org/centers/center-for-the-future-of-aging/alliance-to-improve-dementia-care).
Mr. Super provides strategic direction for the two primary focus areas of CFA: Financial Wellness and Healthy Longevity, and oversees data-driven research, meaningful policy initiatives, and impactful convenings around the world.
Launched in 2020, the Alliance to Improve Dementia Care seeks to transform and improve the complex health and long-term care systems that people at risk for and living with dementia must navigate.
Ms. Super studied political science at Tulane University and completed her master’s degree in public administration, with a concentration in health policy, at George Washington University, and is a respected thought leader, frequent speaker, and prolific writer on healthy longevity and the economic and social impact of global population aging. In 2019, she authored two major reports: “Reducing the Cost and Risk of Dementia: Recommendations to Improve Brain Health and Decrease Disparities” and “Age-Forward Cities for 2030.”
Before joining the Milken Institute, Ms. Super held several key leadership roles in the public and private sectors. In 2014, President Barack Obama appointed Ms. Super Executive Director of the White House Conference on Aging, where she received wide recognition for her nationwide efforts to improve the lives of older Americans. In 2015, Ms. Super was recognized as one of America’s top 50 “Influencers in Aging” by PBS Next Avenue and was the Honoree for Outstanding Service to Medicare Beneficiaries by the Medicare Rights Center.
Ms. Super has also held leadership roles at the US Department of Health and Human Services, AARP, Kaiser Permanente, and the National Association of Area Agencies on Aging.
Ms. Super serves on several boards, including the Long-Term Quality Alliance, the Brain Health Partnership Advisory Board, the Bipartisan Policy Center’s Advisory Committee on Improving Care Delivery for Individuals with Serious Illness, the Better Medicare Alliance Beneficiary Education Technical Advisory Council, the Brookings Institution and Kellogg School of Management Retirement Security Advisory Board, Columbia University Medical Center’s Health and Aging Policy Fellows Program Steering Committee, Retirement Income Institute’s Scholars Advisory Group, and Gerontological Society of America’s Policy and Aging Report Editorial Board and Reframing Aging Initiative Advisory Board.
