Interesting as I recall Aubrey lamenting that he had met Bezos several times over the years but never got a dime from him. Also I wonder where he would put the cash. Just donor all h by is SENS? Pick a company like Age-x?
Jeff Bezos is said to get into the Longevity Industry next month according to Aubrey De Grey. Having a billionaire invest into finding a cure for aging is both amazing and worrisome. The field of longevity research was long underfunded but recently, with more and more results coming in, investors like Jeff Bezos are getting more and more interested in the field.
Last week, the most prominent figure in the longevity-research community, Aubrey The gray, has announced that one of the biggest event of this community will transpire in around a month. Previous investors were other tech entrepreneur like Peter Thiel or Googles Larry Page. – Every day is a day closer to the Technological Singularity. Experience Robots learning to walk & think, humans flying to Mars and us finally merging with technology itself. And as all of that happens, we at AI News cover the absolute cutting edge best technology inventions of Humanity.
If you enjoyed this video, please consider rating this video and subscribing to our channel for more frequent uploads. Thank you! smile – TIMESTAMPS: 00:00 A Secret Investor? 00:53 Aubrey De Grey Interview. 01:49 The History of Longevity Investors. 04:08 Why invest in Longevity Research. 06:49 Last Words. – #aubreydegrey #longevity #jeffbezos
Hey guys — you might like this interview I did with Alex Steele about counter-ageing and the quest for biological immortality (focused around his new book ‘Ageless: The New Science of Getting Old Without Getting Older’. If you do very grateful for any subs to help support the channel!
I speak with Andrew Steele; author, scientist and anti-ageing campaigner about his book Ageless: The New Science of Getting Old Without Getting Older”. Interview covers why humans age, the growing anti-ageing movement, scientific progress over the past decade and potential anti-ageing treatments.
You can buy Andrew’s book here: https://www.amazon.co.uk/Ageless-Science-Getting-Older-Without/dp/152660826X
The third episode of our podcast, ImmortaliCast, is now available! We interviewed Didier Coeurnelle, chair and co-founder of HEALES, and Marion Steenacker, biologist from HEALES, who updated us on the partial results from the lifespan experiments on rats conducted by Harold Katcher and Rodolfo Goya and funded by HEALES. Didier also discusses the more important trends in the rejuvenation field, and the other activities and goals of HEALES.
You can watch this episode via YouTube or on the main podcast platforms:
In this interview for the podcast ImmortaliCast, Didier Coeurnelle, chair and co-founder of HEALES (https://heales.org/), and Marion Steenacker, biologist from HEALES, update us on the partial results from the lifespan experiments on rats conducted by Harold Katcher and Rodolfo Goya and funded by HEALES (https://heales.org/2020/12/22/studies-financed-by-heales-effect-of-young-rat-plasma-on-the-lifespan-of-aging-rats-21-december-2020/). Didier also discusses the more important trends in the rejuvenation field, and the other activities and goals of HEALES.
The Fable of the Dragon-Tyrant: https://www.nickbostrom.com/fable/dragon.html.
Remnant Cholesterol and Atherosclerotic Cardiovascular Disease Risk: https://www.jacc.org/doi/10.1016/j.jacc.2020.10.
The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling: https://www.sciencedirect.com/science/article/pii/S0753332220309781
Joint distribution of lipoprotein cholesterol classes. The Framingham study: https://pubmed.ncbi.nlm.nih.gov/6573877/
Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS): https://pubmed.ncbi.nlm.nih.gov/20223457/
Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease: https://pubmed.ncbi.nlm.nih.gov/33272365/
Criticism of a recent video denouncing resveratrol.
Following Doctor Brad Stanfield’s latest ‘why I stopped video’, this last one about resveratrol and pterostilbene, many of you asked for my opinion, well here it is.
I hope you enjoy my content and find it interesting or informative, hopefully both, if so, please consider supporting the channel by signing up to the one you prefer:
*Buy me a Kofi: https://ko-fi.com/mynmnexperiment. *Patreon: https://bit.ly/3hhfjl5 *Subscribestar: https://bit.ly/3psYo23 So, I am not a Medical Doctor (MD) Like Dr. Brad Stanfield nor a PhD in the longevity field, I am not going to pick apart the medical content of the Dr. Brad Stanfield resveratrol video, I am just going to give you my opinion as a lay person. When I first saw the thumbnail, I was, like you I am sure was intrigued, this is the job of the thumbnail, many YouTube Gurus advice is to use your face and if possible, a shocked look, some can do this, I just can’t, Dr. Brad Stanfield can. After watching the video, I wasn’t overly concerned, the latest study was 8 months ago, if David Sinclair (or his family members) had said he was going to stop or reduce his intake of Resveratrol after taking it for more 10 years, then I definitely would have paid more attention to the Brad Stanfield video. Dr. Brad Stanfield gives a good Intro setting the scene, and he talks about a timeline, which is also something that I will use as a metric to possibly question the timing, the need and the agenda, hidden or otherwise for the third Dr. Brad Stanfield Resveratrol video. I am not sure why he has to apologise, he like most YouTubers in the longevity space just report on the facts, they don’t advise or make recommendations. On first sight this CRISP Resveratrol Report does seem damming, but the statement that Brad Stanfield makes that Resveratrol stresses the cell is in line with what David Sinclair says, he calls it hormesis, molecular stress and not mental stress is good. In his Intro Dr. Brad Stanfield talked about using a timeline, this trial was conducted in 2013 (8 years ago), if you didn’t pause the video and check the date you may be thinking this took place after the CRISPR resveratrol trial (the 2020 knockout blow that Brad Stanfield has already described). An MD getting caught up in opinion and hype that clouded his judgement, but the human medical studies that Dr. Brad Stanfield supported in his February 2020 resveratrol video weren’t opinion and hype they were human clinal studies posted on PubMed.gov (as Brad Stanfield says ‘what the good human clinical trials show’), if you use the same logic maybe the latest CRISPR resveratrol study is now just opinion and hype? I am not comfortable with people giving these kinds of apologies, especially when those people hold positions of authority and trust. I have read the comments and lots of people think this latest Dr. Brad Stanfield Resveratrol video has improved their opinion of him. Patreons’ generally pay for extra content, so Dr. Brad Stanfield Patreon offers extra advice to those who can afford it Dr. Brad Stanfield Patreon benefits are because all this content is behind a ‘pay wall.’ But you can see here that a $9 a month Dr. Brad Stanfield Patreon gets to ‘discuss the most cutting-edge research and help each other to achieve our goals.’ So, although all of the science was out there – good and bad, if he was mirroring his YouTube channel behind the Dr. Brad Stanfield Patreon Pay Wall, he was taking money for badly researched content. Maybe a refund for the Dr. Brad Stanfield Patreon $9 is in order? Brad Stanfield’s latest video from 09 May 2021 (the one that prompted this review) has no new information here at all, and if it did, why wasn’t this Knock-Out Blow video posted eight months ago following the CRISPR Resveratrol report, why did he wait until now? Dr. Brad Stanfield’s Resveratrol videos 1 to 7 (he has made 10 Resveratrol videos in total) are still up, if he thinks that Resveratrol is not effective, he should do the right thing and take them down, or will the loss in Ad revenue be too hard to take? Apologies and Words are fine, but if you fall short of the mark (which Dr. Brad Stanfield admits up until now he has), actions speak louder than words, remember the first reason to apologize is that the person ‘truly believe that they have done wrong/made a genuine mistake and will do everything in their power to it right.’ I think Dr. Brad’s Content in this video, as always was great, just passing on the information, but I just found the un-chronological timeline a little misleading and the sudden change in protocol, when there has been no new evidence for 8 months a little baffling. #DavidSinclair #BradStanfied #CheckWithYourDrFirst. DISCLAIMER: This video and description contain discount codes, which means that if you use the code, I will receive a small commission.
Humans are distinguished from other species by several aspects of cognition. While much comparative evolutionary neuroscience has focused on the neocortex, increasing recognition of the cerebellum’s role in cognition and motor processing has inspired considerable new research. Comparative molecular studies, however, generally continue to focus on the neocortex. We sought to characterize potential genetic regulatory traits distinguishing the human cerebellum by undertaking genome-wide epigenetic profiling of the lateral cerebellum, and compared this to the prefrontal cortex of humans, chimpanzees, and rhesus macaque monkeys. We found that humans showed greater differential CpG methylation–an epigenetic modification of DNA that can reflect past or present gene expression–in the cerebellum than the prefrontal cortex, highlighting the importance of this structure in human brain evolution. Humans also specifically show methylation differences at genes involved in neurodevelopment, neuroinflammation, synaptic plasticity, and lipid metabolism. These differences are relevant for understanding processes specific to humans, such as extensive plasticity, as well as pronounced and prevalent neurodegenerative conditions associated with aging.
Citation: Guevara EE, Hopkins WD, Hof PR, Ely JJ, Bradley BJ, Sherwood CC (2021) Comparative analysis reveals distinctive epigenetic features of the human cerebellum. PLoS Genet 17: e1009506. https://doi.org/10.1371/journal.pgen.
Editor: Takashi Gojobori, National Institute of Genetics, JAPAN.
While the mitochondrion has long fascinated biologists and the sheer diversity of druggable targets has made it attractive for potential drug development, there has been little success translatable to the clinic. Given the diversity of inborn errors of metabolism and mitochondrial diseases, mitochondrially mediated oxidative stress (myopathies, reperfusion injury, Parkinson’s disease, ageing) and the consequences of disturbed energetics (circulatory shock, diabetes, cancer), the potential for meaningful gain with novel drugs targeting mitochondrial mechanisms is huge both in terms of patient quality of life and health care costs. In this themed issue of the British Journal of Pharmacology, we highlight the key directions of the contemporary advances in the field of mitochondrial biology, emerging drug targets and new molecules which are close to clinical application. Authors’ contributions are diverse both in terms of species and organs in which the mitochondrially related studies are performed, and from the perspectives of mechanisms under study. Defined roles of mitochondria in disease are updated and previously unknown contributions to disease are described in terms of the interface between basic science and pathological relevance.
Getting older is a fact of life. As we age, we can grow bigger, smarter and stronger. But at a certain point, our bodies often start to slow down. The idea behind why we age and why our bodies slow down is that we start to lose the ability to make enough energy to support all the different functions that our body carries out.
Hazel H. Szeto, MD, PhD, is a medical doctor and a research scientist. She may have found the answer to reversing the aging process by restoring a person’s ability to make energy. Szeto presented her work last month at Experimental Biology 2021.
To better understand Szeto’s discovery, we must first understand how the body makes energy. We produce energy in the form of a small molecule called adenosine triphosphate, or ATP. When ATP is broken down, it releases energy that allows our bodies to do work, such as contracting the muscles in our arms and legs so we can lift a box. Mitochondria are small structures in the cells that make ATP from the food we eat.
