Join Aubrey de Grey and Vitalik Buterin on our fireside chat where they discuss and answer questions at the intersection of longevity and web3.
The AMA is hosted by VitaDAO — VitaDAO is the world’s first decentralized intellectual property collective.
Its mission is to extend the human lifespan by collectively financing and commercializing longevity therapeutics in an open and democratic manner.
VitaDAO and its members will own the intellectual property assets that result from the projects it supports. Members can contribute work or funds to join VitaDAO by purchasing or earning VITA tokens.
Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.
Human skin aging is a complex biological process, not yet fully understood. It is the result of two biologically independent processes. The first is intrinsic or innate aging, an unpreventable process, which affects the skin in the same pattern as it affects all internal organs. The second is extrinsic aging, which is the result of exposure to external factors, mainly ultraviolet (UV) irradiation, that is also referred to as photoaging.1 Intrinsic skin aging is influenced by hormonal changes that occur with age,2 such as the gradual decreased production of sex hormones from the mid-twenties and the diminution of estrogens and progesterone associated with menopause. It is well established that the deficiency in estrogens and androgens results in collagen degradation, dryness, loss of elasticity, epidermal atrophy and wrinkling of the skin.3
A clinical-stage leader in immune-stimulatory vaccines for cancer announced the publication of its favorable long-term Overall Survival (OS) data from a Phase I trial evaluating a universal cancer vaccine candidate, UV1, in combination with checkpoint inhibitor ipilimumab, in patients with metastatic malignant melanoma.
UV1 is a peptide-based vaccine inducing a specific T cell response against the universal cancer antigen telomerase.
Published in the Frontiers in Immunology journal on May 11, 2021, Norway-based Ultimovacs ASA’s UV1 vaccine candidate achieved the primary endpoints of safety and tolerability.
Paolo Garagnani and colleagues, in collaboration with several research groups in Italy and a research team led by Patrick Descombes at Nestlé Research in Lausanne, Switzerland, recruited 81 semi-supercentenarians (those aged 105 years or older) and supercentenarians (those aged 110 years or older) from across the Italian peninsula. They compared these with 36 healthy people matched from the same region who were an average age of 68 years old.
They took blood samples from all the participants and conducted whole-genome sequencing to look for differences in the genes between the older and younger group. They then cross-checked their new results with genetic data from another previously published study which analyzed 333 Italian people aged over 100 years old and 358 people aged around 60 years old.
Scientists at UC San Francisco are learning how immune cells naturally clear the body of defunct—or senescent—cells that contribute to aging and many chronic diseases. Understanding this process may open new ways of treating age-related chronic diseases with immunotherapy.
In a healthy state, these immune cells —known as invariant Natural Killer T (iNKT) cells—function as a surveillance system, eliminating cells the body senses as foreign, including senescent cells, which have irreparable DNA damage. But the iNKT cells become less active with age and other factors like obesity that contribute to chronic disease.
Finding ways to stimulate this natural surveillance system offers an alternative to senolytic therapies, which to date have been the primary approach to removing senescent cells. It could be a boon to a field that has struggled with how to systemically administer these senolytics without serious side effects.
We’ve updated our list of top longevity conferences and events for 2021, adding 4 new ones and removing 3 that are no longer happening:
Update 5/10/2021: This post has been updated since we originally published it in August 2020. Several new longevity conferences have been added and several which are no longer happening have been removed.
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Usually, when you approach a random stranger and immediately begin talking about things like DNA methylation rates and NAD+ precursors, you’re lucky if all you get is a weird look.
7:01 they talk about Church’s comments of ending aging by 2030. Also this appears to be a part one.
In this video Professor Church talks about his theory of aging and touches on his ideas on the future of aging.
George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book “Regenesis”.
George Church Links. Professor Church’s Lab at Harvard. https://arep.med.harvard.edu/
Professor Church’s Book on Amazon. Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves. https://amzn.to/3vTAVKo.
Twitter Link. https://twitter.com/geochurch. *********************************************************************************** If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan.
Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130883/
Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels: https://pubmed.ncbi.nlm.nih.gov/27567458/
Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study: https://pubmed.ncbi.nlm.nih.gov/7474221/
Total plasma homocysteine values among elderly subjects: findings from the Maracaibo Aging Study: https://pubmed.ncbi.nlm.nih.gov/16959233/
Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491750/
Excerpts from an interview with Dr. María Blasco, Director of the Spanish National Cancer Research Center (CNIO), where she covers how telomeres shortening induce aging, how artificially lenghtening telomeres has proven to extend lifespan in animal models like mice, and what the impact will be in human health and lifespan once the techniques (gene therapies) get effectively translated into humans.
The interview took place on May 6, 2021 as part of a program organized by the Madrid Planetarium, to contribute to a better orientation of the students of the last years of high school when deciding which university studies further engage.
The language used is not intended for an audience of scientists but rather accessible to all audiences.
The entire interview was made in Spanish but I ADDED S/T in ENGLISH FOR THE EXCERPTS SHOWN in this video.
In the description is the link to the entire interview which as I said was made in Spanish.
Extractos de entrevista realizada a la Dra. María Blasco, Directora del Centro Nacional de Investigaciones Oncológicas de España (CNIO). La entrevista tuvo lugar el día 06 de mayo del 2021 como parte de un programa organizado por el Planetario de Madrid, para contribuir a una mejor orientación de los estudiantes de los últimos cursos de bachillerato a la hora de decidir sus estudios universitarios. El lenguaje usado no es pensado en una audiencia de científicos sino más bien accesible para todo público. Para ver la entrevista completa hacer clic aquí: https://youtu.be/SDCk7yFSyqY
In English: Excerpts from an interview with Dr. María Blasco, Director of the Spanish National Cancer Research Center (CNIO). The interview took place on May 6, 2021 as part of a program organized by the Madrid Planetarium, to contribute to a better orientation of the students of the last years of high school when deciding their university studies. The language used is not intended for an audience of scientists but rather accessible to all audiences.
0:00 — Title. 0:35 — Into. 1:15 — Super People of The Future. 1:46 — Neal VanDeree ‘Living Long Healthy Lives Will be Possible’ — https://www.churchofperpetuallife.org/ — https://www.youtube.com/user/COPL18 3:24 — Dr. Bill Andrews ‘Super Wonderful Future’ — https://www.sierrasci.com/ 6:27 — Selim Bakırcı ‘1000 years long life’ 6:58 — Rodrigo Guinea ‘Great Responsibility’ — https://www.linkedin.com/in/rodguinea/ 9:22 — Significant Research. 9:40 — Significant Research — Liz Parrish — https://bioviva-science.com/ 10:44 — Significant Research — Brent Nally — https://longevityplan.net/ — https://www.linkedin.com/in/brentnally/ — https://www.youtube.com/user/BrentAltonNally. 13:10 — Significant Research — Cain Hillier — https://www.linkedin.com/in/cain-hillier-50571a18a/ 14:43 — Significant Research — Chris Curwen — https://www.linkedin.com/in/chris-curwen-67144b169/ 17:16 — The Threshold Times. 18:41 — The Threshold Times — Brent Nally. 21:35 — The Threshold Times — Chris Curwen 24:25 — The Threshold Times — Liz Parrish. 26:21 — The Threshold Times — Nicolas Chernavsky https://www.linkedin.com/in/nicolas-chernavsky-25265835/ — https://www.youtube.com/channel/UCUASjdn96BRlGVytmbDgRRA 27:00 — The Threshold Times — Josh Martin. 27:42 — The Threshold Times — Cain Hillier. 28:50 — The Threshold Times — Vikram Pandya — https://www.linkedin.com/in/vikrampandya/ 31:24 — Ageing Is a Disease. 32:49 — Ageing Is a Disease — Neal VanDeree. 34:09 — Ageing Is a Disease — Dr. Bill Andrews. 37:48 — Ageing Is a Disease — Liz Parrish. 39:28 — Ageing Is a Disease — Brent Nally. 42:10 — Ageing Is a Disease — Aaron King. 44:44 — Ageing Is a Disease — Lukas Vismantas — https://www.linkedin.com/in/lukas-vismantas/?originalSubdomain=dk. 46:07 — Ageing Is a Disease — Cain Hillier. 48:02 — Ageing Is a Disease — Chris Curwen. 50:23 — Ageing Is a Disease — Nicolas Chernavsky. 52:49 — The Big Times. 54:40 — The Big Times — Dr. Bill Andrews. 56:52 — The Big Times — Liz Parrish. 59:16 — The Big Times — Brent Nally. 01:03:50 — The Big Times — Nicholas Mohnacky — https://www.bundleiq.com/ — https://www.linkedin.com/in/mohnacky/ 01:05:00 — The Big Times — Bolek Kerous — https://www.linkedin.com/in/bolekkerous/ — https://www.youtube.com/channel/UCSpv8MA3xPskco9qdIBeNuQ 01:08:24 — The Big Times — Nicolas Chernavsky. 01:08:58 — The Big Times — Chris Curwen. 01:09:48 — The Big Times — Nicolas Chernavsky. 01:11:19 — The Big Times — Jeremy Rumble — https://www.linkedin.com/in/jeremy-rumble-42910b38/ 01:12:22 — The Big Times — Jakub Czubak — https://www.linkedin.com/in/jakub-czubak-603624a9/ 01:14:20 — The Big Times — Josh Martin. 01:14:50 — The Big Times — Nicolas Chernavsky. 01:20:15 — The Big Times — Brent Nally. 01:22:09 — Ending.
Omitting natural disasters like an asteroid smashing Earth or a volcano eruption we can say that improving human health and condition is the most important safety case/concern and the fundamental thing to consider and accomplish on our way to be super cosmic humanity. Significant health improvements will free us from all diseases, allow us to develop superhuman intelligence, let us totally self-realize, and consequently, help realize the infinity in the matter for the common good. However intensively we focus on intelligence, it is not possible to experience its natural consequence or the next level of its advancement/evolution if there is no good health. Coherent and consistent collective mind continuum experience is not possible without super health (Healthy life that is free from the danger of uncontrollable death). Our bodies are short-timed and not strong enough to hold up the Earth-Gravity-Geometry sized/adjusted thoughts that are necessary to naturally manage and effectively inhabit our planet.
Our lives often seem to be episodic where the memories and thoughts get lost — one might say that this is the matter of learning and perfecting the mind but this is as far from the truth as big is the number of people who struggle with having a comprehensive perspective, not because of the lack of will to do so but because of the lack of comfort of having good health and life conditions. The comfort of the living space we got ourselves on the planet after the ages of technological developments and evolution is not a direct effect of our intelligence — The main factor for human intelligence is common health. Weak wiring of the nervous system makes it difficult to communicate progress, and therefore, build with the big human intelligence. We need to constructively adjust our metabolic paths, understand and fix our cells, learn to touch and manipulate our DNA, improve internal signaling, and get super healthy if we want to use real great human intelligence to build a wonderful future. The house we can create on the fundaments of super long healthspans will be the first of its kind and magnitude — I hope to give a good vision of the new world in order to get the good motivation to proceed in life and actually get there.
