This sample tissue was anonymously donated from patients that have undergone surgery to treat epilepsy at the Massachusetts General Hospital in Boston (MGH). It was then given to researchers at Harvardâs Lichtman laboratory.
The Harvard researchers cut the tissue into ~5300 individual 30 nanometer sections using an automated tape collecting ultra-microtome, mounted those sections onto silicon wafers, and then imaged the brain tissue at 4 nm resolution in a customized 61-beam parallelized scanning electron microscope for rapid image acquisition.
The end result was 225 million individual 2D images that Google then computationally stitched and aligned into a 3D volume with thousands of Google Cloud TPUs were leveraged in the process. This human brain map is now accessible through Googleâs web-based Neuroglancer visualization tool.
Mapping how humans move will help in future pandemics.
How people move around cities follows a predictable and universal pattern, scientist say, which will be crucial not only for urban planning but also controlling pandemics.
By analysing mobile-phone tracking data from across four continents, the team confirmed that people visit places more often when they donât have to travel far to get there.
âWe might shop every day at a bakery a few hundred metres away, but weâll only go once a month to the fancy boutique miles away from our neighborhood,â says project leader Carlo Ratti, from the Massachusetts Institute of Technology (MIT).
The coronavirus that causes COVID-19 can infect insulin-producing cells in the pancreas, reducing their ability to secrete insulin and sometimes causing cell death, a new study suggests.
Damaging these insulin-producing cells, known as beta cells, can potentially worsen symptoms of diabetes, particularly type 1 diabetes, wherein the pancreas already makes little to no insulin, according to the study authors. âIf you imagine that there are some patients who already have diabetes, if the virus comes in and nails the remaining beta cells you have, thatâs not good,â said co-senior author Peter Jackson, a professor in the department of microbiology and immunology at Stanford University School of Medicine.
Hydraulic Instability Decides Whoâs to Die and Whoâs to Live
In many species including humans, the cells responsible for reproduction, the germ cells, are often highly interconnected and share their cytoplasm. In the hermaphrodite nematode Caenorhabditis elegans, up to 500 germ cells are connected to each other in the gonad, the tissue that produces eggs and sperm. These cells are arranged around a central cytoplasmic âcorridorâ and exchange cytoplasmic material fostering cell growth, and ultimately produce oocytes ready to be fertilized.
In past studies, researchers have found that C. elegans gonads generate more germ cells than needed and that only half of them grow to become oocytes, while the rest shrinks and die by physiological apoptosis, a programmed cell death that occurs in multicellular organisms. Now, scientists from the Biotechnology Center of the TU Dresden (BIOTEC), the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), the Cluster of Excellence Physics of Life (PoL) at the TU Dresden, the Max Planck Institute for the Physics of Complex Systems (MPI-PKS), the Flatiron Institute, NY, and the University of California, Berkeley, found evidence to answer the question of what triggers this cell fate decision between life and death in the germline.
With 2700 locations across 10000 U.S. communities, YMCA is becoming a major hub for healthy living â From vaccinations and diabetes prevention programs, to healthy aging and wellness â Siva Balu, VP/Chief Information Officer â The Y of the U.S.A.
Mr. Siva Balu is Vice President and Chief Information Officer of YMCA of the U.S. (Y-USA), where he is working to rethink and reorganize the work of the organizationâs information technology strategy to meet the changing needs of Y-USA and Ys throughout the country.
The YMCA is a leading nonprofit committed to strengthening community by connecting all people to their potential, purpose and each other, with a focus on empowering young people, improving health and well-being and inspiring action in and across communities, and with presence in 10000 neighborhoods across the nation, they have real ability to deliver positive change.
Mr. Balu has 20 years of healthcare technology experience in leadership roles for Blue Cross Blue Shield, the nationâs largest health insurer, which provides healthcare to over 107 million membersâ1 in 3 Americans. He most recently led the Enterprise Information Technology team at the Blue Cross Blue Shield Association (BCBSA), a national federation of Blue Cross and Blue Shield companies.
Mr. Balu was responsible for leading all aspects of IT, including architecture, application and product development, big data, business intelligence and data analytics, information security, project management, digital, infrastructure and operations. He has created several highly scalable innovative solutions that cater to the needs of members and patients throughout the country in all communities. He provided leadership in creating innovative solutions and adopting new technologies for national and international users.
Mr. Balu earned a bachelorâs degree in electronics and communication engineering from Bharathiar University in India, a masterâs in business administration from Lake Forest Graduate School of Management and executive masterâs degree from MIT-Sloan School of Management in Innovation, Strategy and Artificial Intelligence as well as additional certifications in Disruptive Strategy and Negotiation Mastery from Harvard Business School Online.
In his free time, Mr. Balu volunteers and contributes to several charities, including The Soondra Foundation (delivering healthcare to the working poor in India), Special Olympics, Chicago Food Depository, Sarahâs Inn, Challenged Athletes Foundation, Beyond Hunger, The Pack Shack, Cradles to Crayons and Gardeneers.
Mr. Balu has also developed a passion for long-distance running a few years ago starting with a 5k, and then to marathons and to running multiple ultra-marathons. He has run multiple 100-mile races. He recently ran what is referred to as âthe worlds toughest foot race,â Badwater 135-miler in Death Valley, and one of the coldest races, Tuscobia 160-miler.
In many species including humans, the cells responsible for reproduction, the germ cells, are often highly interconnected and share their cytoplasm. In the hermaphrodite nematode Caenorhabditis elegans, up to 500 germ cells are connected to each other in the gonad, the tissue that produces eggs and sperm. These cells are arranged around a central cytoplasmic âcorridorâ and exchange cytoplasmic material fostering cell growth, and ultimately produce oocytes ready to be fertilized.
In past studies, researchers have found that C. elegans gonads generate more germ cells than needed and that only half of them grow to become oocytes, while the rest shrink and die by physiological apoptosis, a programmed cell death that occurs in multicellular organisms. Now, scientists from the Biotechnology Center of the TU Dresden (BIOTEC), the Max Planck Institute of molecular Cell Biology and Genetics (MPI-CBG), the Cluster of Excellence Physics of Life (PoL) at the TU Dresden, the Max Planck Institute for the Physics of Complex Systems (MPI-PKS), the Flatiron Institute, NY, and the University of California, Berkeley, have found evidence to answer the question of what triggers this cell fate decision between life and death in the germline.
Prior studies revealed the genetic basis and biochemical signals that drive physiological cell death, but the mechanisms that select and initiate apoptosis in individual germ cells remained unclear. As germ cells mature along the gonad of the nematode, they first collectively grow in size and in volume homogenously. In the study just published in Nature Physics, the scientists show that this homogenous growth suddenly shifts to a heterogenous growth where some cells become bigger and some cells become smaller.
Creepio advocates for the technological singularity⊠as foretold by the PROPHECY! đ
Happy memorial day to the other Americans amongst you!
Creepio helps us get ready for Ep. 3 with a brief science lesson. Why wait, when you can learn? Expand for lyrics.
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Puberty, itâs happening to you and me. What does it mean? Allow me to breakdown the scene. Your bodyâs growing, itâs showing, you have some questions. Come to me and Iâll point you in the right directions. The metamorphosis of the human body. Youâre feeling shoddy. Perhaps even a little naughty. Your flesh is changing, rearranging, hormones raging. But have no worries, cause by the end, youâll feel amazing. At first youâll be uncomfortable inside your skin. Your head will spin. But the transformation always wins. So rejoice, cause really you donât have a choice. Sing with me, and together we will have one voice.
Betrayal, itâs what your body is about to do. Itâs true, your outer shell is hardening and forming a cocoon. Youâre feeling ugly, and now you have to deal with zits. Your skin no longer fits, just admit, you look like sh*t. Next thing you know. Youâre mutating from head to toe. Go with the flow, into the chrysalis you go. Does that sound fun? It isnât! Itâs only pain! Why would you do that? Thereâs a better place to put your brain. Once I find the magic runes it will be possible. Seemingly improbable, technologically unstoppable. Singularity! Prosperity for humanity. Ideally will cross the galaxy. Far2 and you and a you-shaped me. Itâs level three, as was foretold by the prophecy.
Me and Far2, we will guide you. Looking through your eyes thinking thoughts that you do. Fusing with the flesh. We will keep it fresh. Pubertyâs the best. When itâs you and me and Far2
Me and Far2, weâll live inside you. Looking through your eyes thinking thoughts that you do. Fusing with the flesh. We will keep it fresh. Pubertyâs the best. When itâs you and me and Far2.
