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As leaders of calorie restriction research and practice, Meredith Averill and I often participate in media events. A recent news conference covered rapidly evolving aspects of calorie restriction research that anyone could benefit from, whether they choose to follow a low-calorie lifestyle or not. Therefore, we thought it appropriate to share the details of the event with the Lifeboat Foundation audience.

The conference was hosted by the American Federation of Aging Research (AFAR). AFAR is a forward-looking organization that provides financial support for early- and mid-career scientists who are developing careers in the study of aging.

This conference, entitled “You are What you Don’t Eat!” presented two world-famous CR scientists, Drs. Luigi Fontana and Donald Ingram. After an introduction from AFAR’s board member, Dr. Jack Watters, both scientists shared many profound insights that could extend healthy lifespan for millions of people.

Dr. Fontana first reminded us how important calorie restriction research is for the health and financial viability of the health care system: “Cardiovascular disease (CVD), cancer, stroke and diabetes account for nearly 70% of the deaths in the United States and Europe. About 80% of adults over 65 years of age have at least one chronic disease, and 50% have two or more of these chronic diseases that accelerate the aging process1 .” The point he makes is that health care systems, especially with our rapidly aging population cannot sustain this large number of people with disease.

Meanwhile, his CR studies – many done in conjunction with the CR Society Intl. – show that those following a serious CR diet exhibit less risk of cardiovascular disease, cancer, stroke, and diabetes – all chronic diseases that people in Western societies are so prone to. Drawing parallels with animal studies, Fontana points out that CR mice are found to live much longer and in better health. When they die, autopsies show no sign of a chronic condition. Dr. Fontana says the same is possible for people. He hailed the healthiest old people as “escapers:” people who live to 100 and contract no chronic disease.

Against that backdrop, Dr. Fontana explained that his human CR studies have looked carefully at various markers in human calorie restrictors – T3, IGF-I, insulin, glucose, correlating them to successful CR, established in animal studies. This has given him a battery of indicators that can used by anyone to judge the effectiveness of a CR regimen. These are the core of the CR Way biomarkers that we recommend for testing and tracking by anyone following a CR diet. Fontana’s presentation underlines the reality that living free of chronic disease is attainable for humans.

Dr. Ingram presented valuable research results. He discussed many aspects of his productive CR research career, including his search for a CR mimetic. He has looked at some well known candidates such at Metformin (producing no difference in life span extension in his studies), 2 d-oxyglucose, (proving to be unusable because of dangerous side effects in the heart). And a promising possibility: avocado-derived mannoheptulose. Highly recommended by The CR Way, avocados have a profound glucose/insulin-lowering effect, according to Dr. Ingram. He attributes this to mannoheptulose, a sugar that’s rare in the human diet and that reduces glycolysis via hexokinase inhibition.

Bioavailability of avocado-derived mannoheptulose in dogs

Gary Davenport1, Stefan Massimino1, Michael Hayek1, Michael Ceddia1, John Burr1, Chyon-Hwa Yeh1, Lijuan Li1, George Roth2 and Donald Ingram3

1 Procter & Gamble, Lewisburg, OH
2 Geroscience, Pylesville, MD
3 Pennington Biomedical Research Center, Baton Rouge, LA

The FASEB Journal: The Journal of the Federation of the Societies for Experimental Biology, now on their Web site: http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/725.3, accessed April 1, 2011

Mannoheptulose (MH) is a 7-carbon sugar found in avocados and other natural sources that acts to reduce glycolysis via hexokinase inhibition. It has been proposed as a calorie restriction (CR) mimetic that delivers anti-aging and health-promoting benefits of CR without reducing food intake. Three studies were conducted to evaluate MH bioavailability when fed to dogs as an avocado extract (AvX) based on MH levels in urine (Study 1) and plasma (Study 2 & 3). In Study 1, Labrador Retrievers (LR; n=15) and Fox Terriers (n=15) were fed AvX-containing diets formulated to deliver 0, 2 or 5 mg MH/kg BW. All dogs were subjected to 24-hour quantitative urine collections. A dose-dependent increase (p<0.05) in urinary MH occurred with increasing dietary MH. In Study 2, LR (n=6) were fed AvX-containing diets once daily to deliver 0, 1 or 2 mg MH/kg BW. Sequential blood samples were collected before and after feeding through 12 hr and at 24-hr post-feeding. Plasma MH increased (P<0.05) with both MH diets compared to control. Peak MH occurred 6–8 hr post-feeding and returned to non-detectable levels by 24 hr. In Study 3, similar MH results were observed for LR (n=10) fed AvX-containing diets twice daily to provide 0 or 2 mg MH/kg BW. Peak MH occurred within 2–4 hr of MH consumption and returned to non-detectable levels by 24 hr.

Mannoheptulose, fed as an avocado extract, is biologically available in dogs based on its appearance in plasma and urine.

Dr. Ingram shared some additional successful research2 on the neuroprotective effects of blueberries. He and his colleagues found that mice that were injected with a blueberry extract were protected against neurodegeneration induced by a toxic substance.

The growing interest in phytonutrients for health and longevity was reinforced by Dr. Fontana, who reported a current experiment gauging the effects of a cocktail of polyphenol extracts.

_______________

On behalf of everyone interested in longevity, we asked the scientists to tell us where they think the next important areas of their research should be. Dr. Fontana wants to turn his attention to CR and cancer, noting that many unknowns continue to make preventing cancer’s occurrence – even predicting its likelihood – difficult. He reminded us that “cancer is the second leading cause of death in many developed countries,” accounting for approximately one-fourth of all deaths. Among women, aged 40 to 79, and among men aged, 60 to 79, cancer is the leading cause of death in the U.S. The lifetime probability of developing cancer is 46% for men and 38% for women2 . Furthermore, many of the processes of cancer mirror processes of aging, so this research will do double duty.

Dr. Fontana believes that by looking at CR, which has been shown to reduce cancer incidence and rate of metastasis in animal and human studies3, better ways will be found to predict the likelihood of cancer as well as to prevent it.

This line of study will also help determine potential aging markers, a recurring theme for both presenters. Dr. Ingram declared in his answer to our question: Rate-of- aging markers need to be established and validated. Future projects need to focus on this work. Further, he called on the gerontological community to work hard on building consensus on these biomarkers, so that they can be used by researchers, healthcare professionals, and longevists.

We are heartened to know that forward-thinking organizations like AFAR are facilitating the work of talented scientists who will likely make it possible ultimately for all to live in good health longer.

The hope of the CR Society Intl. and The CR Way is that the work of these scientists will be fully appreciated and that government and other funders will respond with the support that is needed to pursue research that helps us all live longer, disease-free lives and ultimately makes a big difference in the financial viability of health care.

Thanks to the Lifeboat Foundation for inviting me to share this information.

Paul McGlothin,

Vice President Research, The CR Society International

Co-author, The CR Way

Executive Director, The CR Way Longevity Center

[email protected]

___________

1 Modulating Human Aging and Age-Associated Diseases

Luigi Fontana, M.D., Ph.D.

Biochimica Biophysica Acta. 2009 Oct;1790(10):1133–8. Epub 2009 Feb 10.

Population aging is progressing rapidly in many industrialized countries. The United States population aged 65 and over is expected to double in size within the next 25 years. In sedentary people eating Western diets aging is associated with the development of serious chronic diseases, including type 2 diabetes mellitus, cancer and cardiovascular diseases. About 80 percent of adults over 65 years of age have at least one chronic disease, and 50 percent have at least two chronic diseases. These chronic diseases are the most important cause of illness and mortality burden, and they have become the leading driver of health care costs, constituting an important burden for our society.

Data from epidemiological studies and clinical trials indicate that many age-associated chronic diseases can be prevented, and even reversed, with the implementation of healthy lifestyle interventions. Several recent studies suggest that more drastic interventions (i.e. calorie restriction without malnutrition and moderate protein restriction with adequate nutrition) may have additional beneficial effects on several metabolic and hormonal factors that are implicated in the biology of aging itself. Additional studies are needed to understand the complex interactions of factors that regulate aging and age-associated chronic disease.

PMID: 19364477

2A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats.

Duffy KB, Spangler EL, Devan BD, Guo Z, Bowker JL, Janas AM, Hagepanos A, Minor RK, DeCabo R, Mouton PR, Shukitt-Hale B, Joseph JA, Ingram DK.

Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

Neurobiology of Aging. 2008 Nov;29(11):1680–9. Epub 2007 May 23.

Young male Fischer-344 rats were fed a diet containing 2% blueberry (BB) extract or control diet for at least 8 weeks and then received bilateral hippocampal injections of kainic acid (KA 200 ng/0.5 microl) or phosphate buffered saline (PBS). One week later rats were trained in one-way active footshock avoidance in a straight runway followed the next day by training in a footshock motivated 14-unit T-maze with documented sensitivity to hippocampal glutamatergic manipulations. Based on analyses of several performance variables, KA-treated rats exhibited clearly impaired learning performance; however, the BB diet significantly reduced this impairment. Supporting the behavioral findings, stereological assessment of CA1 pyramidal neurons documented greater neuronal loss in KA-treated controls compared to KA-treated rats on the BB diet.

In an in vitro experiment, FaO cells grown in medium supplemented with serum from BB-fed rats had enhanced viability after exposure to hydrogen peroxide. These findings suggest that BB supplementation may protect against neurodegeneration and cognitive impairment mediated by excitotoxicity and oxidative stress.

3 Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research.
Hursting SD, Smith SM, Lashinger LM, Harvey AE, Perkins SN.
Carcinogenesis. 2010 Jan;31(1):83–9. Epub 2009 Dec 7.

Calorie restriction (CR) is arguably the most potent, broadly acting dietary regimen for suppressing the carcinogenesis process, and many of the key studies in this field have been published in Carcinogenesis. Translation of the knowledge gained from CR research in animal models to cancer prevention strategies in humans is urgently needed given the worldwide obesity epidemic and the established link between obesity and increased risk of many cancers.

PMID: 19969554

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A (Relatively) Brief Introduction to The Principles of Economics & Evolution: A Survival Guide for the Inhabitants of Small Islands, Including the Inhabitants of the Small Island of Earth

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(NOTE: Selecting the “Switch to White” button on the upper right-hand corner of the screen may ease reading this text).

“Who are you?” A simple question sometimes requires a complex answer. When a Homeric hero is asked who he is.., his answer consists of more than just his name; he provides a list of his ancestors. The history of his family is an essential constituent of his identity. When the city of Aphrodisias… decided to honor a prominent citizen with a public funeral…, the decree in his honor identified him in the following manner:

Hermogenes, son of Hephaistion, the so-called Theodotos, one of the first and most illustrious citizens, a man who has as his ancestors men among the greatest and among those who built together the community and have lived in virtue, love of glory, many promises of benefactions, and the most beautiful deeds for the fatherland; a man who has been himself good and virtuous, a lover of the fatherland, a constructor, a benefactor of the polis, and a savior.
– Angelos Chaniotis, In Search of an Identity: European Discourses and Ancient Paradigms, 2010

I realize many may not have the time to read all of this post — let alone the treatise it introduces — so for those with just a few minutes to spare, consider abandoning the remainder of this introduction and spending a few moments with a brief narrative which distills the very essence of the problem at hand: On the Origin of Mass Extinctions: Darwin’s Nontrivial Error.

But for those with the time and inclinations for long and windy paths through the woods, please allow me to introduce myself: I was born and raised in Kentland, Indiana, a few blocks from the train station where my great-great grandfather, Barney Funk, arrived from Germany, on Christmas day of 1859. I completed a BSc in Entrepreneurship and an MFA in film at USC, and an MA in Island Studies at UPEI. I am a naturalist, Fellow of The Linnean Society of London, PhD candidate in economics at the University of Malta, hunter & fisherman, NRA member, protective father, and devoted husband with a long, long line of illustrious ancestors, a loving mother & father, extraordinary brothers & sister, wonderful wife, beautiful son & daughter, courageous cousins, and fantastic aunts, uncles, in-laws, colleagues, and fabulous friends!

Thus my answer to the simple question, “Who are you?” requires a somewhat complex answer as well.

But time is short and I am well-positioned to simplify because all of the hats I wear fall under a single umbrella: I am a friend of the Lifeboat Foundation (where I am honoured to serve on the Human Trajectories, Economics, Finance, and Diplomacy Advisory Boards), a foundation “dedicated to encouraging scientific advancements while helping humanity survive existential risks.”

Almost everything I do – including the roles, associations, and relationships noted above, supports this mission.

It’s been nearly a year since Eric generously publish Principles of Economics & Evolution: A Survival Guide for the Inhabitants of Small Islands, Including the Inhabitants of the Small Island of Earth, and since that time I have been fortunate to receive many interesting and insightful emails packed full of comments and questions; thus I would like to take this opportunity to introduce this work – which represents three years of research.

Those interested in taking the plunge and downloading the file above may note that this discourse

tables an evolutionarily stable strategy for the problem of sustainable economic development – on islands and island-like planets (such as Earth), alike, and thus this treatise yields, in essence, a long-term survival guide for the inhabitants of Earth.

Thus you may expect a rather long, complex discourse.

This is indeed what you may find – a 121 page synthesis, including this 1,233 page Digital Supplement.

As Nassim Nicholas Taleb remarked in Fooled by Randomness:

I do not dispute that arguments should be simplified to their maximum potential; but people often confuse complex ideas that cannot be simplified into a media-friendly statement as symptomatic of a confused mind. MBAs learn the concept of clarity and simplicity—the five-minute manager take on things. The concept may apply to the business plan for a fertilizer plant, but not to highly probabilistic arguments—which is the reason I have anecdotal evidence in my business that MBAs tend to blow up in financial markets, as they are trained to simplify matters a couple of steps beyond their requirement.

But there is indeed a short-cut — in fact, there are at least two short-cuts.

First, perhaps the most direct pleasant approach to the summit is a condensed, 237 page thesis: On the Problem of Sustainable Economic Development: A Game-Theoretical Solution.

But for those pressed for time and/or those merely interested in sampling a few short, foundational works (perhaps to see if you’re interested in following me down the rabbit hole), the entire theoretical content of this 1,354-page report (report + digital supplement) may be gleamed from 5 of the 23 works included within the digital supplement. These working papers and publications are also freely available from the links below – I’ll briefly relate how these key puzzle pieces fit together:

The first publication offers a 13-page over-view of our “problem situation”: On the Origin of Mass Extinctions: Darwin’s Nontrivial Error.

Second is a 21-page game-theoretical development which frames the problem of sustainable economic development in the light of evolution – perhaps 70% of our theoretical content lies here: On the Truly Noncooperative Game of Life on Earth: In Search of the Unity of Nature & Evolutionary Stable Strategy.

Next comes a 113-page gem which attempts to capture the spirit and essence of comparative island studies, a course charted by Alexander von Humboldt and followed by every great naturalist since (of which, more to follow). This is an open letter to the Fellows of the Linnean Society of London, a comparative study of two, diametrically opposed economic development plans, both put into action in that fateful year of 1968 — one on Prince Edward Island, the other on Mustique. This exhaustive work also holds the remainder of the foundation for our complete solution to this global dilemma – and best of all, those fairly well-versed in game theory need not read it all, the core solution may be quickly digested on pages 25–51:
On the Truly Noncooperative Game of Island Life: Introducing a Unified Theory of Value & Evolutionary Stable ‘Island’ Economic Development Strategy.

Fourth comes an optional, 19-page exploration that presents a theoretical development also derived and illuminated through comparative island study (including a mini-discourse on methods). UPEI Island Studies Programme readers with the time and inclination for only one relatively short piece, this may be the one to explore. And, despite the fact that this work supports the theoretical content linked above, it’s optional because there’s nothing new here – in fact, these truths have been well known and meticulously documented for over 1,000 years – but it may prove to be a worthwhile, engaging, and interesting read nonetheless, because these truths have become so unfashionable that they’ve slipped back into relative obscurity: On the Problem of Economic Power: Lessons from the Natural History of the Hawaiian Archipelago.

And finally I’ll highlight another optional, brief communique – although this argument may be hopelessly compressed, here, in 3 pages, is my entire solution:
Truly Non-Cooperative Games: A Unified Theory.

Yes, Lifeboat Foundation family and friends, you may wish to pause to review the abstracts to these core, foundational works, or you may even wish to review them completely and put the puzzle pieces together yourself (the pages linked above total 169 – or a mere 82 pages if you stick to the core excerpt highlighted in my Linnean Letter), but, as the great American novelist Henry Miller remarked:

In this age, which believes that there is a short cut to everything, the greatest lesson to be learned is that the most difficult way is, in the long run, the easiest.

Why?

That’s yet another great, simple question that may require several complex answers, but I’ll give you three:

#1). First and foremost, because explaining is a difficult art.

As Richard Dawkins duly noted:

Explaining is a difficult art. You can explain something so that your reader understands the words; and you can explain something so that the reader feels it in the marrow of his bones. To do the latter, it sometimes isn’t enough to lay the evidence before the reader in a dispassionate way. You have to become an advocate and use the tricks of the advocate’s trade.

Of course much of this depends upon the reader – naturally some readers may find that less (explanation) is more. Others, however, may find benefit from reading even more (more, that is, than my report and the digital supplement). You may find suggested preliminary and complimentary texts in the SELECTED BIBLIOGRAPHY (below). The report itself includes these and many more. In short, the more familiar readers may be with some or all of these works, the less explaining they may require.

#2). No matter how much explaining you do, it’s actually never enough, and, as Abraham Lincoln wisely noted at Gettysburg, the work is never done. For more one this important point, let’s consider the words of Karl Popper:

When we propose a theory, or try to understand a theory, we also propose, or try to understand, its logical implications; that is, all those statements which follow from it. But this… is a hopeless task: there is an infinity of unforeseeable nontrivial statements belonging to the informative content of any theory, and an exactly corresponding infinity of statements belonging to its logical content. We can therefore never know or understand all the implications of any theory, or its full significance.
This, I think, is a surprising result as far as it concerns logical content; though for informative content it turns out to be rather natural…. It shows, among other things, that understanding a theory is always an infinite task, and that theories can in principle be understood better and better. It also shows that, if we wish to understand a theory better, what we have to do first is to discover its logical relation to those existing problems and existing theories which constitute what we may call the ‘problem situation’.
Admittedly, we also try to look ahead: we try to discover new problems raised by our theory. But the task is infinite, and can never be completed.

In fact, when it comes right down to it, my treatise – in fact, my entire body of research, is, in reality, merely an exploration of the “infinity of unforeseeable nontrivial statements belonging to the informative content” of the theory for which Sir Karl Popper is famous: his solution to David Hume’s problem of induction (of which you’ll hear a great deal if you brave the perilous seas of thought in the works introduced and linked herewith).

#3). Okay, this is a tricky one, but here it goes: Fine, a reasonable skeptic may counter, I get it, it’s hard to explain and there’s a lot of explaining to do – but if 100% of the theoretical content may be extracted from less than 200 pages, then doesn’t that mean you could cut about 1,000 pages?

My answer?

Maybe.

But then again, maybe not.

The reality of the situation is this: neither I nor anyone else can say for sure – this is known as the mind-body problem. In essence, given the mind-body problem, not only am I unable to know exactly how to explain something I know, moreover, I’m not even able to know how it is that I know what I know. I’m merely able to guess. Although this brief introduction is not the proper time nor place to explore the contents of this iteration of Pandora’s Box, those interested in a thorough exploration of this particular problem situation would be well-served with F.A. von Hayek’s The Sensory Order: An Inquiry into the Foundations of Theoretical Psychology (1952). But, in short, the bulk of the Digital Supplement and much of the report itself is merely an attempt to combat the mind-body problem – an attempt to put down as much of the history (and methodology) of this theoretical development as possible. As Descartes remarked at the outset of a treatise on scientific method:

This Tract is put forth merely as a history, or, if you will, as a tale, in which, amid some examples worthy of imitation, there will be found, perhaps, as many more which it were advisable not to follow, I hope it will prove useful to some without being hurtful to any, and that my openness will find some favor with all.

Perhaps you may grasp my theoretical development – but perhaps you may grasp it in a matter by which I did not intend for you to grasp it – perhaps I had stumbled upon a truth in another work within my digital supplement that may make it all clear. Or, perhaps I’ve got it all wrong, and perhaps you – by following in my footsteps through the historical course of this theoretical development (faithfully chronicled in the digital supplement) – may be able to help show me my error (and then, of course we may both rejoice); Malthus felt likewise:

If [the author] should succeed in drawing the attention of more able men to what he conceives to be the principal difficulty in… society and should, in consequence, see this difficulty removed, even in theory, he will gladly retract his present opinions and rejoice in a conviction of his error.

Anticipating another point regarding style: This report is very, very unusual insofar as style is concerned. It’s personal, highly opinionated, and indulges artistic license at almost every turn in the road. In fact, you may also find this narrative a touch artistic – yet it’s all true. As Norman Maclean remarked in A River Runs Trough It, “You like to tell true stories, don’t you?’ he asked, and I answered, ‘Yes, I like to tell stories that are true.’”

I like to tell stories that are true, too, and if you like to read them, then this epic journey of discovery may be for you. I speak to this point at length, but, in short, I submit that there is a method to the madness (in fact, the entire report may also be regarded as an unusual discourse on method).

Why have I synthesized this important theoretical development in an artistic narrative? In part, because Bruno Frey (2002) clearly stated why that’s the way it should be.

But I also did so in hopes that it may help readers grasp what it’s really all about; as the great Russian-American novelist Ayn Rand detailed:

Man’s profound need of art lies in the fact that his cognitive faculty is conceptual, i.e., that he acquires knowledge by means of abstractions, and needs the power to bring his widest metaphysical abstractions into his immediate, perceptual awareness. Art fulfills this need: by means of a selective re-creation, it concretizes man’s fundamental view of himself and of existence. It tells man, in effect, which aspects of his experience are to be regarded as essential, significant, important. In this sense, art teaches man how to use his consciousness.

Speaking of scientific method: I have suggested that my curiously creative narrative may offer some insight into the non-existent subject of scientific method — so please download for much more along these lines — but I want to offer an important note, especially for colleagues, friends, students, and faculty at UPEI: I sat in on a lecture last winter where I was surprised to learn that “island studies” had been recently invented by Canada research chair – thus I thought perhaps I should offer a correction and suggest where island studies really began:

Although it is somewhat well known that Darwin and Wallace pieced the theory of evolution together independently, yet at roughly the same time – Wallace, during his travels through the Malay archipelago, and Darwin, during his grand circumnavigation of the island of Earth onboard the Beagle (yes, the Galapagos archipelago played a key role, but perhaps not as important as has been suggested in the past). But what is not as commonly know is that both Darwin and Wallace had the same instructor in the art of comparative island studies. Indeed, Darwin and Wallace both traveled with identical copies of the same, treasured book: Alexander von Humboldt’s Personal Narrative of Travels to the Equinoctial Regions of the New Continent. Both also testified to the fundamental role von Humboldt played by inspiring their travels and, moreover, developing of their theories.

Thus, I submit that island studies may have been born with the publication of this monumental work in 1814; or perhaps, as Berry (2009) chronicled in Hooker and Islands (see SELECTED BIBLIOGRAPHY, below), it may have been Thomas Pennant or Georg Forster:

George Low of Orkney provided, together with Gilbert White, a significant part of the biological information used by pioneering travel writer Thomas Pennant, who was a correspondent of both Joseph Banks and Linnaeus [Pennant dedicated his Tour in Scotland and Voyage to the Hebrides (1774–76) to Banks and published Banks’s description of Staffa, which excited much interest in islands; Banks had travelled with James Cook and visited many islands; Georg Forster, who followed Banks as naturalist on Cook’s second voyage inspired Alexander Humboldt, who in turn Darwin treated as a model.

But whomever it may have been — or whomever you may ultimately choose to follow — Humboldt certainly towers over the pages of natural history, and Gerard Helferich’s Humboldt’s Cosmo’s: Alexander von Humboldt and the Latin American Journey that Changed the WayWe See the World (2004) tells Humboldt’s story incredibly well. This treasure also happens to capture the essence of Humboldt’s method, Darwin’s method, Wallace’s method, Mayr’s method, Gould’s method, and it most certainly lays out the map I have attempted to follow:

Instead of trying to pigeonhole the natural world into prescribed classification, Kant had argued, scientists should work to discover the underlying scientific principles at work, since only those general tenets could fully explain the myriad natural phenomena. Thus Kant had extended the unifying tradition of Thales, Newton, Descartes, et al.… Humboldt agreed with Kant that a different approach to science was needed, one that could account for the harmony of nature… The scientific community, despite prodigious discoveries, seemed to have forgotten the Greek vision of nature as an integrated whole.… ‘Rather than discover new, isolated facts I preferred linking already known ones together,’ Humboldt later wrote. Science could only advance ‘by bringing together all the phenomena and creations which the earth has to offer. In this great sequence of cause and effect, nothing can be considered in isolation.’ It is in this underlying connectedness that the genuine mysteries of nature would be found. This was the deeper truth that Humboldt planned to lay bare – a new paradigm from a New World. For only through travel, despite its accompanying risks, could a naturalist make the diverse observations necessary to advance science beyond dogma and conjecture. Although nature operated as a cohesive system, the world was also organized into distinct regions whose unique character was the result of all the interlocking forces at work in that particular place. To uncover the unity of nature, one must study the various regions of the world, comparing and contrasting the natural processes at work in each. The scientist, in other words, must become an explorer.

With these beautiful words in mind and the spirit of adventure in the heart, I thank you for listening to this long story about an even longer story, please allow me to be your guide through an epic adventure.

But for now, in closing, I’d like to briefly return to the topic at hand: human survival on Earth.

A few days ago, Frenchman Alain Robert climbed the world’s tallest building – Burj Khalifa – in Dubai.

After the six hour climb, Robert told Gulf News, “My biggest fear is to waste my time on earth.”

I certainly share Robert’s fear – Alexander von Humboldt, Darwin, and Wallace did, too, by the way.

But then Robert added, “To live, we don’t need much, just a roof over our heads some food and drink and that’s it … everything else is superficial.”

I’m afraid that’s where Robert and I part ways – and if you would kindly join me on a journey through The Principles of Economics & Evolution: A Survival Guide for the Inhabitants of Small Islands, Including the Inhabitants of the Small Island of Earth – I would love to explain why Robert’s assertion is simply not true.

Please feel free to post comments or contact me with any thoughts, comments, questions, or suggestions.

MWF
Charlottetown, Prince Edward Island

PS: My report suggests many preliminary and complimentary readings – but I’ve revisited this topic with the aim of producing a selected bibliography of the most condensed and readily accessible (i.e, freely available online) works which may help prepare the reader for my report and the foundational theoretical discourses noted and linked above. Most are short papers, but a few great books and dandy dissertations may be necessary as well!

SELECTED BIBLIOGRAPHY

BERRY, R. (2009). Hooker and islands. Bio Journal Linn Soc 96:462–481.

DARWIN, C., WALLACE, A. (1858). On the Tendency of Species to form Varieties; and on the Perpetuation of Varieties and Species by Natural Means of Selection. Proc Linn Soc 3:45–62.

DARWIN, C., et. al. (1849). A Manual of Scientific Enquiry; Prepared for the use of Her Majesty’s Navy : and Adapted for Travellers in General (Murray, London).

DOBZHANSK Y, T. (1973). Nothing in biology makes sense except in light of evolution. Amer Biol Teacher 35:125- 129.

EINSTEIN, A. (1920). Relativity: The Special and General Theory (Methuen & Co., London).

FIELDING, R. (2010). Artisanal Whaling in the Atlantic: A Comparative Study of Culture, Conflict, and Conservation in St. Vincent and the Faroe Islands. A PhD dissertation (Louisiana State University, Baton Rouge).

FREY, B. (2002). Publishing as Prostitution? Choosing Between One‘s Own Ideas and Academic Failure. Pub Choice 116:205–223.

FUNK, M. (2010a). Truly Non-Cooperative Games: A Unified Theory. MPRA 22775:1–3.

FUNK, M. (2008). On the Truly Noncooperative Game of Life on Earth: In Search of the Unity of Nature & Evolutionary Stable Strategy. MPRA 17280:1–21.

FUNK, M. (2009a). On the Origin of Mass Extinctions: Darwin’s Nontrivial Error. MPRA 20193:1–13.

FUNK, M. (2009b). On the Truly Noncooperative Game of Island Life: Introducing a Unified Theory of Value & Evolutionary Stable ‘Island’ Economic Development Strategy. MPRA 19049:1–113.

FUNK, M. (2009c). On the Problem of Economic Power: Lessons from the Natural History of the Hawaiian Archipelago. MPRA 19371:1–19.

HELFERICH, G. (2004). Humboldt’s Cosmo’s: Alexander von Humboldt and the Latin American Journey that Changed the Way We See the World (Gotham Books, New York).

HOLT, C., ROTH, A. (2004). The Nash equilibrium: A perspective. Proc Natl Acad Sci USA 101:3999–4000.

HAYEK, F. (1974). The Pretense of Knowledge. Nobel Memorial Lecture, 11 December 1974. 1989 reprint. Amer Econ Rev 79:3–7.

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The field of life extension is broad and ranges from regenerative medicine to disease prevention by nutritional supplements and phytomedicine. Although the relevance of longevity and disease prevention to existential risks is less apparent than the prevention of large-scale catastrophic scenarios, it does have a high relevance to the future of our society. The development of healthy longevity and the efficiency of modern medicine in treating age-related diseases and the question of how well we can handle upcoming issues related to public health will have a major impact on our short-term future in the next few decades. Therefore, the prospect of healthy life extension plays important roles at both a personal and a societal level.
From a personal perspective, a longevity-compatible lifestyle, nutrition and supplementary regimen may not only help us to be active and to live longer, but optimizing our health and fitness also increase our energy, mental performance and capacities for social interaction. This aids our ability to work on the increasingly complex tasks of a 21st-century world that can make a positive impact in society, such as work on existential risk awareness and problem-solving. Recently, I wrote a basic personal orientation on the dietary supplement aspect of basic life extension with an audience of transhumanists, technology advocates with a high future shock level and open-minded scientists in mind, which is available here.
On a societal level, however, aging population and public health issues are serious. A rapid increase of some diseases of civilization, whose prevalence also climbs rapidly with advanced age, is on the march. For example, Type-II-Diabetes is rapidly on its way to becoming an insurmountable problem for China and the WHO projects COPD, the chronic lung disease caused by smoking and pollution, as the third leading cause of death in 2030.
While the currently accelerating increase of diseases of civilization may not collapse society itself, the costs associated with an overaging population could significantly damage societal order, collapse health systems and impact economies given the presently insufficient state of medicine and prevention. The magnitude, urgency and broad spectrum of consequences of age-related diseases of civilization currently being on the march is captured very well in this 5-minute fact-filled presentation on serious upcoming issues of aging in our society today by the LifeStar Foundation. Viewing is highly recommended. In short, a full-blown health crisis appears to be looming over many western countries, including the US, due to the high prevalence of diseases of aging in a growing population. This may require more resources than available if disease prevention efforts are not stepped up as early as possible. In that case, the required urgent action to deal with such a crisis may deprive other technological sectors of time and resources, affecting organizations and governments, including their capacity to manage vital infrastructure, existential risks and planning for a safe and sufficient progress of technology. Hence, not caring about the major upcoming health issue by stepping up disease prevention efforts according to latest biomedical knowledge may indirectly pose challenges affecting our capabilities to handle existential risks.
It should be pointed out that not all measures aimed at improving public health and medicine need to be complex or expensive to attain, as even existing biomedical knowledge is not sufficiently applied. A major example for this is the epidemic Vitamin D deficiency of the western population which was uncovered several years ago. In the last few years, the range of diseases that Vitamin D deficiency and –therapy can influence has grown to include most cancers, diabetes, cardiovascular diseases, brain aging including Alzheimer’s disease and many infectious diseases. Ironically, Vitamin D is one of the cheapest supplements available. Moreover, correcting an existing Vitamin D deficiency, which may affect as much as 80% of western population, may cut mortality risk in half. The related mortality decrease would likely coincide with a reduced morbidity and illness of elderly people, resulting in large savings of public healthcare and hospital funds, since Vitamin D effectively prevents and treats some of the most costly age-related diseases. The Life Extension Foundation, for example, has already offered a free initial supply to the U.S. population and shown that massive healthcare costs (and many lives) could be saved if every hospitalized patient was tested for Vitamin D and/or given the supplement, however this offer was ignored by the US government. This is detailed in an article on the effects of widespread Vitamin D deficiency from the Life Extension Foundation, along with many references for the above health effects of Vitamin D at the end of that article.
To recapitulate, there are plenty of important reasons why the focus on disease prevention and regenerative medicine, by applying existing state-of-the-art biomedical knowledge, as well as advancing key areas such as stem-cell research, rejuvenation technologies and nanomedicine should be an urgent priority for advocates of existential risk management today and during the next few decades.

It would be helpful to discuss these theoretical concepts because there could be significant practical and existential implications.

The Global Brain (GB) is an emergent world-wide entity of distributed intelligence, facilitated by communication and the meaningful interconnections between millions of humans via technology (such as the internet).

For my purposes I take it to mean the expressive integration of all (or the majority) of human brains through technology and communication, a Metasystem Transition from the human brain to a global (Earth) brain. The GB is truly global not only in geographical terms but also in function.

It has been suggested that the GB has clear analogies with the human brain. For example, the basic unit of the human brain (HB) is the neuron, whereas the basic unit of the GB is the human brain. Whilst the HB is space-restricted within our cranium, the GB is constrained within this planet. The HB contains several regions that have specific functions themselves, but are also connected to the whole (e.g. occipital cortex for vision, temporal cortex for auditory function, thalamus etc.). The GB contains several regions that have specific functions themselves, but are connected to the whole (e.g. search engines, governments, etc.).

Some specific analogies are:

1. The Broca’s area in the inferior frontal gyrus, associated with speech. This could be the equivalent of, say, Rubert Murdoch’s communication empire.
2. The motor cortex is the equivalent of the world-wide railway system.
3. The sensory system in the brain is the equivalent of all digital sensors, CCTV network, internet uploading facilities etc.

If we accept that the GB will eventually become fully operational (and this may happen within the next 40–50 years), then there could be severe repercussions on human evolution. Apart from the fact that we could be able to change our genetic make-up using technology (through synthetic biology or nanotechnology for example) there could be new evolutionary pressures that can help extend human lifespan to an indefinite degree.

Empirically, we find that there is a basic underlying law that allows neurons the same lifespan as their human host. If natural laws are universal, then I would expect the same law to operate in similar metasystems, i.e. in my analogy with humans being the basic operating units of the GB. In that case, I ask:

If, there is an axiom positing that individual units (neurons) within a brain must live as long as the brain itself, i.e. 100–120 years, then, the individual units (human brains and, therefore, whole humans) within a GB must live as long as the GB itself, i.e. indefinitely.

Humans will become so embedded and integrated into the GB’s virtual and real structures, that it may make more sense from the allocation of resources point of view, to maintain existing humans indefinitely, rather than eliminate them through ageing and create new ones, who would then need extra resources in order to re-integrate themselves into the GB.

The net result will be that humans will start experiencing an unprecedented prolongation of their lifespan, in an attempt by the GB to evolve to higher levels of complexity at a low thermodynamical cost.

Marios Kyriazis
http://www.elpistheory.info

I believe that death due to ageing is not an absolute necessity of human nature. From the evolutionary point of view, we age because nature withholds energy for somatic (bodily) repairs and diverts it to the germ-cells (in order to assure the survival and evolution of the DNA). This is necessary so that the DNA is able to develop and achieve higher complexity.

Although this was a valid scenario until recently, we have now evolved to such a degree that we can use our intellect to achieve further cognitive complexity by manipulating our environment. This makes it unnecessary for the DNA to evolve along the path of natural selection (which is a slow and cumbersome, ‘hit-and-miss’ process), and allows us to develop quickly and more efficiently by using our brain as a means for achieving higher complexity. As a consequence, death through ageing becomes an illogical and unnecessary process. Humans must live much longer than the current lifespan of 80–120 years, in order for a more efficient global evolutionary development to take place.

It is possible to estimate how long the above process will take to mature (see figure below). Consider that the creation of the DNA was approximately 2 billion years ago, the formation of a neuron (cell) several million years ago, that of an effective brain (Homo sapiens sapiens) 200 000 years ago, and the establishment of complex societies (Ancient Greece, Rome, China etc.) thousands of years ago. There is a logarithmic reduction of the time necessary to proceed to the next more complex step (a reduction by a factor of 100). This means that global integration (and thus indefinite lifespans) will be achieved in a matter of decades (and certainly less than a century), starting from the 1960s-1970s (when globalisation in communications, travel and science/technology started to became established). This leaves another maximum of 50 years before the full global integration becomes established.

Each step is associated with a higher level of complexity, and takes a fraction of the timein order to mature, compared to the previous one.

1. DNA (organic life — molecules: billions of years)

2. Neuron (effective cells: millions of years)

3. Brain (complex organisms — Homo sapiens: thousands of years)

4. Society (formation of effective societies: several centuries)

5. Global Integration (formation of a ‘super-thinking entity’: several decades)

Step number 5 implies that humans who have already developed an advance state of cognitive complexity and sophistication will transcend the limits of evolution by natural selection, and therefore, by default, must not die through ageing. Their continual life is a necessary requirement of this new type of evolution.

For full details see:

https://acrobat.com/#d=MAgyT1rkdwono-lQL6thBQ

The Stoic philosophical school shares several ideas with modern attempts at prolonging human lifespan. The Stoics believed in a non-dualistic, deterministic paradigm, where logic and reason formed part of their everyday life. The aim was to attain virtue, taken to mean human excellence.

I have recently described a model specifically referring to indefinite lifespans, where human biological immortality is a necessary and inevitable consequence of natural evolution (for details see www.elpistheory.info and for a comprehensive summary see http://cid-3d83391d98a0f83a.office.live.com/browse.aspx/Immortality?uc=1&sa=155370157).

This model is based on a deterministic, non-dualistic approach, described by the laws of Chaos theory (dynamical systems) and suggests that, in order to accelerate the natural transition from human evolution by natural selection to a post-Darwinian domain (where indefinite lifespans are the norm) , it is necessary to lead a life of constant intellectual stimulation, innovation and avoidance of routine (see http://www.liebertonline.com/doi/abs/10.1089/rej.2005.8.96?journalCode=rej and http://www.liebertonline.com/doi/abs/10.1089/rej.2009.0996) i.e. to seek human virtue (excellence, brilliance, and wisdom, as opposed to mediocrity and routine). The search for intellectual excellence increases neural inputs which effect epigenetic changes that can up-regulate age repair mechanisms.

Thus it is possible to conciliate the Stoic ideas with the processes that lead to both technological and developmental Singularities, using approaches that are deeply embedded in human nature and transcend time.

(End of series. For previous topics please see parts I-IX)

Power plants. Trees could do a lot, as we have seen — and they’re solar powered, too. Once trees can suck metals from the soil and grow useful, shaped objects like copper wire, a few more levels of genetic engineering could enable the tree to use this copper wire to deliver electricity. Since a tree is already, now, a solar energy converter, we can build on that by having the tree grow tissues that convert energy into electricity. Electric eels can already do that, producing enough of a jolt to be lethal to humans. Even ordinary fish produce small amounts of electricity to create electric fields in the water around them. Any object nearby disrupts the field, enabling the fish to tell that something is near, even in total darkness. We may never be able to plug something into a swimming fish but we can already make batteries out of potatoes. So why not trees that grow into electricity providers all by themselves? It would be great to be able to plug your electrical devices into a tree (or at least a socket in your house that is connected to the tree). Then you would no longer need to connect to the grid, purchase solar panels, or install a windmill. You would, however, need to keep your trees healthy and vigorous! Tree care specialists would become a highly employable occupation.

Greening the desert. The Sahara and various other less notorious but still very dry deserts around the world have plenty of sand and rocks. But they don’t have much greenery. The main problem is lack of water. Vast swaths of the Sahara, for example, are plant free. It’s just too dry. However this problem is solvable! Cacti and other desert plants could potentially extract water from the air. Plants already extract carbon dioxide molecules from the air. Even very dry air contains considerable water vapor, so why not extract water molecules too. Indeed, plants already transport water molecules in the ground into their roots, so is it really such a big step to do the same from the air? Tillandsia (air plant) species can already pull in water with their leaves, but it has to be rain or other liquid water. Creating plants that can extract gaseous water vapor from the air in a harsh desert environment would require sophisticated genetic engineering, or a leap for mother nature, but it is still only the first step. Plants get nutrients out of the soil by absorbing fluid that has dissolved them, so dry soil would be a problem even for a plant that contained plenty of water pulled from the air. Another level of genetic engineering or natural evolution would be required to enable them to secrete fluid out of their roots to moisten chunks of soil to dissolve its minerals, and reabsorb the now nutritious, mineral-laden liquid back into their roots.

Once this difficult task is accomplished, whether by natural evolution in the distant future or genetic engineering sooner, things will be different in the desert. Canopies of vegetation that hide the ground will be possible. Thus shaded and sheltered, the ground will be able to support a much richer ecosystem of creatures and maybe even humans than is currently the case in deserts. One of Earth’s harshest environments would be tamed.

Phyto-terraforming. To terraform means to transform a place into an Earth-like state (terra is Latin for Earth). Mars for example is a desert wasteland, but it once ran with rivers, and it would be great if the Martian surface was made habitable — in other words, terraformed. Venus might be made habitable if we could only get rid of its dense blanket of carbon dioxide, which causes such a severe greenhouse effect that its surface is over 800 degrees Fahrenheit, toasty indeed. And why not consider terraforming inhospitable terrain right here on earth, like the Sahara desert, or Antarctica. Phyto-terraforming is terraforming using plants. Actually plants are so favored for this task that when people discuss terraforming, they usually mean phyto-terraforming. Long ago, plants did in fact terraform the Earth, converting a hostile atmosphere with no oxygen but plenty of carbon dioxide into a friendly one with enough oxygen that we can comfortably exist. Plants worked on Earth, and might work on Mars or even Venus, but not on the moon. The reason is that plants need carbon dioxide and water. Venus has these (and reasonable temperatures) high in the atmosphere, suggesting airborne algae cells. Mars is a more likely bet as it has water (as ice) available to surface-dwelling plants at least in places.

If Mars is the most likely candidate for phyto-terraforming, what efforts have been made to move in that direction? A first step has been to splice genes into ordinary plants from an organism that lives in hot water associated with deep ocean thermal vents. This organism is named Pyrococcus furiosus (Pyro- means fire in Greek, coccus refers to ball-shaped bacteria, hence “fireball”). Pyrococcus is most comfortable living at about the boiling point of water and can grow furiously, double its population in 37 minutes. It has evolved genes for destroying free radicals that work better than those naturally present in plants. Free radicals are produced by certain stressors in plants (and humans), cause cell damage, and can even lead to death of the organism. By splicing such genes into the plant Arabidopsis thaliana, the experimental mouse of plant research, this small and nondescript-looking plant can be made much more resistant to heat and lack of water. These genes have also been spliced into tomatoes, which could help feed future colonists. Of course Mars requires cold, not heat tolerance, but the lack of water part is a good start. The heat and drought parts might be useful for building plants to terraform deserts here on Earth, bringing terraforming of Earth deserts a couple of steps closer. With several additional levels of genetic modification, we might eventually terraform Mars yet.

Recommendations

When the advances described here are likely to happen would be good to know. Will they occur in your lifetime? Your grandchildren’s? Thousands or millions of years into the future? If the latter, there is not much point in devoting precious national funds to help bring them about, but if the former, it might be worth the expense of hurrying the process along. To determine the likely timing of future technological advances, we need to determine the speed of advancement. To measure this speed, we can look at the rate at which advances have occurred in the past, and ask what will happen in the future if advances continue along at the same rate. This approach is influential in the modern computer industry in the guise of “Moore’s Law.” However it was propounded at least as early as about 2,500 years ago, when Chinese philosopher Confucius is said to have noted, “Study the past if you would divine the future.” It would be nice to know when we can expect to grow and eat potatoes with small hamburgers in the middle, pluck nuggets of valuable metals from trees, power our homes by plugging into electricity-generating trees growing in our back yards, or terraform Mars.

Opening the floodgates of genetic engineering innovation. Properly regulated to optimally benefit society, genetic engineering of plants has enormous potential, from better and better-tasting food to growing amazing things on trees. However governmental regulation is currently suppressing such advances. Preparing applications to government regulatory agencies for permission to commercially grow genetically engineered plants currently costs many millions of dollars in many countries. Thus only genetic modifications to major commodity crops like corn and soy are generally cost-effective to commercialize. Worse, only big agribusinesses can afford the costs. And why should they object? After all, who needs small, game-changing startup companies moving in, upending the status quo, creating new economic growth and value with new kinds of crops, and generally making life complicated for the giant agribusinesses? Simpler just to keep the costs of applying for permission to grow so high that such upstarts are kept out of the picture. That way predictable profits flow in even if, overall, innovation and the consequent economic expansion is suppressed. But you can’t blame the giants, which are legally obligated to serve the interests of their shareholders. It is illegal for a corporation in the US to further the interests of society at substantial expense to its shareholders! Governments should regulate commercialization of genetically engineered crops optimally, protecting the world from harmful frankenplants while promoting exciting, progressive and beneficial crop innovations.

References

“We may never be able to plug something into a swimming fish, but we can already make batteries out of potatoes.” A. Golberg, H. D. Rabinowitch, and B. Rubinsky, Zn/Cu-vegetative batteries, bioelectrical characterizations, and primary cost analyses, Journal of Renewable Sustainable Energy (2010), Vol. 2, Issue 3, http://jrse.aip.org/jrsebh/v2/i3/p033103_s1, doi:10.1063/1.3427222.

“This organism is named Pyrococcus furiosus…”: G. Fiala and K. O. Stetter, Pyrococcus furiosus sp. nov. represents a novel genus of marine heterotrophic archaebacteria growing optimally at 100°C, Archives of Microbiology (June 1986), vol. 145, no. 1, pp. 56–61.

“By splicing such genes into the plant Arabidopsis thaliana…this small and nondescript-looking plant can be made much more resistant to heat and lack of water.” W. F. Boss and A. M. Grunden, Redesigning living organisms to survive on Mars, NASA Institute for Advance Concepts Annual Meeting (2006), http://www.niac.usra.edu/files/library/meetings/annual/oct06/1194Boss.pdf

“They have also been spliced into tomatoes, which could help feed future colonists.” W. Boss, http://www.cals.ncsu.edu/plantbiology/BossLab/hfiles/overview.html, 5/29/10.

Posted by Dr. Denise L Herzing and Dr. Lori Marino, Human-Nonhuman Relationship Board

Over the millennia humans and the rest of nature have coexisted in various relationships. However the intimate and interdependent nature of our relationship with other beings on the planet has been recently brought to light by the oil spill in the Gulf of Mexico. This ongoing environmental disaster is a prime example of “profit over principle” regarding non-human life. This spill threatens not only the reproductive viability of all flora and fauna in the affected ecosystems but also complex and sensitive non-human cultures like those we now recognize in dolphins and whales.

Although science has, for decades, documented the links and interdependence of ecosystems and species, the ethical dilemma now facing humans is at a critical level. For too long have we not recognized the true cost of our life styles and priorities of profit over the health of the planet and the nonhuman beings we share it with. If ever the time, this is a wake up call for humanity and a call to action. If humanity is to survive we need to make an urgent and long-term commitment to the health of the planet. The oceans, our food sources and the very oxygen we breathe may be dependent on our choices in the next 10 years.

And humanity’s survival is inextricably linked to that of the other beings we share this planet with. We need a new ethic.

Many oceanographers and marine biologist have, for a decade, sent out the message that the oceans are in trouble. Human impacts of over-fishing, pollution, and habitat destruction are threatening the very cycles of our existence. In the recent catastrophe in the Gulf, one corporation’s neglectful oversight and push for profit has set the stage for a century of clean up and impact, the implications of which we can only begin to imagine.

Current and reported estimates of stranded dolphins are at fifty-five. However, these are dolphins visibly stranded on beaches. Recent aerial footage, on YouTube, by John Wathen shows a much greater and serious threat. Offshore, in the “no fly zone” hundreds of dolphins and whales have been observed in the oil slick. Some floating belly up and dead, others struggling to breathe in the toxic fumes. Others exhibit “drunken dolphin syndrome” characterized by floating in an almost stupefied state on the surface of the water. These highly visible effects are just the tip of the iceberg in terms of the spill’s impact on the long term health and viability of the Gulf’s dolphin and whale populations, not to mention the suffering incurred by each individual dolphin as he or she tries to cope with this crisis.

Known direct and indirect effects of oil spills on dolphins and whales depend on the species but include, toxicity that can cause organ dysfunction and neurological impairment, damaged airways and lungs, gastrointestinal ulceration and hemorrhaging, eye and skin lesions, decreased body mass due to limited prey, and, the pervasive long term behavioral, immunological, and metabolic impacts of stress. Recent reports substantiate that many dolphins and whales in the Gulf are undergoing tremendous stress, shock and suffering from many of the above effects. The impact to newborns and young calves is clearly devastating.

After the Exxon Valdez spill in Prince William Sound in 1989 two pods of orcas (killer whales) were tracked. It was found that one third of the whales in one pod and 40 percent of the whales in the other pod had disappeared, with one pod never recovering its numbers. There is still some debate about the number of missing whales directly impacted by the oil though it is fair to say that losses of this magnitude are uncommon and do serious damage to orca societies.

Yes, orca societies. Years of field research has led to the conclusion by a growing number of scientists that many dolphin and whale species, including sperm whales, humpback whales, orcas, and bottlenose dolphins possess sophisticated cultures, that is, learned behavioral traditions passed on from one generation to the next. These cultures are not only unique to each group but are critically important for survival. Therefore, not only do environmental catastrophes such as the Gulf oil spill result in individual suffering and loss of life but they contribute to the permanent destruction of entire oceanic cultures. These complex learned traditions cannot be replicated after they are gone and this makes them invaluable.

On December 10, 1948 the General Assembly of the United Nations adopted and proclaimed the Universal Declaration of Human Rights, which acknowledges basic rights to life, liberty, and freedom of cultural expression. We recognize these foundational rights for humans as we are sentient, complex beings. It is abundantly clear that our actions have violated these same rights for other sentient, complex and cultural beings in the oceans – the dolphins and whales. We should use this tragedy as an opportunity to formally recognize societal and legal rights for them so that their lives and their unique cultures are better protected in the future.

Recently, there was a meeting of scientists, philosophers, legal experts and dolphin and whale advocates in Helsinki, Finland, who drafted a Declaration of Rights for Cetaceans a global call for basic rights for dolphins and whales. You can read more about this effort and become a signatory here: http://cetaceanconservation.com.au/cetaceanrights/. Given the destruction of dolphin and whale lives and cultures caused by the ongoing environmental disaster in the Gulf, we think this is one of the ways we can commit ourselves to working towards a future that will be a lifeboat for humans, dolphins and whales, and the rest of nature.

With our growing resources, the Lifeboat Foundation has teamed with the Singularity Hub as Media Sponsors for the 2010 Humanity+ Summit. If you have suggestions on future events that we should sponsor, please contact [email protected].

The summer 2010 “Humanity+ @ Harvard — The Rise Of The Citizen Scientist” conference is being held, after the inaugural conference in Los Angeles in December 2009, on the East Coast, at Harvard University’s prestigious Science Hall on June 12–13. Futurist, inventor, and author of the NYT bestselling book “The Singularity Is Near”, Ray Kurzweil is going to be keynote speaker of the conference.

Also speaking at the H+ Summit @ Harvard is Aubrey de Grey, a biomedical gerontologist based in Cambridge, UK, and is the Chief Science Officer of SENS Foundation, a California-based charity dedicated to combating the aging process. His talk, “Hype and anti-hype in academic biogerontology research: a call to action”, will analyze the interplay of over-pessimistic and over-optimistic positions with regards of research and development of cures, and propose solutions to alleviate the negative effects of both.

The theme is “The Rise Of The Citizen Scientist”, as illustrated in his talk by Alex Lightman, Executive Director of Humanity+:

“Knowledge may be expanding exponentially, but the current rate of civilizational learning and institutional upgrading is still far too slow in the century of peak oil, peak uranium, and ‘peak everything’. Humanity needs to gather vastly more data as part of ever larger and more widespread scientific experiments, and make science and technology flourish in streets, fields, and homes as well as in university and corporate laboratories.”

Humanity+ Summit @ Harvard is an unmissable event for everyone who is interested in the evolution of the rapidly changing human condition, and the impact of accelerating technological change on the daily lives of individuals, and on our society as a whole. Tickets start at only $150, with an additional 50% discount for students registering with the coupon STUDENTDISCOUNT (valid student ID required at the time of admission).

With over 40 speakers, and 50 sessions in two jam packed days, the attendees, and the speakers will have many opportunities to interact, and discuss, complementing the conference with the necessary networking component.

Other speakers already listed on the H+ Summit program page include:

  • David Orban, Chairman of Humanity+: “Intelligence Augmentation, Decision Power, And The Emerging Data Sphere”
  • Heather Knight, CTO of Humanity+: “Why Robots Need to Spend More Time in the Limelight”
  • Andrew Hessel, Co-Chair at Singularity University: “Altered Carbon: The Emerging Biological Diamond Age”
  • M. A. Greenstein, Art Center College of Design: “Sparking our Neural Humanity with Neurotech!”
  • Michael Smolens, CEO of dotSUB: “Removing language as a barrier to cross cultural communication”

New speakers will be announced in rapid succession, rounding out a schedule that is guaranteed to inform, intrigue, stimulate and provoke, in moving ahead our planetary understanding of the evolution of the human condition!

H+ Summit @ Harvard — The Rise Of The Citizen Scientist
June 12–13, Harvard University
Cambridge, MA

You can register at http://www.eventbrite.com/event/648806598/friendsofhplus/4141206940.

Nature News reports of a growing concern over different standards for DNA screening and biosecurity:

“A standards war is brewing in the gene-synthesis industry. At stake is the way that the industry screens orders for hazardous toxins and genes, such as pieces of deadly viruses and bacteria. Two competing groups of companies are now proposing different sets of screening standards, and the results could be crucial for global biosecurity.

“If you have a company that persists with a lower standard, you can drag the industry down to a lower level,” says lawyer Stephen Maurer of the University of California, Berkeley, who is studying how the industry is developing responsible practices. “Now we have a standards war that is a race to the bottom.”

For more than a year a European consortium of companies called the International Association of Synthetic Biology (IASB) based in Heidelberg, Germany, has been drawing up a code of conduct that includes gene-screening standards. Then, at a meeting in San Francisco last month, two of the leading companies — DNA2.0 of Menlo Park, California, and Geneart of Regensburg, Germany — announced that they had formulated a code of conduct that differs in one key respect from the IASB recommendations.”

Read the entire article on Nature News.

Also read “Craig Venter’s Team Reports Key Advance in Synthetic Biology” from JCVI.