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[Crossposted from the blog of Starship Reckless]

Views of space travel have grown increasingly pessimistic in the last decade. This is not surprising: SETI still has received no unambiguous requests for more Chuck Berry from its listening posts, NASA is busy re-inventing flywheels and citizens even of first-world countries feel beleaguered in a world that seems increasingly hostile to any but the extraordinarily privileged. Always a weathervane of the present, speculative fiction has been gazing more and more inwardly – either to a hazy gold-tinted past (fantasy, both literally and metaphorically) or to a smoggy rust-colored earthbound future (cyberpunk).

The philosophically inclined are slightly more optimistic. Transhumanists, the new utopians, extol the pleasures of a future when our bodies, particularly our brains/minds, will be optimized (or at least not mind that they’re not optimized) by a combination of bioengineering, neurocognitive manipulation, nanotech and AI. Most transhumanists, especially those with a socially progressive agenda, are as decisively earthbound as cyberpunk authors. They consider space exploration a misguided waste of resources, a potentially dangerous distraction from here-and-now problems – ecological collapse, inequality and poverty, incurable diseases among which transhumanists routinely count aging, not to mention variants of gray goo.

And yet, despite the uncoolness of space exploration, despite NASA’s disastrous holding pattern, there are those of us who still stubbornly dream of going to the stars. We are not starry-eyed romantics. We recognize that the problems associated with spacefaring are formidable (as examined briefly in Making Aliens 1, 2 and 3). But I, at least, think that improving circumstances on earth and exploring space are not mutually exclusive, either philosophically or – perhaps just as importantly – financially. In fact, I consider this a false dilemma. I believe that both sides have a much greater likelihood to implement their plans if they coordinate their efforts, for a very simple reason: the attributes required for successful space exploration are also primary goals of transhumanism.

Consider the ingredients that would make an ideal crewmember of a space expedition: robust physical and mental health, biological and psychological adaptability, longevity, ability to interphase directly with components of the ship. In short, enhancements and augmentations eventually resulting in self-repairing quasi-immortals with extended senses and capabilities – the loose working definition of transhuman.

Coordination of the two movements would give a real, concrete purpose to transhumanism beyond the rather uncompelling objective of giving everyone a semi-infinite life of leisure (without guarantees that either terrestrial resources or the human mental and social framework could accommodate such a shift). It would also turn the journey to the stars into a more hopeful proposition, since it might make it possible that those who started the journey could live to see planetfall.

Whereas spacefaring enthusiasts acknowledge the enormity of the undertaking they propose, most transhumanists take it as an article of faith that their ideas will be realized soon, though the goalposts keep receding into the future. As more soundbite than proof they invoke Moore’s exponential law, equating stodgy silicon with complex, contrary carbon. However, despite such confident optimism, enhancements will be hellishly difficult to implement. This stems from a fundamental that cannot be short-circuited or evaded: no matter how many experiments are performed on mice or even primates, humans have enough unique characteristics that optimization will require people.

Contrary to the usual supposition that the rich will be the first to cross the transhuman threshold, it is virtually certain that the frontline will consist of the desperate and the disenfranchised: the terminally ill, the poor, prisoners and soldiers – the same people who now try new chemotherapy or immunosuppression drugs, donate ova, become surrogate mothers, “agree” to undergo chemical castration or sleep deprivation. Yet another pool of early starfarers will be those whose beliefs require isolation to practice, whether they be Raëlians or fundamentalist monotheists – just as the Puritans had to brave the wilderness and brutal winters of Massachusetts to set up their Shining (though inevitably tarnished) City on the Hill.

So the first generation of humans adjusted to starship living are far likelier to resemble Peter Watts’ marginalized Rifters or Jay Lake’s rabid Armoricans, rather than the universe-striding, empowered citizens of Iain Banks’ Culture. Such methods and outcomes will not reassure anyone, regardless of her/his position on the political spectrum, who considers augmentation hubristic, dehumanizing, or a threat to human identity, equality or morality. The slightly less fraught idea of uploading individuals into (ostensibly) more durable non-carbon frames is not achievable, because minds are inseparable from the neurons that create them. Even if technological advances eventually enable synapse-by synapse reconstructions, the results will be not transfers but copies.

Yet no matter how palatable the methods and outcomes are, it seems to me that changes to humans will be inevitable if we ever want to go beyond the orbit of Pluto within one lifetime. Successful implementation of transhumanist techniques will help overcome the immense distances and inhospitable conditions of the journey. The undertaking will also bring about something that transhumanists – not to mention naysayers – tend to dread as a danger: speciation. Any significant changes to human physiology (whether genetic or epigenetic) will change the thought/emotion processes of those altered, which will in turn modify their cultural responses, including mating preferences and kinship patterns. Furthermore, long space journeys will recreate isolated breeding pools with divergent technology and social mores (as discussed in Making Aliens 4, 5 and 6).

On earth, all “separate but equal” doctrines have wrought untold misery and injustice, whether those segregated are genders in countries practicing Sharia, races in the American or African South, or the underprivileged in any nation that lacks decent health policies, adequate wages and humane laws. Speciation of humanity on earth bids fair to replicate this pattern, with the ancestral species (us) becoming slaves, food, zoo specimens or practice targets to our evolved progeny, Neanderthals to their Cro-Magnons, Eloi to their Morlocks. On the other hand, speciation in space may well be a requirement for success. Generation of variants makes it likelier that at least one of our many future permutations will pass the stringent tests of space travel and alight on another habitable planet.

Despite their honorable intentions and progressive outlook, if the transhumanists insist on first establishing a utopia on earth before approving spacefaring, they will achieve either nothing or a dystopia as bleak as that depicted in Paolo Bacigalupi’s unsparing stories. If they join forces with the space enthusiasts, they stand a chance to bring humanity through the Singularity some of them so fervently predict and expect – except it may be a Plurality of sapiens species and inhabited worlds instead.

The Economist has a piece on the Global Viral Forecasting Initiative (GVFI):

Dr [Nathan] Wolfe, [a virologist at the University of California, Los Angeles], is attempting to create what he calls the Global Viral Forecasting Initiative (GVFI). This is still a pilot project, with only half a dozen sites in Africa and Asia. But he hopes, if he can raise the $50m he needs, to build it into a planet-wide network that can forecast epidemics before they happen, and thus let people prepare their defences well in advance. […]

The next stage of the project is to try to gather as complete an inventory as possible of animal viruses, and Dr Wolfe has enlisted his hunters to take blood samples from whatever they catch. He is collaborating with Eric Delwart and Joe DeRisi of the University of California, San Francisco, to screen this blood for unknown viral genes that indicate new species. The GVFI will also look at people, monitoring symptoms of ill health of unknown cause and trying to match these with unusual viruses.

More here. See also the Lifeboat Foundation’s BioShield program.

Today, the University of Colorado at Boulder made an announcement regarding a very promising technology:

Known as optical frequency comb spectroscopy, the technique is powerful enough to sort through all the molecules in human breath and sensitive enough to distinguish rare molecules that may be biomarkers for specific diseases

Combined with other rapid-response technologies, this could be part of the detection side of a BioShield, a technological immune system for humanity.

The optical frequency comb is a very precise laser for measuring different colors, or frequencies, of light, said Ye. Each comb line, or “tooth,” is tuned to a distinct frequency of a particular molecule’s vibration or rotation, and the entire comb covers a broad spectral range — much like a rainbow of colors — that can identify thousands of different molecules.

Source: University of Colorado at Boulder

Cross posted from Next big future

Since a journal article was submitted to the Royal Society of Chemistry, the U of Alberta researchers have already made the processor and unit smaller and have brought the cost of building a portable unit for genetic testing down to about $100 Cdn. In addition, these systems are also portable and even faster (they take only minutes). Backhouse, Elliott and McMullin are now demonstrating prototypes of a USB key-like system that may ultimately be as inexpensive as standard USB memory keys that are in common use – only tens of dollars. It can help with pandemic control and detecting and control tainted water supplies.

This development fits in with my belief that there should be widespread inexpensive blood, biomarker and genetic tests to help catch disease early and to develop an understanding of biomarker changes to track disease and aging development. We can also create adaptive clinical trials to shorten the development and approval process for new medical procedures


The device is now much smaller than size of a shoe-box (USB stick size) with the optics and supporting electronics filling the space around the microchip

Canadian scientists have succeeded in building the least expensive portable device for rapid genetic testing ever made. The cost of carrying out a single genetic test currently varies from hundreds to thousands of pounds, and the wait for results can take weeks. Now a group led by Christopher Backhouse, University of Alberta, Edmonton, have developed a reusable microchip-based system that costs just 500 (pounds) to build, is small enough to be portable, and can be used for point-of-care medical testing.

To keep costs down, ‘instead of using the very expensive confocal optics systems currently used in these types of devices we used a consumer-grade digital camera’, Backhouse explained.

The device can be adapted for used in many different genetic tests. ‘By making small changes to the system you could test for a person’s predisposition to cancer, carry out pharmacogenetic tests for adverse drug reactions or even test for pathogens in a water supply,’ said Backhouse.

The heart of the unit, the ‘chip,’ looks like a standard microscope slide etched with fine silver and gold lines. That microfabricated chip applies nano-biotechnologies within tiny volumes, sometimes working with only a few molecules of sample. Because of this highly integrated chip (containing microfluidics and microscale devices), the remainder of the system is inexpensive ($1,000) and fast.

There are many possible uses for such a portable genetic testing unit:

Backhouse notes that adverse drug reactions are a major problem in health care. By running a quick genetic test on a cancer patient, for example, doctors might pinpoint the type of cancer and determine the best drug and correct dosage for the individual.

Or health-care professionals can easily look for the genetic signature for a virus or E. coli – also making it useful for testing water quality.

“From a public health point of view, it would be wonderful during an epidemic to be able to do a quick test on a patient when they walk into an emergency room and be able to say, ‘you have SARS, you need to go into that (isolation) room immediately.’ ”

A family doctor might determine a person’s genetic predisposition to an illness during an office visit and advise the patient on preventative lifestyle changes.

FURTHER READING
Microfabrication technologies research at the University of Alberta

Rapid genetic analysis

In collaboration with the Glerum Lab we have been developing microchip based implementations of genetic amplification (PCR — the polymerase chain reaction) and capillary electrophoresis (CE) that are extremely fast.

- Cancer diagnostics

- Cell manipulation on a chip

- On chip PCR (polymerase chain reaction)

- Single cell PCR

- DNA Sequencing

According to ScienceDaily:

The British-American biotech company Acambis reports the successful conclusion of Phase I trials of the universal flu vaccine in humans. The universal influenza vaccine has been pioneered by researchers from VIB and Ghent University. This vaccine is intended to provide protection against all ‘A’ strains of the virus that causes human influenza, including pandemic strains. Therefore, this vaccine will not need to be renewed annually.

InfluenzaWhat would make this new vaccine different from the ones already available is that it would target M2e, a conserved region of influenza “A” strains. Since that part doesn’t constantly mutate and about 2/3 of seasonal epidemics and all pandemics are due to type “A” strains, it could be a very efficient weapon against repeats of the “Spanish Flu” (1918−1919) that killed at least 50 million people worldwide. Only the future will tell if phase II and III trials are successful.

You can learn more about the Lifeboat Foundation BioShield program here.

Reposted from Next Big Future which was advancednano.

A 582,970 base pair sequence of DNA has been synthesized.

It’s the first time a genome the size of a bacterium has chemically been synthesized that’s about 20 times longer than [any DNA molecule] synthesized before.

This is a huge increase in capability. It has broad implications for DNA nanotechnology and synthetic biology.

It is particularly relevant for the lifeboat foundation bioshield project

This means that the Venter Institute is on the brink of sythesizing a new bacterial life.

The process to synthesize and assemble the synthetic version of the M. genitalium chromosome

began first by resequencing the native M. genitalium genome to ensure that the team was starting with an error free sequence. After obtaining this correct version of the native genome, the team specially designed fragments of chemically synthesized DNA to build 101 “cassettes” of 5,000 to 7,000 base pairs of genetic code. As a measure to differentiate the synthetic genome versus the native genome, the team created “watermarks” in the synthetic genome. These are short inserted or substituted sequences that encode information not typically found in nature. Other changes the team made to the synthetic genome included disrupting a gene to block infectivity. To obtain the cassettes the JCVI team worked primarily with the DNA synthesis company Blue Heron Technology, as well as DNA 2.0 and GENEART.

From here, the team devised a five stage assembly process where the cassettes were joined together in subassemblies to make larger and larger pieces that would eventually be combined to build the whole synthetic M. genitalium genome. In the first step, sets of four cassettes were joined to create 25 subassemblies, each about 24,000 base pairs (24kb). These 24kb fragments were cloned into the bacterium Escherichia coli to produce sufficient DNA for the next steps, and for DNA sequence validation.

The next step involved combining three 24kb fragments together to create 8 assembled blocks, each about 72,000 base pairs. These 1/8th fragments of the whole genome were again cloned into E. coli for DNA production and DNA sequencing. Step three involved combining two 1/8th fragments together to produce large fragments approximately 144,000 base pairs or 1/4th of the whole genome.

At this stage the team could not obtain half genome clones in E. coli, so the team experimented with yeast and found that it tolerated the large foreign DNA molecules well, and that they were able to assemble the fragments together by homologous recombination. This process was used to assemble the last cassettes, from 1/4 genome fragments to the final genome of more than 580,000 base pairs. The final chromosome was again sequenced in order to validate the complete accurate chemical structure.

The synthetic M. genitalium has a molecular weight of 360,110 kilodaltons (kDa). Printed in 10 point font, the letters of the M. genitalium JCVI-1.0 genome span 147 pages.

The New York Times is reporting today that continued acceleration of the rate at which the Greeland ice sheets are melting have scientists scrambling for answers. In particular, a combination of changes have the glaciologists particularly concerned. They say the accumulation of meltwater on the surface of the ice in the form of ponds and streams absorbs as much as four times more heat than the lighter colored ice thereby accelerating the rate at which the surface melts.

Additionally, this meltwater eventually finds its way to bedrock where it appears to ever so slightly lubcricate the surface between ice and rock thereby facilitating more rapid shifting of the ice towards the ocean. A third factor in the trifecta is the breakup of huge semi-submerged clots of ice that typically block narrow fjords. As these blockages are cleared that accelerates the flow of the frozen glacial rivers.

While there is still a tremendous amount about this cycle that remains unknown, what is clear is that the best estimates to date have fallen far short in terms of the speed at which these rare environments are changing. Although questions remain about how much of these changes are cyclical and how much are due specifically to man-originated global warming it is imperative that we gain a more complete understanding of these events so that we can take whatever steps we must to ameliorate any damage we’ve caused before the situation becomes so critical that massive changes come about as a result of our negligent handling of our environment.

Planning for the first Lifeboat Foundation conference has begun. This FREE conference will be held in Second Life to keep costs down and ensure that you won’t have to worry about missing work or school.

While an exact date has not yet been set, we intend to offer you an exciting line up of speakers on a day in the late spring or early summer of 2008.

Several members of Lifeboat’s Scientific Advisory Board (SAB) have already expressed interest in presenting. However, potential speakers need not be Lifeboat Foundation members.

If you’re interested in speaking, want to help, or you just want to learn more, please contact me at [email protected].

(Source: Wikipedia)

Full name: Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on their Destruction

Short name: Biological Weapons Convention (BWC)
Open for signature: April 10, 1972
Entered into force: March 26, 1975
Member states: 158
Map of member states:

Summary:

Article I: Never under any circumstances to acquire or retain biological weapons.
Article II: To destroy or divert to peaceful purposes biological weapons and associated resources prior to joining.
Article III: Not to transfer, or in any way assist, encourage or induce anyone else to acquire or retain biological weapons.
Article IV: To take any national measures necessary to implement the provisions of the BWC domestically.
Article V: To consult bilaterally and multilaterally to solve any problems with the implementation of the BWC.
Article VI: To request the UN Security Council to investigate alleged breaches of the BWC and to comply with its subsequent decisions.
Article VII: To assist States which have been exposed to a danger as a result of a violation of the BWC.
Article X: To do all of the above in a way that encourages the peaceful uses of biological science and technology.

Determining the structure of a protein called hemagglutinin on the surface of influenza B is giving researchers at Baylor College of Medicine and Rice University in Houston clues as to what kinds of mutations could spark the next flu pandemic.

This is interesting research and progress in understanding and possibly blocking changes that would lead to pandemics.

In a report that goes online today in the Proceedings of the National Academy of Sciences (PNAS), Drs. Qinghua Wang, assistant professor of biochemistry and molecular biology at BCM, and Jianpeng Ma, associate professor in the same department and their colleagues describe the actual structure of influenza B virus hemagglutinin and compare it to a similar protein on influenza A virus. That comparison may be key to understanding the changes that will have to occur before avian flu (which is a form of influenza A virus) mutates to a form that can easily infect humans, said Ma, who holds a joint appointment at Rice. He and Wang have identified a particular residue or portion of the protein that may play a role in how different types of hemagglutinin bind to human cells.

“What would it take for the bird flu to mutate and start killing people” That’s the next part of our work,” said Ma. Understanding that change may give scientists a handle on how to stymie it.

There are two main forms of influenza virus – A and B. Influenza B virus infects only people while influenza A infects people and birds. In the past, influenza A has been the source of major worldwide epidemics (called pandemics) of flu that have swept the globe, killing millions of people. The most famous of these was the Pandemic of 1918–1919, which is believed to have killed between 20 and 40 million people worldwide. It killed more people than World War I, which directly preceded it.

The Asian flu pandemic of 1957–1958 is believed to have killed as many as 1.5 million people worldwide, and the so-called Hong Kong flu pandemic of 1968–1969 is credited with as many as 1 million deaths. Each scourge was accompanied by a major change in the proteins on the surface of the virus.

The Lifeboat Foundation has the bioshield project