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Category: biological

Tracking your health is a growing phenomenon. People have historically measured and recorded their health using simple tools: a pencil, paper, a watch and a scale. But with custom spreadsheets, streaming wifi gadgets, and a new generation of people open to sharing information, this tracking is moving online. Pew Internet reports that 70–80% of Internet users go online for health reasons, and Health 2.0 websites are popping up to meet the demand.

David Shatto, an online health enthusiast, wrote in to CureTogether, a health-tracking website, with a common question: “I’m ‘healthy’ but would be interested in tracking my health online. Not sure what this means, or what a ‘healthy’ person should track. What do you recommend?”

There are probably as many answers to this question as there are people who track themselves. The basic measure that apply to most people are:
- sleep
- weight
- calories
- exercise
People who have an illness or condition will also measure things like pain levels, pain frequency, temperature, blood pressure, day of cycle (for women), and results of blood and other biometric tests. Athletes track heart rate, distance, time, speed, location, reps, and other workout-related measures.

Another answer to this question comes from Karina, who writes on Facebook: “It’s just something I do, and need to do, and it’s part of my life. So, in a nutshell, on most days I write down what I ate and drank, how many steps I walked, when I went to bed and when I woke up, my workouts and my pain/medication/treatments. I also write down various comments about meditative activities and, if it’s extreme, my mood.”

David’s question is being asked by the media too. Thomas Goetz, deputy editor of Wired Magazine, writes about it in his blog The Decision Tree. Jamin Brophy-Warren recently wrote about the phenomenon of personal data collection in the Wall Street Journal, calling it the “New Examined Life”. Writers and visionaries Kevin Kelly and Gary Wolf have started a growing movement called The Quantified Self, which holds monthly meetings about self-tracking activities and devices. And self-experimenters like David Ewing Duncan (aka “Experimental Man”) and Seth Roberts (of the “Shangri-La Diet”) are writing books about their experiences.

In the end, what to track really depends on what each person wants to get out of it:
- Greater self-awareness and a way to stick to New Year’s resolutions?
- Comparing data to other self-trackers to see where you fit on the health curve?
- Contributing health data to research into finding cures for chronic conditions?

Based on answers to these questions, you can come up with your own list of things to track, or take some of the ideas listed above. Whatever the reason, tracking is the new thing to do online and can be a great way to optimize and improve your health.

Alexandra Carmichael is co-founder of CureTogether, a Mountain View, CA startup that launched in 2008 to help people optimize their health by anonymously comparing symptoms, treatments, and health data. Its members track their health online and share their experience with 186 different health conditions. She is also the author of The Collective Well and Ecnalab blogs, and a guest blogger at the Quantified Self.

November 14, 2008
Computer History Museum, Mountain View, CA

http://ieet.org/index.php/IEET/eventinfo/ieet20081114/

Organized by: Institute for Ethics and Emerging Technologies, the Center for Responsible Nanotechnology and the Lifeboat Foundation

A day-long seminar on threats to the future of humanity, natural and man-made, and the pro-active steps we can take to reduce these risks and build a more resilient civilization. Seminar participants are strongly encouraged to pre-order and review the Global Catastrophic Risks volume edited by Nick Bostrom and Milan Cirkovic, and contributed to by some of the faculty for this seminar.

This seminar will precede the futurist mega-gathering Convergence 08, November 15–16 at the same venue, which is co-sponsored by the IEET, Humanity Plus (World Transhumanist Association), the Singularity Institute for Artificial Intelligence, the Immortality Institute, the Foresight Institute, the Long Now Foundation, the Methuselah Foundation, the Millenium Project, Reason Foundation and the Accelerating Studies Foundation.

SEMINAR FACULTY

  • Nick Bostrom Ph.D., Director, Future of Humanity Institute, Oxford University
  • Jamais Cascio, research affiliate, Institute for the Future
  • James J. Hughes Ph.D., Exec. Director, Institute for Ethics and Emerging Technologies
  • Mike Treder, Executive Director, Center for Responsible Nanotechnology
  • Eliezer Yudkowsky, Research Associate. Singularity Institute for Artificial Intelligence
  • William Potter Ph.D., Director, James Martin Center for Nonproliferation Studies

REGISTRATION:
Before Nov 1: $100
After Nov 1 and at the door: $150

Open source has emerged as a powerful set of principles for solving complex problems in fields as diverse as education and physical security. With roughly 60 million Americans suffering from a chronic health condition, traditional research progressing slowly, and personalized medicine on the horizon, the time is right to apply open source to health research. Advances in technology enabling cheap, massive data collection combined with the emerging phenomena of self quantification and crowdsourcing make this plan feasible today. We can all work together to cure disease, and here’s how.

Read more…

Following is a discussion of two potential threats to humanity – one which has existed for eons, the second we have seen recently resurfacing having thought it had been laid to rest.

First, a recent story on PhysOrg describes the work researchers at Vanderbilt University have performed in isolating antibodies from elderly people who had survived the 1918 flu pandemic. This comes three years after researchers at Mount Sinai and the Armed Forces Institute of Pathology in Washington, D.C isolated the same virus which caused this outbreak from the frozen bodies of people in Alaska who had died in the pandemic.

In addition to being an impressive achievement of biomedical science, which involved isolating antibody-secreting B cells from donors and generating “immortalized” cell lines to produce large amounts of antibodies, this research also demonstrates the amazing memory the immune system has (90 years!), as well as the ability scientists have to use tissue samples from people born nearly a century ago and fashion them into a potential weapon against future similar outbreaks. Indeed, these manufactured antibodies proved effective against 1918 flu virus when tested in mice.

Furthermore, such research provides tools which could help generate antibodies to treat other viruses which still blight humanity (such as HIV) or are seen as potential threats, such as avian influenza.

http://www.physorg.com/news138198336.html

Second, nuclear annihilation. Russia’s recent foray into Georgia and the ensuing tensions with the west have brought the specter of the cold war back from the dead, and with it increasing levels of aggressive rhetoric from both sides and more or less veiled threats of action, some of it diplomatic, some military.

During the past twenty years, ever since the fall of the former Soviet Union, we have become used to living in a world no longer directly and overtly threatened by complete annihilation through world war III. Is this about to change? It would seem that despite current tensions, present conditions are far from fostering a renewed cold war.

Modern day Russia (and China can be described along similar lines) is inexorably tied to the world economy and does not represent a conflicting ideology striving for world domination as was the case during the most of the latter half of the twentieth century. This deep international integration stems from the almost global acceptance of the market economy as the preferred driving force for economic growth, albeit under different forms of government. Both Russia and China are (currently) fueled more by the will being recognized as premier global forces rather than the will to rule the world, the former wishing to return to its previous position and reclaim the respect it feels it lost during the last couple of decades, and the latter rising anew after centuries in the shadows.

Of course, the coming elections in the US may change the tone prevalent in the international brinkmanship game, although the involvement of the EU, led by French premier Sarkozy means that such strong statements coming from Western Europe are not set to change fundamentally.

So, unless further surprises are in store for us (a possibility which cannot be ignored when dealing with political and military maneuvering, especially those involving the tense conditions prevalent in many of the former Soviet republics), a compromise will eventually be reached and respected. The seeds of a calming effort have already been felt in recent days with much less inflammatory declarations from both sides, and signs of a Russian willingness to tone down at least the public face of disagreements with the EU and US. This is likely set to continue…at least until the next outbreak of nationalistic violence or political sword-brandishing in a region in which tensions run high.

An interesting analysis of the current situation can be found at: http://www.cnn.com/2008/WORLD/europe/08/29/oakley.eu.russia/

Something to post to your websites and to vote online.

Aubrey de Grey can get $1.5 million for the Methuselah Foundation if enough people vote.

Voting ends September 1st, take a second to vote now.
Any US Amex cardmember or US resident (who makes a guest account) can vote.

Here is the page where you can vote “nominate”

The Methuselah Foundation Page with some more details if you are interested, to vote though you only need click on the above link…

Researchers have devised a rapid and efficient method for generating protein sentinels of the immune system, called monoclonal antibodies, which mark and neutralize foreign invaders.

For both ethical and practical reasons, monoclonals are usually made in mice. And that’s a problem, because the human immune system recognizes the mouse proteins as foreign and sometimes attacks them instead. The result can be an allergic reaction, and sometimes even death.

To get around that problem, researchers now “humanize” the antibodies, replacing some or all of mouse-derived pieces with human ones.

Wilson and Ahmed were interested in the immune response to vaccination. Conventional wisdom held that the B-cell response would be dominated by “memory” B cells. But as the study authors monitored individuals vaccinated against influenza, they found that a different population of B cells peaked about one week after vaccination, and then disappeared, before the memory cells kicked in. This population of cells, called antibody-secreting plasma cells (ASCs), is highly enriched for cells that target the vaccine, with vaccine-specific cells accounting for nearly 70 percent of all ASCs.

“That’s the trick,” said Wilson. “So instead of one cell in 1,000 binding to the vaccines, now it is seven in 10 cells.”

All of a sudden, the researchers had access to a highly enriched pool of antibody-secreting cells, something that is relatively easy to produce in mice, but hard to come by for human B cells.

To ramp up the production and cloning of these antibodies, the researchers added a second twist. Mouse monoclonal antibodies are traditionally produced in the lab from hybridomas, which are cell lines made by fusing the antibody-producing cell with a cancer cell. But human cells don’t respond well to this treatment. So Wilson and his colleagues isolated the ASC antibody genes and transferred them into an “immortalized” cell line. The result was the generation of more than 100 different monoclonals in less than a year, with each taking just a few weeks to produce.

In the event of an emerging flu pandemic, for instance, this approach could lead to faster production of human monoclonals to both diagnose and protect against the disease.

Journal Nature article: Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

Nature 453, 667–671 (29 May 2008) | doi:10.1038/nature06890; Received 16 October 2007; Accepted 4 March 2008; Published online 30 April 2008

Pre-existing neutralizing antibody provides the first line of defence against pathogens in general. For influenza virus, annual vaccinations are given to maintain protective levels of antibody against the currently circulating strains. Here we report that after booster vaccination there was a rapid and robust influenza-specific IgG+ antibody-secreting plasma cell (ASC) response that peaked at approximately day 7 and accounted for up to 6% of peripheral blood B cells. These ASCs could be distinguished from influenza-specific IgG+ memory B cells that peaked 14–21 days after vaccination and averaged 1% of all B cells. Importantly, as much as 80% of ASCs purified at the peak of the response were influenza specific. This ASC response was characterized by a highly restricted B-cell receptor (BCR) repertoire that in some donors was dominated by only a few B-cell clones. This pauci-clonal response, however, showed extensive intraclonal diversification from accumulated somatic mutations. We used the immunoglobulin variable regions isolated from sorted single ASCs to produce over 50 human monoclonal antibodies (mAbs) that bound to the three influenza vaccine strains with high affinity. This strategy demonstrates that we can generate multiple high-affinity mAbs from humans within a month after vaccination. The panel of influenza-virus-specific human mAbs allowed us to address the issue of original antigenic sin (OAS): the phenomenon where the induced antibody shows higher affinity to a previously encountered influenza virus strain compared with the virus strain present in the vaccine1. However, we found that most of the influenza-virus-specific mAbs showed the highest affinity for the current vaccine strain. Thus, OAS does not seem to be a common occurrence in normal, healthy adults receiving influenza vaccination.

Researchers from Imperial College in London, England, isolated the receptor in the lungs that triggers the immune overreaction to flu.

With the receptor identified, a therapy can be developed that will bind to the receptor, preventing the deadly immune response. Also, by targeting a receptor in humans rather than a particular strain of flu, therapies developed to exploit this discovery would work regardless of the rapid mutations that beguile flu vaccine producers every year.

The flu kills 250,000 to 500,000 people in an average year with epidemics reaching 1 to 2 million deaths (other than the spanish flu which was more severe

This discovery could lead to treatments which turn off the inflammation in the lungs caused by influenza and other infections, according to a study published today in the journal Nature Immunology. The virus is often cleared from the body by the time symptoms appear and yet symptoms can last for many days, because the immune system continues to fight the damaged lung. The immune system is essential for clearing the virus, but it can damage the body when it overreacts if it is not quickly contained.

The immune overreaction accounts for the high percentage of young, healthy people who died in the vicious 1918 flu pandemic. While the flu usually kills the very young or the sickly and old, the pandemic flu provoked healthy people’s stronger immune systems to react even more profoundly than usual, exacerbating the symptoms and ultimately causing between 50 and 100 million deaths world wide. These figures from the past make the new discovery that much more important, as new therapies based on this research could prevent a future H5N1 bird flu pandemic from turning into a repeat of the 1918 Spanish flu.

In the new study, the researchers gave mice infected with influenza a mimic of CD200, or an antibody to stimulate CD200R, to see if these would enable CD200R to bring the immune system under control and reduce inflammation.

The mice that received treatment had less weight loss than control mice and less inflammation in their airways and lung tissue. The influenza virus was still cleared from the lungs within seven days and so this strategy did not appear to affect the immune system’s ability to fight the virus itself.

The researchers hope that in the event of a flu pandemic, such as a pandemic of H5N1 avian flu that had mutated to be transmissible between humans, the new treatment would add to the current arsenal of anti-viral medications and vaccines. One key advantage of this type of therapy is that it would be effective even if the flu virus mutated, because it targets the body’s overreaction to the virus rather than the virus itself.

In addition to the possible applications for treating influenza, the researchers also hope their findings could lead to new treatments for other conditions where excessive immunity can be a problem, including other infectious diseases, autoimmune diseases and allergy.

What is metabolomics?

Genes are similar to the plans for a house; they show what it looks like, but not what people are getting up to inside. One way of getting a snapshot of their lives would be to rummage through their rubbish, and that is pretty much what metabolomics does. […]

Metabolomics studies metabolites, the by-products of the hundreds of thousands of chemical reactions that continuously go on in every cell of the human body. Because blood and urine are packed with these compounds, it should be possible to detect and analyse them. If, say, a tumour was growing somewhere then, long before any existing methods can detect it, the combination of metabolites from the dividing cancer cells will produce a new pattern, different from that seen in healthy tissue. Such metabolic changes could be picked up by computer programs, adapted from those credit-card companies use to detect crime by spotting sudden and unusual spending patterns amid millions of ordinary transactions.

This could be used for traditional medicine, both to prevent pathologies and to detect those that are already present so they can be treated. But another use would be as part of an early-detection system to defend against pandemics and biological attacks. As mentioned previously, network-theory can help us better use vaccines. But once you have a cure or antidote, you also need to identify people that are already infected but haven’t died yet, and the earlier you can do that after the infection, the more chances they have to live.

Once the techniques of metabolomics are sufficiently advanced and inexpensive to use, they might provide better data than simply relying on reported symptoms (might be too late by then), and might scale better than traditional detection methods (not sure yet — something else might make more economic sense). It’s a bit too early to tell, but it’s a very promising field.

For more information, see Douglas Kell’s site or Wikipedia: Metabolomics.

Source: The Economist. See also Lifeboat’s BioShield program.

If a pandemic strikes and hundreds of millions are at risk, we won’t have enough vaccines for everybody, at least not within the time window where vaccines would help. But a new strategy could help use the vaccines we have more effectively:

Researchers are now proposing a new strategy for targeting shots that could, at least in theory, stop a pandemic from spreading along the network of social interactions. Vaccinating selected people is essentially equivalent to cutting out nodes of the social network. As far as the pandemic is concerned, it’s as if those people no longer exist. The team’s idea is to single out people so that immunizing them breaks up the network into smaller parts of roughly equal sizes. Computer simulations show that this strategy could block a pandemic using 5 to 50 percent fewer doses than existing strategies, the researchers write in an upcoming Physical Review Letters.

vaccine-targeting.jpg

So you break up the general social network into sub-networks, and then you target the most important nodes of these sub-networks and so on until you run out of vaccines. The challenge will be to get good information about social networks, something not quite as easy as mapping computer networks, but there is progress on that front.

In one of the most dramatic illustrations of their technique, the researchers simulated the spread of a pandemic using data from a Swedish study of social connections, in which more than 310,000 people are represented and connected based on whether they live in the same household or they work in the same place. With the new method, the epidemic spread to about 4 percent of the population, compared to nearly 40 percent for more standard strategies, the team reports.

Source: ScienceNews. See also Lifeboat’s BioShield program.

Cross posted from Nextbigfuture

Click for larger image

I had previously looked at making two large concrete or nanomaterial monolithic or geodesic domes over cities which could protect a city from nuclear bombs.

Now Alexander Bolonkin has come up with a cheaper, technological easy and more practical approach with thin film inflatable domes. It not only would provide protection form nuclear devices it could be used to place high communication devices, windmill power and a lot of other money generating uses. The film mass covered of 1 km**2 of ground area is M1 = 2×10**6 mc = 600 tons/km**2 and film cost is $60,000/km**2.
The area of big city diameter 20 km is 314 km**2. Area of semi-spherical dome is 628 km2. The cost of Dome cover is 62.8 millions $US. We can take less the overpressure (p = 0.001atm) and decrease the cover cost in 5 – 7 times. The total cost of installation is about 30–90 million $US. Not only is it only about $153 million to protect a city it is cheaper than a geosynchronous satellite for high speed communications. Alexander Bolonkin’s website

The author suggests a cheap closed AB-Dome which protects the densely populated cities from nuclear, chemical, biological weapon (bombs) delivered by warheads, strategic missiles, rockets, and various incarnations of aviation technology. The offered AB-Dome is also very useful in peacetime because it shields a city from exterior weather and creates a fine climate within the ABDome. The hemispherical AB-Dome is the inflatable, thin transparent film, located at altitude up to as much as 15 km, which converts the city into a closed-loop system. The film may be armored the stones which destroy the rockets and nuclear warhead. AB-Dome protects the city in case the World nuclear war and total poisoning the Earth’s atmosphere by radioactive fallout (gases and dust). Construction of the AB-Dome is easy; the enclosure’s film is spread upon the ground, the air pump is turned on, and the cover rises to its planned altitude and supported by a small air overpressure. The offered method is cheaper by thousand times than protection of city by current antirocket systems. The AB-Dome may be also used (height up to 15 and more kilometers) for TV, communication, telescope, long distance location, tourism, high placed windmills (energy), illumination and entertainments. The author developed theory of AB-Dome, made estimation, computation and computed a typical project.

His idea is a thin dome covering a city with that is a very transparent film 2 (Fig.1). The film has thickness 0.05 – 0.3 mm. One is located at high altitude (5 — 20 km). The film is supported at this altitude by a small additional air pressure produced by ground ventilators. That is connected to Earth’s ground by managed cables 3. The film may have a controlled transparency option. The system can have the second lower film 6 with controlled reflectivity, a further option.

The offered protection defends in the following way. The smallest space warhead has a
minimum cross-section area 1 m2 and a huge speed 3 – 5 km/s. The warhead gets a blow and overload from film (mass about 0.5 kg). This overload is 500 – 1500g and destroys the warhead (see computation below). Warhead also gets an overpowering blow from 2 −5 (every mass is 0.5 — 1 kg) of the strong stones. Relative (about warhead) kinetic energy of every stone is about 8 millions of Joules! (It is in 2–3 more than energy of 1 kg explosive!). The film destroys the high speed warhead (aircraft, bomber, wing missile) especially if the film will be armored by stone.

Our dome cover (film) has 2 layers: top transparant layer 2, located at a maximum altitude (up 5 −20 km), and lower transparant layer 4 having control reflectivity, located at altitude of 1–3 km (option). Upper transparant cover has thickness about 0.05 – 0.3 mm and supports the protection strong stones (rebbles) 8. The stones have a mass 0.2 – 1 kg and locate the step about 0.5 m.

If we want to control temperature in city, the top film must have some layers: transparant dielectric layer, conducting layer (about 1 — 3 microns), liquid crystal layer (about 10 — 100 microns), conducting layer (for example, SnO2), and transparant dielectric layer. Common thickness is 0.05 — 0.5 mm. Control voltage is 5 — 10 V. This film may be produced by industry relatively cheaply.

If some level of light control is needed materials can be incorporated to control transparency. Also, some transparent solar cells can be used to gather wide area solar power.


As you see the 10 kt bomb exploded at altitude 10 km decreases the air blast effect about in 1000
times and thermal radiation effect without the second cover film in 500 times, with the second reflected film about 5000 times. The hydrogen 100kt bomb exploded at altitude 10 km decreases the air blast effect about in 10 times and thermal radiation effect without the second cover film in 20 times, with the second reflected film about 200 times. Only power 1000kt thermonuclear (hydrogen) bomb can damage city. But this damage will be in 10 times less from air blast and in 10 times less from thermal radiation. If the film located at altitude 15 km, the
damage will be in 85 times less from the air blast and in 65 times less from the thermal radiation.
For protection from super thermonuclear (hydrogen) bomb we need in higher dome altitudes (20−30 km and more). We can cover by AB-Dome the important large region and full country.

Because the Dome is light weight it could be to stay in place even with very large holes. Multiple shells of domes could still be made for more protection.

Better climate inside a dome can make for more productive farming.

AB-Dome is cheaper in hundreds times then current anti-rocket systems.
2. AB-Dome does not need in high technology and can build by poor country.
3. It is easy for building.
4. Dome is used in peacetime; it creates the fine climate (weather) into Dome.
5. AB-Dome protects from nuclear, chemical, biological weapon.
6. Dome produces the autonomous existence of the city population after total World nuclear war
and total confinement (infection) all planet and its atmosphere.
7. Dome may be used for high region TV, for communication, for long distance locator, for
astronomy (telescope).
8. Dome may be used for high altitude tourism.
9. Dome may be used for the high altitude windmills (getting of cheap renewable wind energy).
10. Dome may be used for a night illumination and entertainment