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Transhumanists will know that the science fiction author Zoltan Istvan has unilaterally leveraged the movement into a political party contesting the 2016 US presidential election. To be sure, many transhumanists have contested Istvan’s own legitimacy, but there is no denying that he has generated enormous publicity for many key transhumanist ideas. Interestingly, his lead idea is that the state should do everything possible to uphold people’s right to live forever. Of course, he means to live forever in a healthy state, fit of mind and body. Istvan cleverly couches this policy as simply an extension of what voters already expect from medical research and welfare provision. And while he may be correct, the policy is fraught with hazards – especially if, as many transhumanists believe, we are on the verge of revealing the secrets to biological immortality.

In June, Istvan and I debated this matter at Brain Bar Budapest. Let me say, for the record, that I think that we are sufficiently close to this prospect that it is not too early to discuss its political and economic implications.

Two months before my encounter with Istvan, I was on a panel at the Edinburgh Science Festival with the great theorist of radical life extension Aubrey de Grey, where he declared that people who live indefinitely will seem like renovated vintage cars. Whatever else, he is suggesting that they would be frozen in time. He may actually be right about this. But is such a state desirable, given that throughout history radical change has been facilitated generational change? Specifically, two simple facts make the young open to doing things differently: The young have no memory of past practices working to anyone else’s benefit, and they have not had the time to invest in those practices to reap their benefits. Whatever good is to be found in the past is hearsay, as far as the young are concerned, which they are being asked to trust as they enter a world that they know is bound to change.

Questions have been already raised about whether tomorrow’s Methuselahs will wish to procreate at all, given the time available to them to realize dreams that in the past would have been transferred to their offspring. After all, as human life expectancy has increased 50% over the past century, the birth rate has correspondingly dropped. One can only imagine what will happen once ageing can be arrested, if not outright reversed!

So, where will the new ideas of the future come from? The worry here is that society may end up being ruled by people with overlong memories who value stability over change: Think China and Japan. But perhaps the old Soviet Union is the most telling example, as its self-consciously revolutionary image gradually morphed into a ritualistic veneration of the original 1917 revolutionary moment. To these gerontocratic indicators, the recent UK vote to leave the European Union (‘Brexit’) adds a new twist. There were some clear age-related patterns in the outcome: The older the voter, the more likely to vote to leave – and the more likely to vote at all. To be sure, given the closeness of the vote (52% to leave vs. 48% to remain), had the young voted in comparable numbers to their elders, Brexit would have lost.

One might think that the simple solution is to encourage, if not force, the young to vote in larger numbers. However, this does not take into account the liabilities of their elders when it comes to dictating the terms for living in the future. Whatever benefits might accrue to people living longer, the clarity of the memories of such people may not be an unmitigated good, as it might incline them to perpetuate what they regard as the best of their own pasts. One way around this situation is to weight votes inversely to age. In other words, the youngest voters would effectively get the most votes and the oldest voters the least. This would continually force the elders to make their case in terms that their juniors can appreciate. The exercise would serve to destabilize any sense of nostalgia that members of the same generation might experience simply by virtue of having experienced the same events at the same age.

However, two technologically based solutions also come to mind. One is for the elderly to be subject to the strategic memory loss procedure described in the film, The Eternal Sunshine of the Spotless Mind, which might be understood as a the cognitive correlate of an inheritance tax – or even a high-class lobotomy! In other words, the elders would lose their personal attachment to events which would nevertheless remain available in the historical record for more detached scrutiny vis-à-vis their lessons for the future. The other, more drastic solution involves incentivizing the elders to exchange biological for digital immortality. This would enable them to enjoy a virtual existence in perpetuity. They might be resurrected (‘downloaded’) on a regular or simply a need-to-remember basis, depending on prior contractual arrangements. The former might be seen as more ‘religious’, as in a Roman Catholic feast day, and the latter more ‘secular’, as in an ‘on tap’ consultant. But in either virtual form, the elders could retain their attachment to certain past events with impunity while at the same time not inflicting their memories needlessly on present generations.

David Wood, the head of the main UK transhumanist organization, London Futurists, has recently published a summa of anti-ageing arguments, which makes a cumulatively persuasive case for indefinite life extension being within our grasp. But most assuredly, this would create as many social problems as it solves biological ones. Under most direct threat would be the sorts of values historically associated with generational change, namely, those related to new thinking and fresh starts. Of course, as I have suggested, there are ways around this, but they will invariably revive in a new high-tech key classic debates concerning the desirability of brainwashing and suicide.

Philosophers have been debating the meaning of life for millennia. Billions of people believe that the principal aim in life is to experience pleasure, and they try to enjoy life as much as possible before they die. A minority of others, make it their life’s aim to achieve something which is over and above simple pleasure: not merely to help others, not even to help humanity at large. They aim, whether knowingly or unknowingly, to improve the evolutionary process of nature as a whole.

So far, so good. But it appears that the view we hold about our life, our worldview, has a direct impact on our biology. We know that thinking positively may help improve the immune system. But research also shows that people who aim for pleasure (Hedonia) may have an impaired genetic profile, compared to those who aim for higher virtues (Eudaimonia). There is a distinction between these two terms and it is worth providing a definition here:

Hedonia is an exclusive search for pleasure and avoidance of discomfort. It may involve increased emphasis on eating well, drinking, dancing, playing, and generally enjoying simple pleasures in life. It is contentment, gratification, fun, merriment, satisfaction and, perhaps necessarily, a lack of motivation to search for a nobler aim in life. One may argue that hedonia involves a risk that leads to bad health due to a tendency to excesses (smoking, alcohol, coffee, sweets), a general inclination to avoid uncomfortable physical activity, and a lack of challenging cognitive effort. The risk of addiction may be increased. Erosion of social bonds become a possibility when a hedonist is more concerned about his/her own pleasure and is less sensitive to the needs of others.

Eudaimonia is a term reflecting the highest ‘intellectual good’. It is virtue plus excellence, superior ethical refinement, cognitive sophistication, as well as other qualities such as persistent motivation, wisdom, imagination, creativity, vision and a feeling of purpose. The term has been discussed by many ancient Greek philosophers particularly Aristotle and the Stoics. In modern times and in a wider sense, eudaimonia may be equated with meaningful technological hyperconnection, or ‘Intentional Evolution’, an attempt to constructively improve the human condition in all respects (including those relating to the wider universe). Hedonia is found both in animals and in humans, whereas eudaimonia is only found in humans.

The above descriptions deliberately avoid the mention of the term ‘happiness’. People may fulfil either hedonic or eudaimonic characteristics and still be happy or unhappy nevertheless. Although hedonia and eudaimonia are distinct concepts, both are philosophical notions of happiness.

It has been suggested that eudaimonic well-being is associated with increased volume of a specific part of our brain, the right insular cortex although it is not known if this increase is the cause or the result of eudaimonia. The insula has been implicated in higher abstract functions such as self-awareness, self-reflection, cognitive control and intentional, creative goal-directed behaviour.

Eudaimonia is influenced by genetic factors and not so much by the environment. In a classic paper, high eudaimonic well-being was associated with a decreased risk of depression, improved physical health, improved sleep patterns, a reduction of inflammation and stress markers, together with a lower risk of cardiovascular disease. By contrast, high hedonic well-being was not associated with any of these.

We know that the immune system may have an impact on social behaviour. In a study published yesterday, scientists have shown that a component of the immune system, namely interferon-γ, can control neuronal connectivity in areas of the brain which are implicated in social interactions. This is the new science of Social Genomics, which may help us understand the mechanisms involved in the interaction between our social and emotional self and our biology. Social Genomics study the influence of social factors such as loneliness, stress, conflict, cooperation, and interaction with technology, upon our genetic profile and gene expression. Scientists in social genomics have analysed gene expression in the white blood cells of healthy adults, and showed that those who fulfilled the hedonic criteria exhibited a higher expression of stress-related and inflammation-increasing factors. We know that stress and inflammation are implicated in ageing. In contrast, those people who fulfilled primarily the eudaimonic characteristics showed the opposite genetic features, namely a down-regulation of inflammatory markers and an improvement of certain immune factors. These findings were confirmed again. Although both hedonia and eudaimonia may contribute to a feeling of subjective well-being, it appears that eudaimonia is associated with a measurable health effect which is defined by objective genetic and biological characteristics.

This begs the question: Does ageing and early death have something to do with hedonism? And at the same time, is the pursuit of eudaimonia one of the prerequisites for long, healthy life? I addressed this issue from different perspectives in a blog and a paper. Over the past years I have argued that being meaningfully hyperconnected and searching for a nobler aim in life are characteristics associated with longevity (because such characteristics increase the information content of the individual and may improve cellular repair – the Indispensable Soma hypothesis).

Evolution tends to follow a trajectory defined by survival and, in the case of humans, it is biased towards achieving a higher common good, a stage which is better than the previous one. If this is the case, there should be conserved signalling pathways and other biological mechanisms which favour a continuation of survival AND the ability to contribute to the universal good. Merely seeking pleasure is seen, from an evolutionary perspective, as just surviving without the need to achieve anything higher. Thus, hedonia appears to be in conflict with the basic trajectory of evolution. In addition, there is another puzzling question: Why is eudaimonia found only in humans and not in other animals? If eudaimonia is a pathway that leads to an improvement in the human condition we may need to espouse it fully, in order to improve ourselves and achieve longer life as a result. In fact, it could be the ONLY path towards achieving extreme longevity. Waiting for others to come up with pills and treatments to ‘cure’ ageing, is just…hedonic, it reflects an avoidance of effort and unwillingness to deal with the matter ourselves.

So, here is a concept for debate: People who live within a cognitive ecosystem and actively pursue eudaimonic characteristics are likely to enjoy better health, and have increased chances of living longer, compared to those who merely seek personal pleasure. This makes sense from clinical, biological, evolutionary and philosophical standpoints.

Fox 29 — Good Day Philadelphia

http://www.fox29.com/140735577-video

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NBC TV 10

http://www.nbcphiladelphia.com/news/local/Zombies-from-Philly_-Local-Firm-Hopes-to-Bring-People-Back-from-the-Dead_Philadelphia-378365101.html

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http://cnnespanol.cnn.com/video/cnnee-encuentro-intvw-joel-osorio-bioquantina-muerte-cerebral/

Researcher-test

Bioquark, Inc., (http://www.bioquark.com) a company focused on the development of novel biologics for complex regeneration and disease reversion, and Revita Life Sciences, (http://revitalife.co.in) a biotechnology company focused on translational therapeutic applications of autologous stem cells, have announced that they have received IRB approval for a study focusing on a novel combinatorial approach to clinical intervention in the state of brain death in humans.

This first trial, within the portfolio of Bioquark’s Reanima Project (http://www.reanima.tech) is entitled “Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury” (https://clinicaltrials.gov/ct2/show/NCT02742857?term=bioquark&rank=1), will enroll an initial 20 subjects, and be conducted at Anupam Hospital in Rudrapur, Uttarakhand India.

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“We are very excited about the approval of our protocol,” said Ira S. Pastor, CEO, Bioquark Inc. “With the convergence of the disciplines of regenerative biology, cognitive neuroscience, and clinical resuscitation, we are poised to delve into an area of scientific understanding previously inaccessible with existing technologies.”

Death is defined as the termination of all biological functions that sustain a living organism. Brain death, the complete and irreversible loss of brain function (including involuntary activity necessary to sustain life) as defined in the 1968 report of the Ad Hoc Committee of the Harvard Medical School, is the legal definition of human death in most countries around the world. Either directly through trauma, or indirectly through secondary disease indications, brain death is the final pathological state that over 60 million people globally transfer through each year.

While human beings lack substantial regenerative capabilities in the CNS, many non-human species, such as amphibians, planarians, and certain fish, can repair, regenerate and remodel substantial portions of their brain and brain stem even after critical life-threatening trauma.

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Additionally, recent studies on complex brain regeneration in these organisms, have highlighted unique findings in relation to the storage of memories following destruction of the entire brain, which may have wide ranging implications for our understanding of consciousness and the stability of memory persistence.

“Through our study, we will gain unique insights into the state of human brain death, which will have important connections to future therapeutic development for other severe disorders of consciousness, such as coma, and the vegetative and minimally conscious states, as well as a range of degenerative CNS conditions, including Alzheimer’s and Parkinson’s disease,” said Dr. Sergei Paylian, Founder, President, and Chief Science Officer of Bioquark Inc.

Over the years, clinical science has focused heavily on preventing such life and death transitions and made some initial progress with suspended animation technologies, such as therapeutic hypothermia. However, once humans transition through the brain death window, currently defined by the medical establishment as “irreversible”, they are technically no longer alive, despite the fact that human bodies can still circulate blood, digest food, excrete waste, balance hormones, grow, sexually mature, heal wounds, spike a fever, and gestate and deliver a baby. It is even acknowledged by thought leaders that recently brain dead humans still may have residual blood flow and electrical nests of activity in their brains, just not enough to allow for an integrated functioning of the organism as a whole.

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“We look forward to working closely with Bioquark Inc. on this cutting edge clinical initiative,” said Dr. Himanshu Bansal, Managing Director of Revita Life Sciences.

About Bioquark, Inc.

Bioquark Inc. is focused on the development of natural biologic based products, services, and technologies, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing both biological pharmaceutical candidates, as well as products for the global consumer health and wellness market segments.

About Revita Life Sciences

Revita Life Sciences is a biotechnology company focused on the development of stem cell therapies that target areas of significant unmet medical need. Revita is led by Dr. Himanshu Bansal MD, PhD. who has spent over two decades developing novel MRI based classifications of spinal cord injuries as well as comprehensive treatment protocols with autologous tissues including bone marrow stem cells, dural nerve grafts, nasal olfactory tissues, and omental transposition.

I have spent the last 30 years in various aspects of the biopharmaceutical industry, which for the most part has been a very rewarding experience.

However, during this time period, having been immersed many different components of therapeutic development and commercialization, one thing has always bothered me: a wide array of promising research never makes it off the bench to see the translational light of day, and gets lost in the historical scientific archives.

bqiinclab

I always believed that scientific progress happened in a very linear narrative, with each new discovery supporting the next, resulting ultimately in an eventual stairway of scientific enlightenment.

What the reality turned out to be was much more of a fragmented, research “evolutionary tree”, with dozens of potential pathways, only very few branches of which ever resulted in scientific maturity, and not always the most fruitful ones by any means.

The premature extinction of these promising discovery pathways were the result of a variety of factors, including, but not limited to, funding priorities, competing industrial interests, “out of vogue” concepts, lack of intellectual properties, non-existent regulatory models, conflicted legislative initiatives, and even religious implications.

In 2016, as in previous years, we continue to see these “valleys of death” swallow up pathways of scientific possibility, with few popular segments attracting the majority of attention and support.

gene sequencing

The preponderance of resources focused on the somatic mutation model of carcinogenesis, despite an endless range of research highlighting that the disease is extremely heterogenic and rarely ever follows such a clonal model, is one example that continues to be inappropriately manifested in the oncology system, decades into the “war on cancer”.

On a similar plane, the jettisoning of most studies of the biophysical aspects of human genetics, despite the gross incompleteness offered by the central dogma to explain higher biological form and function, is another example that has become all too pervasive in the research community.

And then there are the areas of human consciousness, memory, and information processing / storage, where in many ways we are still operating in the dark ages, with materialists and dualists battling it out for centuries.

One topic that I have written quite a bit about is that of death, specifically that of the death of the human brain — http://www.singularityweblog.com/is-death-reversible/

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While I am a staunch supporter and advocate of the life-extension / anti-aging movement, I am equally vocal about our need to develop technologies, products, and services that can actually reverse our ultimate transition between the living and dead states, a transition that occurs annually for 60 million humans around the globe.

Death, however, is unfortunately seen by many as a natural, biological progression for human beings, and in many circles, deemed an unnecessary area of scientific research and exploration.

I beg to differ.

Far too often, death arrives too early and too unexpectedly for many of us and our loved ones. And the best modern medicine has to offer today is “Sorry. There is nothing else we can do.”

But what if there was?

There are a variety of species across the natural world that are capable of regenerating and repairing themselves from forms of severe CNS damage that bring them to the transitional grey zone between life and death. Along the evolutionary timeline however, this ability gradually disappeared hundreds of millions of years ago and does not manifest in higher species.

lizard and lady

Now, in the 21st century, with the convergence of the disciplines of regenerative biology, cognitive neuroscience, and clinical resuscitation, we may finally be poised to take back these capabilities for humans.

Over the years, clinical science has focused heavily on preventing such life and death transitions and made some initial progress with suspended animation technologies, such as therapeutic hypothermia. But once we transition through the brain death window, currently defined by the medical establishment as “irreversible” (per the 1968 Ad Hoc Committee of the Harvard Medical School definition), we are technically no longer alive.

surgeons

To add insult to injury, a human can be declared dead, even while our bodies can still circulate blood, digest food, excrete waste, balance hormones, grow, sexually mature, heal wounds, spike a fever, and gestate and deliver a baby. It is even acknowledged by thought leaders that recently brain dead humans still may have residual blood flow and electrical nests of activity in their brains, just not enough to allow for an integrated functioning of the organism as a whole.

Several prominent cases in the media over the past few years have further served to highlight the current situation, as well as the substantial anatomical and functional differences between the state known as brain death, and other severe disorders of consciousness, such as coma, and the vegetative and minimally conscious states.

It is now time to take the necessary steps to provide new possibilities of hope, in order to counter the pain, sorrow, and grief that is all too pervasive in the world when we experience a loved one’s unexpected or untimely death, due to lesions which might be potentially reversible with the application of promising neuro-regeneration and neuro-reanimation technologies and therapies.

bqaproduction

It is time to undertake the required research, based on 2016 technological knowledge, in order to bring about such transformational change.

My name is Ira S. Pastor and I am the CEO of the biotechnology company Bioquark Inc.

Welcome to the unveiling of the Reanima project.

Reanima Video

[From CNN]

Human ‘mini brains’ grown in labs may help solve cancer, autism, Alzheimer’s

mini_brain

  • Ohio State biomedical research team grows nearly complete human ‘mini brain’
  • Brain organoids can be used to learn more about diseases like cancer, Alzheimer’s and Parkinson’s
  • Brain organoids could yield autism breakthrough within 10 years, researcher says

| Video Source: CNN
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