Posted in aging, bioengineering, biotech/medical, business, DNA, futurism, health, Peter Diamandis, science, transhumanism | Leave a Comment on The Regenerage Show- Episode #4 — “Whole Organism Rejuvenation and Combinatorial Biologics” — Ira Pastor — Host
Posted in aging, biotech/medical, DNA, government, health, life extension, military, neuroscience, nuclear weapons, posthumanism | Leave a Comment on Dr. Wendy Dean, M.D., Senior Vice President of Program Operations, Henry M. Jackson Foundation for the Advancement of Military Medicine — ideaXme — Ira Pastor
Investigators at Harvard Medical School have identified the key cellular mechanisms behind vascular aging and its effects on muscle health, and they have successfully reversed the process in animals.
The scientists used a chemical compound that’s an NAD+ booster called NMN which plays a critical role in repairing cellular DNA as well as maintaining cell vitality to test what would happen.
Could reversing the aging of blood vessels hold the key to restoring youthful vitality? If the old adage “you are as old as your arteries” reigns true then the answer is yes, at least in mice.
According to a new study by Harvard Medical School researchers, they have identified the cellular mechanisms that cause the aging of vascular arteries as well as the effects of such aging on the health of muscles. The Medical team was also able to successfully reverse this aging process.
What these findings seem to indicate is that there’s a glitch in the normal crosswalk between both muscles and blood vessels and keeping both tissues healthy. The scientists were also able reverse the demise of blood vessels and muscle atrophy in the aging mice by using the synthetic precursors of two molecules naturally present in the body. This boosted their exercise endurance in the process.
The Medical team is excited because such a breakthrough will now pave the way to identifying new therapies for humans.
Study senior investigator David Sinclair, professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School stated “we’ve discovered a way to reverse vascular aging by boosting the presence of naturally occurring molecules in the body that augment the physiological response to exercise.”
Because there are some very important differences in biology between humans and mice there’s a possibility that this treatment may not have the same effect in humans. Nonetheless, the research team plans to follow through with human clinical trials because the results of this experiment were important enough to prompt the research team in doing so.
Sinclair, who is also a professor at the University of New South Wales School of Medical Sciences in Sydney, Australia stated, “the approach stimulates blood vessel growth and boosts stamina and endurance in mice and sets the stage for therapies in humans to address the spectrum of diseases that arise from vascular aging.”
One of the side effects of aging is reduced blood flow and the compromise of oxygenation of organs and tissue because our tiniest blood vessels began to wither and die. Cardiac and neurologic conditions, muscle loss, impaired wound healing and overall frailty, and among other things are the results of vascular aging. As these blood vessels die there’s a loss of blood flow to organs and tissues which causes toxins build-up and a loss of oxygen.
For quite some time scientists have known the essential role that endothelial cells, which line blood vessels, play in the health and growth of blood vessels that supply oxygen-rich and nutrient-loaded blood to organs and tissues. Unfortunately, as with all things on the human body, these endothelial cells age having a detrimental effect on the body. New blood vessels fail to form, blood vessels atrophy, and the overall blood flow to most parts of the body diminishes. This has a powerful impact on muscles, which heavily rely on robust blood supply to function because they’re heavily vascularized.
Typically we exercise in hopes of slowing down sarcopenia, but unfortunately even that doesn’t last forever. Gradually our muscles grow weaker and begin to shrivel as part of the aging process.
What precisely curtails the blood flow and precipitates this unavoidable decline? Why does even exercise lose its protective power to sustain muscle vitality? Is this process reversible? There were some of the leading questions Sinclair and team had.
The Experiment/Results:
Sinclair and his team discovered through a series of experiments that the flow of blood is reduced as endothelial cells start to lose a critical protein known as sirtuin1, or SIRT1. SIRT1 delays aging and extends life in yeast and mice as shown in previous studies.
Research done previously by Sinclair and others has shown that NAD+ boosts the activity of SIRT1. SIRT1 loss is a result of the loss of NAD+, which is a key regulator of protein interactions and DNA repair that was identified more than a century ago. As NAD+ declines with age so does the protein SIRT1.
The results showed that the critical interface that enables the conversation between endothelial cells in the walls of blood vessels and muscle cells is provided by NAD+ and SIRT1.
SIRT1 signaling is activated and generates new capillaries, the tiniest blood vessels in the body that supply oxygen and nutrients to tissues and organs in young mice muscles. As the mice aged, however, the study found that muscle tissue was left nutrient-deprived and oxygen-starved as a result in the diminishment of NAD+ and SIRT1.
The researchers hope that their findings may pave the way to therapeutic advances that hold promise for the millions of older people for whom regular physical activity is not an option.
Abhirup Das, the studies first author, who conducted the work as a post-doctoral fellow in Sinclair’s lab, currently a visiting scholar in genetics at Harvard Medical School and a post-doctoral research fellow at the University of South New Wales School of Medical Sciences, said that “we reasoned that declining NAD+ levels reduce SIRT1 activity and thus interfere with aging mice’s ability to grow new blood vessels.”
The researchers then set their sights on the NAD+, which is a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate-ribose) polymerases.
The scientists used a chemical compound that’s an NAD+ booster called NMN (no not m&m!) which plays a critical role in repairing cellular DNA as well as maintaining cell vitality to test what would happen.
One of the results showed that treatment from NMN caused endothelial cells from humans and mice to have strong growth capacity and reduced cell death.
The team then wondered what would happen to a group of mice that were 20 months old—the rough equivalent of 70 in human years given NMN. After a 2 month time span the results showed that NMN treatment restored the number of blood capillaries and capillary density to those seen in younger mice. Blood flow to the muscles also increased and was significantly higher than blood supply to the muscles seen in same-age mice that didn’t receive NMN.
That wasn’t the most surprising result to the researchers however. What they discovered was that the aging mice showed in comparison to the entreated mice that they regained the capacity to exercise by 56 and 80% more. The untreated mice could only run 240 meters, or 780 feet, on average whereas the mice treated with NMN could run 430 meters, or about 1,400 feet, on average. This treatment could be an answer to humans who have lost the capacity to exercise due to other disabilities or age-related diseases.
The next step for the researchers was to explore methods for boosting the activity of SIRT1. To do this the researchers added a second compound NaHS, sodium hydrosulfide, which is known to be a precursor of SIRT1.
For four weeks a group of mice that were 32-month-old mice—the rough equivalent to 90 in human years—receiving the combo treatment. The results were significant! Not only were the mice able to run longer and faster but they were able to outperform the untreated mice by a longshot. The treated mice ran 1.6 times further than the untreated mice.
Study co-author James Mitchell, associate professor of genetics and complex diseases at the Harvard T. H. Chan School of Public Health stated that “these are really old mice so our finding that the combo treatment doubles their running capacity is nothing short of intriguing.”
“This observation underscores the notion that age plays a critical role in the crosstalk between blood vessels and muscles and points to a loss of NAD+ and SIRT1 as the reason behind loss of exercise effectiveness after middle age,” Das said.
One of the ultimate goals for the team is to eventually move forward in developing small-molecule, NMN-based drugs that mimic the effects of exercise—enhanced blood flow and oxygenation of muscles and other tissues. Though they must first replicate their findings first. Such therapies could potentially help with new vessel growth of organs that suffer tissue-damaging loss of blood supply and oxygen, a common scenario in heart attacks and ischemic strokes, the team said.
Posted in aging, bioengineering, biotech/medical, disruptive technology, DNA, genetics, health, life extension, posthumanism, science | Leave a Comment on Bioquark Inc. and Lakmus LLC Announce Research Collaboration to Study Novel Biopharmaceuticals for Healthy Longevity Enhancement
Philadelphia, PA, USA / Moscow, Russia — Bioquark, Inc., (www.bioquark.com) a life sciences company focused on the development of novel bio-products for regeneration, disease reversion, and healthy aging, and Moscow based, Lakmus LLC, a diversified investment company with business interests in pharmacies, restaurants, and real estate, announced a multi-disciplinary research collaboration with the FSBI Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences (http://www.academpharm.ru/), and the Pavlov Institute of Physiology of the Russian Academy of Sciences (http://www.infran.ru/), to jointly study the pharmacotherapeutic longevity enhancement properties of its combinatorial regenerative biologic candidates.
“We are very excited about this continued collaboration with Lakmus,” said Ira S. Pastor, CEO, Bioquark Inc. “The disciplined development of our combinatorial biologic candidates (Bioquantines) for healthy longevity enhancement, represents another important step in our continued evolution as a company focused on a broad range of therapeutic products and services in the regenerative healthcare space.”
Throughout the 20th century, natural products formed the basis for a majority of all pharmaceuticals, biologics, and consumer healthcare products used by patients around the globe, generating trillions of dollars of wealth. However, many scientists believe we have only touched the surface with what the natural world, and its range of organisms, which from a health and wellness perspective are much further advanced than human beings, has to teach us.
The integration of a complex set of newer research disciplines, including interkingdom signaling, semiochemical communication, and evolutionary biology, as well as significant recent activity in the areas of the microbiome, are highlighting a myriad of new ways that non-human bio-products can affect the human genome for positive transitions in health and wellness dynamics.
“Bioquark has spent several years studying the natural ability of many species to turn back biological time in order to maintain health, fitness, and survival, developing a broad understanding of the combinatorial biochemical approaches they use to control nested hierarchies of disease (i.e. gene, cell, tissue, organism, environment),” said Dr. Sergei Paylian, Founder, CSO, and President, Bioquark Inc. “This research initiative is one more step in the path in allowing humans to recapture these capabilities to effectively counter our unfortunate progression into aging, disease and degeneration.”
About Bioquark, Inc.
Bioquark Inc. is focused on the development of natural biologic based products, services, and technologies, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing both biological pharmaceutical candidates, as well as products for the global consumer health and wellness market segments.
Posted in aging, bioengineering, biological, biotech/medical, cryonics, disruptive technology, futurism, health, life extension, neuroscience | Leave a Comment on Bioquark Inc. and Revita Life Sciences Receive IRB Approval for First-In-Human Brain Death Study
Bioquark, Inc., (http://www.bioquark.com) a company focused on the development of novel biologics for complex regeneration and disease reversion, and Revita Life Sciences, (http://revitalife.co.in) a biotechnology company focused on translational therapeutic applications of autologous stem cells, have announced that they have received IRB approval for a study focusing on a novel combinatorial approach to clinical intervention in the state of brain death in humans.
This first trial, within the portfolio of Bioquark’s Reanima Project (http://www.reanima.tech) is entitled “Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury” (https://clinicaltrials.gov/ct2/show/NCT02742857?term=bioquark&rank=1), will enroll an initial 20 subjects, and be conducted at Anupam Hospital in Rudrapur, Uttarakhand India.
“We are very excited about the approval of our protocol,” said Ira S. Pastor, CEO, Bioquark Inc. “With the convergence of the disciplines of regenerative biology, cognitive neuroscience, and clinical resuscitation, we are poised to delve into an area of scientific understanding previously inaccessible with existing technologies.”
Death is defined as the termination of all biological functions that sustain a living organism. Brain death, the complete and irreversible loss of brain function (including involuntary activity necessary to sustain life) as defined in the 1968 report of the Ad Hoc Committee of the Harvard Medical School, is the legal definition of human death in most countries around the world. Either directly through trauma, or indirectly through secondary disease indications, brain death is the final pathological state that over 60 million people globally transfer through each year.
While human beings lack substantial regenerative capabilities in the CNS, many non-human species, such as amphibians, planarians, and certain fish, can repair, regenerate and remodel substantial portions of their brain and brain stem even after critical life-threatening trauma.
Additionally, recent studies on complex brain regeneration in these organisms, have highlighted unique findings in relation to the storage of memories following destruction of the entire brain, which may have wide ranging implications for our understanding of consciousness and the stability of memory persistence.
“Through our study, we will gain unique insights into the state of human brain death, which will have important connections to future therapeutic development for other severe disorders of consciousness, such as coma, and the vegetative and minimally conscious states, as well as a range of degenerative CNS conditions, including Alzheimer’s and Parkinson’s disease,” said Dr. Sergei Paylian, Founder, President, and Chief Science Officer of Bioquark Inc.
Over the years, clinical science has focused heavily on preventing such life and death transitions and made some initial progress with suspended animation technologies, such as therapeutic hypothermia. However, once humans transition through the brain death window, currently defined by the medical establishment as “irreversible”, they are technically no longer alive, despite the fact that human bodies can still circulate blood, digest food, excrete waste, balance hormones, grow, sexually mature, heal wounds, spike a fever, and gestate and deliver a baby. It is even acknowledged by thought leaders that recently brain dead humans still may have residual blood flow and electrical nests of activity in their brains, just not enough to allow for an integrated functioning of the organism as a whole.
“We look forward to working closely with Bioquark Inc. on this cutting edge clinical initiative,” said Dr. Himanshu Bansal, Managing Director of Revita Life Sciences.
About Bioquark, Inc.
Bioquark Inc. is focused on the development of natural biologic based products, services, and technologies, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing both biological pharmaceutical candidates, as well as products for the global consumer health and wellness market segments.
About Revita Life Sciences
Revita Life Sciences is a biotechnology company focused on the development of stem cell therapies that target areas of significant unmet medical need. Revita is led by Dr. Himanshu Bansal MD, PhD. who has spent over two decades developing novel MRI based classifications of spinal cord injuries as well as comprehensive treatment protocols with autologous tissues including bone marrow stem cells, dural nerve grafts, nasal olfactory tissues, and omental transposition.
Posted in biological, complex systems, cosmology, engineering, existential risks, homo sapiens, human trajectories, humor, information science, particle physics, philosophy, physics | 1 Comment on Today, a Young Man on Acid Realized that all Matter is Merely Energy Condensed to a…
…here’s Tom with the Weather.
That right there is comedian/philosopher Bill Hicks, sadly no longer with us. One imagines he would be pleased and completely unsurprised to learn that serious scientific minds are considering and actually finding support for the theory that our reality could be a kind of simulation. That means, for example, a string of daisy-chained IBM Super-Deep-Blue Gene Quantum Watson computers from 2042 could be running a History of the Universe program, and depending on your solipsistic preferences, either you are or we are the character(s).
It’s been in the news a lot of late, but — no way, right?
Because dude, I’m totally real
Despite being utterly unable to even begin thinking about how to consider what real even means, the everyday average rational person would probably assign this to the sovereign realm of unemployable philosophy majors or under the Whatever, Who Cares? or Oh, That’s Interesting I Gotta Go Now! categories. Okay fine, but on the other side of the intellectual coin, vis-à-vis recent technological advancement, of late it’s actually being seriously considered by serious people using big words they’ve learned at endless college whilst collecting letters after their names and doin’ research and writin’ and gettin’ association memberships and such.
So… why now?
Well, basically, it’s getting hard to ignore.
It’s not a new topic, it’s been hammered by philosophy and religion since like, thought happened. But now it’s getting some actual real science to stir things up. And it’s complicated, occasionally obtuse stuff — theories are spread out across various disciplines, and no one’s really keeping a decent flowchart.
So, what follows is an effort to encapsulate these ideas, and that’s daunting — it’s incredibly difficult to focus on writing when you’re wondering if you really have fingers or eyes. Along with links to some articles with links to some papers, what follows is Anthrobotic’s CliffsNotes on the intersection of physics, computer science, probability, and evidence for/against reality being real (and how that all brings us back to well, God).
You know, light fare.
First — Maybe we know how the universe works: Fantastically simplified, as our understanding deepens, it appears more and more the case that, in a manner of speaking, the universe sort of “computes” itself based on the principles of quantum mechanics. Right now, humanity’s fastest and sexiest supercomputers can simulate only extremely tiny fractions of the natural universe as we understand it (contrasted to the macro-scale inferential Bolshoi Simulation). But of course we all know the brute power of our computational technology is increasing dramatically like every few seconds, and even awesomer, we are learning how to build quantum computers, machines that calculate based on the underlying principles of existence in our universe — this could thrust the game into superdrive. So, given ever-accelerating computing power, and given than we can already simulate tiny fractions of the universe, you logically have to consider the possibility: If the universe works in a way we can exactly simulate, and we give it a shot, then relatively speaking what we make ceases to be a simulation, i.e., we’ve effectively created a new reality, a new universe (ummm… God?). So, the question is how do we know that we haven’t already done that? Or, otherwise stated: what if our eventual ability to create perfect reality simulations with computers is itself a simulation being created by a computer? Well, we can’t answer this — we can’t know. Unless…
[New Scientist’s Special Reality Issue]
[D-Wave’s Quantum Computer]
[Possible Large-scale Quantum Computing]
Second — Maybe we see it working: The universe seems to be metaphorically “pixelated.” This means that even though it’s a 50 billion trillion gajillion megapixel JPEG, if we juice the zooming-in and drill down farther and farther and farther, we’ll eventually see a bunch of discreet chunks of matter, or quantums, as the kids call them — these are the so-called pixels of the universe. Additionally, a team of lab coats at the University of Bonn think they might have a workable theory describing the underlying lattice, or existential re-bar in the foundation of observable reality (upon which the “pixels” would be arranged). All this implies, in a way, that the universe is both designed and finite (uh-oh, getting closer to the God issue). Even at ferociously complex levels, something finite can be measured and calculated and can, with sufficiently hardcore computers, be simulated very, very well. This guy Rich Terrile, a pretty serious NASA scientist, sites the pixelation thingy and poses a video game analogy: think of any first-person shooter — you cannot immerse your perspective into the entirety of the game, you can only interact with what is in your bubble of perception, and everywhere you go there is an underlying structure to the environment. Kinda sounds like, you know, life — right? So, what if the human brain is really just the greatest virtual reality engine ever conceived, and your character, your life, is merely a program wandering around a massively open game map, playing… well, you?
[Lattice Theory from the U of Bonn]
[NASA guy Rich Terrile at Vice]
[Kurzweil AI’s Technical Take on Terrile]
Thirdly — Turns out there’s a reasonable likelihood: While the above discussions on the physical properties of matter and our ability to one day copy & paste the universe are intriguing, it also turns out there’s a much simpler and straightforward issue to consider: there’s this annoyingly simplistic yet valid thought exercise posited by Swedish philosopher/economist/futurist Nick Bostrum, a dude way smarter that most humans. Basically he says we’ve got three options: 1. Civilizations destroy themselves before reaching a level of technological prowess necessary to simulate the universe; 2. Advanced civilizations couldn’t give two shits about simulating our primitive minds; or 3. Reality is a simulation. Sure, a decent probability, but sounds way oversimplified, right?
Well go read it. Doing so might ruin your day, JSYK.
[Summary of Bostrum’s Simulation Hypothesis]
Lastly — Data against is lacking: Any idea how much evidence or objective justification we have for the standard, accepted-without-question notion that reality is like, you know… real, or whatever? None. Zero. Of course the absence of evidence proves nothing, but given that we do have decent theories on how/why simulation theory is feasible, it follows that blithely accepting that reality is not a simulation is an intrinsically more radical position. Why would a thinking being think that? Just because they know it’s true? Believing 100% without question that you are a verifiably physical, corporeal, technology-wielding carbon-based organic primate is a massive leap of completely unjustified faith.
Oh, Jesus. So to speak.
If we really consider simulation theory, we must of course ask: who built the first one? And was it even an original? Is it really just turtles all the way down, Professor Hawking?
Okay, okay — that means it’s God time now
Now let’s see, what’s that other thing in human life that, based on a wild leap of faith, gets an equally monumental evidentiary pass? Well, proving or disproving the existence of god is effectively the same quandary posed by simulation theory, but with one caveat: we actually do have some decent scientific observations and theories and probabilities supporting simulation theory. That whole God phenomenon is pretty much hearsay, anecdotal at best. However, very interestingly, rather than negating it, simulation theory actually represents a kind of back-door validation of creationism. Here’s the simple logic:
If humans can simulate a universe, humans are it’s creator.
Accept the fact that linear time is a construct.
The process repeats infinitely.
We’ll build the next one.
The loop is closed.
God is us.
Heretical speculation on iteration
Even wonder why older polytheistic religions involved the gods just kinda setting guidelines for behavior, and they didn’t necessarily demand the love and complete & total devotion of humans? Maybe those universes were 1st-gen or beta products. You know, like it used to take a team of geeks to run the building-sized ENIAC, the first universe simulations required a whole host of creators who could make some general rules but just couldn’t manage every single little detail.
Now, the newer religions tend to be monotheistic, and god wants you to love him and only him and no one else and dedicate your life to him. But just make sure to follow his rules, and take comfort that your’re right and everyone else is completely hosed and going to hell. The modern versions of god, both omnipotent and omniscient, seem more like super-lonely cosmically powerful cat ladies who will delete your ass if you don’t behave yourself and love them in just the right way. So, the newer universes are probably run as a background app on the iPhone 26, and managed by… individuals. Perhaps individuals of questionable character.
The home game:
Latest title for the 2042 XBOX-Watson³ Quantum PlayStation Cube:*
Crappy 1993 graphic design simulation: 100% Effective!
And hey, if true, it’s not exactly bad news
All these ideas are merely hypotheses, and for most humans the practical or theoretical proof or disproof would probably result in the same indifferent shrug. For those of us who like to rub a few brain cells together from time to time, attempting to both to understand the fundamental nature of our reality/simulation, and guess at whether or not we too might someday be capable of simulating ourselves, well — these are some goddamn profound ideas.
So, no need for hand wringing — let’s get on with our character arc and/or real lives. While simulation theory definitely causes reflexive revulsion, “just a simulation” isn’t necessarily pejorative. Sure, if we take a look at the current state of our own computer simulations and A.I. constructs, it is rather insulting. So if we truly are living in a simulation, you gotta give it up to the creator(s), because it’s a goddamn amazing piece of technological achievement.
Addendum: if this still isn’t sinking in, the brilliant
Dinosaur Comics might do a better job explaining:
(This post originally published I think like two days
ago at technosnark hub www.anthrobotic.com.)
