Bioquark, Inc., (http://www.bioquark.com) a company focused on the development of novel biologics for complex regeneration and disease reversion, and Revita Life Sciences, (http://revitalife.co.in) a biotechnology company focused on translational therapeutic applications of autologous stem cells, have announced that they have received IRB approval for a study focusing on a novel combinatorial approach to clinical intervention in the state of brain death in humans.
This first trial, within the portfolio of Bioquark’s Reanima Project (http://www.reanima.tech) is entitled “Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury” (https://clinicaltrials.gov/ct2/show/NCT02742857?term=bioquark&rank=1), will enroll an initial 20 subjects, and be conducted at Anupam Hospital in Rudrapur, Uttarakhand India.
“We are very excited about the approval of our protocol,” said Ira S. Pastor, CEO, Bioquark Inc. “With the convergence of the disciplines of regenerative biology, cognitive neuroscience, and clinical resuscitation, we are poised to delve into an area of scientific understanding previously inaccessible with existing technologies.”
Death is defined as the termination of all biological functions that sustain a living organism. Brain death, the complete and irreversible loss of brain function (including involuntary activity necessary to sustain life) as defined in the 1968 report of the Ad Hoc Committee of the Harvard Medical School, is the legal definition of human death in most countries around the world. Either directly through trauma, or indirectly through secondary disease indications, brain death is the final pathological state that over 60 million people globally transfer through each year.
While human beings lack substantial regenerative capabilities in the CNS, many non-human species, such as amphibians, planarians, and certain fish, can repair, regenerate and remodel substantial portions of their brain and brain stem even after critical life-threatening trauma.
Additionally, recent studies on complex brain regeneration in these organisms, have highlighted unique findings in relation to the storage of memories following destruction of the entire brain, which may have wide ranging implications for our understanding of consciousness and the stability of memory persistence.
“Through our study, we will gain unique insights into the state of human brain death, which will have important connections to future therapeutic development for other severe disorders of consciousness, such as coma, and the vegetative and minimally conscious states, as well as a range of degenerative CNS conditions, including Alzheimer’s and Parkinson’s disease,” said Dr. Sergei Paylian, Founder, President, and Chief Science Officer of Bioquark Inc.
Over the years, clinical science has focused heavily on preventing such life and death transitions and made some initial progress with suspended animation technologies, such as therapeutic hypothermia. However, once humans transition through the brain death window, currently defined by the medical establishment as “irreversible”, they are technically no longer alive, despite the fact that human bodies can still circulate blood, digest food, excrete waste, balance hormones, grow, sexually mature, heal wounds, spike a fever, and gestate and deliver a baby. It is even acknowledged by thought leaders that recently brain dead humans still may have residual blood flow and electrical nests of activity in their brains, just not enough to allow for an integrated functioning of the organism as a whole.
“We look forward to working closely with Bioquark Inc. on this cutting edge clinical initiative,” said Dr. Himanshu Bansal, Managing Director of Revita Life Sciences.
About Bioquark, Inc.
Bioquark Inc. is focused on the development of natural biologic based products, services, and technologies, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing both biological pharmaceutical candidates, as well as products for the global consumer health and wellness market segments.
About Revita Life Sciences
Revita Life Sciences is a biotechnology company focused on the development of stem cell therapies that target areas of significant unmet medical need. Revita is led by Dr. Himanshu Bansal MD, PhD. who has spent over two decades developing novel MRI based classifications of spinal cord injuries as well as comprehensive treatment protocols with autologous tissues including bone marrow stem cells, dural nerve grafts, nasal olfactory tissues, and omental transposition.
Since ancient times people have been searching for the secret of immortality. Their quest has always been, without exception, about a physical item: a fountain, an elixir, an Alchemist’s remedy, a chalice, a pill, an injection of stem cells or a vial containing gene-repairing material. It has never been about an abstract concept.
Our inability to find a physical cure for ageing is explained by a simple fact: We cannot find it because it does not exist. It will never exist.
Those who believe that someday some guy is going to discover a pill or a remedy and give it to people so that we will all live forever are, regrettably, deluded.
I should highlight here that I refer to a cure for the ageing process in general, and not a cure for a specific medical disease. Biotechnology and other physical therapies are useful in alleviating many diseases and ailments, but these therapies will not be the answer to the basic biological process of ageing.
In a paper I published in the journal Rejuvenation Research I outline some of the reasons why I think biotechnology will not solve the ageing problem. I criticise projects such as SENS (which are based upon physical repairs of our ageing tissues) as being essentially useless against ageing. The editor’s rebuttal (being weak and mostly irrelevant) proved and strengthened my point. There are insurmountable basic psychological, anatomical, biological and evolutionary reasons why physical therapies against ageing will not work and will be unusable by the general public. Some of these reasons include pleiotropy, non-compliance, topological properties of cellular networks, non-linearity, strategic logistics, polypharmacy and tolerance, etc. etc.
So, am I claiming that we are doomed to live a life of age-related pathology and degeneration, and never be able to shake off the aging curse? No, far from it. I am claiming that it is quite possible, even inevitable, that ageing will be eliminated but this will not be achieved through a physical intervention based on bio-medicine or bio-technology. Ageing will be eliminated through fundamental evolutionary and adaptation mechanisms, and this process will take place independently of whether we want it or not.
It works like this: We now age and die because we become unable to repair random background damage to our tissues. Resources necessary for this have been allocated by the evolutionary process to our germ cell DNA (in order to assure the survival of the species) and have been taken away from our bodily cells. Until now, our environment was so full of dangers that it was more thermodynamically advantageous for nature to maintain us up to a certain age, until we have progeny and then die, allowing our progeny to continue life.
However, this is now changing. Our environment is becoming increasingly more secure and protective. Our technology protects us against dangers such as infections, famine and accidents. We become increasingly embedded into the network of a global techno-cultural society which depends upon our intelligence in order to survive. There will come a time when biological resources spent to bring up children would be better spent in protecting us instead, because it would be more economical for nature to maintain an existing, well-embedded human, rather than allow it to die and create a new one who would then need more resources in order to re-engage with the techno-cultural network. Disturbing the network by taking away its constituents and trying to re-engage new inexperienced ones is not an ideal action and therefore it will not be selected by evolution.
The message is clear: You have more chances of defying ageing if, instead of waiting for someone to discover a pill to make you live longer, you become a useful part of a wider network and engage with a technological society. The evolutionary process will then ensure that you live longer-as long as you are useful to the whole.
Ray Kurzweil’s well-received book, The Singularity is Near, is perhaps the best known book related to transhumanism and presents a view of inevitable technological evolution that closely resembles the claim in the later (2010) book What Technology Wants by Wired co-founder Kevin Kelly.
Kurzweil describes six epochs in the history of information. Each significant form of information is superseded by another in a series of stepping stones, exposing a universal will at work within technology towards extropy (this is seen by Kevin Kelly as intelligence and complexity attaining their maximum state possible). The first epoch is physics and chemistry, and is succeeded by biology, brains, technology, the merger of technology and human intelligence and finally the epoch in which the universe “wakes up”. The final epoch achieves what could be called godhood for the universe’s surviving intelligences (p. 15).
Artificial intelligence, which Kurzweil predicts to compete with and soon after overtake the human brain, will mean reverse-engineering the human brain as a direct offshoot of developing higher resolution when scanning the brain (much as genome synthesis was the offshoot of being able to sequence a complete genome) (p. 25–29, 111–198). This is a source of particular excitement to many, because of Kurzweil and Google’s genuine efforts to make it a reality.
An interest in abundance and a read of J. Craig Venter’s Life at the Speed of Light will make Chapter 5 of Kurzweil’s book of particular interest, as it discusses genetics and its relationship to the singularity. Genetics, nanotechnology and robotics are seen as overlapping revolutions that are set to characterize the first half of the Twenty-First Century (p.205). Kurzweil addresses the full understanding of genetics, e.g. knowing exactly how to program and hack our DNA as in J. Craig Venter’s synthetic biology revolution (p. 205–212).
Kurzweil predicts “radical life-extension” on top of the elimination of disease and expansion of human potential through the genetics advancements of teams like J. Craig Venter’s. J. Craig Venter covered life extension and human enhancement in his 2013 book, but also drew special attention to the ongoing engineering of beneficial microbes for purposes of making renewable resources and cleaning the environment. Another prospect for abundance noted by Kurzweil is the idea of cloning meat and other protein sources in a factory (this being an offshoot of medical cloning advances). Far from simply offering life extension to the privileged few, Kurzweil notes that such a development may have the potential to solve world hunger.
To cover the nanotechnology revolution, Kurzweil visits nanotechnology father K. Eric Drexler’s assessments of the pros and cons in this field. In some ways, Kurzweil could be faulted for expecting too much from nanotechnology, since his treatment of the subject contrasts sharply with Drexler’s characterization of it as simply being “atomically precise manufacturing” (APM) and primarily having industrial ramifications. In Radical Abundance, Drexler specifically discourages the view echoed by Kurzweil of “nanobots” swimming in our body in the near future and delivering miracle cures, seeing such expectations as the product of sci-fi stories and media hype.
On the subject of artificial intelligence, there can be no doubt that Kurzweil is ahead of all of us because of his personal background. In his estimate, artificial intelligence reverse-engineered from the human brain will immediately “exceed human intelligence” for a number of reasons even if we only design it to be on par with our intelligence. For example, computers are able to “pool their resources in ways that humans cannot” (p. 259–298). In addition, Kurzweil forecasts:
The advent of strong AI is the most important transformation this century will see. Indeed, it is comparable in importance to the advent of biology itself. It will mean the creation of biology that has finally mastered its own intelligence and discovered means to overcome its limitations. (p. 296)
From our viewpoint in 2014, some of Kurzweil’s predictions could be criticized for being too optimistic. For example, “computers arriving at the beginning of the next decade will become essentially invisible, woven into our clothing, embedded in our furniture and environment”, as well as providing unlimited Wi-Fi everywhere (p. 312). While no doubt some places and instruments exist that might fit this description, they are certainly not in widespread use at this time, nor is there any particular need among society for this to become widespread (except perhaps the Wi-Fi).
Another likely over-optimistic prediction is the view that “full-immersion virtual reality” will be ready for our use by the late 2020s and it will be “indistinguishable from reality” (p. 341). In Kurzweil’s prediction, by 2029 nanobots in our bodies will be able to hack our nervous systems and trick us into believing a false reality every bit as convincing as the life we knew. We are in 2014. There is no full-immersion virtual reality system based on nanotechnology set to be on the market in 2020. A few dedicated gamers have the Oculus Rift (of which there will no doubt be a constant stream of successors ever reducing weight, trying to look “sexier”, and expanding the resolution and frame-rate over at least one decade), while there is no sign whatsoever of the nanotechnology-based neural interface technology predicted by Kurzweil. If nanotech-based full-immersion virtual reality is going to be possible in the 2020s at all, there ought to at least be some rudimentary prototype already in development, but (unless it is a secret military project) time is running out for the prediction to come true.
Part of the book addresses the exciting possibilities of advanced, futuristic warfare. The idea of soldiers who operate robotic platforms, aided by swarms of drones and focused on disrupting the enemy ability to communicate is truly compelling – all the more so because of the unique inside view that Kurzweil had of DARPA. Kurzweil sees a form of warfare in which commanders engage one another in virtual and physical battlefields from opposite sides of the globe, experiencing conflicts in which cyber-attack and communication disruption are every bit as crippling to armies as physical destruction (p. 330–335). Then again, this trend (like the idea of building missile-defense shields) may ultimately lead to complacency and false assumptions that our security is “complete”, while that foreign suppliers like Russia and China are also modernizing and have many systems that are thought to be on par with the US. A lot of US military success may be down to picking on vulnerable countries, rather than perfecting a safe and clean form of warfare (most of Saddam’s deadliest weapons were destroyed or used up in the First Gulf War, which alone could account for the US having so few casualties in the 2003 war.)
Although saying that the singularity will eliminate the distinction between work and play by making information so easily accessible in our lives, Kurzweil predicts that information will gain more value, making intellectual property more important to protect (p. 339–340). This sentiment is hard to agree with at a time when piracy and (illegally) streaming video without paying is already increasingly a fact of everyone’s life. If all thought and play is going to qualify as a creative act as a result of our eventual integration with machines, it only becomes ever harder to believe that such creative acts are going to need monetary incentives.
The book discusses at length how to balance the risks and benefits of emerging technologies. Of particular resilience is Kurzweil’s view that relinquishing or restraining developments can itself expose us to existential risks (e.g. asteroids). I myself would take this argument further. Failing to create abundance when one has the ability to do so is negligent, and even more morally questionable than triggering a nanotech or biotech disaster that must be overcome in the course of helping people.
Kurzweil goes through what seems like an exhaustive list of criticisms, arming singularitarians with an effective defense of their position. Of interest to me, as a result of penning a response to it myself, was how Kurzweil rebuts the “Criticism from the Rich-Poor Divide” by arguing that poverty is overwhelmingly being reduced and benefits of digital technology for the poor are undeniable. Indeed, among the world’s poor, there is no doubt that digital technology is good and that it empowers people. Anyone who argues this revolution is bad for the poor are just plainly ignoring the opinions of the actual poor people they claim to be defending. There has been no credible connection between digital technology and the supply of disproportionate benefits to wealthy elites. If anything, digital technology has made the world more equal and can even be regarded as part of a global liberation struggle.
Unfortunately, there is a major argument absent from the book. Kurzweil’s book precedes the revelations of mass surveillance by NSA whistleblower Edward Snowden. As a result, it fails to answer the most important criticism of an imminent singularity I can think of. I would have to call this the “Argument from Civil and Political Rights”. It takes into account the fact that greedy and cruel nation-states (the US being the most dangerous) tend to seek the monopoly of power in the current world order, including technological power. By bridging the gap between ourselves and computers before we create a more benevolent political and social order with less hegemony and less cruelty, we will simply be turning every fiber of our existence over to state agencies and giving up our liberty.
Suppose PRISM or some program like it exists, and my mind can be read by it. In that case, my uploaded existence would be no different from a Gitmo detainee. In fact, just interfacing with such a system for a moment would be equivalent to being sent to Gitmo, if the US government and its agencies exist. It does not matter how benevolent the operators even are. The fact that I am vulnerable to the operators means I am being subjected to a constant and ongoing violation of my civil rights. I could be subjected to any form of cruelty or oppression, and the perpetrator would never be stopped or held accountable.
It gets worse. With reality and virtual reality becoming indistinguishable (as predicted in this book), a new sort of sadist may even emerge that does not know the difference between the two or does not care. History has shown that such sadists are most likely to be the ones who have had more experience with and thus have obtained more power over the system. It is this political or social concern that should be deterring people from uploading themselves right now. If we were uploaded, what followed could never evolve beyond being a constant reflection of the flawed social order at the time when the upload occurred. Do we want to immortalize an abusive and cruel superpower, corporate lobbyists, secret police, or a prison? Are these things actually worth saving for all eternity and disseminating across the universe when we reach the singularity?
Despite the questions I have tried to raise in this review, I am still convinced by the broad idea of the singularity, and Kurzweil articulates it well. The idea, as promoted by Max More and quoted by Kurzweil (p. 373) that our view of our role in the universe should be like Nietzche’s “rope over an abyss” trying to reach for a greater existence, with technology playing a key role, helps encourage us to take noble risks. However, I believe the noble risks are not risks taken out of desperation to extend our lives and escape death, or risks taken to make ourselves look nice or something else petty. Noble risks are taken to ensure our future or the future of humanity, often at the expense of the present.
I would discourage people from trying to hasten the singularity because of a personal fear of their own death, as this would probably lead to irrational behavior (as occurs with the traditions that promote transcending death by supernatural means). Complications from society and unforeseen abuses, especially by our deeply paranoid and controlling states that are far too primitive to react responsibly to the singularity, are likely to slow everything down.
The following article was originally published by Immortal Life
When asked what the biggest bottleneck for Radical or Indefinite Longevity is, most thinkers say funding. Some say the biggest bottleneck is breakthroughs and others say it’s our way of approaching the problem (i.e. that we’re seeking healthy life extension whereas we should be seeking more comprehensive methods of indefinite life-extension), but the majority seem to feel that what is really needed is adequate funding to plug away at developing and experimentally-verifying the various, sometimes mutually-exclusive technologies and methodologies that have already been proposed. I claim that Radical Longevity’s biggest bottleneck is not funding, but advocacy.
This is because the final objective of increased funding for Radical Longevity and Life Extension research can be more effectively and efficiently achieved through public advocacy for Radical Life Extension than it can by direct funding or direct research, per unit of time or effort. Research and development obviously still need to be done, but an increase in researchers needs an increase in funding, and an increase in funding needs an increase in the public perception of RLE’s feasibility and desirability.
There is no definitive timespan that it will take to achieve indefinitely-extended life. How long it takes to achieve Radical Longevity is determined by how hard we work at it and how much effort we put into it. More effort means that it will be achieved sooner. And by and large, an increase in effort can be best achieved by an increase in funding, and an increase in funding can be best achieved by an increase in public advocacy. You will likely accelerate the development of Indefinitely-Extended Life, per unit of time or effort, by advocating the desirability, ethicacy and technical feasibility of longer life than you will by doing direct research, or by working towards the objective of directly contributing funds to RLE projects and research initiatives. Continue reading “Longevity’s Bottleneck May Be Funding, But Funding’s Bottleneck is Advocacy & Activism” | >