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If human beings are ever to colonise other planets – which might become necessary for the survival of the species, given how far we have degraded this one – they will almost certainly have to use generation ships: spaceships that will support not just those who set out on them, but also their descendants. The vast distances between Earth and the nearest habitable planets, combined with the fact that we are unlikely ever to invent a way of travelling that exceeds the speed of light, ensures that many generations will be born, raised and die on board such a ship before it arrives at its destination.

A generation ship would have to be a whole society in microcosm, with hospitals and schools, living quarters and perhaps entertainment districts, a security force, maybe even a judiciary. It would need to be able to provide food for its crew, and that might require agriculture or aquaculture, perhaps even domestic animals (which might also be needed for the colonisation effort). Its design therefore presents a major challenge: not just to engineers but also to social scientists. How should the crew be selected and the environment structured to minimise interpersonal conflict? What size of population is optimal for it to remain committed to the single overarching project of colonising a new planet without too much of a risk of self-destructive boredom or excessive narrowing of the gene pool? Does mental health require that a quasi-natural environment be recreated within the ship (with trees, grass and perhaps undomesticated birds and small animals)?

As well as the technological and social challenges confronting the designers of such ships, there are fascinating philosophical and ethical issues that arise. The issue I want to focus on concerns the ethics of a project that locks the next generation into a form of living, the inauguration of which they had no say over, and that ensures their options are extremely limited.

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Fighter pilots and brain surgeons have a lot in common. With limited time and a high degree of risk, they must zero in on a dangerous target with the intent to destroy, making sure to minimise any collateral damage.

Perhaps no one understands that relationship better than Alon Geri and Moty Avisar, veterans of the Israeli Air Force and co-founders of Surgical Theatre, an Ohio-based company that brings state-of-the-art virtual reality to brain surgeons.

Physicians in thick black goggles can step inside a patient’s skull, explore the malformed region, craft a strategy for entry, elimination, and exit, and even do dry runs of the surgery itself. When it comes time to make the first incision, there are fewer surprises.

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The findings showed that the shrinking of the hippocampus — brain region associated with learning and memory — actually precedes the onset of a change in behaviour — namely the loss of memory. “Until now, no one knew the evolution of these changes. Does the hippocampus shrink before or after memory loss? Or do the two happen handin- hand,” said Sumantra Chattarji, Professor at National Centre for Biological Sciences in Bengaluru, Karnataka, in a statement.

Using rats as a model system which reacts to stress much as humans do, the team studied how the brain changes in structure during stress. The results showed that when under stress, rats develop anxiety-related behaviours and their ability to form memories are affected. In the study, rats were subjected to stress for two hours every day over 10 days. The brains were examined with MRI scans on several days over the course of the study, and their ability to form memories were assessed repeatedly.

After just three days of stress, the hippocampus of every stressed rat had shrunk. “Normally structural changes are seen in the brain after a long time — say 10 to 20 days. Three days doesn’t even count as chronic stress,” Chattarji added. Five days after stress exposure, the rats’ hippocampus-based ability to make memories was tested again. The stressed rats were found to perform almost as well as unstressed rats, the researchers said. “Volume loss and shrinkage has happened, yet spatial memory is still holding up,” Chattarji said.

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Last year, OpenBCI burst onto the scene with a Kickstarter campaign to fund development of an open source brain-computer interface for makers. The company more than doubled its goal of raising $100,000 for its EEG platform and, as I write this, OpenBCI is preparing to ship its first run of finished products. Conor does a demo of the technology in the link below:

OpenBCI Demo by Conor Russomano

Recently, I had a chance to talk with OpenBCI co-founder Conor Russomanno to get his thoughts on how open source has changed the brain-computer interface (BCI) landscape and opened new opportunities in the present, and how it might affect future development opportunities as well.

“The one thing that we’re hoping to achieve with OpenBCI is to really lower the barrier of entry – both in terms of educational materials but also cost,” Russomanno said. “I think one really awesome implication is that, in a classroom or laboratory, where one research grade EEG system was used by a number students, now the same amount of money could be used to outfit every student with their own device. And we’ve seen that in our customer base, as a huge proportion of our customers are students, graduate-level researchers and professors who want to use OpenBCI as a learning tool.”

Another exciting change that OpenBCI is creating is an open source community that allows users and makers to connect and share their knowledge to take the technology even further, Russomanno noted. In fact, OpenBCI is dedicating a fair chink of its resources to create that community.

“Probably the quickest people to jump on the preorders and the Kickstarters were students and researchers who were already working with existing EEG devices. We are trying to get more people interested by creating a community, putting out instructional guides and making it more approachable.

“I like to think what we’re doing with OpenBCI as Lego meets EEGs. I think of what we’re building as not a finished product, but as a narrow building block. And we want the world to use these blocks to build the cool stuff,” he said.

While the success and acclaim OpenBCI has received in mainstream media has been exciting, as he looks at the opportunities for further development of open source BCI, Russomanno is cautiously optimistic. In my mentioning of some of the farther-reaching future implications of BCI technologies, Conor brought the conversation back to the present, seeming less interested in far away “what ifs” than in how the next step forward in research might be taken:

“I think its important to be realistic about what the technology is capable of,” he said. “There are still a lot of challenges and they’re not all going to be solved by the same company or by a single field of research. It’s important that people collaborate together, specialize and improve upon a small facet of the problem by sharing that information with someone else who has solved another small facet.

“What we’re trying to do with OpenBCI is to expose all of the weaknesses of the full system and say ‘Hey guys! Jump in! What can you do to improve this other piece?’”

Another hurdle Russomanno hopes open source BCI can bridge in the future is the gap between the enthusiastic expectations of the general public and the realistic limits of the current technology. While an enthusiastic hope of BCI might involve telepathic control of technology or complete conscious “embodiment” in a robotic form, the current reality of BCI is less “far out.” The calibration of today’s external BCI devices still involves a relatively slow process of attuning to individual brain patterns, and isn’t nearly at “telepathic” levels, although some researchers have been able to develop significant control of devices and games with EEG headsets.

“I think many people would agree that the ‘Holy Grail’ of practical, wearable EEG is a sensor. Right now, it’s very difficult to acquire a strong EEG signal from outside the scalp because you’ve got a lot of things that produce ‘noise,’” he continued. “I’m not sure if it will ever happen, but the one problem that needs to be optimized is the electrode problem. We’ve broken out the header pins so you can attach any electrode on, so if that Holy Grail does get found in the next one or two years, hopefully you’ll just be able to plug it right into the OpenBCI board.

“On the other end of the spectrum,” Russomanno continued. “Once you’ve got good spatial resolution, a high number of channels and a good quality of signal, what do you do with this data now that you’re collecting it? How do you classify this information to create a system that responds in a pre-determined way?

“That’s where software and research comes in. You’ve got electrical engineers that need to solve the electrode problem. But then you’ve got data analytics and programmers that need to work together to create algorithms that will classify massive amounts of data,” he noted.

Conor’s earlier comment about the interdisciplinary nature of BCI research starts to hit home, but he wasn’t done yet. After software challenges, there’s one more hurdle left for the full optimization of open source BCI, he added.

“Every brain is similar but every brain is unique. When it gets to that point where we’ve got enough systems producing enough data that it can be scaled cheaply from individual to individual, then it’s a matter of building an interface that’s user customizable that has enough flexibility to be able to refine its classification inputs to match the specific user.”

Ultimately, Russomanno says the mission for OpenBCI is to make the technology more accessible and that, wherever open source BCI goes in the future, a community based on cooperation and collaboration will take it there.

With so much to work on, he’s aiming to facilitate the global conversation necessary to bring BCI to the next level, without funding it all in his own proprietary lab. If all brains are unique, then we’ll learn more about calibrating devices by testing and tinkering with people all over the world. Conor’s aim, however, it not just to use their heads as experiments, but to generate new hypotheses to test and ideas to explore — expanding the field for everyone.

“Putting our heads together” takes on multiple literal interpretations here, and that’s how he intends it.

Conor ended our chat with come practical advice for researchers and makers who want to help the cause: “The best way for people to join that community is to acquire the technology, try to figure out how to make it work, be vocal on the forums and keep spreading the open source wildfire.”

Philadelphia, PA, USA / Mexico City, Mexico — Bioquark, Inc., (www.bioquark.com) a life sciences company focused on the development of novel bioproducts for complex regeneration, disease reversion, and aging, and RegenerAge SAPI de CV, (www.regenerage.clinic/en/) a clinical company focused on translational therapeutic applications of a range of regenerative and rejuvenation healthcare interventions, have announced a collaboration to focus on novel combinatorial approaches in human disease and wellness. SGR-Especializada (http://www.sgr-especializada.com/), regulatory experts in the Latin American healthcare market, assisted in the relationship.

regenerage

“We are very excited about this collaboration with RegenerAge SAPI de CV,” said Ira S. Pastor, CEO, Bioquark Inc. “The natural synergy of our cellular and biologic to applications of regenerative and rejuvenative medicine will make for novel and transformational opportunities in a range of degenerative disorders.”

As we close in on $7 trillion in total annual health care expenditures around the globe ($1 trillion spent on pharmaceutical products; $200 billion on new R&D), we are simultaneously witnessing a paradoxical rise in the prevalence of all chronic degenerative diseases responsible for human suffering and death.

With the emergence of such trends including: personalization of medicine on an “n-of-1” basis, adaptive clinical design, globalization of health care training, compassionate use legislative initiatives for experimental therapies, wider acceptance of complementary medical technologies, and the growth of international medical travel, patients and clinicians are more than ever before, exploring the ability to access the therapies of tomorrow, today.

recovering patient

The estimate of the current market size for procedural medical travel, defined by medical travelers who travel across international borders for the purpose of receiving medical care, is in the range of US $40–55 billion.

Additionally, major clinical trial gaps currently exist across all therapeutic segments that are responsible for human suffering and death. Cancer is one prime example. As a leading cause of morbidity and mortality worldwide for many decades, today there are approximately 14 million new cases diagnosed each year, with over 8 million cancer related deaths annually. It is estimated that less than 5% of these patients, take the initiative to participate in any available clinical studies.

“We look forward to working closely with Bioquark Inc. on this exciting initiative,” said Dr. Joel Osorio, Chief of Clinical Development RegenerAge SAPI de CV. “The ability to merge cellular and biologic approaches represents the next step in achieving comprehensive regeneration and disease reversion events in a range of chronic diseases responsible for human suffering and death.”

bioquarklogo

About Bioquark, Inc.
Bioquark Inc. is focused on the development of natural biologic based products, services, and technologies, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing both biological pharmaceutical candidates, as well as products for the global consumer health and wellness market segments.

About RegenerAge SAPI de CV

RegenerAge SAPI de CV is a novel clinical company focused on translational therapeutic applications, as well as expedited, experimental access for “no option” patients, to a novel range of regenerative and reparative biomedical products and services, with the goal of reducing human degeneration, suffering, and death.

Zombies and texting.


A new study presented by researchers from the Tech3Lab at HEC Montreal, along with the University of Montreal’s Department of Psychology and the Centre hospitalier Notre-Dame has found that “Texting while walking is a widespread and dangerous behaviour.”

In a research presentation called “Mobile Multitasking Distraction: A Pilot Study with Intracranial Electroencephalography”, researchers attempted to determine which neural circuitry is implicated in the act of texting while walking, with the aim of helping to develop future methods of mitigating “this dangerous habit” and perhaps to “assist the development of mobile applications aiming directly at the neural circuitry”.

While online marketers search for ways to increase user “engagement” with smartphones, it’s precisely this engagement that puts people who walk and text at the same time at greatest risk.

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Apple’s new app to help you do deep breathing to improve your mind, intelligence, and over all health.


APPLE is set to launch a new app that aims to make you healthier through just a few minutes a day of deep breathing.

It is based on the growing field of research proving the biological benefits, including genetic changes, of mind-body medicine.

The Breathe app will be released for the Apple Watch later this year and it will prompt people to take a few minutes every day to stop and focus on their breathing, using the heart-rate sensor in the Watch to monitor the reaction.

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To me, maps always conjure up a sense of exploration.

Back in the Age of Discovery, rudimentary maps allowed European explorers to sail into the vast unknown. They began charting new worlds, and in turn, made newer maps that helped future generations better understand the lands and seas that cover our world.

Now, thanks to a new — if slightly different — type of map, we may be approaching a new age of discovery. One that takes us into the uncharted territories of the mysterious three-pound organ that underlies our thoughts, emotions, hopes and dreams: the human brain.

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Quantum physics is the new physics that is pointing to something far greater than the materialistic world that we once believed to be the basis of our existence. Not only is it disproving our original perception of space and time, but it is opening the doors to the possibility of time travel, telepathy, and consciousness creating our reality.

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