For the first time, scientists have found a genetic mutation that appears to offer a measure of protection against some of the biological effects of ageing.
And, as far as we know, it looks like the only community in the world known to harbour it is an Old Order Amish community living in Indiana.
The mutation can occur on one or both copies of a gene called SERPINE1. It’s known that when both gene copies are mutated, it can lead to a rare genetic bleeding disorder — and the Amish community in question is susceptible to it.
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SHOW NOTES WITH TIME STAMPS (COMING SOON)
0:00 Intro 3:02 Brian’s 2 TED Talks https://youtube.com/watch?v=U2u6FJhLfJ0 & https://youtube.com/watch?v=iGSkpIRs6pc 5:05 Brian’s research history & mTOR 8:10 yeast, sirtuins, tumor suppression 9:32 rapamycin 12:01 kickbacks from an approach to targeting human aging 13:40 our healthcare system is really sick and trauma care 15:01 Why Brian is in Singapore 16:38 Nicolas Chernavsky question from the live chat 20:10 targeting aging with TAME trial and metformin — Nir Barzilai 23:25 rapalogs and senolytics 24:10 Is human aging programmed into our genetics? 28:11 Torcept 30:37 TAM-818 31:47 building awareness for human aging research.
Space is getting crowded. Aging satellites and space debris crowd low-Earth orbit, and launching new satellites adds to the collision risk. The most effective way to solve the space junk problem, according to a new study, is not to capture debris or deorbit old satellites: it’s an international agreement to charge operators “orbital-use fees” for every satellite put into orbit.
Dr. Michael R. Rose is Professor at Department of Ecology and Evolutionary Biology at University Of California, Irvine. His main area of work has been the evolution of aging. “Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“ - Nikolai F. Fedorov
We hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime.
Working to Save Lives with Age Reversal Education.
========== Perpetual Life Creed ==========
We believe that all of life is sacred and that we have been given this one life to make unlimited. We believe in our Creator’s divine plan for all of humanity to have infinite lifespans in perfect health and eternal joy, rendering death to be optional.
By following our Gospel we achieve eternal life creating a heaven here on earth.
DNA damage is common to our cells, but when we’re young our bodies can fix it pretty easily. Unfortunately we lose that ability over time, leading to many of the symptoms of aging that we know all too well. A new study from MIT has found that reactivating a certain enzyme improves repair of DNA damage in neurons, which helps Alzheimer’s patients and others with cognitive decline.
Previous studies by the team have shown that an enzyme called HDAC1 seems to be involved in DNA repair in neurons. For the new study, the researchers examined what happens when HDAC1 doesn’t do its job.
The team engineered mice to be deficient in HDAC1, and monitored their health compared to normal mice. Things looked good during the animals’ youth – there were no differences in DNA damage or behavior between the two groups. But as they aged, the decline became clear.
If you’re interested in superlongevity and superintelligence, then I have a book to recommend., by Sonia Contera, is a book about the intersection of biotech and nanotech. Interesting and well written for the layman, the book covers some of the latest developments in nanotechnology as it applies to biological matters. Although there are many topics, I was primarily interested in the DNA nanobots, DNA origami, and the protein nanotechnology sections. My interest is piqued in these arenas due to my expectation that DNA nanobots and protein nanobots, as well as complex self-assembled custom nanostructures, are going to be key to some of the longevity technologies and some of the possible substrates for mind uploading that are key to superlongevity and superintelligence. There are also sections in the book on 3D bioprinted organs — progress and possibilities, as well as difficulties.
There is even a section that clearly was written specifically to address a discussion that has engaged my friends, Dinorah Delfin and Dan Faggella. The title is:
Now, some might be tempted to consider that particular combination to be “woo woo”, however, please keep in mind the author’s credentials. Sonia Contera is a professor of biological physics in the Department of Physics at the University of Oxford.
Increasingly, scientists are gaining control over matter at the nanometer scale. Spearheaded by physical scientists operating at the interfaces of physics and biology, advances in nanoscience and technology are transforming how people think about life and treat human health.
If you’re interested in superlongevity and cognitive enhancement, I have a YouTube video to recommend. Our good friend, Ira Pastor, on his excellent podcast ideaXme, discusses with Dr. Rudolph Tanzi the topic of inflammaging, specifically brain inflammation, plaque, tau tangles, brain health, and Alzheimer’s disease. Then they discuss some emergent therapies to prevent Alzheimer’s by protecting the neurons.
The discussion is concise and complete, but also very easy to follow.
Ira Pastor, ideaXme life sciences ambassador, interviews Dr. Rudolph Tanzi, Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University, Vice-Chair of Neurology, Director of the Genetics and Aging Research Unit, and Co-Director of the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital.
Ira Pastor Comments
On this episode we are going to journey back to the topic of Alzheimer’s, a disease of substantial unmet medical need, projected to affect over a 100 million people globally by mid century.
Dr. Rudolph Tanzi is the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard University, Vice-Chair of Neurology, Director of the Genetics and Aging Research Unit, and Co-Director of the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital (MGH), and has been investigating the genetics of neurological disease since the 1980s when he participated in the first study that used genetic markers to find a disease gene for Huntington’s disease.
In 1990, Dr. Tanzi received his Ph.D. in neurobiology at Harvard Medical School, where his doctoral thesis was on the discovery and isolation of the first Alzheimer’s disease gene — the amyloid precursor protein (APP), published in 1987 in Science.
You might be interested in my latest interview with Natasha Vita-More, transhumanist writer and executive director of Humanity+, covering human augmentation, the world transhumanist movement and whole-body prosthetics.
Trying to grow my transhumanism related channel so super grateful for any subs: https://www.youtube.com/channel/UCnVLqMgLDwO-aSk5YcYo1dA…
I interview Natasha Vita-More, a transhumanist thinker who wrote the ‘Transhumanist Statement’ and is the Executive Director of Humanity+, formerly the World Transhumanist Association.
We cover artificial intelligence, whole body prosthetics, radical life extension, upgrading the human body and the world transhumanist movement amongst other topics.
