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Category: life extension

If you want to live long enough to see a reversal of aging and everlasting youth, exercise should be at the core of your routine.

Here I look at ten amazing benefits that exercise brings to your body and mind, so if you haven’t already got a regime on the go, hopefully this will convince you to start now.

Have an amazing day 🙂

In Why We Should Exercise Regularly, I show ten great areas that exercise benefits the body and mind.
If you want tp live longer and healthier, and slow down aging then regular exercise should be your first thought, especially if you have a sedentary job and have to spend long hours sat down.

Studies referenced.
Weight control.
https://www.nature.com/articles/0803015
https://www.sciencedirect.com/science/article/abs/pii/S1262363620301270

Muscles and bones.
https://pubmed.ncbi.nlm.nih.gov/11255140
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279907/

Health conditions and disease.
https://www.nature.com/articles/nri3041

Brain health.
https://journals.physiology.org/doi/full/10.1152/japplphysiol.00210.2011
https://www.pnas.org/content/108/7/3017?sid%3D82ba1542-3753-49b2-a1e0-2b16c0b8686b=
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad091531

Mood.
https://www.researchgate.net/profile/Brian_Pritschet/publication/236152470_A_comparison_of_post-exercise_mood_enhancement_across_common_exercise_distraction_activities/links/0046352f50ff51710e000000/A-comparison-of-post-exercise-mood-enhancement-across-common-exercise-distraction-activities.pdf.

Energy.
https://science.sciencemag.org/content/335/6066/281.summary.

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Dr. Carolina Reis Oliveria, is the CEO and Co-Founder of OneSkin Technologies, a biotechnology platform dedicated to exploring longevity science.

Carolina holds her Ph.D. in Immunology at the Federal University of Minas Gerais, in collaboration with the Rutgers University, where she conducted research with pluripotent stem cells as a source of retinal pigmented epithelium (RPE) cells, as well as the potential of RPE-stem cells derived as toxicological models for screening of new drugs with intra-ocular applications.

She founded a company called CELLSEQ solutions in Brazil which develops tools to revolutionize the safety and toxicology assays performed by pharmaceutical, cosmetic, agro-chemical and food industries, with technology based on stem cells and big data analysis.

She is an alumnus of IndieBio, the world’s leading biotechnology accelerator.

In 2016, Carolina relocated to Silicon Valley from Latin America to co-found OneSkin, and to lead the development of the company’s technologies.

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Brain on a chip for drug discovery.

Since the advent of organ-on-a-chip, many researchers have tried to mimic the physiology of human tissue on an engineered platform. In the case of brain tissue, structural connections and cell–cell interactions are important factors for brain function. The recent development of brain-on-a-chip is an effort to mimic those structural and functional aspects of brain tissue within a miniaturized engineered platform. From this perspective, we provide an overview of trace of brain-on-a-chip development, especially in terms of complexity and high-content/high-throughput screening capabilities, and future perspectives on more in vivo-like brain-on-a-chip development.

With the advent of an aging society, the disease incidence rate is increasing, and the cost of drug development and disease treatment is expanding exponentially.1,2 According to the World Health Organization (WHO), nearly one billion people in the world suffer from neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s diseases.3 Despite decades of research on neurodegenerative diseases by many biologists and pharmaceutical companies, the underlying mechanism of their onset and progression is still largely unknown. The resolution of these diseases has a long way to go, and such steps are limited due to the lack of a suitable in vitro model system for mechanism study and drug development. In particular, the complex tissue structures and cell–cell interactions of the in vivo system make it challenging to unravel the underlying mechanism of the diseases and to predict the efficacy of clinical medicine.

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Advanced, others might like.

The exact gene that caused stem cell aging has been identified.

Above – When mesenchymal stem/stromal cells (MSCs) age, the transcription factor GATA6 is increasingly produced in the cell to induce aging response. By transcription factor-based cellular reprogramming, aged MSCs are rejuvenated with a reduction in GATA6 effects on cellular aging. CREDIT AlphaMed Press

University of Wisconsin-Madison researchers found that the expression of GATA6, a protein that plays an important role in gut, lung and heart development, was repressed in the reprogrammed cells compared to the control cells. This repression led to an increase in the activity of a protein essential to embryonic development called sonic hedgehog (SHH) as well as the expression level of yet another protein, FOXP1, necessary for proper development of the brain, heart and lung. “Thus, we identified the GATA6/SHH/FOXP1 pathway as a key mechanism that regulates MSC aging and rejuvenation,” Dr. Li said.

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Part of my series to give a good grounding in the basics surrounding the subject of human health and longevity, for anyone interested, this week it is Sirtuins.

Are they one of the keys to the door towards ending aging?

I give a basic explanation of what sirtuins are and how they are being investigated for their influence on health span and length of life.

Sirtuin signaling in cellular senescence and aging
http://www.bmbreports.org/journal/view.html?uid=1333&vmd=Full&

Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.

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I didn’t realize there were so many 3rd-party genetic analysis services. If you’ve already done something like 23andMe have you tried uploading your raw DNA data to one of these other websites?

Note: This piece on genetic analysis is the third in our series of posts about DNA tests for health and longevity. To better understand the basics of DNA and the different types of DNA tests on the market please go back and read our first piece on The Benefits of Genetic Testing for Longevity, and for an in-depth comparison of DNA testing companies please read the second piece on the Best DNA Tests for Health and Longevity.

Affiliate Disclaimer: Longevity Advice is reader-supported. When you buy using links on our site, we may earn commissions.

Imagine, for a moment, that time travel is real.

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Harvard Medical School scientists report they have successfully restored vision in mice by turning back the clock on aged eye cells in the retina to recapture youthful gene function.

The team’s work, described Dec. 2 in the publication Nature, represents the first demonstration that it may be possible to safely reprogram complex tissues, such as the nerve cells of the eye, to an earlier age.

In addition to resetting the cells’ aging clock, the researchers successfully reversed vision loss in animals with a condition mimicking human glaucoma, a leading cause of blindness around the world.

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This is very helpful in reducing signs in aging.

Buy Enzymedica, Stem XCell, Antioxidant Support for Cellular Renewal, Brain Health and Stem Cell Regeneration, Vegetarian and Non-GMO, 60 Capsules (30 Servings) on Amazon.com ✓ FREE SHIPPING on qualified orders.

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Brain Muraresku, author of “The Immortality Key — The Secret History Of The Religion With No Name”, discussing his fascinating journey to discover psychedelic potions from antiquity, reconstruct their history in the development of religion and civilization, and their development into a modern neuro-pharmacopoeia.

On today’s show we are going to be weaving together a really interesting range of themes including psychedelics, pharmacognosy and medicinal botany, history, religion & spirituality, end of life care, dreaming, mental health and a whole lot more.

Brian Muraresku is the author of “The Immortality Key: The Secret History of the Religion with No Name”.

Brian graduated Phi Beta Kappa from Brown University with a degree in Latin, Greek and Sanskrit. As an alumnus of Georgetown Law and a member of the New York Bar, he has been practicing law internationally for fifteen years.

He is also founding executive director of Doctors for Cannabis Regulation. Their work has been featured on CNN and ESPN, as well as The Washington Post and San Francisco Chronicle. In arbitration with the NFL in 2018, Mr. Muraresku represented the first professional athlete in the United States to seek a therapeutic use exemption for cannabis.

The Immortality Key is his debut book.

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