ISRIB, a new drug that reboots protein production in cells can reverse aging declines in memory and cognition in mice, with no side effects.
Category: life extension
Shared last year, but with the talk of future regenerative medicine I think it is important: Regenerative medicine aims to engineer tissue constructs that can recapitulate the functional and structural properties of native organs. Most novel regenerative therapies are based on the recreation of a three-dimensional environment that can provide essential guidance for cell organization, survival, and function, which leads to adequate tissue growth. The primary motivation in the use of conductive nanomaterials in tissue engineering has been to develop biomimetic scaffolds to recapitulate the electrical properties of the natural extracellular matrix, something often overlooked in numerous tissue engineering materials to date. In this review article, we focus on the use of electroconductive nanobiomaterials for different biomedical applications, particularly, very recent advancements for cardiovascular, neural, bone, and muscle tissue regeneration. Moreover, this review highlights how electroconductive nanobiomaterials can facilitate cell to cell crosstalk (i.e., for cell growth, migration, proliferation, and differentiation) in different tissues. Thoughts on what the field needs for future growth are also provided.
Bioelectricity.
Lots of good telomere info but one small problem with Mr Andrews here. He states that he agrees with the FDA that you can’t target aging as a disease since it is not measurable. Well i think this has been shown to be false as a result of epigenetic clocks.
I posted a question under the comments on the matter,(Lord Mon) we’ll see if we get a response.
Andres de Tenyi.
· 1tShponsShrorehd ·
Like.
An experimental drug reversed age-related declines in memory and mental flexibility in old mice after just a few doses, according to a study by researchers from the University of California, San Francisco (UCSF).
The drug, ISRIB, has previously been shown in other studies to restore normal cognitive function in mice after traumatic brain injury, enhance memory in healthy mice and mice with Down syndrome, as well as prevent noise-related hearing loss.
University of rochester — working at the intersection of aging, DNA repair, and cancer.
Dr. Vera Gorbunova is the Doris Johns Cherry Professor, in the Department of Biology, and Co-director, Rochester Aging Research Center, at University of Rochester.
Her research is focused on understanding the mechanisms of longevity and genome stability and on the studies of exceptionally long-lived mammals.
Dr. Gorbunova earned her B.Sc. degrees at Saint Petersburg State University, Russia, and her Ph.D. at the Weizmann Institute of Science, Israel.
Dr. Gorbunova was instrumental in pioneering the comparative biology approach to studying aging and identifying rules that control the evolution of tumor suppressor mechanisms depending on the species lifespan and body mass.
Dr. Gorbunova also investigates the role of Sirtuin proteins in maintaining genome stability.
More recently the focus of her research has been on the longest-lived rodent species, the naked mole rat and the blind mole rat. Dr. Gorbunova identified high molecular weight hyaluronan as the key mediator of cancer-resistance in the naked mole rat.
Dr. Gorbunova’s work has received awards from the Ellison Medical Foundation, the Glenn Foundation, American Federation for Aging Research, and from the National Institutes of Health.
Hello rejuvenation friends! Did you know that Heales, the Belgian entity led by Didier Coeurnelle, is financing two very interesting experiments with the great rejuvenation scientists Harold Katcher and Rodolfo Goya in order to test if Elixir (in the case of Katcher) and plasma of young rats (in the case of Goya) are capable to considerably extend the lifespan of rats? Today I found out on Google that six days ago, Didier published this article in Heales website: https://heales.org/wp-content/plugins/multisite-language-switcher/flags/. In the article, Didier explains in depth both experiments, and put the links to the detailed protocol of the experiments, in two Word files. It’s incredible the power of the collaboration of people who are enthusiastic of rejuvenation science, such as Didier, Harold and Rodolfo. I don’t know if the experiment will extend considerably the rats lives, but it seems that these two experiments deserve a close look from the rejuvenation field.
Today, in spite of the gigantic progress in medicine and research, we still do not know how to be healthy beyond about 85 years of age.
German scientists are researching a method to produce hydrogen using light and photoactive compounds on an organic chemical basis.
Hydrogen is considered to be one of the alternative energy sources of the future. So far, however, the costly and energy-intensive production process has been a major problem with regard to the environmental friendliness of this substance, which is in itself CO2 neutral. For this reason, increasing numbers of scientists around the world are researching other methods of producing hydrogen: from algae, for example. (IO reported). Scientists in Germany at the Friedrich Schiller University, the Leibniz Institute for Photonic Technologies (Leibniz IPHT) and the University of Ulm have taken inspiration from nature for their method of producing hydrogen.
To do so, the team from the “CataLight” Collaborative Research Center at the Universities of Jena and Ulm has combined new organic dyes with non-precious metal catalyst molecules that release gaseous hydrogen in water when irradiated with light. This substitute has shown a remarkable impact in terms of longevity and effect after excitation by visible light, they write in their study, published in Chemistry – A European Journal.
Photosynthesis as inspiration
In nature, sunlight is most effectively stored in chemical bonds through photosynthesis, because the light-collecting and reactive complexes in the thylakoid membrane are fixed in chloroplasts. The researchers led by Prof. Felix Schacher have achieved this type of arrangement with the help of polymers that interact with both hydrophilic and hydrophobic substances. These charged, so-called graft copolymers are produced artificially.
Here’s my latest video!
The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes and/or microbial products. The bacterial metabolite, LPS, increases during aging, and it negatively impacts mitochondrial function, thereby demonstrating a role for microbial products on one of the Hallmarks of Aging, mitochondrial dysfunction.
I am sure you know weak bones break more easily, and the older you get the worse any extended periods of inactivity are, on not just your present health and well being, but also your longevity.
So whether you are lifting free weights for the fun of it, using your body weight in a home scenario or engaging in daily activities you know are physically taxing, you should really be incorporating some form of strength training in your plans for longevity.
Get your copy of Cyberpunk 2077 here:
http://cyberpunk.net/buy.
Sources & further reading:
https://sites.google.com/view/sources-mindupload.
The desire to be free from the limits of the human experience is as old as our first stories. We exist in an endless universe, only bound by the laws of physics and yet, our consciousness is trapped in mortal machines made of meat. With the breathtaking explosion of innovation and progress, for the first time the concept of leaving our flesh piles behind and uploading our minds into a digital utopia seems possible. Even like the logical next step on our evolutionary ladder.
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