We interviewed a group of Russian biohackers who performed a plasma dilution experiment on themselves. This experiment, the first of its kind, was based on previous mouse studies by Drs. Irina and Michael Conboy.
Some molecules, while essential for various body functions, can be harmful when overproduced. Inflammatory cytokines, such as transforming growth factor beta 1 (TGF-ß1), interleukin 6 (IL6), and tumor necrosis factor alpha (TNFa) are good examples. The concentration of these cytokines in our blood rises with age, provoking inflammaging, the chronic inflammation that is associated with aging. It has been long speculated that reducing the harmful molecules in circulation can attenuate aging.
Nice lecture with both technical info and analogy.
Latest study from David Sinclair’s lab have used cellular reprogramming to restore vision in aged mice & more! Suggests reversing aging *may* be possible.
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TIMESTAMPS; Intro — 00:00 Aging is loss of information — 00:45 Correction device & epigenetics — 02:49 Yamanaka factors & OSKM — 04:45 Study results from Sinclair lab — 07:25 Aging reversed? — 10:29 Working model — 12:00 Cellular reprogramming in humans? — 12:36.
REFERENCES; Lu, Y., Brommer, B., Tian, X. et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature 588, 124–129 (2020). https://doi.org/10.1038/s41586-020-2975-4 In Vivo Amelioration… — https://doi.org/10.1016/j.cell.2016.11.052 Yamanaka — https://doi.org/10.1016/j.cell.2006.07.024 News & Views article — https://www.nature.com/articles/d41586-020-03403-0
Icons in intro; “https://www.freepik.com/free-photos-vectors/background“Background vector created by freepik — www.freepik.com
Dr. Steve Horvath, a professor of genetics and biostatistics at UCLA, has found a way to measure biological aging – a type of “clock” – based on the methylation pattern of an organism’s genome. Methylations are biochemical processes that modify the activity of a DNA segment without changing its sequence – a type of epigenetic change. This video primer explains the basics of epigenetic clocks, the topic of our interview with Dr. Steve Horvath, coming soon!
Get the show notes here: https://www.foundmyfitness.com/episodes/epigenetic-clock/
Episode highlights: • 00:00:09 — A person’s risk of disease is more dependent on their biological age than their chronological age. • 00:00:09 — Epigenetics refers to processes that can affect gene expression without changing the DNA sequence. Methylation is a type of epigenetic change that occurs over a lifetime in a predictable way and can be used to measure biological age. • 00:01:17 — The Horvath clock can accurately predict a person’s chronological age based on only the epigenetic information in their blood. • 00:01:54 — The GrimAge clock can predict the risk and time of onset of cancer, heart disease, and death. • 00:02:19 — Certain drugs can reverse a person’s epigenetic age, but the effects on biological age are unknown. • 00:03:09 — The discovery of an anti-aging drug is on the horizon.
A questionnaire developed by XPRIZE and Deep Longevity claims to be able to accurately predict your psychological age by using artificial intelligence (AI) to analyze your answers, which theoretically should fall close to your chronological age. The questionnaire is developed from a study published in Aging that used AI in an attempt to identify key hallmarks of psychological aging and the top risk factors that affect mortality.
While the questionnaire seems like a fun insight into whether you’re an old soul or a young gun at heart, there is an important scientific basis for an age-predicting AI. The newly developed technology represents the first AI aimed solely at using psychological aspects to predict age. The researchers hope it can contribute to understanding the role psychological clocks play in overall aging, as well as improving mental health and the feeling of youth.
“For the first time, AI can predict human psychological and subjective age and help identify the possible interventions that can be applied in order to help people feel and behave younger,” said Alex Zhavoronkov, PhD,founder and CLO of Deep Longevity and co-author of the study, in a statement.
A new study has found that a novel T cell genetically engineered by University of Arizona Health Sciences researchers is able to target and attack pathogenic T cells that cause Type 1 diabetes, which could lead to new immunotherapy treatments.
The immune system fights bacteria, viruses and other pathogens by utilizing several types of T cells, all of which have receptors that are specific to particular antigens. On killer T cells, the receptor works in concert with three signaling modules and a coreceptor to destroy the infected cell. Michael Kuhns, Ph.D., an associate professor in the UArizona College of Medicine—Tucson Department of Immunobiology, copied the evolutionary design to engineer a five-module chimeric antigen receptor, or 5MCAR, T cell.
“The 5MCAR was an attempt to figure out if we could build something by biomimicry, using some of evolution’s natural pieces, and redirect T cells to do what we want them to do. We engineered a 5MCAR that would direct killer T cells to target autoimmune T cells that mediate Type 1 diabetes,” said Dr. Kuhns, who is member of the UArizona Cancer Center, BIO5 Institute and Arizona Center on Aging. “So now, a killer T cell will actually recognize another T cell. We flipped T cell-mediated immunity on its head.”
Here the video of the first discussion panel out of two, during the celebration of the Healthy Masters Conference 2020, which took place on November 29, 2020. Nuno Martins, organizer and moderator of the event, asked all panelists to comment on the following theme: What can we do to improve our health and longevity. Given the essence of the event, the question was surrounded by the objective of achieving radical life extension or super longevity. My intervention starts at minute 20:13 and in the description of the video there are all the time marks that direct to the begining of each talk.
First discussion panel out of two, during the celebration of the Healthy Masters Conference 2020 which took place on November 29, 2020. Nuno Martins, PhD, organizer and moderator of the event, asked all panelists to comment on the following theme: What can we do to improve our health and longevity? Given the essence of the event, the question was surrounded by the objective of achieving radical life extension or super longevity.
Panelists in order of appereance: * Naveen Jain: Founder and CEO of Moon Express Viome (00:21) * Nichola Conlon, PhD: CEO & Founder of Nuchido (03:28) * Kelsey Moody, PhD: Process Oriented Drug Developer and Executive (05:18) * Peter Fedichev, PhD: Head of the Laboratory of Biological Systems (08:38) * James Hughes, PhD: Executive Director of the Institute for Ethics and Emerging Technologies (12:12) * María Entraigues Abramson: Global Outreach Coordinator for the SENS Research Foundation (15:14) * Yael Sorek-Benvesti, PhD: CEO of Mediterranean Towers Venture (18:24) * Andrés Grases, MBA: Owner and Editor of Transhumanplus.com (20:13) * Ines O´Donovan: Founder of the Jeunessima Lifestyle Company (23:52) * Reason, CEO of Repair Biotecnologies (27:39) * Odette Tonnae: Founder of YOAKE, the Healthy Lifestyle Expertise. Simulation at MIPT (31:53)
It is the weekend and time for a new video… following on from last week, this time I am looking at the types of cardiovascular training and how they effect your body at the cellular level, so you can craft your own training program, suited to your lifestyle and preferences, that helps you slow the aging process so you can live long enough to live forever…and be fit enough to enjoy it to the maximum.
After all, if life is boring, why live forever?
In The Benefits Of Cardiovascular Fitness, I look at the benefits of training and exercise, both High Intensity Interval Training (HIIT) and Steady State Cardio training, and how they effect the body in different ways, making them both essential weapons in your arsenal against the effects of aging.
If you missed Why We Should Exercise Regularly — Ten Amazing Benefits, you can find that here… https://youtu.be/ZMXFBgcuaaI So go and get sweaty, and share your preferred workout regime with us in the comments below.
So go and get sweaty, and share your preferred workout regime with us in the comments below.
WASHINGTON (SBG) — Researchers studying cognitive deficits following traumatic brain injuries have discovered what they say is a revolutionary drug that could provide the cure for aging. The study by the University of California San Francisco has shown promising results among mice, essentially reversing age-related declines in memory. “We went on with this crazy experiment… and were able to return their cognitive function to as if they were never injured,” said Dr.
