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2016-03-25-1458872131-9088312-zoltatpeopleunlimited.jpg A crowd gathers to hear about transhumanism and life extension technologies — Photo by Roen Horn

Recently I was asked to be a part of a debate for British think-tank Demos and their quarterly magazine. In the debate, The University of Sheffield Professor Richard Jones and I faced off over the merits and faults of transhumanism. You can read the entire debate here, but I wanted to focus on one part of it, where Jones questions why there’s a need for a transhumanism movement at all.

I used to get asked the question Jones raised all the time. Luckily, the amount of people that ask it has declined, partially because transhumanism has grown so much in popularity. Many people nowadays simply accept transhumanism as part of tech and science culture.

That said, I believe it’s worth sharing my thoughts on why a “transhumanism movement” is needed. Here was my answer in the debate:

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The quest for immortality isn’t something new. Longevity and eternal youth have frequently been sought after down through the ages, and efforts to keep from dying and fight off age have a long and interesting history. Legends about such things as ‘the Elixir of Life’, universal panaceas, and ‘the Fountain of Youth’ can be found in many different cultures from around the world, and the pursuit for immortality actually seems to be as old as mankind itself. Although divided by many generations of great men, the feelings of sheer helplessness and hopelessness that Ray Kurzweil must have felt when he experienced the loss of his father, strongly resembles those of Gilgamesh, the ancient Sumerian king, when he mourned over his friend Enkidu almost 5000 years earlier. As a matter of fact, mortality has probably haunted our conciuousness since the first human in horror witnessed death; and thus realized his or her own eventual demise

Humanity has been in a bitter war with ‘the Grim Reaper’ ever since.

“Six days and seven nights I mourned over him, and I would not allow him to be buried until a maggot fell out of his nose. I was terrified [by his appearance]. I began to fear death, and so roam the wilderness.” –Gilgamesh

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If I am not mistaken she edited The Three Body Problem, she did not write it.


In what seems like a story ripped straight from the pages of an Isaac Asimov novel, a recently deceased Chinese woman named Du Hong just had her brain cryogenically frozen in hopes that, in the future, the technology to bring her back to life will be created. No joke. Hong, a science fiction author herself, paid upwards of $120k to have her brain sent from China to Scottsdale, Arizona to undergo a freezing procedure at the Alcor Life Extension Foundation. Her idea is that while modern tech doesn’t allow for the reanimation of her brain today, inevitable advancements in cryonics will one day bring her back to life.

Before passing away last May from pancreatic cancer, the 61-year-old Du decided she wanted to allow her brain to be the subject of experiments after her death. Though it took some time before the team at Alcor actually conducted the procedure, doctors in Beijing prepped Du’s brain after her official time of death on May 30. Despite the Alcor Life Extension Foundation agreeing to freeze Du’s brain, the organization made it clear that it wouldn’t be the one to actually attempt to bring Du back to life in the future.

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While many tech moguls dream of changing the way we live with new smart devices or social media apps, one Russian internet millionaire is trying to change nothing less than our destiny, by making it possible to upload a human brain to a computer, reports Tristan Quinn.

“Within the next 30 years,” promises Dmitry Itskov, “I am going to make sure that we can all live forever.”

It sounds preposterous, but there is no doubting the seriousness of this softly spoken 35-year-old, who says he left the business world to devote himself to something more useful to humanity. “I’m 100% confident it will happen. Otherwise I wouldn’t have started it,” he says.

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SENS has kindly commented about MMTP and the impact our research should have on aging. We launch a fundraiser in April to test senolytics (ApoptoSENS) with a planned follow up to combine this with stem cell therapy (RepleniSENS). It is time to put the engineering approach to aging to the test!


Some drugs tested have been found to increase mouse lifespan such as Metformin and Rapamycin for example and are considered for human testing. Many more substances have never been tested and we do not know if they might extend healthy lifespan.

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Innovative new project the MMTP aims to fast forward translation from lab to clinic with rapid, parallel mice testing. We caught up with Steve Hill and Elena Milova from the MMTP team to discuss the program and why being pro-actively involved with longevity advocacy is so important.

What’s the gap in the market you’re aiming to fill and the major motivation behind the MMTP?

Steve – The bridge between basic research and taking it to clinical trials. People like The SENS Foundation are spinning a lot of plates doing the high risk, nitty gritty research that isn’t profitable, but crowdfunding can get that done. We want to create a solid gold standard testing platform without the restrictions of government, where any team can come to us for parallel testing and halve development time. The problem with animal testing is there’s this disconnect; it’s not sexy science basically. A common response is let me know when it’s available in humans, but it’s not going to be! No animal data means no human testing, organizations like the FDA, NHS and EMA all insist on a battery of animal testing before human trials. Period. It’s not sexy, it’s not available in humans next week, but if MMTP or other projects don’t get things done on mice for example, it’s never going to get done. It doesn’t matter if one theory turns out to be wrong, let’s get stuck in and find out!

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My new Huff Post story asking why the major presidential candidates don’t discuss transhumanist science:


THE BLOG Why Won’t Sanders, Clinton, Trump and Cruz Discuss Transhumanist Science Issues? 03/11/2016 03:49 pm ET Zoltan Istvan US Presidential candidate of Transhumanist Party; Creator of Immortality Bus; Author of #1 bestselling Philosophy novel ‘The Transhumanist Wager’ Image by DonkeyHotey Have y…

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The preview image below thanks Robert Bradbury(no not Ray Bradbury) who is no longer with us but you can find his work concerning Matrioshka Brains and he has a great life extension lecture on youtube.


The author greatly appreciates and thanks Robert J. Bradbury for doing the painstaking and often tedious original html coding job for 25 of these papers, among the many linked papers cited on this page.

Last updated on 6 July 2013.

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I have spent the last 30 years in various aspects of the biopharmaceutical industry, which for the most part has been a very rewarding experience.

However, during this time period, having been immersed many different components of therapeutic development and commercialization, one thing has always bothered me: a wide array of promising research never makes it off the bench to see the translational light of day, and gets lost in the historical scientific archives.

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I always believed that scientific progress happened in a very linear narrative, with each new discovery supporting the next, resulting ultimately in an eventual stairway of scientific enlightenment.

What the reality turned out to be was much more of a fragmented, research “evolutionary tree”, with dozens of potential pathways, only very few branches of which ever resulted in scientific maturity, and not always the most fruitful ones by any means.

The premature extinction of these promising discovery pathways were the result of a variety of factors, including, but not limited to, funding priorities, competing industrial interests, “out of vogue” concepts, lack of intellectual properties, non-existent regulatory models, conflicted legislative initiatives, and even religious implications.

In 2016, as in previous years, we continue to see these “valleys of death” swallow up pathways of scientific possibility, with few popular segments attracting the majority of attention and support.

gene sequencing

The preponderance of resources focused on the somatic mutation model of carcinogenesis, despite an endless range of research highlighting that the disease is extremely heterogenic and rarely ever follows such a clonal model, is one example that continues to be inappropriately manifested in the oncology system, decades into the “war on cancer”.

On a similar plane, the jettisoning of most studies of the biophysical aspects of human genetics, despite the gross incompleteness offered by the central dogma to explain higher biological form and function, is another example that has become all too pervasive in the research community.

And then there are the areas of human consciousness, memory, and information processing / storage, where in many ways we are still operating in the dark ages, with materialists and dualists battling it out for centuries.

One topic that I have written quite a bit about is that of death, specifically that of the death of the human brain — http://www.singularityweblog.com/is-death-reversible/

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While I am a staunch supporter and advocate of the life-extension / anti-aging movement, I am equally vocal about our need to develop technologies, products, and services that can actually reverse our ultimate transition between the living and dead states, a transition that occurs annually for 60 million humans around the globe.

Death, however, is unfortunately seen by many as a natural, biological progression for human beings, and in many circles, deemed an unnecessary area of scientific research and exploration.

I beg to differ.

Far too often, death arrives too early and too unexpectedly for many of us and our loved ones. And the best modern medicine has to offer today is “Sorry. There is nothing else we can do.”

But what if there was?

There are a variety of species across the natural world that are capable of regenerating and repairing themselves from forms of severe CNS damage that bring them to the transitional grey zone between life and death. Along the evolutionary timeline however, this ability gradually disappeared hundreds of millions of years ago and does not manifest in higher species.

lizard and lady

Now, in the 21st century, with the convergence of the disciplines of regenerative biology, cognitive neuroscience, and clinical resuscitation, we may finally be poised to take back these capabilities for humans.

Over the years, clinical science has focused heavily on preventing such life and death transitions and made some initial progress with suspended animation technologies, such as therapeutic hypothermia. But once we transition through the brain death window, currently defined by the medical establishment as “irreversible” (per the 1968 Ad Hoc Committee of the Harvard Medical School definition), we are technically no longer alive.

surgeons

To add insult to injury, a human can be declared dead, even while our bodies can still circulate blood, digest food, excrete waste, balance hormones, grow, sexually mature, heal wounds, spike a fever, and gestate and deliver a baby. It is even acknowledged by thought leaders that recently brain dead humans still may have residual blood flow and electrical nests of activity in their brains, just not enough to allow for an integrated functioning of the organism as a whole.

Several prominent cases in the media over the past few years have further served to highlight the current situation, as well as the substantial anatomical and functional differences between the state known as brain death, and other severe disorders of consciousness, such as coma, and the vegetative and minimally conscious states.

It is now time to take the necessary steps to provide new possibilities of hope, in order to counter the pain, sorrow, and grief that is all too pervasive in the world when we experience a loved one’s unexpected or untimely death, due to lesions which might be potentially reversible with the application of promising neuro-regeneration and neuro-reanimation technologies and therapies.

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It is time to undertake the required research, based on 2016 technological knowledge, in order to bring about such transformational change.

My name is Ira S. Pastor and I am the CEO of the biotechnology company Bioquark Inc.

Welcome to the unveiling of the Reanima project.

Reanima Video