As we age, our bones become thinner, we suffer fractures more often, and bone-diseases such as osteoporosis are more likely to occur. One responsible mechanism involves the impaired function of the bone-marrow stem cells, which are required for the maintenance of bone integrity. Researchers from the Max Planck Institute for Biology of Ageing and CECAD Cluster of Excellence for Ageing Research at the University of Cologne have now shown that the reduced stem cell function upon aging is due to changes in their epigenome. They were able to reverse these changes in isolated stem cells by adding acetate. This fountain of youth for the epigenome could become important for the treatment of diseases such as osteoporosis.
Aging Researchers have been looking at epigenetics as a cause of aging processes for some time. Epigenetics looks at changes in genetic information and chromosomes that do not alter the sequence of the genes themselves, but do affect their activity. One possibility is changes in proteins called histones, which package the DNA in our cells and thus control access to DNA. The Cologne research group of Peter Tessarz has now studied the epigenome of mesenchymal stem cells. These stem cells are found in bone marrow and can give rise to different types of cells such as cartilage, bone and fat cells.
With all that said, it’s natural for humans to crave and eat limited amounts of sugar. After going through all the research, here’s what I am doing for myself.
For example, foods high in fructose stimulate ghrelin while suppressing leptin—hormones responsible for hunger and satiety. Sugar can promote chronic hyperglycemia, which can both lead to weight gain and is another risk for diabetes. And sugary drinks, especially, are tied directly to obesity.
Sugar and aging: a bad combination (so what should we do?)
People looking to stay young for a long time should limit their sugar consumption. While how added sugar works in the body isn’t simple or predictable, there are literally thousands of studies tying added sugar to diseases of aging.
X-Prize board member Sergey Young on his new book, and the potential for a longevity X-Prize.
“We have created science and technology to extend our life, but we haven’t created life we want to extend.”–Sergey Young, Seeking Delphi™ episode #55, explaining why he believes more people do not support radical life extension.
One of the many areas graphene promises to have transformative effects is in fortifying construction materials like concrete and asphalt. A first-of-a-kind trial now underway seeks to apply the wonder material’s impressive attributes to one of the UK’s major thoroughfares, by deploying it in a road resurfacing project along a stretch of the A1 motorway.
Made up of a single sheet of carbon atoms arranged in a honeycomb pattern, graphene offers incredible strength and flexibility, and by incorporating it into materials like asphalt scientists hope to develop road surfaces that last far longer, and therefore cost less to maintain.
Back in 2017 we looked at an interesting take on this from a pair of Italian companies that developed an asphalt material doped with a graphene additive to make it less likely to soften in the heat and crack in the cold under high loads. This product, known as Gipave, also incorporates plastic pellets and was recently rolled out along stretches of UK roads as part of trials to see how it can extend the lifespan of the surface.
In humans, as well as all vertebrate animals, turning a fertilized egg into an embryo with a little beating heart requires that stem cells differentiate, specialize, and generate specific tissues, such as bones, blood vessels and a nervous system. This process is kickstarted and regulated by retinal. Animals can’t produce their own retinal, though, they must ingest it from plants, or from animals that eat plants.
Plant roots and animal embryos rely on the same chemical for successful development.
What do frog eggs have in common with anti-aging creams? Their success depends on a group of chemical compounds called retinoids, which are capable of generating and re-generating tissues.
A new study in plants shows that retinoids’ tissue-generating capacities are also responsible for the appropriate development of roots.
Check out our second promo for #transvision #future Summit 2021 (#madrid Oct. 8 — 12), featuring the optional dinner/cocktails we are scheduling, and 2 full-day #tours of several #unescoworldheritage sites and historical places near Madrid: Segovia, Ávila, Monsaterio de El Escorial & Valley of the Fallen on Oct. 11 and Alcalá de Henares, Aranjuez & Toledo on Oct. 12. It’s going to be espectacular! You don’t wanna miss those, so get your tickets now! 😊 Get your tickets here -> www.TransVisionMadrid.com.
The event itself will be a lot of fun, so make sure to register to come to Madrid in person, or to watch it via streaming (at a reduced price). There will be talks about #longevity #artificialintelligence #cryonics and much much more.
Promo by Sergio Tarrero for Alianza Futurista as Diamond Sponsor of TransVision Future Summit 2021. Alianza Futurista will also provide live video production, streaming and post production services for this event.
Humanity Plus Humanity Plus Magazine Ilustre Colegio Oficial de Médicos de Madrid (ICOMEM) Alcor Life Extension Foundation Cryonics Institute Cryonics Institute Posthuman Network Posthuman Network Cryonics4U Longevity Conferences Longevity for All International Longevity Alliance U.S. Transhumanist Party Transhumanist Party Australia Transhumanist Party Australia Group Transhumanist UK Rational Transhumanism Singularity University Ray Kurzweil Ray Kurzweil Singularity Ray Kurzweil Singularity Ray Kurzweil’s Singularity Singularity Hub Singularity Network Transhumanismo Brasil SingularityNET Singularitarianism Foresight Institute Lifeboat Foundation Machine Intelligence Research Institute KrioRus The Hedonistic Imperative — Paradise Engineering Future of Life Institute Future of Humanity Institute (Oxford University) The Long Now Foundation Global Catastrophic Risk Institute CLUB DE SEGUIDORES DE JOSÉ LUIS CORDEIRO (OFICIAL) Aubrey de Grey Dr. Aubrey de Grey HashtagTeam 🤩
http://www.TransVisionMadrid.com.
Promo by Sergio M.L. Tarrero for Alianza Futurista, proud Diamond Sponsor of #TransVision Future Summit 2021.
Spain will host the next global future summit #TransVision on October 8 9 and 10 2021. Humanity+ will be the main international organizer of this international event. Afterwards, during October 11 and 12 we will continue with informal conversations while traveling to UNESCO World Heritage Sites around Madrid: Alcalá de Henares, Aranjuez, Ávila, El Escorial, Segovia y Toledo. Every night will finish with optional cocktails in beautiful places for networking and meeting the participants and speakers.
The topics covered will be very broad, from recent medical advances, to artificial intelligence and robotics. The first keynote speakers will be the world famous Ray Kurzweil and Aubrey de Grey. Additionally, #TransVision 2021 will feature other keynote presentations, such as those from futurist movement pioneers Max More, Natasha Vita-More, Ben Goertzel and Anders Sandberg, members of Humanity+ and other leading institutions.
#TransVision 2021 collaborates with leading organizations working on futurist concepts such as life extension, artificial intelligence, robotics, nanotechnology, space travel, human enhancement, blockchain and other future technologies and trends. The first #TransVision conference was held in 1998 in the Netherlands, and since there we have hosted 14 international summits in cities like Berlin, Brussels, Caracas, Chicago, Helsinki, London, Madrid, Milano, Paris, Stockholm and Toronto.
#TransVision 2021 will be hosted in the historic Madrid College of Medicine (Ilustre Colegio Oficial de Médicos de Madrid), and there will be live streaming for those who can’t come in person to beautiful Madrid.
Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD
Levine’s Biological age calculator is embedded as an Excel file in this link from my website: Quantifying Biological Age
DNA methylation GrimAge strongly predicts lifespan and healthspan. https://pubmed.ncbi.nlm.nih.gov/30669119/
Fisetin is a senotherapeutic that extends health and lifespan. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/
Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. https://pubmed.ncbi.nlm.nih.gov/10958819/
NAD and the aging process: Role in life, death and everything in between. https://pubmed.ncbi.nlm.nih.gov/27825999/
A bitter divorce battle in Russia has led to cryogenically frozen bodies being seized in an extraordinary day-time raid.
Staff of a company set up by Valeria Udalova, 59 grabbed the remains of people — including from Britain and the US — who paid thousands of pounds hoping to be brought back to life when science advances to allow this.
She and her team raided the company run by her ex-husband Danila Medvedev, 41 near Moscow, which is home to Russia’s leading cryo-storage facility, say reports.
#ElonMusk is on a better path than Bezos is partly because he’s working on his brain chip and once that brain chip has been made dubbed complete he can make it so it works with tech and we can merge Tech with people which means that we can make a life out of tech and have our body be completely made robotic and as long as we have materials like synthetic blood that feeds and sustains the brain with the proper nutrients to stay alive. Theoretically u could live much longer. He seems to have the robot body and robot made and chip almost complete now he needs the synthetic sustainable blood for a human brain 🧠 implant into the robot tech body using Brian chip to control it. Immortality In theory the brain doesn’t have to be in the robotic body it can still be connected to the body through a central location via #StarLink #Robot links https://fb.watch/7UAKDX92Vh/ https://fb.watch/7Uyo7JYdok/ “Life is a video game in that aspect” But even without the brain merge you will be able to pair our minds with these AI robots and use them on 🌎 earth or beyond like a ship to #Mars or any other place that can get the signal from the brain to the robotic body.
What might happen after the Cybernetic Singularity? Can we refine our theological philosophies in light of new evidence? Are we alone in the Universe? Can you achieve Cybernetic Immortality? When and how can we transcend the human condition? These are some of the questions addressed in my new book THEOGENESIS: Transdimensional Propagation & Universal Expansion. This awe-inspiring volume is to be released on October 1 2021 as part of The Cybernetic Theory of Mind series and is available now to pre-order on Amazon. #THEOGENESIS #TransdimensionalPropagation #UniversalExpansion #CyberneticTheoryofMind #cybernetics #theology #futurism #posthumanism
Ecstadelic Media Group announces the release of the next book in The Cybernetic Theory of Mind series by Alex M. Vikoulov ― THEOGENESIS: Transdimensional Propagation & Universal Expansion ― available as a Kindle eBook on Amazon.
