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Category: life extension

In this video Dr. Katcher reveals his thought on the future of aging if E5 is fulfils on its promise.

Dr Katcher’s book is on Amazon.
The Illusion of Knowledge: The paradigm shift in aging research that shows the way to human rejuvenation.
https://amzn.to/3jJ5deD

Dr Harold Katcher is one of the discovers of the human breast cancer gene BRCA1, and has thousands of citations in the scientific literature with publications ranging from protein structure to bacteriology, bioinformatics and biochemistry. He was the Academic Director for Natural Sciences of the University of Maryland Global Campus and is now the Chief Scientific Officer at Yuvan Research Inc, a company working on the development of rejuvenation treatments.

Dr Katcher’s new book, the Illusion of Knowledge, the paradigm shift in aging research that shows the way to human rejuvenation will be launched on 4th September 2021 and is already available in electronic form. The book launch will take place at The Book Passage in the Ferry Building in San Francisco at 3:00 pm Pacific Time.

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Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation.

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Summary: A new study on aging reveals a surprising discovery about the connection between protein shape and mitochondrial health.

Source: Buck Institute.

Every cell in the body goes through thousands of chemical reactions each day, and each reaction involves tiny protein molecules folded into precise shapes to perform their functions. Misfolded proteins underlie some of the most common and devastating diseases of aging, like Alzheimer’s and Parkinson’s. A major focus of aging research is discovering ways to maintain protein shape and prevent misfolded proteins from wreaking havoc on cellular function.

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Exploring The Gut Microbiota-Brain Axis In Health, Disease, and Aging — Dr. Marina Ezcurra, Ph.D. University of Kent.

Dr. Marina Ezcurra (https://marinaezcurralab.com/) is a Lecturer in the Biology of Aging, and NeuroBiology, at the School of BioSciences, at the University of Kent, UK (https://www.kent.ac.uk/biosciences/people/2081/ezcurra-marina).

Dr. Ezcurra received her PhD from the Karolinska Institute in 2011. Her PhD research was a collaborative project between Karolinska and the Medical Research Council Laboratory of Molecular Biology at Cambridge, where she studied neural circuits and behavior using C. elegans in the lab of Dr. Bill Schafer.

During her PhD, Dr. Ezcurra identified extra-synaptic mechanisms by which nutritional status modulates nociception, involving neuro-peptidergic and dopaminergic signaling. She went on to do a postdoc working on aging with Dr. David Gems at University College London.

During her postdoc, Dr. Ezcurra developed methods to monitor the development of multiple age-related diseases in-vivo in C. elegans, leading to the discovery of a previously unknown process, Intestinal Biomass Conversion. This mechanism enables the C. elegans intestine to be broken down to produce vast amounts of yolk, resulting in poly-morbidity and mortality in aging nematodes. This work illustrates how aging and age-related diseases can be the result of run-on of wild-type gene function, rather than stochastic molecular damage.

Current research in Dr. Ezcurra’s group focuses on how host-microbiome interactions affect host aging, and is funded by The Wellcome Trust and Royal Society.

Dr. Ezcurra is a trustee board member of The British Society of Research on Aging.

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Mentions telomeres.

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People with rare disorders that cause shortened telomeres—protective caps that sit at the end of chromosomes—may be more likely to have blood cancers such as leukemia or myelodyplastic syndrome. Now, Johns Hopkins Medicine scientists have discovered several “self-correcting” genetic mutations in bone marrow that may protect such patients from these cancers.

In a study published online August 3 2021, in the Journal of Clinical Investigation, the researchers also suggest these mutations can serve as biomarkers that may indicate if patients with short telomere syndromes are likely to develop blood cancers.

“These are the most common cancers we see in patients with short telomere syndromes,” says Mary Armanios, M.D., director of the Telomere Center and professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. “We know that at a certain point, the cells of patients with shortened either become cancerous or stay healthy.”

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Summary: Researchers have identified 2,000 genes in humans linked to longevity. The genes are associated with biological mechanisms that drive the prolongation of life in mammals, including DNA repair, coagulation, and immune response.

Source: UPF Barcelona.

What determines the life expectancy of each species? This is a fundamental and highly complex question that has intrigued the field of research throughout history. From the evolutionary point of view, the major cause of these differences between species lies in their ecological adaptations. For example, life expectancy is longer in species adapted to living in trees, underground, or with large body mass, since all these adaptations reduce mortality by predation.

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Youthereum talking about rejuvenation, funding, there is a history lesson here but the modern look starts at 38:01.

My overview of the history of partial reprogramming — a novel approach to epigenetic rejuvenation that uses short bursts of Yamanaka factors expression to periodically roll back the epigenetic state of cells to a younger pattern.

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“After demonstrating that cultured meat can reach cost parity faster than the market anticipated, this production facility is the real game-changer,” said Yaakov Nahmias, Future Meat Technologies founder and chief scientific officer, in a press release. “This facility demonstrates our proprietary media rejuvenation technology in scale, allowing us to reach production densities 10-times higher than the industrial standard.”

Cultured meat is made by extracting cells from animal tissue and giving them nutrients, oxygen, and moisture while keeping them at the same temperature they’d be at inside an animal’s body. The cells divide and multiply then start to mature, with muscle cells joining to create muscle fibers and fat cells producing lipids. The resulting nuggets of meat can be used to make processed products like burgers or sausages. Structured cuts of meat with blood vessels and connective tissue, like steak or chicken breast, require scaffolds, and researchers are creating these with biomaterials, like cellulose from plants. Companies are working on several varieties of more elaborate cultured products, from bacon to salmon.

As reported by Bloomberg, Future Meat aims to start offering its products in US restaurants by the end of next year—but must get approval from the FDA first. On top of that approval, public opinion is another hurdle the company and its competitors will need to clear before they see widespread success; for every person who’s opposed to factory farming, there’s a person who’s squeamish about the idea of meat grown in a bioreactor, despite the avian (or bovine, or porcine) lives being spared. Getting these consumers to view cultured meat favorably will be a matter of education, taste/texture as compared to the ‘real thing,’ and cost competitiveness.

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Thanks Jeff

Jeff Bezos, the world richest man is investing in anti-ageing technology that could extend the average human lifespan by up to 50 years, WITHIN NIGERIA learnt.

It was also learnt that Jeff Bezos is one of the several billionaire investors in Altos Labs, a Silicon Valley tech firm working on experimental – and potentially dangerous – new life extension technologies.

The new company has hired dozens of experts from top universities to research how cells age and how to reverse that process.

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This is an excerpt I made from a conversation between Sergey Young and David Sinclair. Along it, they share their impressions as to how much Longevity science have progressed during the last few years.

The link to the entire conversation and the Q&As from the audience that was watching the webinar is in the description of the video.

𝗛𝗲 𝗮𝗴𝗿𝗲𝗴𝗮𝗱𝗼 𝘀𝘂𝗯𝘁𝗶́𝘁𝘂𝗹𝗼𝘀 𝗲𝗻 𝗘𝘀𝗽𝗮𝗻̃𝗼𝗹 🙂

Excerpt from an interview made by Sergey Young to David Sinclair on may 29 2021.

To watch the entire interview clic here: https://youtu.be/JCnXRJsgnlI

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