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Innovation in the amino-sciences for health, wellness, and aging — dr. tia rains phd, VP customer engagement & strategic development, ajinomoto.

Dr. Tia Rains, Ph.D., is Vice President of Customer Engagement & Strategic Development at Ajinomoto Health & Nutrition North America, Inc. (https://www.ajihealthandnutrition.com/), a division of Japanese food and biotechnology Ajinomoto Corporation (https://www.ajinomoto.com/), which produces seasonings, cooking oils, frozen foods, beverage, sweeteners, amino acids, and pharmaceuticals.

Dr. Rains has over 20 years of experience working on health and wellness initiatives within the food and beverage sector, and enjoys working at the intersection of nutrition research and communications, with the goal of advancing credible research in nutrition and developing truthful messaging on new research results in the context of the body of nutrition evidence.

Dr. Rains most recently headed up the Egg Nutrition Center (ENC) as it’s Executive Director.

Prior to joining ENC, Dr. Rains was the Senior Director of Metabolic Sciences at Biofortis Clinical Research, a global contract research organization specializing in the design and conduct of clinical research for leading food, beverage, and supplement companies around the world.

Prior to that, Dr. Rains held several positions within the Research & Development department of Kraft Foods, including roles in nutrition research and product development.

Dr. Rains holds a BS in Food Science & Human Nutrition from Arizona State University, and a Ph.D. in Nutritional Sciences from University of Illinois. She has authored more than 40 scientific articles and book chapters and is a frequent public speaker at universities, health professional meetings, and industry events.

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Obstructive sleep apnea is widely “underrecognized and underdiagnosed.” But individuals with moderate to severe sleep apnea have a notable elevated risk of mortality from cancer and stroke compared to individuals without. People with obstructive sleep apnea and parasomnia have higher risks of breast cancer. The same study finds that parasomnia also increases the risk of oral cancer.

Update 8/23/2021: This post has been updated since we originally published it in October 2020. I evaluated additional top sleep trackers and apps for 2,022 added Biostrap, updated the post to reflect most recent pricing, and added additional commentary on my reviews. The post has been cleaned up and links were made current.

I didn’t used to have a harmonious relationship with sleep. In fact, sleep used to be a source of anxiety for me. I have parasomnia, an amalgam of disorders that, occasionally, give me hypnopompic hallucinations Severe hallucinations when waking up from a deep sleep. 0 night terrors Nightmares that lead the dreamer to wake up screaming and thrashing without recollection of the dream itself 0 and, most dangerously, somnambulism The fancy word for ‘sleepwalking.’ 0 which has led me to drive while sleeping and scare the living piss out of my poor husband after we watched Paranormal Activity together (it didn’t help that I was mutely standing over him at 4:15 AM with my eyes wide open).

So it should come as no surprise that I’ve built quite the relationship with my own sleep metrics and have more than a layman’s knowledge of sleep science. Which brings me to this article.

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The attachment of the small protein ubiquitin to other proteins (ubiquitination) regulates numerous biological processes, including signal transduction and metabolism / Scientists at the University of Cologne discover the link to aging and longevity.

Scientists have discovered that the protein ubiquitin plays an important role in the regulation of the aging process. Ubiquitin was previously known to control numerous processes, such as signal transduction and metabolism. Prof. Dr. David Vilchez and his colleagues at the CECAD Cluster of Excellence for Aging Research at the University of Cologne performed a comprehensive quantitative analysis of ubiquitin signatures during aging in the model organism Caenorhabditis elegans, a nematode worm which is broadly used for aging research.

This method — called ubiquitin proteomics — measures all changes in ubiquitination of proteins in the cell. The resulting data provide site-specific information and define quantitative changes in ubiquitin changes across all proteins in a cell during aging. A comparison with the total protein content of a cell (proteome) showed which changes have functional consequences in protein turnover and actual protein content during aging. The scientists thus discovered new regulators of lifespan and provide a comprehensive data set that helps to understand aging and longevity. The article, ‘Rewiring of the ubiquitinated proteome determines aging in C. elegans,‘has now been published in Nature.

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Northwestern Medicine investigators have discovered that a subset of proteins in mitochondria of brain and heart cells are long-lived, supporting the long-term stability of mitochondrial complex architecture.

The study, published in the Journal of Cell Biology, was led by Jeffrey Savas, PhD, assistant professor in the Ken & Ruth Davee Department of Neurology’s Division of Behavioral Neurology, of Medicine the in Division of Nephrology and Hypertension, and of Pharmacology.

Previous work led by Savas discovered that nuclear pore complex proteins in post-mitotic neurons are exceptionally long-lived and persist for months in mouse and rat brains. These proteins, termed long-lived proteins, or LLPs, provide long-term stability and structure to the nuclear pore and subsequently to the nuclear envelope of neurons; however, this concept had never been considered for other intracellular organelles, until now.

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Investigators who previously developed a recipe for turning skin cells into primitive muscle-like cells that can be maintained indefinitely in the lab without losing the potential to become mature muscle have now uncovered how this recipe works and what molecular changes it triggers within cells. The research, which was led by scientists at Massachusetts General Hospital (MGH) and is published in Genes & Development, could allow clinicians to generate patient-matched muscle cells to help treat muscle injuries, aging-related muscle degeneration, or conditions such as muscular dystrophy.

It’s known that expression of a regulatory gene called MyoD is sufficient to directly convert into mature ; however, mature muscle do not divide and self-renew, and therefore they cannot be propagated for clinical purposes. “To address this shortcoming, we developed a system several years ago to convert skin cells into self-renewing muscle stem-like cells we coined induced myogenic progenitor cells, or iMPCs. Our system uses MyoD in combination with three chemicals we previously identified as facilitators of cell plasticity in other contexts,” explains senior author Konrad Hochedlinger, Ph.D., a principal investigator at the Center for Regenerative Medicine at MGH and a professor of medicine at Harvard Medical School.

In this latest study, Hochedlinger and his colleagues uncovered the details behind how this combination converts skin cells into iMPCs. They found that while MyoD expression alone causes skin cells to take on the identity of mature muscle cells, adding the three chemicals causes the skin cells to instead acquire a more primitive stem cell–like state. Importantly, iMPCs are molecularly highly similar to muscle tissue stem cells, and muscle cells derived from iMPCs are more stable and mature than muscle cells produced with MyoD expression alone.

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“University Of The 3rd Age” — Seniors Staying Intellectually Challenged, Socially Engaged, And Physically And Mentally Healthy — Maya Abi Chahine, University for Seniors, American University of Beirut (AUB)

AUB (https://www.aub.edu.lb/seniors/Pages/default.aspx).

The University for Seniors is a new life-long learning initiative at AUB, the first of its kind in Lebanon and the Middle East. It gives older adults (who are 50 and above) the opportunity to share their wisdom and passion, to learn things they have always wanted to learn in a friendly academic environment and to interact socially with other seniors, AUB faculty and students.

Ms. Abi Chahine holds an MA in Public Policy & Ageing from King’s College London and is a passionate advocate and researcher in health, well being issues and third age learning. Her portfolio includes collaborations with UN agencies, including WHO, United Nations Population Fund, and International Labour Organization, as well as INGOs such as HelpAge International and universities in the UK.

Ms. Abi Chahine has 21 years of experience in setting-up and managing programs in the fields of public health, gerontology and education, notably universities. Throughout her multifaceted career, she developed skills in establishing and restructuring programs, by spearheading strategies, setting institutionalization mechanisms and driving daily operations that ensured customers and collaborators’ satisfaction and expansion.

Ms. Abi Chahine has been leading AUB’s University for Seniors for the past 10 years along with her team, and she recently co-led, with Dr. Abla Mehio Sibai (Co-founder and the current President of the newly established ‘Center for Studies on Ageing’ in Lebanon) the drafting of the first ever National Strategy on Ageing in Lebanon.

The latest recognition of Ms. Abi Chahine’s work came with WHO’s Centre for Health Development selecting the lifelong learning program she’s been leading and transforming at AUB, as one of the 10 most innovative community-based social innovations in low and middle-income countries.

When not working, Ms. Abi Chahine would be savoring nature, discovering new countries, cultures and people. She also revels in exploring new paths to evolve and grow!

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If you’ve ever seen a petunia with artfully variegated petals, then you’ve seen transposons at work. The flower’s showy color patterns are due to transposable elements, or DNA sequences that can move locations within a genome. Yet when it comes to transposons’ effects on humans, the results might not be as lovely or desirable.

As researchers learn more about these so-called mobile genetic elements, they’ve found increasing evidence that transposons influence and even promote aging and like cancer as well as neurogenerative and autoimmune disorders, says John Sedivy, a professor of biology and director of the Center on the Biology of Aging at Brown. Sedivy is the corresponding author of a new review article in Nature that discusses the latest thinking and research around transposons.

“Let’s put it this way: These things can be pretty dangerous,” said Sedivy. “If they are uncontrolled, and there are many examples of that, transposons can have profound consequences on most forms of life that we know of.”

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The Conboys are looking at human trials soon but not with E5. it will be interesting to see how their trial compares to this E5 dog trial.

In this video Dr. Fahy shares his opinion on some of the up and coming anti-aging therapies, including NAD boosters, Hyperbaric Oxygen Chambers and senolytics.

Intervene Immune website:
http://interveneimmune.com/
Contact to join the trial or invest.
http://interveneimmune.com/?page_id=1148

Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.

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