Lifeboat Foundation: Safeguarding Humanity
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Category: life extension

Hematopoietic stem cells—the precursors to blood cells—have been notoriously difficult to grow in a dish, a critical tool in basic research. Scientists at University of California San Diego School of Medicine have identified the underlying issue and developed a method to keep cultured cells healthy. These findings, they say, are positive news for patients seeking stem cell transplants—and may hint at a new way to ward off aging.

The findings will be published in the August 12 2021 online issue of Cell Stem Cell.

In transplants, hematopoietic stem are infused intravenously to reestablish blood production in patients whose bone marrow or is damaged. The procedure is used to treat diseases such as leukemia, lymphoma, aplastic anemia and immune deficiency disorders. However, are not always available for patients who need them.

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Since 1,988 and formation of the Posthuman Movement, and articles by early adopters like Max Moore were a sign our message was being received — although I always argued on various Extropian & Transhuman bulletin boards & Yahoo groups &c that “Trans” was a redundant middle and we should move straight to Posthuman, now armed with the new MVT knowledge (also figures on the CDR). There will be a new edition of World Philosophy, the first this millennium, to coincided with various Posthuman University events later this year. Here is the text:

THE EXTROPIAN PRINCIPLES V. 2.01 August 7 1992.

Max More Executive Director, Extropy Institute.

1. BOUNDLESS EXPANSION — Seeking more intelligence, wisdom, and.
personal power, an unlimited lifespan, and removal of natural, social.
biological, and psychological limits to self-actualization and self-realization. Overcoming limits on our personal and social.
progress and possibilities. Expansion into the universe and infinite existence.

2. SELF-TRANSFORMATION — A commitment to continual moral.
intellectual, and physical self-improvement, using reason and critical.
thinking, personal responsibility, and experimentation. Biological and.
neurological augmentation.

3. INTELLIGENT TECHNOLOGY — Applying science and technology to.
transcend “natural” limits imposed by our biological heritage and environment.

4. SPONTANEOUS ORDER — Promotion of decentralized, voluntaristic.
social coordination mechanisms. Fostering of tolerance, diversity.
long-term planning, individual incentives and personal liberties.

5. DYNAMIC OPTIMISM — Positive expectations to fuel dynamic action.
Promotion of a positive, empowering attitude towards our individual.
future and that of all intelligent beings. Rejection both of blind.
faith and stagnant pessimism.

These principles are further explicated below. In depth treatments can.
be found in various issues of EXTROPY: The Journal of Transhumanist.
Thought. (Spontaneous Order in #7, Dynamic Optimism in #8, and.
Self-Transformation in the forthcoming #10.)

1. BOUNDLESS EXPANSION
Beginning as mindless matter, parts of nature developed in a.
slow evolutionary advance which produced progressively more powerful brains. Chemical reactions generated tropistic behavior, which was.
superseded by instinctual and Skinnerian stimulus-response behavior.
and then by conscious learning and experimentation. With the advent of.
the conceptual consciousness of humankind, the rate of advancement.
sharply accelerated as intelligence, technology, and the scientific.
method could be applied to our condition. Extropians seek the.
continuation and fostering of this process, transcending biological.
and psychological limits as we proceed into posthumanity.
In aspiring to transhumanity, and beyond to posthumanity, we.
reject natural and traditional limitations on our possibilities. We.
champion the rational use of science and technology to void limits on.
lifespan, intelligence, personal power, freedom, and experience. We.
are immortalists because we recognize the absurdity of accepting.
“natural” limits to our lives. For many the future will bring an.
exodus from Earth — the womb of human and transhuman intelligence
expanding the frontiers of humanity (and posthumanity) to include.
space habitats, other planets and this solar system, neighboring.
systems, and beyond. By the end of the 21st Century, more people may.
be living off-planet than on Earth.
Resource limits are not immutable. The market price system.
encourages conservation, substitution and innovation, preventing any.
need for a brake on growth and progress. Expansion into space will.
vastly expand the energy and resources for our civilization. Living.
extended transhuman lifespans will foster intelligent use of resource.
and environment. Extropians affirm a rational, market-mediated.
environmentalism aimed at maintaining and enhancing our biospheres.
(whether terrestrial or extra-terrestrial). We oppose apocalyptic.
environmentalism, which hallucinates catastrophes, issues a stream of.
doomsday predictions, and attempts to strangle our continued.
evolution.
No mysteries are sacrosanct, no limits unquestionable; the.
unknown must yield to the intelligent mind. We seek to understand and.
to master reality up to and beyond any currently foreseen limits.

2. SELF-TRANSFORMATION

We affirm reason, critical inquiry, intellectual independence.
and intellectual honesty. We reject blind faith and passive.
comfortable thinking that leads to dogmatism, religion, and conformity. A commitment to positive self-transformation requires us.
to critically analyze our current beliefs, behaviors, and strategies.
Extropians therefore choose to place their self-value in continued.
development rather than “being right”. We prefer analytical thought to.
fuzzy but comfortable delusion, empiricism to mysticism, and.
independent evaluation to conformity. Extropians affirm a philosophy.
of life but distance themselves from religious thinking because of its.
blind faith, debasement of human dignity, and systematized.
irrationality.
Perpetual self-improvement — physical, intellectual.
psychological, and ethical — requires us to continually re-examine our lives. Extropians seek to better themselves, yet without denying their.
current worth. The desire to improve should not be confused with the.
belief that one is lacking in current value. But valuing oneself in.
the present cannot mean self-satisfaction, since an intelligent and.
probing mind can can always envisage a superior self in the future.
Extropians are committed to expanding wisdom, fine-tuning.
understanding of rational behavior, and enhancing physical and.
intellectual capacities.
Extropians are neophiles and experimentalists. We are.
neophiles because we track the latest research for more efficient.
means of achieving our goals. We are experimentalists because we are.
willing to explore and test the novel means of self-transformation.
that we uncover. In our quest for advancement to the tranhuman stage.
we rely on our own judgement, seek our own path, and reject both blind.
conformity and mindless rebellion. Extropians frequently diverge from.
the mainstream because they do not allow themselves to be chained by.
dogmas, whether religious, political, or social. Extropians choose.
their values and behavior reflectively, standing firm when required.
but responding flexibly to novel conditions.
Personal responsibility and self-determination goes.
hand-in-hand with neophilic self-experimentation. Extropians take.
responsibility for the consequences of our choices, refusing to blame.
others for the risks involved in our free choices. Experimentation and.
self-transformation require risks; Extropians wish to be free to.
evaluate the risks and potential benefits for ourselves, applying our.
own judgment and wisdom, and assuming responsibility for the outcome.
We neither wish others to force standards upon us through legal.
regulation, nor do we wish to force others to follow our path.
Personal-responsibility and self-determination are incompatible with.
authoritarian centralized control, which stifles the free choices and.
spontaneous ordering of autonomous persons.
External coercion, whether for the purported “good of the.
whole” or the paternalistic protection of the individual, is.
unacceptable to us. Compulsion breeds ignorance and weakens the.
connection between personal choice and personal outcome, thereby.
destroying personal responsibility. The proliferation of outrageous.
liability lawsuits, governmental safety regulations, and the.
rights-destroying drug war result from ignoring these facts of life.
Extropians are rational individualists, living by their own judgment.
making critical, informed, and free choices, and accepting.
responsibility for those choices.
As neophiles, Extropians study advanced, emerging, and future.
technologies for their self-transformative potential in enhancing our.
abilities and freedom. We support biomedical research with the goal of.
understanding and controlling the aging process. We are interested in.
any plausible means of conquering death, including interim measures.
like biostasis/cryonics, and long-term possibilities such as migration.
out of biological bodies into superior vehicles (“uploading”).
We practice and plan for biological and neurological.
augmentation through means such as effective cognitive enhancers or.
“smart drugs\.

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Evidence has been accumulating for almost a decade that the microbiome composition changes with age. In 2,012 research by my colleagues at University College Cork showed that diversity in the microbiome was linked to health outcomes in later life, including frailty.

In 1,895 on turning 50 Elie Metchnikoff became increasingly anxious about aging. As a result, the Russian Nobel prize-winning scientist, and one of the founders of immunology, turned his attention away from immunology and towards gerontology – a term that he coined.

He was fascinated by the role that intestinal bacteria play in health and disease and suggested that people from parts of eastern Europe lived longer because they ate a lot of fermented foods containing lactic acid bacteria.

Although popular at the time, this theory linking gut microbes to healthy aging was largely ignored by scientists until relatively recently. We now recognize the importance that the trillions of bacteria, known as the gut microbiome, have in regulating health and disease.

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Caffeinated coffee might be protective to overall health, but so is decaf. For example, a 2,019 systematic review published in the Journal of Human Nutrition and Dietetics aiming to “investigate the association of caffeinated and decaffeinated coffee consumption and all-cause mortality” found “similar inverse associations [between] caffeinated coffee and decaffeinated coffee [and all-cause mortality.]”

But is coffee healthy? And do coffee drinkers live longer than non-coffee drinkers?

At the turn of the 20th century, it was considered common knowledge that coffee was unhealthy—there were advertising claims that coffee drinking caused blindness and that “you can recover from any ordinary disease by discontinuing coffee.” And while that may obviously be untrue, there are continuing fears about whether coffee is actually healthy or not. Google receives 4,400 queries a month about” why coffee is bad for you” (for context, “why coffee is good for you” gets only 1,300 queries a month).

So with human life extension in mind, I decided to dig into the research. Can coffee consumption actually help spanners extend their healthspan and lifespan? How much is the right dose? How much is too little?

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Still, the timing of this film is remarkable, not only because the pandemic slowed us all down, but because we do live in an aging society. We also live in a time of accelerating technological transformation and precision medicine. It is no secret that transhumanist thinking is proliferating, and not just each time a billionaire flies into space. No less than The World Economic Forum has implicitly endorsed aspects of transhumanism’s agenda under the banner of “human enhancement” and more recently via “The Great Reset.”

The new film opened last Friday.

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A couple people from TRIM are in TRIM-X to see how it works a second time.

In this video Dr. Fahy discusses what we can do to make the most of our thymus without the growth hormone treatment, what the timing makes sense for rejuvenation of the thymus and whether the thymus is tied to the other hallmarks of aging.

Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.

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Driver Clocks And Longevity — Dissecting True Functional “Drivers” Of Aging Phenotypes — Dr. Daniel Ives Ph.D., Founder and CEO — Shift Bioscience Ltd.

Dr. Daniel Ives, Ph.D. is Founder and CEO of Shift Bioscience Ltd. (https://shiftbioscience.com), a biotech company making drugs for cellular rejuvenation in humans through the application of machine-learning ‘driver’ clocks to cellular reprogramming, and is the scientific founder who first discovered the gene shifting targets upon which the Shift drug discovery platform is based.

Dr. Ives graduated from Imperial College with a degree in biochemistry and gained his PhD in 2013 working at the MRC Mitochondrial Biology Unit in Cambridge. He carried out his post-doctoral studies under Ian Holt at the National Institute of Medical Research in Mill Hill, now part of the Crick Institute, pursuing damage-removal strategies for mitochondrial DNA mutations.

In 2016 Dr. Ives left the Crick Institute and founded Shift Bioscience to commercialize mitochondrial targeted drugs for age linked diseases, incorporating novel ageing biomarkers technologies, CRISPR screens, and other tools to dissect true functional ‘drivers’ of ageing phenotypes.

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Although visible signs of aging are usually unmistakable, unraveling what triggers them has been quite a challenge. Researchers at Baylor College of Medicine and collaborating institutions have discovered that a cellular phenomenon called cryptic transcription, which had been previously described and linked to aging in yeasts and worms, is elevated in aging mammalian stem cells.

The team reports in the journal Nature Aging that cryptic transcription occurs because a that keeps it in check falls apart as cells get old. The findings suggest that strategies that control cryptic transcription could have pro-longevity effects.

“In previous work, we showed that cryptic transcription in yeasts and worms is not only a marker of aging but also a cause,” said corresponding author Dr. Weiwei Dang, assistant professor of molecular and and the Huffington Center on Aging at Baylor. “Reducing the amount of this aberrant transcription in these organisms prolonged their lifespan.”

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