Lifeboat Foundation: Safeguarding Humanity
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Category: life extension

New research exploring theories of aging has found that small mutations accumulating in DNA are unlikely to be fully responsible for this process.

The research, a collaboration between the Wellcome Sanger Institute, University of Birmingham, University of Edinburgh and others, found that and tissues can accumulate many more than are normally present, without the body showing the features associated with aging.

The new study, published today (30 September) in Nature Genetics, compared DNA taken from individuals with inherited mutations in genes involved in DNA replication with DNA from individuals who have normal versions of these genes. The researchers aimed to understand the impact of defective DNA replication on and features associated with aging. The results suggest that build-up of mutations in is unlikely to be the only factor in the development of age-related disease, adding to the ongoing debate about the causes of aging.

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(https://www.linkedin.com/in/evelyne-yehudit-bischof/) is an expert in internal medicine and oncology, with a focus on preventative and precision medicine, bio-gerontology, and geronto-oncology.

Dr. Bischof is deeply passionate about next-generation medical technology, and the applications of artificial intelligence for biomedical research and practice.

Dr. Bischof spent a decade practicing medicine and performing translational research in Switzerland, US, and China.

Dr. Bischof is a medical doctor with an MD from Max Planck Institute for Molecular Biology and Genetics, and interned at Columbia University, Harvard MGH, and Beth Israel Medical Deaconess.

Dr. Bischof is the author of over 40 peer-reviewed papers and is a frequent speaker at scientific and medical conferences.

Dr. Bischof serves as Assistant Professor — Shanghai University of Medicine and Health Sciences; Associate Faculty Shanghai Jiao Tong University, and Researcher at University Hospital of Basel.

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Like many other living organisms, humans are born, survive, compete for resources, reach maturity, reproduce, take care of their young, sometimes the young of their young, continuously decline, and die. Evolution needs us for just two purposes – adapt and reproduce. But, unlike other species, humans are very conscious of their fate. Humans are very much aware that after reaching peak performance they will eventually grow old and die. We are very conscious of our fate after reaching peak performance – loss of function, frailty, and eventual loss of everything we worked so hard to earn.

We observe our parents, and other elderly around them, attend funerals, and understand that eventually we will get into this state. We are also very contempt with that fate as evolution made sure that. The more ambitious of us are trying to advance science, the rest seek refuge in religion, some in philosophy, some in accumulation of wealth, and some see the continuation of ourselves in our children. But despite the many technological advances transpiring in the laboratories all over the world, there is nothing we can do at this point to escape aging. There are diets, exercises, sleep, and supplements, but these provide very marginal benefits. We do not see 120+ old yoga and diet practitioners or marathon runners around. But these simple habits do help look younger longer. And many people that have very harmful habits like smoking but still diet and exercise to look younger.

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$100 million a year. All you gotta do is apply for funding.

A consortium of biotech founders, clinicians, and leading longevity research institutions announced today the launch of the Longevity Science Foundation. The new Swiss foundation has committed to distributing more than $1 billion over the next ten years to research, institutions and projects advancing healthy human longevity and extending the healthy human lifespan to more than 120 years.

Longevity. Technology: The Foundation is advised by a aptly-named “Visionary Board” of leading longevity researchers, led by Evelyne Bischof and joined by Andrea B Maier, Eric Verdin, Matt Kaeberlein and Alex Zhavoronkov, all key opinion leaders who be top picks for a longevity dream team.

We love the bold and simple drive of the fund– projects that can realise rapid change, making “a significant difference in people’s lives as soon as possible” and setting a hopeful goal of possibly effecting that difference within a five-year time frame.

The Longevity Science Foundation will provide funding to promising longevity research institutions and groups around the world. The focus of the Foundation will be to select support projects in four major areas of healthy longevity medicine and tech – therapeutics, personalised medicine, AI and predictive diagnostics. The Foundation is seeking to fund projects that can make a significant difference in people’s lives as soon as possible – even within five years.

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Metabolism and total energy expenditure change throughout our lives, and now a new study documents a series of distinct, related changes in unprecedented detail. The data – drawn from a large cohort of humans spanning from birth to old age – shed new light on human development and aging and could help shape targeted nutrition and health strategies across the human lifespan.

The complex machine that is the human body requires a substantial amount of energy to fuel day-to-day physical activity and sustain life. However, while energy use is central to understanding many aspects of human health and physiology, including daily nutritional requirements and metabolic investment in myriad activities, very little is known about total energy expenditure in humans or how it varies over the human lifespan.

Most large-scale surveys of human energy expenditure have focused on basal expenditure, which only accounts for roughly half of total expenditure. And, while doubly labeled water (DLW) studies can provide a measure of total energy expenditure in free-living individuals, they, too, are often limited in sample size and diversity.

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Bill Andrews gives us the simplest definition of aging as well as what he thinks to be accomplished to really admit aging has been cured.

This is an excerpt of a presentation he made last year at the NHIMA. See the description of the video for details.

Longevity scientist Dr. Bill Andrews, PhD in Molecular Biology and President and CEO of Sierra Sciences, describes in few words and images what aging is.

The videoclip was taken from a presentation Dr. Andrews made at the National Health Insurance Management Authority (NHIMA) in october 2020.

To watch the entire presentation clic here: https://youtu.be/0SIgfYiO2PI

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Dr. Jennifer Garrison, PhD (http://garrisonlab.com/) is Assistant Professor, Buck Institute for Research on Aging, Founder & Faculty Director, Global Consortium for Reproductive Longevity & Equality (https://www.buckinstitute.org/gcrle/), Assistant Professor in Residence, Cellular and Molecular Pharmacology, UCSF and Adjunct Assistant Professor of Gerontology, USC Leonard Davis School of Gerontology.

Dr. Garrison’s lab is interested in understanding how neuropeptides (a large class of signaling molecules which are secreted from neurons and transmit messages within the brain and across the nervous system) regulate changes in normal and aging animals as well in understanding how they control behavior at both the cell biological and neural circuit level.

Dr. Garrison received her PhD from the University of California San Francisco in Chemistry and Chemical Biology in the laboratory of Dr. Jack Taunton, where she discovered the molecular target of a natural product and elucidated a novel mechanism by which small molecules can regulate protein biogenesis. As a postdoctoral fellow in Dr. Cori Bargmann’s lab at the Rockefeller University, she showed that the nematode C. elegans produces a neuropeptide that is an evolutionary precursor of the mammalian peptides vasopressin and oxytocin, and mapped a neural circuit by which this molecule, nematocin, modulates mating behavior.

Dr. Garrison was named an Alfred P. Sloan Research Fellow and received a Glenn Foundation Award for Research in Biological Mechanisms of Aging in 2,014 and a Next Generation Leader at the Allen Institute for Brain Science in 2015. Her work is funded by the NIH National Institute of General Medical Sciences, the Glenn Foundation for Medical Research, the Alfred P. Sloan Foundation, and the Larry L. Hillblom Foundation.

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We interviewed four longevity experts (including several Lifeboat Foundation board members) to learn how they think about their diets. I was particularly struck by how different they all were (except almost all of them fasted)!

Food.

In all our research into longevity so far, from quantifying how we sleep to exploring the science behind whether human life extension is possible, nutrition has remained the most controversial and confusing subject that we’ve covered. For example, when we surveyed 101 of our readers on their longevity diet, we got 101 very different answers. There is little consensus on what the perfect life extension diet should look like.

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In case this hasn’t been posted here yet.

Ageing is inevitable, but what if everything we’ve come to believe about ageing is wrong and we’re able to choose our lifespans? What if ageing is a disease?

In this week’s #HealthyLongevity #webinar, Prof David Sinclair from Harvard Medical School shares a bold new theory for why we age. Prof Sinclair is also the author of “Lifespan, Why We Age – and Why We Don’t Have To” (https://lifespanbook.com/).

Register for upcoming webinar sessions at https://nus-sg.zoom.us/webinar/register/9516279955794/WN_JhWMZNz0QGOgNqxtSBYedw.

#NUSMedicine #webinarseries

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References:
- Closing video source: https://www.youtube.com/watch?v=vIFEpwA9qVk.

Disclaimer: The opinions and advice expressed in this webinar are those of the speakers and do not represent the views and opinions of the organizers and National University of Singapore or any of its subsidiaries or affiliates. The information provided in this webinar is for general information purposes only as part of a general discussion on public health. The information is not intended to be a substitute for professional medical advice, diagnoses or treatment; and cannot be relied on in place of consultation with your licensed healthcare provider.

All Rights Reserved.
All of the proceedings of this webinar, including the presentation of scientific papers, are intended for limited publication only, and all property rights in the material presented, including common-law copyright, are expressly reserved to the speaker or NUS. No statement or presentation made is to be regarded as dedicated to the public domain. Any sound reproduction, transcript or other use of the material presented at this course without the permission of the speaker or NUS is prohibited to the full extent of common-law copyright in such material.

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