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This blog is a status update on one of the most powerful tools humanity will ever create: Nanotechnology (or nanotech).

My goal here is to give you a quick overview of the work going on in labs around the world, and the potential applications this nanotech work will have in health, energy, the environment, material sciences, data storage and processing.

As artificial intelligence has been getting a lot of the attention lately, I believe we’re going to start to see and hear about incredible breakthroughs in the nanotech world very soon.

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On Reddit Futurology today!


The Major Mouse Testing Program is an ambitious project of the International Longevity Alliance, featuring an international team of scientists and advocates testing therapies against aging decline. This experiment is is lead by world class stem cell researcher Dr Alexandra Stolzing and was inspired by our scientific advisor and colleague Dr Aubrey De Grey.

The Major Mouse Testing Program is seeking to speed up scientific progress in the field of regenerative medicine and bio-gerontology. After ILA experts conducted an analysis of delays preventing the development of life extension technologies, it was shown that a serious problem was the lack of robust animal data for the potential of different compounds to promote health and extend maximum lifespan. Without this data promising interventions cannot enter clinical trials and become available to the general public.

The MMTP is currently running a crowdfunding campaign at https://www.lifespan.io/campaigns/the-major-mouse-testing-program/

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A team led by scientists at the National Institutes of Health (NIH) has reported a research trifecta. They discovered a new vulnerable site on HIV for a vaccine to target, a broadly neutralizing antibody that binds to that target site, and how the antibody stops the virus from infecting a cell. The study was led by scientists at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases, part of NIH.

The new target is a part of HIV called the fusion peptide, a string of eight amino acids that helps the virus fuse with a cell to infect it. The fusion peptide has a much simpler structure than other sites on the virus that HIV vaccine scientists have studied.

The scientists first examined the blood of an HIV-infected person to explore its ability to stop the virus from infecting cells. The blood was good at neutralizing HIV but did not target any of the vulnerable spots on the virus where broadly neutralizing HIV antibodies (bnAbs) were known to bind.

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Fox 29 — Good Day Philadelphia

http://www.fox29.com/140735577-video

Reanimalogo

NBC TV 10

http://www.nbcphiladelphia.com/news/local/Zombies-from-Philly_-Local-Firm-Hopes-to-Bring-People-Back-from-the-Dead_Philadelphia-378365101.html

fmri5

CNN en Espanol

http://cnnespanol.cnn.com/video/cnnee-encuentro-intvw-joel-osorio-bioquantina-muerte-cerebral/

Researcher-test

Check out LEAF President Keith Comito explain the origin of Lifespan.io and why crowdfunding research to extend healthy lifespan is both important and exciting.

Our current campaign is here: https://www.lifespan.io/campaigns/the-major-mouse-testing-program/ and there will be more to follow soon! Connect with us on social media and subcribe on YouTube to stay informed. #CrowdfundTheCure #LifespanIO


LEAF President Keith Comito explains the origin of Lifespan.io — a crowdfunding platform specifically for biomedical research aimed at extending healthy human lifespan. Learn more, and help us Crowdfund the Cure for Aging: https://www.lifespan.io

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Monday May 16th 17:00 GMT 13:00 EST 10:00 PST r/futurology.


The Major Mouse Testing Program is an ambitious project of the International Longevity Alliance, seeking to speed up scientific progress in the field of regenerative medicine and bio-gerontology. After ILA experts conducted an analysis of bottlenecks preventing the development of life extension technologies, it was revealed that one of these bottlenecks is the deficiency of robust animal data for the potential of different compounds to promote health and extend maximum lifespan. Without this data promising interventions cannot enter clinical trials and become available to the general public.

The ILA decided to initiate a fundraising program to fund a series of these high-risk studies: Major Mouse Testing Program. We are currently running a crowdfunding campaign for the first experiment to test a combination of Senolytics. They have been shown to help seek out and destroy senescent “death resistant” cells and improve various aspects of health. We wish to see if Senolytics are able increase maximum lifespan in addition to healthspan promotion. We have big plans for the future with combination testing of senolytics, stem cells and more to help speed up scientific progress. So go ahead ASK US ANYTHING!

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Very promising. I hope within the next 10 years that Glioblastoma is eradicated.


A team from the International School for Advanced Studies (SISSA) in Trieste has obtained very promising results by applying gene therapy to glioblastoma. Tests in vitro and in vivo on mice provided very clear-cut results, and modelling demonstrates that the treatment targets at least six different points of tumour metabolism. Gene therapy, a technique that selectively attacks a tumour, might provide hope in the fight against this type of deadly cancer, for which surgery is practically impossible and chemo- and radiotherapy are ineffective against very aggressive recurrences. The study was published in the journal Oncotarget.

Only a few days ago, the press (especially in English-speaking countries) enthusiastically announced the publication of a study that described in great detail the genetics of breast cancer, a discovery that according to many marks a breakthrough in the battle against this cancer. This kind of news confirms the impression that in the near future the war against cancer will be fought on the battlefields of genetics. Italy too, is working on this front. At SISSA, for example, where Antonello Mallamaci and his group have just published highly promising results on the application of gene therapy against glioblastomas, a family of brain tumours among the most common and aggressive. A diagnosis of glioblastoma is literally equal to a very imminent death sentence: “surgery is rarely curative, as these tumours insinuate themselves in healthy tissues, and also chemo- and radiotherapy have little effectiveness.

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Nice and interesting Gene Mutation Discovery.


A single defect in a gene that codes for a histone — a “spool” that wraps idle DNA — is linked to pediatric cancers in a study published in the journal Science.

“Unlike most cancers that require multiple hits, we found that this particular mutation can form a tumor all by itself,” says Peter W. Lewis, an assistant professor of biomolecular chemistry in the School of Medicine and Public Health at the University of Wisconsin-Madison.

Histones derive their pattern from the same genome that they help to pack up and organize. “A histone’s day job is compacting the genome,” says Lewis. “The histone takes six feet of DNA and packs it in something that is a few microns in diameter.”

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I remember years ago when researchers identified that families with high rates for severe allergies also had high rates of cancer. Today, we talk about cancer and immunology as an intertwined dependency. Just means we’re still understanding cancer, genetic mutations, and the trigger/s in causing cancer among families and individual.


Scientists say the NLCR5 gene allows cancer cells to escape the immune system. A test for the biomarker may predict how long a cancer patient can survive.

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