Lifeboat Foundation: Safeguarding Humanity
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Category: genetics

The origins are still too unknown. This is entirely new life a more parasitic lifeform. Bit still new lifeforms entirely. My experiencers tell me of alien origin though the rate of spread also the complexity. No human could make this no even government can make this. We can mimic life not create something new. Sure new things can be added but the signature tells me it is definitely of alien origin. Not even nature can create something this quick nor even governments. Sure there may be like similar things but why does it spread so fast in near systematic precision. Which leads to essentially of exterrestial origin. This is essentially new life we are dealing with.

Nat Rev Microbiol. 2019 Mar;17:181–192. doi: 10.1038/s41579-018‑0118-9.

Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century. Both viruses likely originated in bats, and genetically diverse coronaviruses that are related to SARS-CoV and MERS-CoV were discovered in bats worldwide. In this Review, we summarize the current knowledge on the origin and evolution of these two pathogenic coronaviruses and discuss their receptor usage; we also highlight the diversity and potential of spillover of bat-borne coronaviruses, as evidenced by the recent spillover of swine acute diarrhoea syndrome coronavirus (SADS-CoV) to pigs.

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In the past few decades, researchers discovered that the rate at which we age is strongly influenced by biochemical processes that, at least in animal models, can be controlled in the laboratory. Telomere shortening is one of these processes; another is the ability of cells to detect nutrients mediated by the mTOR protein. Researchers have been able to prolong life in many species by modifying either one of them. But what if they manipulate both?

A team from the Spanish National Cancer Research Centre (CNIO) has studied it for the first time, with unexpected results. Blocking nutrient sensing by treatment with rapamycin, an mTOR inhibitor, delays the aging of healthy , but curiously, it worsens diseases and premature aging that occur in mice with short telomeres. This finding has important implications for the treatment of diseases associated with short telomeres, but also for that are also associated with short telomeres. The study, done by the Telomeres and Telomerase Group headed by Maria Blasco at the CNIO, is published in Nature Communications with Iole Ferrara-Romeo as the first author.

Telomeres, regions of repetitive nucleotide sequences at the end of chromosomes, preserve the genetic information of the cells. They shorten with age until they can no longer fulfill their function: The cells stop dividing and the tissues age since they are no longer able to regenerate.

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Would you want to know if you’re at risk of Alzheimer’s disease, for example?

The integration of sequencing into health care doesn’t fit very well in the model of how medicine is practiced today, but is well aligned with the future vision of health care that so many of us have — a vision that focuses upon prediction and prevention.

We imagine that personal genome sequencing could play a central role in bringing about a more personalized and participatory form of medicine — including a health care system where patients have more knowledge of their own risks and diagnoses and are empowered to act upon that information.

With that in mind, more of us are asking this question: Rather than focusing only on people with a suspected or diagnosed genetic disease, why not also use genome sequencing to help seemingly healthy people screen for all sorts of conditions, even diseases for which they have no known family history?

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Gene therapy is the introduction of DNA into a patient to treat a genetic disease or a disorder. The newly inserted DNA contains a correcting gene to correct the effects of a disease, causing mutations. Gene therapy is a promising treatment for genetic diseases and also includes cystic fibrosis and muscular dystrophy. Gene therapy is a suitable treatment for infectious diseases, inherited disease and cancer.

Over the last few centuries, infectious diseases have been understood and tackled, through advances in sanitation, anti-microbial medications and vaccination. One day we may also be able to tackle genetic diseases – lifelong conditions arising from mutations that we inherit from our ancestors or that occur during our development.

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My editorial from today’s (3/18/19) Financial Times:

Far sooner than most people realise, the genetics revolution will transform the world within and around us. Although we think about genetic technologies primarily in the context of healthcare, these tools are set to change the way we make babies, the nature of the babies we make and, ultimately, our evolutionary trajectory as a species — and we are not remotely ready for what’s coming. Yet we must be, to optimise the benefits and minimise the potential harms of genetic technologies.

Scientists are now able to manipulate biology to a previously unimaginable degree. In the past year, we’ve seen two female mice having their own babies, dramatic increases in the precision of gene-editing tools, and the birth in China of the first gene-edited humans. As this science advances exponentially, however, the regulations guiding how it should best be used are struggling to keep up. If the applications race forward without appropriate guard rails, the danger increases that more scientists like He Jiankui, the Chinese biophysicist who genetically altered two girls, will put people’s health at risk. But if the regulations are hastily written before the issues are clear, are too strong or are not flexible enough, many people who would otherwise have benefited from applied genetic technologies will be condemned to unnecessary suffering or even death.

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For the first time, doctors have attempted to cure blindness by gene-hacking a patient with CRISPR technology.

A team from Oregon Health & Science Institute injected three droplets of fluid that delivered the CRISPR DNA fragments directly into a patient’s eyeball, The Associated Press reports, in hopes that it will reverse a rare genetic condition called Leber congenital amaurosis, which causes blindness early in childhood.

“We literally have the potential to take people who are essentially blind and make them see,” Charles Albright, chief scientific officer of Editas Medicine, told the AP.

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Scientists say they have used the gene editing tool CRISPR inside someone’s body for the first time — offering a new frontier for efforts to operate on DNA, the chemical code of life, to treat diseases.

A patient recently had it done at the Casey Eye Institute at Oregon Health & Science University in Portland for an inherited form of blindness, according to the companies that make the treatment. The company would not give details on the patient or when the surgery occurred.

It may take up to a month to see if it worked to restore the patient’s vision. If the first few attempts seem safe, doctors plan to test it on 18 children and adults.

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If there was a public vote about human gene enhancement, would you vote YES or NO?

Our species is on the cusp of a revolution that will change every aspect of our lives but we’re hardly talking about it.

After three and a half billion years of evolution, two hundred and fifty thousand years of them as the ass-kicking bipedal hominins we call homo sapiens, we are on the verge of taking control of our evolutionary process unlike never before. This revolution will take hundreds of years to play out but it has already begun.

Sure, we influenced natural selection when we invented farming and modern medicine, but take a human baby from eleven thousand years ago and place him in a modern family and he’ll grow up just like any other kid. Then take a kid from a thousand years from now and place him in the same family. My belief is that the future child brought back to the present will not fit in nearly as well. He will be stronger and smarter with enhanced sensory and other capabilities. And we will have engineered him. We will have engineered us all.

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For the first time, doctors have attempted to cure blindness by gene-hacking a patient with CRISPR technology.

A team from Oregon Health & Science Institute injected three droplets of fluid that delivered the CRISPR DNA fragments directly into a patient’s eyeball, The Associated Press reports, in hopes that it will reverse a rare genetic condition called Leber congenital amaurosis, which causes blindness early in childhood.

“We literally have the potential to take people who are essentially blind and make them see,” Charles Albright, chief scientific officer of Editas Medicine, told the AP. Editas is one of the biotech companies that actually developed the treatment. “We think it could open up a whole new set of medicines to go in and change your DNA.”

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The 2019 novel coronavirus or coronavirus disease (COVID-19) outbreak has threatened the entire world at present. Scientists are working day and night to understand the origin of COVID-19. You may have heard the news recently that the complete genome of COVID-19 has been published. How did scientists figure out the complete genome of COVID-19? In this article, I will explain how we can do this.

A genome is considered as all the genetic material, including all the genes of an organism. The genome contains all the information of an organism that is required to build and maintain it.

How can we read the information present in the genome? This is where sequencing comes into action. Assuming you have read my previous article on DNA analysis, you know that sequencing is used to determine the sequence of individual genes, full chromosomes or entire genomes of an organism.

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