A year marked by climate protests, political uncertainty and debate over the ethics of gene editing in human embryos proved challenging for science. But researchers also celebrated some exciting firsts — a quantum computer that can outperform its classical counterparts, a photo of a black hole and samples gathered from an asteroid.
Climate strikes, marsquakes and gaming AIs are among the year’s top stories.
Who is responsible when a robot harms a human? Robot ethics tackle this and other interesting robot issues.
Human-animal hybrids are set to be developed at the University of Tokyo after the Japanese government recently lifted a ban on the controversial stem-cell research.
Hiromitsu Nakauchi—director for Stem Cell Biology and Regenerative Medicine at the University of Tokyo and team leader at Stanford’s Nakauchi Lab—is the first to receive approval for the questionable experiments which will attempt to grow human cells in rat and mouse embryos before being brought to term in a surrogate animal.
Despite many feeling that such studies are the equivalent of playing God, scientists say that the objective is far from sinister. It’s theorized that developing animals with organs constructed from human cells will create organs that can then be used for transplants in humans, cutting the long organ donation waitlists.
The Future of Intelligence, Artificial and Natural
Ray Kurzweil is one of the world’s leading inventors, thinkers, and futurists, with a thirty-year track record of accurate predictions. Called “the restless genius” by The Wall Street Journal and “the ultimate thinking machine” by Forbes magazine, he was selected as one of the top entrepreneurs by Inc. magazine, which described him as the “rightful heir to Thomas Edison.” PBS selected him as one of the “sixteen revolutionaries who made America.”
Ray was the principal inventor of the first CCD flat-bed scanner, the first omni-font optical character recognition, the first print-to-speech reading machine for the blind, the first text-to-speech synthesizer, the first music synthesizer capable of recreating the grand piano and other orchestral instruments, and the first commercially marketed large-vocabulary speech recognition.
Among Ray’s many honors, he received a Grammy Award for outstanding achievements in music technology; he is the recipient of the National Medal of Technology, was inducted into the National Inventors Hall of Fame, holds twenty-one honorary Doctorates, and honors from three U.S. presidents.
Ray has written five national best-selling books, including New York Times best sellers The Singularity Is Near (2005) and How To Create A Mind (2012). He is Co-Founder and Chancellor of Singularity University and a Director of Engineering at Google heading up a team developing machine intelligence and natural language understanding.
Ci2019 featured over 40 global leaders including Chief Technology Officer of Google Ray Kurzweil (USA), CEO of NESTA Geoff Mulgan CBE (UK), Chief Data and Transformation Officer at DBS Bank Paul Cobban (Singapore), A.I. Experts Professor Toby Walsh and Liesl Yearsley (USA), Co-founder of Oxford Insights Emma Martinho-Truswell (UK), Ethics leader Professor Simon Longstaff, Ethics and Culture of Robots and AI Professor Kathleen Richardson (UK), brain performance neuroscientist Dr Etienne Van Der Walt (South Africa), transdisciplinary Behavioural Scientist Dr Richard Claydon (Hong Kong), Director of the Learning Technology Research Centre Carl Smith (UK), Australia’s Chief Scientist Dr Alan Finkel AO, Deakin University Vice Chancellor Professor Jane Den Hollander, ATO’s Jane King, Innovation & Science Australia CEO Dr Charles Day, CEDA CEO Melinda Cilento, Jobs for NSW CEO Nicole Cook, Behaviour Innovation founder & CEO John Pickering, People and Performance expert Andrew Horsfield, TEDx Melbourne’s Jon Yeo and many more to be announced.
Posted in bitcoin, ethics, finance, life extension, media & arts, neuroscience, transhumanism | Leave a Comment on Brent Nally interviews Dr. Michael Fossel about Telocyte and telomerase gene therapy on 11/16/2019
Haven’t heard from Fossel in awhile. This is long but well indexed in the notes.
My mission is to drastically improve your life by helping you break bad habits, build and keep new healthy habits to make you the best version of yourself.
This video me, Brent Nally, interviewing Dr. Michael Fossel about Telocyte and telomerase gene therapy on November 16, 2019.
- Please consider a donation to me: My PayPal https://paypal.me/BrentNally or my Bitcoin Cash (BCH) address: qr9gcfv92pzwfwa5hj9sqk3ptcnr5jss2g78n7w6f2
SHOW NOTES:
0:20 Dr. Michael Fossel intro — Follow Michael on LinkedIn: https://www.linkedin.com/in/michael-fossel-4196255/ ; http://www.michaelfossel.com/
2:00 Planned January 2020 interview with Michael.
2:25 Buy Michael’s 3 books: 1) Reversing Human Aging 2) Cells Aging & Human Disease 3) The Telomerase Revolution.
4:15 https://telocyte.com/
5:07 Aging complexities
8:20 Small molecules won’t reverse human aging.
9:01 People are fixed in their incorrect beliefs about aging.
12:50 Sometimes we have to first go backwards to move forwards. My March 26, 2019 interview with Dr. Ed Park at Recharge Biomedical: https://youtube.com/watch?v=xHgfYKsH0uw&list=UUCwpkla04tVxHJUds2J2aqA&index=6
15:55 Economics of radically increasing the human healthspan.
19:01 Leonard Hayflick
21:05 The rate of telomere loss is linked to many organism’s lifespan.
22:30 Lengthening human telomeres in aging cells “resets” the cells to make them biologically younger.
24:10 Cells, Aging, and Human Disease preface.
28:20 human population if we radically increase human healthspan/lifespan.
31:20 biological vs chronological aging
32:25 telomerase activation is the best point of clinical and financial intervention to cure and prevent age related diseases.
37:30 Data generally doesn’t support the idea that making telomerase more active in humans can cause cancer. Michael beliefs this idea has been propagated by misinterpreting data.
45:02 Causation & Pathology in Alzheimer’s Disease.
46:30 standard cell aging process
49:53 What can you do to help cure human aging? understand the concepts, share this info & invest.
53:40 the FDA is excited about Telocyte’s model.
55:30 Phase 1 human FDA trial costs about $10 million but costs should drop after that.
57:50 It costs Telocyte about $4 million to initially produce the telomerase gene therapy they need to treat their first 12 patients.
58:55 Lets “elephant hunt” to find billionaire investors for Telocyte.
1:01:18 Michael discusses BioViva/Integrated Health Systems & Liz Parrish. My July 10, 2019 interview with BioViva CEO Liz Parrish: https://youtube.com/watch?v=oBFTwGPaPr4
1:02:10 My May 30, 2019 interview with Sierra Sciences CEO Dr. Bill Andrews: https://youtube.com/watch?v=Tx9yG6iTROQ
1:09:45 ethics and risks of telomerase gene therapy.
1:11:15 Unnatural selection on Netflix
1:14:30 Is reality a simulation?
1:18:10 The mind is like a parachute. It only works if it’s open. Data trumps everything always.
1:19:50 telomerase activator pills
1:24:30 Dr. Greg Fahy
1:28:40 https://lifelength.com/ & https://teloyears.com/home/
1:32:40 My July 17, 2019 interview with Dr. Aubrey de Grey https://www.youtube.com/watch?v=TquJyz7tGfk
1:38:34 Dr. Michael West
1:41:10 Inject snake venom for anti-aging? https://www.youtube.com/watch?v=8q_m-rDUNw0
1:45:15 Bill Haast https://en.wikipedia.org/wiki/Bill_Haast
1:45:50 My October 6, 2019 interview of Dr. Duncan Ross about Kimera exosomes: https://www.youtube.com/watch?v=X8eIxo3eqvQ&t=3s
1:46:15 Brent’s stem cell’s treatment and recovery playlist https://www.youtube.com/playlist?list=PLGjySL94COVQzsAauqp6lZHHzmzBQSmhH
1:51:52 Dr. Maria Blasco
1:52:45 Michael almost got $1 billion for a non-profit translational research for telomerase gene therapy from a wealthy couple in California in 1999.
1:55:45 Dr. Elizabeth Blackburn
1:57:57 Dr. Elissa Epel
2:00:09 Dr. Calvin Harley
2:02:20 Radical honesty and compassion
2:06:25 I recommend the book: Sapiens by Dr. Yuval Noah Harari
2:11:15 Michael’s fascinating experiences.
2:26:30 telomerase gene therapy economies of scale.
2:35:10 Dr. Peter Attia
2:36:50 Peter Rayson, CEO Telocyte. Curing human aging is a systems approach.
2:39:43 Forever Labs 1 year free cryogenic storage discount code ($250 value): BN801 https://foreverlabs.com
2:42:10 Dave Asprey — lack of funding for Telocyte is holding back the potential cure for Alzheimer’s.
2:44:30 Chan Zuckerberg Initiative
2:49:08 health advice
2:56:38 Viome for microbiome
3:01:04 the best current way to measure someone’s age is guessing based off how they look and behave.
3:04:51 transhumanism and ignosticism
3:08:23 Stay curious to continue learning.
3:16:28 “What important truth do very few people agree with you on?”
3:23:30 be considerate
- Intro music by: SoundSage
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TABLE OF CONTENTS —————
0:00–17:57 : Introduction (Meaning of Life)
17:58–37:45 CHAPTER 1: Longevism and Life Extension
—————————————————————————————–
WHY DOES AGING HAPPEN?
—————————————————————————————–
37:46–54:39 CHAPTER 2 : Gerontonology and Aging a. Free Radical Theory of Aging b. Waste Accumulation Theory of Aging c. Stem Cell Theory of Aging d. DNA Damage Theory of Aging.
—————————————————————————————–
HOW DO WE CURE AGING?
—————————————————————————————–
54:39–1:08:39 : CHAPTER 3 :The Biochemical Solution (#1)
a. mitoSENS
b. oncoSENS
c. lysoSENS
d. amyloSENS
e. apoptoSENS
f. repliSENS
g. glycoSENS
1:08:40–2:13:12 CHAPTER 4 : The Physiological Solution (#2)
a. Parabiosis and Biovampirism b. Regeneration and Stem Cells c. Lab Grown Organs and Bioprinting d. Head Transplants and Doppleganger Bodies.
2:13:12–2:33:19 CHAPTER 5 : The Genetic Solution (#3)
a. TALEN genetic engineering b. Zinc-Finger gene tailoring c. CRISPR-Cas9 gene editing.
—————————————————————————————–
WILL WE CURE AGING GENETICALLY?
—————————————————————————————–
2:33:20–2:49:58 : CHAPTER 6 : Genomics and DNA
2:49:59–3:05:48 : CHAPTER 7 : Transcriptomics and RNA
3:05:49–3:22:08 : CHAPTER 8 : Proteomics and TNA
3:22:09–3:39:38 : CHAPTER 9 : Xenobiology and XNA
a. alien proteins b. alien base pairs c. alien DNA
3:39:39–3:54:58 : CHAPTER 10 : Vectors and Gene Therapy (Gene Editing #1)
3:54:59–4:14:57 : CHAPTER 11 : Synthetic Biology (Gene Editing #2)
4:14:58–4:32:14 : CHAPTER 12 : Chimeras, Rianths, and Splices (Gene Editing #3)
4:32:15–4:48:35 : CHAPTER 13 : Ouroborology and Immortal Chimeras (Gene Editing #4)
4:48:36-:5:03:52 : CHAPTER 14 : Kleptoplasty and Photosynthesis (Gene Editing #5)
—————————————————————————————-
HOW TO SURVIVE UNTIL AGING IS CURED
—————————————————————————————-
5:03:53–5:14:27 : CHAPTER 15 : Survive to the Singularity a. the breakeven point b. longevity escape velocity c. the longevity dividend.
5:14:28–5:30:16 : CHAPTER 16 : Centennarians and Blue Zones (Survival Method #0)
a. loma linda b. ikaria c. sardinia d. okinawa.
5:30:17–5:42:26 : CHAPTER 17 : Risk Aversion and Micromorts (Survival Method #1)
a. micromorts
b.microlives
5:42:27–5:58:18 : CHAPTER 18 : Nutraceuticals and Geroprotectors (Survival Method #2)
a. rapamycin b. metformin c. selegilene d. nicotinamide riboside e. resverratrol.
5:58:19–6:12:51 : CHAPTER 19 : Caloric Restriction (Survival Method #3)
a. endocrine b. epigenetic c. genetic
6:12:52–6:51:57 : CHAPTER 20 : Cryonics & Cryogenics (Survival Method #4)
a. the efficacy question b. the cost question c. the resurrection question d. the identity question e. the legal question f. the catastrophe question g. the culture question.
—————————————————————————————–
CAN WE BE IMMORTAL WITHOUT CURING AGING?
—————————————————————————————–
_______________________________________________________
6:51:58–7:04:08 : CHAPTER 21 : Genetic Immortality — Test Tube Babies
7:04:09–7:24:02 : CHAPTER 22 : Genetic Immortality — Designer Babies
7:24:03–7:41:55 : CHAPTER 23 : Genetic Immortality — Clone Babies
7:41:56–7:53:08 : CHAPTER 24 : Genetic Immortality — Artificial Wombs
7:53:08–7:53:09 CHAPTER 25 : Immortalism and Ethics a. the crime argument b. the natural argument c. the boredom argument d. the inequality argument e. the overpopulation argument f. the gerontocracy argument g. the economic argument h. EPILOGUE
Patreon https://www.patreon.com/transhumania
KEYWORDS :
Immortology, Athanophy, Biotechnology, Biotech, Bioviva, Alcor, Calico, Nanotechnology, Nanotech, Reverse Aging, Live Forever, Caloric Restriction, Blue Zone, Centenarian, Singularity, Nutraceuticals, Geroprotectors, Metformin, Seligiline, Rapamycin, Nikolai Fedorov, Aubrey De Grey, Immortalism, Peter Thiel, Gerontology, Telomere, Elizabeth Blackburn, Free Radicals, Oxidative Stress, SENS, Bioinformatic, Transcriptomics, Proteonomics, Genomics, CRISPR Cas9, Synthetic Biology, Craig Venter, Retrovirus, Gene Therapy, Gene Editing, Xenobiology, Epigenetics, RNAi interference, C2C2, David Sinclair, Resveratrol, Sirtuin, Gene, Kleptoplasty, Splice, Spidergoat, Rianth, Chimera, IVF, Test Tube Designer Baby, Cloning South Korea, Artificial Womb, Ectogenesis, Human Cloning, Panyotis Zavos, Stem Cell, Parabiosis, 3D Bioprinting, Regenerative Medicine, Thomas Rando, Sergio Canavero, Head Transplant, Biostasis, Cryopreservation, Cryonics, Vitrification, Extropianism.
You might take it for granted that you can load up Twitter or browse through Reddit whenever you like, but around half of the 7.7 billion people living on the planet right now aren’t yet able to get online.
And that’s a big problem, according to one researcher. Merten Reglitz, a philosopher and global ethics lecturer from the University of Birmingham in the UK says internet access should be established as a basic human right that everyone is entitled to.
“Internet access is a unique and non-substitutable way for realising fundamental human rights such as free speech and assembly,” he writes in a new paper.
“What foundational values need to be in place for an ethical utilitronium shockwave?”
What foundational values need to be in place for an ethical utilitronium shockwave?
We discuss:
- (following on from a previous video) more on Nozick’s experience machines (see https://www.youtube.com/watch?v=CxBvNbuYud0).
- given that in each age there has been different conceptions of utopia, what would utopia be for a post-human superintelligence?
- classical utilitarian vs negative utilitarian approaches to the long term good of life in the universe.
- whether a perfect decision theory would be equal to negative utilitarianism.
- how much attention should we give to preferences in improving well-being beyond eliminating suffering?
- if one does believe in the objectivity of value should we be concerned about being damned in a local maximum of well-being?
- what is God’s utility function?
https://youtu.be/0uKNVVVdqrI #ethics #utilitarianism #futurology
Filmed inside the Melbourne Museum in Victoria, Australia.
David Pearce is interested in the use of biotechnology to abolish suffering throughout the living world: http://abolitionist.com
Many thanks for watching!
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Kind regards.
Adam Ford
- Science, Technology & the Future.
“…consider Robert Nozick’s thought-experiment in conjunction with Felipe De Brigard’s inverse experience machine argument: “If you like it, does it matter if it’s real?”
Does Nozick’s experience machine prove anything?
Perhaps consider Robert Nozick’s thought-experiment in conjunction with Felipe De Brigard’s inverse experience machine argument: “If you like it, does it matter if it’s real?”
For sure, many subjects say they wouldn’t plug into Nozick’s Experience Machine; but conversely, many of these same respondents claim they wouldn’t want to unplug from an Experience Machine if told their existing lives were based on a lie. In short, maybe what is really being measured is not simply our (lack of) commitment to hedonism or realism, but rather status quo bias.
Even self-avowed classical utilitarians may balk on realising what their own ethics entails.
Back in the real world, does the imminence of utopian designer drugs and technologies of immersive VR mean we must all shortly choose between the Red Pill and the Blue Pill, so to speak, i.e. between sordid reality and escapist fantasy worlds of delusion?
Not necessarily. For a revolution in genomic medicine is brewing. Enrichment of your reward circuitry, and radical recalibration of the set-point of your hedonic treadmill, promises life based on gradients of intelligent bliss – and without sacrificing your existing preference architecture and core values.
Perhaps take the Purple Pill instead?
