There is no cure for the disease, for which Alzheimer’s is the most common form (about 75% of dementia cases).
But finding out what raises the risk can help people try and prevent it.
A new study has offered more clues about the type of people who typically get Alzheimer’s.
Posted in biotech/medical, economics, health | Leave a Comment on The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency
The COVID-19 pandemic, caused by SARS-CoV-2, continues to rage in many countries, straining health systems and economies. Vaccines protect against severe disease and death and are considered central to ending the pandemic. COVID-19 vaccines (and SARS-CoV-2 infection) elicit antibodies that are directed against the viral spike (S) protein and neutralize the virus. However, the emergence of SARS-CoV-2 variants with S protein mutations that confer resistance to neutralization might compromise vaccine efficacy[1]. Furthermore, emerging viral variants with enhanced transmissibility, likely due to altered virus-host cell interactions, might rapidly spread globally. Therefore, it is important to investigate whether emerging SARS-CoV-2 variants exhibit altered host cell interactions and resistance against antibody-mediated neutralization.
A ‘visual prosthesis’ implanted directly into the brain has allowed a blind woman to perceive two-dimensional shapes and letters for the first time in 16 years.
The US researchers behind this phenomenal advance in optical prostheses have recently published the results of their experiments, presenting findings that could help revolutionize the way we help those without sight see again.
At age 42 Berna Gomez developed toxic optic neuropathy, a deleterious medical condition that rapidly destroyed the optic nerves connecting her eyes to her brain.
The non-E5 made rats healthier with a small increase in lifespan. The E5 part 2 is still ongoing with rats at 31 months that generally at most live 36 months.
In this video we give a brief update on the parallel experiments being conducted by Dr Katcher and Professor Goya. In these studies they are injecting E5 and young blood plasma into rats in repeatedly to see if the maximum lifespan can be extended.
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Papers mentioned in this video.
The original paper on BioXriv.
Reversing age: dual species measurement of epigenetic age with a single clock.
https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1
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In “The Genetic Lottery: Why DNA Matters for Social Equality,” Kathryn Paige Harden explores how genetics can affect life outcomes.
Nearly four billion years ago, life on Earth began with a single living cell containing a replicating molecule of DNA. From that point on, that original cell, the first to develop the awesome capacity for reproduction, divided and redivided and subdivided its protoplasm to fill the oceans with life. And since the Cambrian Explosion, half a billion years ago, complex organisms have proliferated and evolved into the myriad plants and animals, including ourselves, that now inhabit and comprise this beautiful planet. But no matter how many times a cell fissions in the process of embryological development, all the daughter cells collectively continue to comprise but one single organism. Thus the entire biosphere of Earth comprises the body of a single vast living being—Mother Earth Herself: Gaea.
#TheaGenesis #GaiaHypothesis #SyntellectEmergence
In order to understand the nature of Gaea, we must first understand our own origins. Each of us began our individual life as a single fertilized cell—a zygote…all the daughter cells collectively continue to comprise but one single organism.
Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences in cells, and that detection then triggers production of a specific protein from a transgene, or artificial gene.
Because transgenes can have negative and even dangerous effects when expressed in the wrong cells, the researchers wanted to find a way to reduce off-target effects from gene therapies. One way of distinguishing different types of cells is by reading the RNA sequences inside them, which differ from tissue to tissue.
By finding a way to produce transgene only after “reading” specific RNA sequences inside cells, the researchers developed a technology that could fine-tune gene therapies in applications ranging from regenerative medicine to cancer treatment. For example, researchers could potentially create new therapies to destroy tumors by designing their system to identify cancer cells and produce a toxic protein just inside those cells, killing them in the process.
It will focus on projects that illuminate the basic biology of the adeno-associated virus, one of the most common gene-delivery vectors.
Researchers have confirmed cases of the disease among two unconnected West African populations of chimpanzees, in Guinea-Bissau and the Ivory Coast.
Analysis published in the journal Nature shows the strains of leprosy are different, and both are uncommon among humans.
The origins of the infections are unclear, but the research team – led by the University of Exeter and the Robert Koch Institute – say the findings show leprosy is probably circulating in more wild animals than was previously suspected, either as a result of exposure to humans or other unknown environmental sources.
Cell culture is an essential in vitro experimental tool. An attempt to recapitulate the body in a dish, in two and three dimensions, it has provided the basis for decades of research and probably thousands of PhDs. When it goes wrong, however, whether through accident, infection, misidentification, cross-contamination or uncontrolled differentiation (for stem cells), it can be very stressful, especially in the case of longer-term experiments or when using hard-to-replace cell lines. Another important consideration is reproducibility, which is an acknowledged life sciences industry issue. A 2015 PLOS Biol ogy study, for example, reported in an analysis of previous studies that the prevalence of irreproducible research was over 50% – equivalent to USD $28 billion per year on irreproducible preclinical research.1 Inconsistencies in cell culture approaches are a potential issue in this regard, as if cells are not maintained or used in a consistent way, or are contaminated with an infection (like mycoplasma), this can negatively impact results and make it more difficult to reproduce and/or accurately interpret data.
“Quality control (QC) is a key part of assuring the quality of outputs from any cell culture process, and is an essential part of assuring reproducibility of scientific quality in research as well as assurance of the quality and safety of cell culture-derived products,” comments Glyn N Stacey, International Stem Cell Banking Initiative, Cambridge, UK, and the Institute for Stem Cells and Regeneration and National Stem Cell Resource Centre, Chinese Academy of Sciences, Beijing, China. “These topics are currently very much in the minds of journal editors, research funders and regulators and are thus of crucial significance to researchers.”
This article will look at these different aspects of cell culture quality control and the types of protocols that can be implemented to help ensure reliable and reproducible results.
