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Bio-Printing Complex Human Tissues & Organs — Dr. Anthony Atala, MD — Director, Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Wake Forest University.


Dr. Anthony Atala, MD, (https://school.wakehealth.edu/Faculty/A/Anthony-Atala) is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology.

A practicing surgeon and a researcher in the area of regenerative medicine, fifteen applications of technologies developed Dr. Atala’s laboratory have been used clinically. He is Editor of 25 books and 3 journals, has published over 800 journal articles, and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering.

Dr. Atala is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society; the World Technology Award in Health and Medicine, for achieving significant and lasting progress; the Edison Science/Medical Award for innovation, the R&D Innovator of the Year Award, and the Smithsonian Ingenuity Award for Bioprinting Tissue and Organs. Dr. Atala’s work was listed twice as Time Magazine’s Top 10 medical breakthroughs of the year, and once as one of 5 discoveries that will change the future of organ transplants. He was named by Scientific American as one of the world’s most influential people in biotechnology, by U.S. News & World Report as one of 14 Pioneers of Medical Progress in the 21st Century, by Life Sciences Intellectual Property Review as one of the top key influencers in the life sciences intellectual property arena, and by Nature Biotechnology as one of the top 10 translational researchers in the world.

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society.

TABLE OF CONTENTS —————
0:00–21:02 : Introduction (Meaning of Life)
21:03–46:14 CHAPTER 1: Transhumanism and Life Extension.

TWITTER https://twitter.com/Transhumanian.
PATREON https://www.patreon.com/transhumania.
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#1 ) THE GENETIC PATHWAY

46:15–58:52 CHAPTER 2 : Biological Aging a. “Programmed Cell Death” Theory of Aging b. “Intercellular Competition” Theory of Aging c. “Antagonistic Pleiotropy” Theory of Aging.

#2 ) THE CYBERNETIC PATHWAY

58:53–1:12:26 CHAPTER 3 : Cyborgs.
1:12:27–1:24:35 CHAPTER 4 : Artiforgs.
1:24:36–1:41:10 CHAPTER 5 : Prosthetics.
1:41:11–2:00:44 CHAPTER 6 : Bionics.

The company is developing novel therapeutics targeting aging in humans and dogs by using genetically modified adeno-associated virus (AAV) vectors to deliver copies of the SIRT6 gene variant found in centenarians. SIRT6 has already been shown to have significant capabilities to repair DNA damage, and Genflow’s aim is to show that it can also improve healthspan and, potentially, increase lifespan. “Our business model is to develop our lead compound, GF-1002, that has already yielded encouraging pre-clinical results,” Leire told us. “We are currently undertaking pre-clinical trials which are expected to take approximately two years.


SIRT6 targeting longevity biotech announces intention to float on the London Stock Exchange, with IPO later this month.

Cages meshed over with women’s tights and crawling with mosquitoes are stashed in a Swedish laboratory. Every day, researchers feed them beetroot juice laced with deadly toxins, part of a grand plan designed to fight malaria.

With hopes of field trials delayed repeatedly by the COVID-19 pandemic, researchers in Sweden still believe they have found the secret to a new environmentally friendly way of killing off the Anopheles species of mosquitoes that transmit .

So hopeful are they, they have founded a company with a view to turning their discovery into a commercially viable alternative to the pesticides currently used to kill mosquitoes, but which can also harm humans and the environment.

A Cypriot scientist defended his assertion that a new strain of Covid-19 exists that combines characteristics of the delta and omicron variants.

Other scientists have speculated that Leonidos Kostrikis’s findings are a result of laboratory contamination. But he told Bloomberg in an emailed statement Sunday that the cases he has identified “indicate an evolutionary pressure to an ancestral strain to acquire these mutations and not a result of a single recombination event.”

𝙀𝙫𝙤𝙡𝙪𝙩𝙞𝙤𝙣𝙖𝙧𝙮 𝙗𝙞𝙤𝙡𝙤𝙜𝙞𝙨𝙩𝙨 𝙝𝙖𝙫𝙚 𝙩𝙧𝙤𝙪𝙗𝙡𝙚 𝙚𝙭𝙥𝙡𝙖𝙞𝙣𝙞𝙣𝙜 𝙬𝙝𝙮 𝙨𝙘𝙝𝙞𝙯𝙤𝙥𝙝𝙧𝙚𝙣𝙞𝙖 𝙖𝙣𝙙 𝙗𝙞𝙥𝙤𝙡𝙖𝙧 𝙙𝙞𝙨𝙤𝙧𝙙𝙚𝙧 — 𝙬𝙝𝙞𝙘𝙝 𝙖𝙧𝙚 𝙝𝙞𝙜𝙝𝙡𝙮 𝙝𝙚𝙧𝙞𝙩𝙖𝙗𝙡𝙚 𝙘𝙤𝙣𝙙𝙞𝙩𝙞𝙤𝙣𝙨 — 𝙥𝙚𝙧𝙨𝙞𝙨𝙩 𝙞𝙣 𝙥𝙤𝙥𝙪𝙡𝙖𝙩𝙞𝙤𝙣𝙨 𝙙𝙚𝙨𝙥𝙞𝙩𝙚 𝙝𝙖𝙧𝙢𝙞𝙣𝙜 𝙧𝙚𝙥𝙧𝙤𝙙𝙪𝙘𝙩𝙞𝙫𝙚 𝙛𝙞𝙩𝙣𝙚𝙨𝙨.

𝙍𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙢𝙖𝙮 𝙝𝙖𝙫𝙚 𝙛𝙤𝙪𝙣𝙙 𝙖𝙣 𝙚𝙭𝙥𝙡𝙖𝙣𝙖𝙩𝙞𝙤𝙣 𝙞𝙣 𝙧𝙚𝙘𝙚𝙣𝙩𝙡𝙮 𝙚𝙫𝙤𝙡𝙫𝙚𝙙 𝙧𝙚𝙜𝙞𝙤𝙣𝙨 𝙤𝙛 𝙩𝙝𝙚 𝙝𝙪𝙢𝙖𝙣 𝙜𝙚𝙣𝙤𝙢𝙚 𝙩𝙝𝙖𝙩 𝙖𝙧𝙚 𝙣𝙤𝙩 𝙪𝙨𝙪𝙖𝙡𝙡𝙮 𝙧𝙚𝙘𝙤𝙜𝙣𝙞𝙯𝙚𝙙 𝙖𝙨 𝙜𝙚𝙣𝙚𝙨 𝙗𝙪𝙩 𝙘𝙖𝙣 𝙨𝙩𝙞𝙡𝙡 𝙘𝙤𝙙𝙚 𝙛𝙤𝙧 𝙥𝙧𝙤𝙩𝙚𝙞𝙣𝙨.

𝙏𝙝𝙞𝙨 “𝙙𝙖𝙧𝙠 𝙜𝙚𝙣𝙤𝙢𝙚” 𝙢𝙖𝙮 𝙜𝙚𝙣𝙚𝙧𝙖𝙩𝙚 𝙥𝙧𝙤𝙩𝙚𝙞𝙣𝙨 𝙩𝙝𝙖𝙩 𝙖𝙧𝙚 𝙫𝙞𝙩𝙖… See more.

The Neuro-Network.

𝐂𝐥𝐮𝐞𝐬 𝐭𝐨 𝐨𝐫𝐢𝐠𝐢𝐧𝐬 𝐨𝐟 𝐛𝐢𝐩𝐨𝐥𝐚𝐫 𝐚𝐧𝐝 𝐬𝐜𝐡𝐢𝐳𝐨𝐩𝐡𝐫𝐞𝐧𝐢𝐚 𝐟𝐨𝐮𝐧𝐝 𝐢𝐧 ‘𝐝𝐚𝐫𝐤 𝐠𝐞𝐧𝐨𝐦𝐞’


The authors of a recent study on the genetics of schizophrenia and bipolar disorder identify a potential role for the so-called dark genome.

Sinclair’s first episode. Enjoy.


In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of “ex-differentiation” in which cells begin to lose their identity, and how all of this makes up the “Information Theory of Aging”, and the difference between “biological age” and “chronological age” and how we can measure biological age through DNA methylation clocks.

Thank you to our sponsors:
Athletic Greens — https://athleticgreens.com/sinclair.
InsideTracker — https://insidetracker.com/sinclair.
Levels — https://levels.link/sinclair.

Our Patreon page:
https://www.patreon.com/davidsinclair.

Lifespan book:
https://amzn.to/3sUqurT

Dr. David Sinclair Social:
Instagram — https://www.instagram.com/davidsinclairphd.
Twitter — https://twitter.com/davidasinclair.
Facebook — https://www.facebook.com/davidsinclairphd.

Matthew LaPlante’s Social:
Twitter — https://twitter.com/mdlaplante.

Timestamps:
00:00:00 Introduction.
00:03:14 Goal of the Lifespan Podcast.
00:07:11 Acknowledgement of Sponsors.
00:10:45 Aging is a Controllable Process that can be Slowed & Reversed.
00:16:42 Organisms with Extreme Longevity.
00:21:47 Genes that Regulate Aging: mTOR, AMPK, Sirtuins.
00:21:55 mTOR & Rapamycin.
00:24:33 AMP-activated protein kinase (AMPK) & Metformin.
00:30:57 Sirtuin Proteins as Epigenetic Regulators of Aging.
00:35:33 Ex-Differentiation.
00:43:30 Measuring Aging — Biological Age vs. Chronological Age.
00:49:30 “No Law That Says We Have To Age“
00:50:33 Episode Summary & Key Takeaways — Why Do We Age?
00:54:00 Information Theory of Aging.
00:57:59 Aging is a Medical Condition.
01:01:00 Aging Myths — Telomeres & Antioxidants.
01:01:55 Options for Subscription and Support.

DNA damage is constantly occurring in cells, either due to external sources or as a result of internal cellular metabolic reactions and physiological activities. Accurate repair of such DNA damages is critical to avoid mutations and chromosomal rearrangements linked to diseases including cancer, immunodeficiencies, neurodegeneration, and premature aging.

A team of researchers at Massachusetts General Hospital and the National Cancer Research Centre have identified a way to repair genetic damage and prevent DNA alterations using machine learning techniques.

The researchers state that it is possible to learn more about how cancer develops and how to fight it if we understand how DNA lesions originate and repair. Therefore, they hope that their discovery will help create better cancer treatments while also protecting our healthy cells.