In the case of DMD caused by a duplication mutation, CRISPR can simply snip away the harmful duplicate gene, which is much simpler than delivering a new gene or replacing the old.
For the first time in a live animal, researchers have successfully reversed a gene mutation, called a “duplication mutation,” by gene editing.
When Renaldo Hudson left the Danville Correctional Center on Sept. 2, he was beaming. As the sun shone down on a hot day in Eastern Illinois, Hudson took his first free steps in 37 years.
Later that day, he arrived at the Precious Blood Ministry of Reconciliation, a restorative justice nonprofit that helps former prisoners get on their feet. There, he saw friends for the first time in years and hugged his attorney, Jennifer Soble.
He was also handed a Samsung smartphone, a piece of technology that wouldn’t have been imaginable to an American in 1983.
“The results were surprising, but convincing, says Yannick Pauchet, a molecular entomologist also at the Max Planck Institute for Chemical Ecology. ” According to the data they provide, horizontal gene transfer is the most parsimonious explanation,” he says.
But how the whitefly managed to swipe a plant gene is unclear. One possibility, says Turlings, is that a virus served as an intermediate, shuttling genetic material from a plant into the whitefly genome.
As researchers s… See More.
Discovery that a whitefly uses a stolen plant gene to elude its host’s defences may offer a route to new pest-control strategies.
COVID-21 is the product of all these changes in aggregate. It’s the disease as it will be experienced in the months and years to come: with new variants of the virus, new public policies and health behaviors, various degrees of immune memory, and—most important—a cavalcade of new vaccines.
One-quarter of all Americans have now received at least one shot, and that number is racing up. This month, New Yorkers lined up outside Yankee Stadium throughout the night at a makeshift 24/7 vaccination site, until the supply ran out. “If we open 3000 appointments, they will immediately fill,” says Ramon Tallaj, a physician who oversees clinical care in underserved communities across New York City. Demand seems to be growing. If there were sufficient supply, Tallaj told me, his team could be giving out 40000 doses every day. And this should happen soon; the White House says that shortages will end in the coming weeks.
The vaccination effort is sure to change the nature of COVID in unexpected ways. The habitat for the virus is changing: It may still stick in the nasal passages of an immunized person, but it shouldn’t continue on its way into the lungs, much less the toes. The key question is just how long this protection will last, especially against a rapidly mutating virus. Clinical trials have shown the vaccines to be fantastic at preventing serious illness so far, but haven’t yet been able to observe how protection might dissipate over long periods.
And unexpectedly, Covid-19 has proved to be the catalyst. “What the pandemic has done is accelerate the adoption of genomics into infectious disease by several years,” says deSouza, the Illumina chief executive. He also told me he believes that the pandemic has accelerated the adoption of genomics into society more broadly — suggesting that quietly, in the midst of chaos and a global catastrophe, the age of cheap, rapid sequencing has arrived.
Ultrafast and ultracheap sequencing could reshape the future of health care.
Post-mortem changes may shed light on important brain studies.
In the hours after we die, certain cells in the human brain are still active. Some cells even increase their activity and grow to gargantuan proportions, according to new research from the University of Illinois Chicago.
In a newly published study in the journal Scientific Reports, the UIC researchers analyzed gene expression in fresh brain tissue — which was collected during routine brain surgery — at multiple times after removal to simulate the post-mortem interval and death. They found that gene expression in some cells actually increased after death.
“The Office of Racial Equity at the San Francisco Human Rights Commission will handle the program and artists from ”historically marginalized communities” are encouraged to apply.
Other basic income programs under development in San Francisco include funds for emergency medical technicians and Black and Pacific Islander expectant mothers, FOX 2 reported.
You could call it art for art’s sake — plus $1000 a month.
San Francisco plans to start paying 130 local artists $1000 a month starting in May through the fall in a pilot program announced on Thursday.
It follows other so-called ”universal basic income” efforts being launched in California amid the coronavirus pandemic.
Discovery “requires us to rethink everything we thought we knew about peroxisomes.”
In his first year of graduate school, Rice University biochemist Zachary Wright discovered something hidden inside a common piece of cellular machinery that’s essential for all higher order life from yeast to humans.
What Wright saw in 2015 — subcompartments inside organelles called peroxisomes — is described in a study published today in Nature Communications.
A new Covid-19 variant from the Amazon is now responsible for the majority of new infections in Brazil, with many doctors there saying they are seeing more young and otherwise healthy patients falling ill. Hopefully Covid doesnt bounce back and turn into the 1918 flu.
“We’re in the trenches here, fighting a war,” said Andréia Cruz, a 42-year-old emergency-ward nurse in the southern Brazilian city of Porto Alegre. In the past three weeks alone, the surrounding state of Rio Grande do Sul has seen nearly 5000 people die from Covid-19, more than in the final three months of last year.
The spread of the virus in Brazil threatens to turn this country of 213 million into a global public-health hazard. The so-called P.1 strain, present in more than 20 countries and identified in New York last week, is up to 2.2 times more contagious and as much as 61% more able to reinfect people than previous versions of the coronavirus, according to a recent study.
The P.1 is now responsible for the majority of new infections in Brazil, with many doctors here saying they are seeing more young and otherwise healthy patients falling ill. About 30% of people dying from Covid-19 are now under 60, compared with an average of about 26% during Brazil’s previous peak between June and August, according to official figures analyzed by The Wall Street Journal.
Necessity truly can be the mother of invention. A new university president explains how the pandemic forced massive changes at his institution — and why smart use of technology was invaluable.
