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Category: biotech/medical

Circa 2019

An add-on device for smartphones could replace blood glucose meters for measuring blood sugar. Blood sugar measurements are essential for diabetes patients who need to know their blood glucose concentration in order to regulate it with insulin. Failure to do so might result in complications from the disease. The device, designed by researchers in Taiwan, achieved 100% accuracy in a test with 20 blood samples from diabetes patients (J. Biomed. Opt. 10.1117/1.JBO.24.2.027002).

The researchers designed a compact device containing no electrical components that can be used in combination with a smartphone. The light from the smartphone’s display reflects onto the blood glucose test site (BGTS) inside the device, which contains a colorimetric test strip. The user adds a blood drop to the test strip, which is then assessed for a colour change using the phone’s front camera.

In this study, the blood drop was obtained from a vein, but the device is designed to work on drops extracted from the patient’s finger using a disposable lance that is then inserted into the device. The observed colour is split into its red, green and blue components. The researchers used the green component as an indicator of blood glucose concentration, as it could reliably distinguish the widest concentration range out of the three components.

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Circa 2018

A major challenge in treating type 1 diabetes is figuring out how to overcome the destruction of insulin-producing beta cells. The body mistakenly targets and destroys these cells leaving the body unable to manage blood sugar levels on its own. Individuals with this disease must be vigilant about checking their blood sugar and administering insulin as needed, which can be an exhausting task.

Current treatment options include injection of insulin, use of continuous glucose monitors and insulin pumps, stem cell therapies and implants, partial transplants, and other strategies. These treatments vary in effectiveness from person to person as well as how long they last. In addition, some require patients to continue taking anti-rejection drugs which can be hard on the body.

However, a new treatment may offer longer lasting, more effective results in the battle against type 1 diabetes. A recent study found that by using gene therapy targeting two specific genes, insulin-producing cells may be able to be recreated in the body using existing alpha cells. A healthy pancreas contains both alpha and beta cells. In those with type 1 diabetes, insulin-producing beta cells are destroyed. But when mice were injected with gene therapy to reprogram some alpha cells to take over the function of these beta cells, they were once again able to produce insulin and manage blood sugar.

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Effective COVID-19 vaccines arrived in record time. That success story, years in the making, offers lessons that could help prevent future outbreaks, including pandemic influenza.

This article was produced for Sabin Vaccine Institute by Scientific American Custom Media, a division separate from the magazine’s board of editors.

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Pear-shaped people, whose weight is generally distributed more evenly, rather than “apple shaped” individuals with fat clustered around their middle and often around internal organs like the liver in the abdominal cavity, are considered less at risk for cardiometabolic problems like heart disease and diabetes, as well as cognitive decline, says Stranahan, neuroscientist at the Medical College of Georgia at Augusta University.

Summary: Adipocytes, or beige fat cells, are indispensable to the anti-inflammatory and neuroprotective effects of subcutaneous fat, researchers say.

Source: Medical College of Georgia at Augusta University

Beige is considered a calming paint color, and scientists have new evidence that beige fat has a similar impact on the brain, bringing down the inflammation associated with the more common white fat and providing protection from dementia.

They have found that beige fat cells, which are typically intermingled with white fat cells in the subcutaneous fat present on “pear shaped” people, mediate subcutaneous fat’s brain protection, Dr. Alexis M. Stranahan and her colleagues report in the journal Nature Communications.

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When the resulting paste is applied to a wet surface such as blood-covered tissue, the oil repels the blood and other substances that may be present, allowing the adhesive microparticles to crosslink and form a tight seal over the wound. Within 15 to 30 seconds of applying the glue, with gentle pressure applied, the glue sets and bleeding stops, the researchers showed in tests in rats.

A new adhesive that mimics the sticky substance barnacles use to cling to rocks may offer a better way to treat traumatic injuries.

Inspired by the sticky substance that barnacles use to cling to rocks, MIT

MIT is an acronym for the Massachusetts Institute of Technology. It is a prestigious private research university in Cambridge, Massachusetts that was founded in 1861. It is organized into five Schools: architecture and planning; engineering; humanities, arts, and social sciences; management; and science. MIT’s impact includes many scientific breakthroughs and technological advances.

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The Astronomy, Technology, and Space Science News Podcast.
SpaceTime Series 24 Episode 91
*Astronomers zero in on source of the impactor that wiped out the dinosaurs.
A new study claims the impactor believed to have wiped out and 75 percent of all life on Earth 66 million years ago including all the non-avian dinosaurs — likely came from the outer half of the main asteroid belt between Mars and Jupiter.
*Producing matter out of pure energy.
Scientists have directly converted pure light energy into matter in a single process for the first time.
The findings reported in the journal Physical Review Letters involved the creation of Electrons and their antimatter counter parts positrons — by colliding quantum packets of photons – light particles.
*Discovery of a galactic stream of galaxy clusters.
Astronomers have discovered a never-before-seen galaxy cluster with a black hole at its centre, travelling at high speed along an intergalactic road of matter.
*Solar Orbiter and BepiColombo making space history with double flyby of Venus.
As we go to air tonight the European Space Agency is making space history with two of its space craft6 undertaking almost simultaneous flybys of the planet Venus.
*The Science Report.
New US congressional report says COVID-19 leaked out of Chinese Government Wuhan Lab.
Wearing masks and social distancing even when vaccinated key to combat new COVID strains.
Rising sea levels may mean fewer eruptions from volcanic islands.
How slowing of the planet’s rotation could have paved the way for life on Earth.
Skeptic’s guide to low vaccination and low IQ.
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Researchers at CU Boulder have developed a platform which can quickly identify common mutations on the SARS-CoV-2 virus that allow it to escape antibodies and infect cells.

Published today in Cell Reports, the research marks a major step toward successfully developing a universal vaccine for not only COVID-19, but also potentially for influenza, HIV and other deadly global viruses.

“We’ve developed a predictive tool that can tell you ahead of time which antibodies are going to be effective against circulating strains of virus,” said lead author Timothy Whitehead, associate professor of chemical and biological engineering. “But the implications for this technology are more profound: If you can predict what the variants will be in a given season, you could get vaccinated to match the sequence that will occur and short-circuit this seasonal variation.”

Researchers have developed a platform which can quickly identify common mutations on the SARS-CoV-2 virus that allow it to escape antibodies and infect cells, which could inform the development of more effective booster vaccines and tailored antibody treatments for patients with COVID-19.

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Learn More.

World Economic Forum.

Would you like to live on Mars for a year?

Learn more about what it’s like living in space.

Being forced into isolation and confinement creates a number of potentially stressful demands. However, we might be able to learn a thing or two about coping with these demands, from people who choose a life in such settings.

Despite the glorified image of being an astronaut, isolation and confinement remains a challenge for the star sailors that live above us. Demands associated with isolation and confinement are known as a red risk for long duration human spaceflight, which means they have the highest “likelihood of occurrence and the severity of their impact on human health, performance in mission, and long term quality of life”.

Astronauts know that by choosing to fly in space, they are going to have to live, work and play under isolated and confined conditions. Clearly, being a well trained astronaut flying in space is different to being thrust into another pandemic related lockdown. Yet instead of trivialising what we are going through, we can look to astronauts’ experiences for tips to improve our own situation.

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