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Info for those who may need it.
The Editors of BMC Cancer and BMC Medicine invite of submissions to our ‘Targeted Therapy’ cross journal collection. Guest edited by Prof. Min Li (University of Oklahoma Health Sciences Center, USA) and Dr. Yanis Boumber (The Northwestern University, USA).
We advise to submit by 1st August 2021 if you would like your manuscript to be ready for the launch date.
A new Yale study provides important insights into breakthrough COVID-19 cases — instances where fully vaccinated individuals are infected by SARS-CoV-2 — and who is particularly vulnerable to serious illness.
In a study of hospitalized patients in the Yale New Haven Health System, researchers identified 969 individuals who tested positive for the SARS-CoV-2 infection during a 14-week period between March and July 2021. Of that group, 54 were fully vaccinated.
“These cases are extremely rare, but they are becoming more frequent as variants emerge and more time passes since patients are vaccinated,” said Hyung Chun, associate professor of medicine (cardiology) at Yale and senior author of the study published Sept. 7 in Lancet Infectious Diseases.
U of M researchers have developed a novel virus-like particle vaccine against COVID-19. Having been successfully tested in animals, the novel vaccine — created as part of a study whose findings were recently published in the scientific journal PLOS Pathogens — offers a new approach in the global battle against COVID-19 and its emerging variants.
The researchers combined the advantages of the two types of traditional vaccines — virus-based vaccines and protein-based vaccines — by preparing a bacterial protein that self-assembles into a virus-like particle. By displaying a COVID-19 protein on the surface of this virus-like particle, researchers produced a novel vaccine that is well recognized by the mammalian immune system, but yet does not have any viral infectivity.
Some electronics can bend, twist and stretch in wearable displays, biomedical applications and soft robots. While these devices’ circuits have become increasingly pliable, the batteries and supercapacitors that power them are still rigid. Now, researchers in ACS’ Nano Letters report a flexible supercapacitor with electrodes made of wrinkled titanium carbide — a type of MXene nanomaterial — that maintained its ability to store and release electronic charges after repetitive stretching.
One major challenge stretchable electronics must overcome is the stiff and inflexible nature of their energy storage components, batteries and supercapacitors. Supercapacitors that use electrodes made from transitional metal carbides, carbonitrides or nitrides, called MXenes, have desirable electrical properties for portable flexible devices, such as rapid charging and discharging. And the way that 2D MXenes can form multi-layered nanosheets provides a large surface area for energy storage when they’re used in electrodes. However, previous researchers have had to incorporate polymers and other nanomaterials to keep these types of electrodes from breaking when bent, which decreases their electrical storage capacity. So, Desheng Kong and colleagues wanted to see if deforming a pristine titanium carbide MXene film into accordion-like ridges would maintain the electrode’s electrical properties while adding flexibility and stretchability to a supercapacitor.
The researchers disintegrated titanium aluminum carbide powder into flakes with hydrofluoric acid and captured the layers of pure titanium carbide nanosheets as a roughly textured film on a filter. Then they placed the film on a piece of pre-stretched acrylic elastomer that was 800% its relaxed size. When the researchers released the polymer, it shrank to its original state, and the adhered nanosheets crumpled into accordion-like wrinkles.
Those who were infected at Bukit Merah View market typically did not wear their masks properly, were unvaccinated and tended to touch produce with bare hands…at straitstimes.com.
NASA’s long-delayed James Webb Space Telescope is close to entering service. The agency now plans to launch the telescope on December 18th, 2,021 just a few months after testing completed in late August. The hardware will reach orbit aboard an ESA-supplied Ariane 5 rocket lifting off from French Guiana. NASA still has to ship the telescope to the launchpad, although much of the rocket has already arrived.
The JWST was deemed complete in 2016 ahead of an expected 2018 launch, but faced a number of delays due to its elaborate construction. It wasn’t assembled until 2019, and factors like the COVID-19 pandemic further hindered NASA’s efforts. That’s not including earlier setbacks — development started in 1996 with an expected 2007 deployment, but the team scrapped much of its work and redesigned the equipment in 2005.
The telescope’s importance hasn’t changed. It’s considered the successor to the Hubble Space Telescope. It includes a much larger mirror along with a focus on lower-frequency observations (particularly mid-infrared) that will help it detect early galaxies that even Hubble can’t find. That priority also helps explain some of its technical challenges. The JWST’s instruments will need to stay extremely cold (−370F) to avoid interference with infrared measurements, requiring both a large sunshield and an insertion near a Sun-Earth Lagrange point.
Scientists have long been interested in plasma’s biological implications. In the late 19th century, the Finnish physicist Karl Selim Lemström observed that the width of growth rings in fir trees near the Arctic Circle followed the cycle of the aurora borealis, widening when the northern lights were strongest. He hypothesized that the light show somehow encouraged plant growth. To artificially emulate the northern lights, he placed a metal wire net over growing plants and ran a current through it. Under the right conditions, he reported, the treatment produced larger vegetable yields.
For decades, scientists have known that exposure to plasma can safely kill pathogenic bacteria, fungi and viruses. Small studies in animals also suggest that plasma can prompt the growth of blood vessels in skin. In his research, Reuter studies ways to harness these properties to inhibit new infections in wounds and expedite healing or treat other skin conditions. But more recently, he and other physicists have been working on ways to use the power of plasma to improve food production.
Experiments conducted in the last decade or so have tested a mix of ways to apply plasma to seeds, seedlings, crops and fields. These include plasma generated using noble gases, as well as plasma generated from air. In some cases, plasma is directly applied through plasma “jets” that stream over the seeds or plants. Another approach uses plasma-treated water that can do double duty: irrigation and fertilization. Some studies have reported a range of benefits, from helping plants grow faster and bigger to resisting pests.
Researchers have developed artificial cell-like structures using inorganic matter that autonomously ingest, process, and push out material—recreating an essential function of living cells.
Their article, published in Nature, provides a blueprint for creating “cell mimics,” with potential applications ranging from drug delivery to environmental science.
A fundamental function of living cells is their ability to harvest energy from the environment to pump molecules in and out of their systems. When energy is used to move these molecules from areas of lower concentration to areas of higher concentration, the process is called active transport. Active transport allows cells to take in necessary molecules like glucose or amino acids, store energy, and extract waste.
A newly discovered antibody was able to neutralize not only all strains of COVID-19, but other coronaviruses known to cause respiratory infections in humans — a potential silver bullet for a whole class of deadly, flu-like viruses.
Mutant viruses: As viruses spread, they undergo tiny genetic mutations, and when we find a unique version of the virus, we call it a new strain.
Occasionally, new strains appear that can spread more easily, evade the immune system, or cause more severe disease.
This makes sense, as we believe that inflammation in the central nervous system can start the autoimmune process (when a person’s immune system attacks part of their body) that causes MS.
Summary: A new study links viral infections including mononucleosis and pneumonia experienced during adolescence with an increased risk of developing multiple sclerosis.
Source: The Conversation
Multiple sclerosis (MS) is most often diagnosed between the ages of 20 and 50. Certain genes put a person at greater risk of getting this disease of the central nervous system, but scientists are still trying to understand the triggers.
My colleagues and I have been studying these triggers for many years. Our earlier research found that pneumonia in adolescence is associated with a raised risk of MS, so we decided to investigate whether other types of infection are associated with the condition.