Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: neuroscience

I have been asked to mention the following.
The Nature of The Identity — with Reference to Androids

The nature of the identity is intimately related to information and information processing.

The importance and the real nature of information is only now being gradually realised.

But the history of the subject goes back a long way.

In ancient Greece, those who studied Nature – the predecessors of our scientists – considered that what they studied – material reality – Nature – had two aspects – form and substance.

Until recent times all the emphasis was on substance — what substance(s) subjected to sufficient stress would transmute into gold; what substances in combination could be triggered into releasing vast amounts of energy – money and weapons – the usual Homo Sap stuff.

You take a block of marble – that is substance. You have a sculptor create a beautiful statue from it – that is form.

The form consists of the shapes imposed by the sculptor; and the shapes consist of information. Now, if you were an unfeeling materialistic bastard you could describe the shapes in terms of equations. And if you were an utterly depraved unfeeling materialistic bastard you could have a computer compare the sets of equations from many examples to find out what is considered to be beauty.

Dr Foxglove – the Great Maestro of Leipzig, is seated at the concert grand — playing on a Steinway (of course) with great verve, (as one would expect). In front of him, under a low light, there is a sheet of paper with black marks – information of some kind – the music for Chopin’s Nocturne Op. 9, no. 2.

Aahh! Wonderful.

Sublime….

But … all is not as it seems….

Herr Doktor Foxglove thinks he is playing music.

A grand illusion my friend! You see, the music – it is, how you say — all in the heads of the listeners.

What the Good Doktor is doing, and doing manfully — is operating a wooden acoustic-wave generator – albeit very skilfully, and not just any old wooden acoustic-wave generator – but a Steinway wooden acoustic-wave generator.

There is no music in the physical world. The acoustic waves are not music. They are just pressure waves in the atmosphere. The pressure waves actuate the eardrum. And that in turn actuates a part of the inner ear called the cochlea. And that in turn causes streams of neural impulses to progress up into the higher brain.

Dr Foxglove hits a key on the piano corresponding to 440 acoustic waves per second; this is replicated in a slightly different form within the inner ear, until it becomes a stream of neural impulses….

But what the listener hears is not 440 waves or 440 neural impulses or 440 anything – what the listener hears is one thing – a single tone.

The tone is an exact derivative of the pattern of neural impulses. There are no tones in physical reality.

Tones exist only in the experience of the listener – only in the experience of the observer.

And thanks to some fancy processing not only will the listener get the illusion that 440 cycles per second is actually a “tone” – but a further illusion is perpetrated – that the tone is coming from a particular direction, that what one is hearing is Dr. Foxglove at the Steinway, over there, under the lights – that is where the sound is.

But no, my friend….

What the listener is actually listening to is his eardrums. He is listening to a derivative of a derivative … of his eardrums rattling.

His eardrums are rattling because someone is operating an acoustic wave generator in the vicinity.

But what he is hearing is pure information.

And as for the music ….

A single note – a tone – is neither harmonious nor disharmonious in itself. It is only harmonious or disharmonious in relation to another note.

Music is derived from ratios – a still further derivative — and ratios are pure information.

Take for example the ratio of 20 Kg to 10 Kg.

The ratio of 20 Kg to 10 Kg is not 2 Kg.

The ratio of 20 Kg to 10 Kg is 2 – just 2 – pure information.

20 kg/10 kg = 2.

Similarly, we can also show that there is no colour in reality, there are no shapes in reality; depth perception is a derivative – and just as what one is listening to is the rattling of one’s eardrums – so what one is watching is the inside of one’s eyeballs – one is watching the shuddering impact of photons on one’s retina.

The sensations of sound, of light and colour and shapes are all in one’s mind – as decodings of neural messages – which in turn are derivatives of physical processes.

The wonderful aroma coming from the barbecue is all in one’s head.

There are no aromas or tastes in reality – all are conjurations of the mind.

Like the Old Guy said, all is maya, baby….

The only point that is being made here is that Information is too important a subject to be so neglected.

What you are doing here is at the leading edge beyond the leading edge and in that future Information will be a significant factor.

What we away back in the dim, distant and bewildered early 21st Century called Information Technology (I.T.) will be seen as Computer Technology (CT) which is all it ever was – but there will be a real IT in the future.

Similarly what has been referred to for too long as Information Science will be seen for what it is — Library Technology.

Now – down to work.

One of the options – the android – is to upload all stored data from a smelly old bio body to a cool Designer Body (DB).

This strategy is based on the unproven but popular belief that one’s identity is contained by one’s memory.

There are two critical points that need to be addressed.

The observer is the cameraman — not the picture. Unless you are looking in a mirror or at a film of yourself, then you are the one person who will not appear in your memory.

There will be memories of that favourite holiday place, of your favorite tunes, of the emotions that you felt when … but you will only “appear” in your memories as the point of observation.

You are the cameraman – not the picture.

So, we should view with skepticism ideas that uploading the memory will take the identity with it.

If somebody loses their memory – they do not become someone else – hopping and skipping down the street,

‘Hi – I’m Tad Furlong, I’m new in town….’

If somebody loses their memory – they may well say – ‘I do not know my name….’

That does not mean they have become someone else – what they mean is ‘I cannot remember my name….’

The fact that this perplexes them indicates that it is still the same person – it is someone who has lost their name.

If a person changes their name they do not become someone else; nor do they become someone else if they can’t remember their name – or as it is more commonly, and more dramatically, and more loosely put – “cannot remember who they are”.

So, what is the identity?

There is the observer – whatever that is – and there are observations.

There are different forms of information – visual, audible, tactile, olfactory … which together form the environment of the observer. By “projection” the environment is observed as being external. The visual image from one eye is compared with that of the other eye to give depth perception. The sound from one ear is compared with that from the other ear to give surround sound. You are touched on the arm and immediately the tactile sensation – which actually occurs in the mind, is mapped as though coming from that exact spot on your arm.

You live and have your being in a world of sensation.

This is not to say that the external world does not exist – only that our world is the world “inside” – the place where we hear, and see, and feel, and taste….

And all those projections are like “vectors” leading out from a projection spot – a locus of projection – the 0,0 spot – the point which is me seeing and me tasting and me hearing and me scenting even though through the magic of projection I have the idea that the barbeque smells, that there is music in the piano, that the world is full of color, and that my feet feel cold.

This locus of projection is the “me” –it is the point of observation, the 0,0 reference point. This, the observer not the observation, is the identity … the me, the 0,0.

And that 0,0 may be a lot easier to shift than a ton and a half of squashed memories. Memories of being sick; of being tired; of the garden; of your dog; of the sound of chalk on the blackboard, of the humourless assistant bank manager; of the 1982 Olympics; of Sadie Trenton; of Fred’s tow bar; and so on and on and on –

So – if memory ain’t the thing — how do we do it … upload the identity?
(To be continued)

carboncopies.org

Concerns arose recently about the concept of so-called “catchment areas”, evolutionary developments that result in a very tight interdependence between requirements for survival and behavioral drives. In particular, the concern has been raised that such catchment might render any significant modification of the human mind, such as through brain enhancement, impossible (Suzanne Gildert, “Pavlov’s AI: What do superintelligences REALLY want?”, Humanity+@Caltech, 2010).

The concept of a catchment area assumes that beneath the veneer of goal-oriented rational planning, learned behavior and skill lies a basic set of drives and reward mechanisms. The only purpose of those drives and reward mechanisms is genetic survival, a necessary result of eons of natural selection. It follows that all of our perceived goals, our desires and interests, the pursuit of wealth, social acceptance or fame, love, scientific understanding, all of it is merely a means to an end. All of it points back to the set of drives and reward mechanisms that best enable us as individuals, us as a tribe and us as a species to survive in our given environment.

Why does that describe a catchment area, a type of prison of behavior? It is assumed that the distribution of behaviors that have enabled long-term survival is a narrow one with little real variance. Stray too far from the norm and your behaviors become counter-productive to survival. Worst of all, if you recognize your enslavement to those single-purpose drives and reward mechanisms, if you realize that they have no meaning beyond a survival that itself links to no universal purpose, then you risk embarking upon a nihilistic course that would likely end in your extermination or self-termination.

How risky is modifying reward mechanisms?

If the catchment problem is real, and if it indeed implies that we live in a precarious balance of behavioral drives that keep us alive, then any modification brings with it the risk that we tip the balance. One significant change, or a series of changes could push us into a condition where our mental reward system is no longer aligned with requirements for survival. One form of this problem has been popularized as “wire-heading” (Larry Niven, Known Space & Ringworld novels, 1970–1996), where an individual exists in a short-circuited reward-loop, living only to repeatedly and directly deliver reward stimulus to herself.

There are of course numerous possible critiques of the catchment hypothesis, which bears a heavy burden of proof. There is plenty of evidence that evolution is not an actual optimizer. If the process of natural selection is not an optimizer, then why should we assume that we exist in a delicately optimized state? We may also consider changes in our mental experience in the recent past. For example, humans generally live longer now than they did previously, so that the extended experience itself is a novel condition for human mental function, and brings with it different survival challenges to which behavior needs to be adapted. And, while we share many behavioral traits as a species, there are clearly differences in behavior between individuals, most of whom appear to function and survive. In fact, some behaviors do not seem at all optimal for survival, such as extreme sports. Those critiques do not mean that the notion of catchment areas is wrong, but they demonstrate that we must take care before drawing extreme conclusions in the matter.

If we represent behavioral traits as variables in a multi-dimensional landscape, and the survival suitability of combinations of traits as elevation in that landscape, does the landscape look like a Himalayan mountain ridge with sharp peaks, steep cliffs and deep valleys? Or does it look more like a rolling vista of hills, or perhaps even a concatenation of several contiguous high-altitude plateaus? If we do not know what this landscape looks like, then it is extremely difficult to make informed statements about the results that we should expect when reward mechanisms and consequent behaviors are modified.

Can we modify while specifying conditions for survival?

Is there anything about past developments that we might use as a guide, to tell us if modifications of reward mechanisms and behaviors are survivable, and how that might work? I believe there is. I think the process is unavoidable, as it is a result of selection among differences. Darwin got us here, and he can get us out too.

Let us assume that modifying our reward mechanisms can result in personal destruction. That is not a fanciful assumption. We need only look at the worst-case scenarios in cases of addiction to see relevant examples. Similarly, we may observe that suicide is such a case, unless it is a sacrifice that serves the greater purpose of tribe or species survival.

Do all modifications lead to destruction? That seems highly unlikely, given that humans have not existed forever. There have been ancestors who probably had different brains and at least somewhat different drives and reward mechanisms. The further back you look, the more different and strange those drives and mechanisms may seem, since the species involved will have had somewhat different challenges and requirements for survival.

If there was a way that led from there to what we are now through natural selection, then why should we assume that this is the terminal state? It seems reasonable to assume that if we carried out a large number of experiments in which we modified our brains and their underlying drives and reward mechanisms to some degree, some of those experiments would not result in catastrophe. There would still be a selection process. The question is not whether there exist ways to achieve brain enhancement. Rather, we should seek out the best process. We should determine how to carry out intelligent experimentation that minimizes that rate of failure and maximizes the rate of success.

Image attribution

Wirehead Darwin: modified from George Grantham Bain press photo collection, purchased by the library of Congress. No restrictions.
Survival landscape: modified Height map (Wikipedia), unknown author. Public domain.

It would be helpful to discuss these theoretical concepts because there could be significant practical and existential implications.

The Global Brain (GB) is an emergent world-wide entity of distributed intelligence, facilitated by communication and the meaningful interconnections between millions of humans via technology (such as the internet).

For my purposes I take it to mean the expressive integration of all (or the majority) of human brains through technology and communication, a Metasystem Transition from the human brain to a global (Earth) brain. The GB is truly global not only in geographical terms but also in function.

It has been suggested that the GB has clear analogies with the human brain. For example, the basic unit of the human brain (HB) is the neuron, whereas the basic unit of the GB is the human brain. Whilst the HB is space-restricted within our cranium, the GB is constrained within this planet. The HB contains several regions that have specific functions themselves, but are also connected to the whole (e.g. occipital cortex for vision, temporal cortex for auditory function, thalamus etc.). The GB contains several regions that have specific functions themselves, but are connected to the whole (e.g. search engines, governments, etc.).

Some specific analogies are:

1. The Broca’s area in the inferior frontal gyrus, associated with speech. This could be the equivalent of, say, Rubert Murdoch’s communication empire.
2. The motor cortex is the equivalent of the world-wide railway system.
3. The sensory system in the brain is the equivalent of all digital sensors, CCTV network, internet uploading facilities etc.

If we accept that the GB will eventually become fully operational (and this may happen within the next 40–50 years), then there could be severe repercussions on human evolution. Apart from the fact that we could be able to change our genetic make-up using technology (through synthetic biology or nanotechnology for example) there could be new evolutionary pressures that can help extend human lifespan to an indefinite degree.

Empirically, we find that there is a basic underlying law that allows neurons the same lifespan as their human host. If natural laws are universal, then I would expect the same law to operate in similar metasystems, i.e. in my analogy with humans being the basic operating units of the GB. In that case, I ask:

If, there is an axiom positing that individual units (neurons) within a brain must live as long as the brain itself, i.e. 100–120 years, then, the individual units (human brains and, therefore, whole humans) within a GB must live as long as the GB itself, i.e. indefinitely.

Humans will become so embedded and integrated into the GB’s virtual and real structures, that it may make more sense from the allocation of resources point of view, to maintain existing humans indefinitely, rather than eliminate them through ageing and create new ones, who would then need extra resources in order to re-integrate themselves into the GB.

The net result will be that humans will start experiencing an unprecedented prolongation of their lifespan, in an attempt by the GB to evolve to higher levels of complexity at a low thermodynamical cost.

Marios Kyriazis
http://www.elpistheory.info

My generation was the last one to learn to use a slide rule in school. Today that skill is totally obsolete. So is the ability to identify the Soviet Socialist Republics on a map, the ability to write an operation in FORTAN, or how to drive a car with a standard transmission.

We live in a world of instant access to information and where technology is making exponential advances in synthetic biology, nanotechnology, genetics, robotics, neuroscience and artificial intelligence. In this world, we should not be focused on improving the classrooms but should be devoting resources to improving the brains that the students bring to that classroom.

To prepare students for this high-velocity, high-technology world the most valuable skill we can teach them is to be better learners so they can leap from one technological wave to the next. That means education should not be about modifying the core curricula of our schools but should be about building better learners by enhancing each student’s neural capacities and motivation for life-long learning.

Less than two decades ago this concept would have been inconceivable. We used to think that brain anatomy (and hence learning capacity) was fixed at birth. But recent breakthroughs in the neuroscience of learning have demonstrated that this view is fundamentally wrong.

In the past few decades, neuroscience research has demonstrated that, contrary to popular belief, the brain is not static. Rather, it is highly modifiable (“plastic”) throughout life, and this remarkable “neuroplasticity” is primarily experience-dependent. Neuroplasticity research shows that the brain changes its very structure with each different activity it performs, perfecting its circuits so it is better suited to the task at hand. Neurological capacities and competencies are both measurable and significantly consequential to educational outcomes.

This means that the neural capacities that form the building blocks for learning — attention & focus, memory, prediction & modeling, processing speed, spatial skills, and executive functioning — can be improved throughout life through training. Just as physical exercise is a well-known and well-accepted means to improve health for anyone, regardless of age or background, so too can the brain be put “into shape” for optimal learning.

If any of these neural capacities are enhanced, you would see significant improvements in a person’s ability to understand and master new situations.

While these basic neural capacities are well known by scientists and clinicians today, they are rarely used to develop students into better learners by schools, teachers or parents. There is too little awareness and too few tools available for enhancing a student’s capacity and ability to learn. The failure to focus on optimizing each student’s neural capacities for learning is resulting in widespread failure of the educational systems, particularly for the underprivileged.

Gone are the days when you could equip students with slide rules and a core of knowledge and skills and expect them to achieve greatness. Our children already inhabit a world where new game platforms and killer apps appear and are surpassed in dizzying profusion and speed. They are already adapting to the dynamics of the 21st century. But we can help them adapt more methodically and systematically by focusing our attention on improving their capacity to learn throughout their lives.

This far-reaching and potentially revolutionary conclusion is based on recent research breakthroughs and thus may be contrary to the past beliefs of many teachers, administrators, parents and students, who have historically emphasized classroom size and curriculum as the key to improved learning.

Just as new knowledge and understanding is revolutionizing the way we communicate, trade, or practice medicine so too must it transform the way we learn. For students, that revolution is already well under way but it’s happening outside of their schools. We owe it to them to equip them with all the capabilities they’ll need to thrive in the limitless world beyond the classroom.

I believe that while it’s important to leave better country for our children, it’s more important that we leave better children for our country.

Naveen Jain is a philanthropist, entrepreneur and technology pioneer. He is a founder and CEO of Intelius, a Seattle-based company that empowers consumers with information to make intelligent decisions about personal safety and security. Prior to Intelius, Naveen Jain founded InfoSpace and took it public in 1998 on NASDAQ. Naveen Jain has been awarded many honors for his entrepreneurial successes and leadership skills including “Ernst & Young Entrepreneur of the Year”, “Albert Einstein Technology Medal” for pioneers in technology, “Top 20 Entrepreneurs” by Red Herring, “Six People Who Will Change the Internet” by Information Week, among other honors.

The Stoic philosophical school shares several ideas with modern attempts at prolonging human lifespan. The Stoics believed in a non-dualistic, deterministic paradigm, where logic and reason formed part of their everyday life. The aim was to attain virtue, taken to mean human excellence.

I have recently described a model specifically referring to indefinite lifespans, where human biological immortality is a necessary and inevitable consequence of natural evolution (for details see www.elpistheory.info and for a comprehensive summary see http://cid-3d83391d98a0f83a.office.live.com/browse.aspx/Immortality?uc=1&sa=155370157).

This model is based on a deterministic, non-dualistic approach, described by the laws of Chaos theory (dynamical systems) and suggests that, in order to accelerate the natural transition from human evolution by natural selection to a post-Darwinian domain (where indefinite lifespans are the norm) , it is necessary to lead a life of constant intellectual stimulation, innovation and avoidance of routine (see http://www.liebertonline.com/doi/abs/10.1089/rej.2005.8.96?journalCode=rej and http://www.liebertonline.com/doi/abs/10.1089/rej.2009.0996) i.e. to seek human virtue (excellence, brilliance, and wisdom, as opposed to mediocrity and routine). The search for intellectual excellence increases neural inputs which effect epigenetic changes that can up-regulate age repair mechanisms.

Thus it is possible to conciliate the Stoic ideas with the processes that lead to both technological and developmental Singularities, using approaches that are deeply embedded in human nature and transcend time.

With our growing resources, the Lifeboat Foundation has teamed with the Singularity Hub as Media Sponsors for the 2010 Humanity+ Summit. If you have suggestions on future events that we should sponsor, please contact [email protected].

The summer 2010 “Humanity+ @ Harvard — The Rise Of The Citizen Scientist” conference is being held, after the inaugural conference in Los Angeles in December 2009, on the East Coast, at Harvard University’s prestigious Science Hall on June 12–13. Futurist, inventor, and author of the NYT bestselling book “The Singularity Is Near”, Ray Kurzweil is going to be keynote speaker of the conference.

Also speaking at the H+ Summit @ Harvard is Aubrey de Grey, a biomedical gerontologist based in Cambridge, UK, and is the Chief Science Officer of SENS Foundation, a California-based charity dedicated to combating the aging process. His talk, “Hype and anti-hype in academic biogerontology research: a call to action”, will analyze the interplay of over-pessimistic and over-optimistic positions with regards of research and development of cures, and propose solutions to alleviate the negative effects of both.

The theme is “The Rise Of The Citizen Scientist”, as illustrated in his talk by Alex Lightman, Executive Director of Humanity+:

“Knowledge may be expanding exponentially, but the current rate of civilizational learning and institutional upgrading is still far too slow in the century of peak oil, peak uranium, and ‘peak everything’. Humanity needs to gather vastly more data as part of ever larger and more widespread scientific experiments, and make science and technology flourish in streets, fields, and homes as well as in university and corporate laboratories.”

Humanity+ Summit @ Harvard is an unmissable event for everyone who is interested in the evolution of the rapidly changing human condition, and the impact of accelerating technological change on the daily lives of individuals, and on our society as a whole. Tickets start at only $150, with an additional 50% discount for students registering with the coupon STUDENTDISCOUNT (valid student ID required at the time of admission).

With over 40 speakers, and 50 sessions in two jam packed days, the attendees, and the speakers will have many opportunities to interact, and discuss, complementing the conference with the necessary networking component.

Other speakers already listed on the H+ Summit program page include:

  • David Orban, Chairman of Humanity+: “Intelligence Augmentation, Decision Power, And The Emerging Data Sphere”
  • Heather Knight, CTO of Humanity+: “Why Robots Need to Spend More Time in the Limelight”
  • Andrew Hessel, Co-Chair at Singularity University: “Altered Carbon: The Emerging Biological Diamond Age”
  • M. A. Greenstein, Art Center College of Design: “Sparking our Neural Humanity with Neurotech!”
  • Michael Smolens, CEO of dotSUB: “Removing language as a barrier to cross cultural communication”

New speakers will be announced in rapid succession, rounding out a schedule that is guaranteed to inform, intrigue, stimulate and provoke, in moving ahead our planetary understanding of the evolution of the human condition!

H+ Summit @ Harvard — The Rise Of The Citizen Scientist
June 12–13, Harvard University
Cambridge, MA

You can register at http://www.eventbrite.com/event/648806598/friendsofhplus/4141206940.

Another risk is loss of human rationality, while preserving human life. In a society there are always so many people with limited cognitive abilities, and most of the achievements are made by a small number of talented people. Genetic and social degradation, reducing the level of education, loss of skills of logic can lead to a temporary decrease in intelligence of individual groups of people. But as long as humanity is very large in population, it is not so bad, because there will always be enough intelligent people. Significant drop in population after nonglobal disaster may exacerbate this problem. And the low intelligence of the remaining people will reduce their chances of survival. Of course, one can imagine such an absurd situation that people are so degraded that by the evolutionary path new species arise from us, which is not having a full-fledged intelligence — and that back then this kind of evolving reasonable, developed a new intelligence.
More dangerous is decline of intelligence because of the spread of technological contaminants (or use of a certain weapon). For example, I should mention constantly growing global arsenic contamination, which is used in various technological processes. Sergio Dani wrote about this in his article “Gold, coal and oil.” http://sosarsenic.blogspot.com/2009/11/gold-coal-and-oil-regulatory-crisis-of.html, http://www.medical-hypotheses.com/article/S0306-9877 (09) 00666-5/abstract
Disengaged during the extraction of gold mines in the arsenic remains in the biosphere for millennia. Dani binds arsenic with Alzheimer’s disease. In his another paper is demonstrated that increasing concentrations of arsenic leads to an exponential increase in incidence of Alzheimer’s disease. He believes that people are particularly vulnerable to arsenic poisoning, as they have large brains and longevity. If, however, according to Denis, in the course of evolution, people will adapt to high levels of arsenic, it will lead to a decline in the brain and life expectancy, resulting in the intellect of people will be lost.
In addition to arsenic contamination occurs among many other neurotoxic substances — CO, CO2, methane, benzene, dioxin, mercury, lead, etc. Although the level of pollution by each of them separately is below health standards, the sum of the impacts may be larger. One reason for the fall of the Roman Empire was called the total poisoning of its citizens (though not barbarians) of lead from water pipes. Of course, they could not have knowledge about these remote and unforeseen consequences — but we also may not know about the many consequences of our affairs.
In addition to dementia is alcohol and most drugs, many drugs (eg, side effect in the accompanying sheets of mixtures of heartburn called dementia). Also rigid ideological system, or memes.
Number of infections, particularly prion, also leads to dementia.
Despite this, the average IQ of people is growing as life expectancy.

I recently began to worry that something/someone, some field, force, disease, prion, virus, bad luck and/or natural causes could threaten and perhaps destroy the most valuable entity in the universe, an entity more valuable than life itself. Consciousness. What good is life extension without conscious awareness? What is consciousness?

We know the brain works a lot like a computer, with neuron firings and synapses acting like bit states and switches. Brain-as-computer works very well to account for sensory processing, control of behavior, learning and other cognitive functions. These functions may in some cases be non-conscious, and other times associated with conscious experience and control. Scientists seek the distinction – the essential feature, or trick for consciousness.

Some suggest there is no trick, consciousness emerges as a by-product of cognitive computation among neurons. Others say we don’t know, that consciousness may indeed require some feature related to, but not quite the same as neuron-to-neuron cognition.

In either case, humans and other creatures could in principle become devoid of consciousness while maintaining cognitive behaviors, appearing more-or-less normal to outside observers. Such hypothetical non-conscious behaving entities are referred to in literature, films and philosophical texts as ‘zombies’. Philosopher David Chalmers introduced the philosophical zombie, a test case for whether or not consciousness is distinct from cognitive neurocomputation.

I’ve studied and researched consciousness for over 35 years, and work as an anesthesiologist, erasing and restoring consciousness several times per day for surgery. Patients under anesthesia are not zombies. They lack consciousness but also lack cognition. On the other hand, for a very brief period after first emerging from anesthesia following surgery, my patients seem like zombies, behaving purposely but blankly. Like in the old song “She’s not there” by…..The Zombies.

During a routine surgery recently, one of the nurses was talking about a book called ‘Patient Zero’ in which a terrorist group turned people into zombies the terrorists were then able to control. I later discovered there exists an entire genre of zombie terror books and films (‘Invasion of the body snatchers’ being perhaps the original). Could it be possible? How could we protect ourselves from consciousness-snatchers who want to turn us into zombies? Well, we need to understand what consciousness is (but, so do ‘they’).

We do know consciousness correlates with a particular coherent EEG gamma synchrony. Somehow selectively blocking EEG brain-wide coherence while sparing neuron-to-neuron computation and cognition could conceivably erase consciousness. But I would bet on an even more subtle and profound feature or trick. For example I personally believe (with Sir Roger Penrose) that consciousness involves quantum computations in microtubules inside brain neurons.

Microtubules are the major structural component of the neuronal cytoskeleton whose disruption is an essential feature of Alzheimers disease. Microtubules dynamically organize intra-neuronal and synaptic activities, conduct signals, have collective vibrational and electromagnetic modes and quite possibly mesoscopic quantum states. Motor proteins and biomolecular agents traverse and interact with microtubules.

I became obsessed with microtubules in medical school in the early 1970s. Their cylindrical lattice structure of ‘tubulin’ protein subunits looked to me like a computing switching circuit. Through the 1980s, colleagues and I developed models of microtubule information processing in which states of tubulin subunits were bits interacting with lattice neighbor tubulins. With about 107 (10 to the seventh) tubulins per neuron switching at 10^−9 seconds, we calculated a potential for 1016 operations per second in each neuron. This was, and remains unpopular in AI/Singularity circles because it potentially pushes the goalpost for brain capacity significantly. Recent evidence has shown collective microtubule excitations at 10^−7 seconds (rather than the 10^−9 seconds we assumed), indicating a neuronal information capacity of ‘only’ 1014 operations per second.

But here’s the really good news. Microtubules self-assemble. With proper conditions tubulins polymerize into microtubules, and with associated proteins into networks of cross-linked microtubules. In principle, tubulin and other necessary proteins can be genetically mass-produced, and then self-assemble into large arrays. If microtubules process molecular-scale information (quantum or classical), appropriate arrays of microtubules could serve as a repository of consciousness — a ‘Lifeboat’.

These could be useful. Evil forces aside, consciousness-snatchers include aging, disease and death. In 1987 I wrote a book about microtubule information processing based entirely on classical (non-quantum) processes. The brief, concluding chapter considered arrays of microtubules as orbiting consciousness Lifeboats. It foreshadowed the Singularity, and in retrospect also applies to quantum processes. The chapter follows below. And we should understand consciousness not just to preserve it, but to enhance it in any way possible.

From
Ultimate computing: Biomolecular consciousness and nanotechnology
Elsevier, 1987
http://www.quantumconsciousness.org/ultimatecomputing.html

11 The Future of Consciousness

Nanotechnology may enable the dream of Mind/Tech merger to materialize. At long last, debates about the nature of consciousness will move from the domain of philosophy to large scale experiments. The visions of consciousness interfacing with, or existing within, computers or mind piloted robots expressed by Moravec, Margulis, Sagan and Max Headroom could be realized. Symbiotic association of replicative nanodevices and cytoskeletal networks within living cells could not only counter disease processes, but lead to exchange of information encoded in the collective dynamic patterns of cytoskeletal subunit states. If these are indeed the roots of consciousness, a science fiction-like deciphering and transfer of mind content may become possible. One possible scenario could utilize a small window in a specific brain region. Hippocampal temporal lobe, a site where memories enter and where electromagnetic radiation from outside the skull penetrates most readily and harmlessly, is one possible area where information distributed throughout the brain may perhaps be accessed and manipulated. Techniques such as laser interferometry, electroacoustical probes scanned over brain surfaces, or replicative nanoprobes immunotargeted to key hippocampal tubulins, MAPs, and other cytoskeletal components might be developed to perceive and transmit the content of consciousness.

What technological device would be capable of receiving and housing the information emanating from some 1015 tubulin subunits changing state some 109 times per second? One possibility is a customized array of nanoscale automata, perhaps utilizing superconducting materials. Another possibility is a genetically engineered array of some 1015 tubulin subunits (or many more) assembled into parallel tensegrity arrays of interconnected microtubules, and other cytoskeletal structures. Current and near future genetic engineering capabilities should enable isolation of genes responsible for a specific individual’s brain cytoskeletal proteins, and reconstitution in an appropriate medium. Thus the two evident sources of mind content (heredity and experience) may be eventually reunited in an artificial consciousness environment. A polymerized cytoskeletal array would be highly unstable and dependent on biochemical, hormonal, and pharmacological maintenance of its medium. Precise monitoring and control of cytoskeletal consciousness environments may become an important new branch of anesthesiology. Polymerization of cell-free cytoskeletal lattices would be limited in size (and potential intellect) due to gravitational collapse. Possible remedies might include hybridizing the cytoskeletal array by metal deposition, symbiosis with synthetic nanoreplicators, or placement of the cytoskeletal array in a zero gravity environment. Perhaps future consciousness vaults will be constructed in orbiting space stations or satellites. People with terminal illnesses may choose to deposit their mind in such a place, where their consciousness can exist indefinitely, and (because of enhanced cooperative resonance) in a far greater magnitude. Perhaps many minds can comingle in a single large array, obviating loneliness, but raising new sociopolitical issues. Entertainment, earth communication, and biochemical mood and maintenance can be supplied by robotics, perhaps leading to the next symbiosis-robotic space voyagers (shaped like centrioles?) whose intelligence is derived from cytoskeletal consciousness.

Yes, this is science fiction. Will it become reality like so much previous science fiction has? Probably not precisely as suggested; but if past events are valid indicators, the future of consciousness may be even more outrageous.

Artificial brain ’10 years away’

By Jonathan Fildes
Technology reporter, BBC News, Oxford

A detailed, functional artificial human brain can be built within the next 10 years, a leading scientist has claimed.

Henry Markram, director of the Blue Brain Project, has already simulated elements of a rat brain.

He told the TED Global conference in Oxford that a synthetic human brain would be of particular use finding treatments for mental illnesses.

Around two billion people are thought to suffer some kind of brain impairment, he said.

“It is not impossible to build a human brain and we can do it in 10 years,” he said.

“And if we do succeed, we will send a hologram to TED to talk.”

‘Shared fabric’

The Blue Brain project was launched in 2005 and aims to reverse engineer the mammalian brain from laboratory data.

In particular, his team has focused on the neocortical column — repetitive units of the mammalian brain known as the neocortex.

Neurons

The team are trying to reverse engineer the brain

“It’s a new brain,” he explained. “The mammals needed it because they had to cope with parenthood, social interactions complex cognitive functions.

“It was so successful an evolution from mouse to man it expanded about a thousand fold in terms of the numbers of units to produce this almost frightening organ.”

And that evolution continues, he said. “It is evolving at an enormous speed.”

Over the last 15 years, Professor Markram and his team have picked apart the structure of the neocortical column.

“It’s a bit like going and cataloguing a bit of the rainforest — how may trees does it have, what shape are the trees, how many of each type of tree do we have, what is the position of the trees,” he said.

“But it is a bit more than cataloguing because you have to describe and discover all the rules of communication, the rules of connectivity.”

The project now has a software model of “tens of thousands” of neurons — each one of which is different — which has allowed them to digitally construct an artificial neocortical column.

Although each neuron is unique, the team has found the patterns of circuitry in different brains have common patterns.

“Even though your brain may be smaller, bigger, may have different morphologies of neurons — we do actually share the same fabric,” he said.

“And we think this is species specific, which could explain why we can’t communicate across species.”

World view

To make the model come alive, the team feeds the models and a few algorithms into a supercomputer.

“You need one laptop to do all the calculations for one neuron,” he said. “So you need ten thousand laptops.”

Computer-generated image of a human brain

The research could give insights into brain disease

Instead, he uses an IBM Blue Gene machine with 10,000 processors.

Simulations have started to give the researchers clues about how the brain works.

For example, they can show the brain a picture — say, of a flower — and follow the electrical activity in the machine.

“You excite the system and it actually creates its own representation,” he said.

Ultimately, the aim would be to extract that representation and project it so that researchers could see directly how a brain perceives the world.

But as well as advancing neuroscience and philosophy, the Blue Brain project has other practical applications.

For example, by pooling all the world’s neuroscience data on animals — to create a “Noah’s Ark”, researchers may be able to build animal models.

“We cannot keep on doing animal experiments forever,” said Professor Markram.

It may also give researchers new insights into diseases of the brain.

“There are two billion people on the planet affected by mental disorder,” he told the audience.

The project may give insights into new treatments, he said.

The TED Global conference runs from 21 to 24 July in Oxford, UK.

Unique opportunity to sponsor research investigating an infectious cause and potential treatment for Alzheimer’s disease



Alzheimer’s disease afflicts some 20 million people world-wide, over 5 million people of whom reside in the United States. It is currently the seventh-leading cause of death in the US. The number of people with the disease is predicted to increase by over 50% by 2030. The economic as well as emotional costs are huge, the costs being estimated as more than $148 billion each year (direct and indirect, for of all types of dementia, to Medicare, Medicaid and businesses).

The causes of Alzheimer’s disease are unknown, apart from the very small proportion with familial disease. We are investigating the involvement of infectious agents in the disease, with particular emphasis on the virus that causes oral herpes/cold sores/fever blisters. We discovered that most elderly humans harbour this virus in their brains and that in those (and only those) who possess a certain genetic factor, the virus confers a strong risk of developing Alzheimer’s disease. Also, we found that the virus is directly involved with the characteristic abnormalities seen in the brains of Alzheimer’s disease patients.

There are several treatment possibilities available to combat this virus and all would be suitable candidates as therapies in Alzheimer’s disease. However, much more research is needed before trials of these agents for Alzheimer’s disease in humans can begin.

In these financially difficult times many funding bodies have to prioritise projects based around long established hypotheses. Projects involving new avenues of investigation can receive very positive comments by scientific reviewers, yet are rarely funded, as they almost always appear risky compared with projects largely confirming or expanding existing ideas. Such conservative projects are almost guaranteed to produce useful data, though with modest impact. This situation can mean that research proposals with the potential to transform our understanding of a disease and offer new approaches to its treatment never reach the threshold for funding and are not implemented, even though the potential and quality of the science is acknowledged by reviewers and funding panel.

It appears that our work examining a viral cause for Alzheimer’s disease is in this category. Despite our publishing a large number of potentially very exciting papers on this topic, and despite our research projects being reviewed favourably by scientific referees, few funding panels are prepared to commit resources to fund our work, as by doing so they deny funding to other more straightforward, very low risk projects.

We are therefore actively seeking sponsorship for several projects of varying costs to investigate the interaction of virus and specific genetic factor, the pathways of viral damage in the brain, and the effects of antiviral agents. All the projects would provide significant evidence strengthening the case for trialling antiviral agents in Alzheimer’s disease.

Antiviral agents would inhibit a likely major cause of the disease in contrast to current treatments, which merely inhibit the symptoms.

If any Lifeboat member knows of a company or individual that would be interested in sponsoring some of our research on Alzheimer’s disease then please contact me for further details.

Ruth Itzhaki

Contact details:

[email protected]

Faculty of Life Sciences, Moffat Building, The University of Manchester, Manchester M60 1QD, UK


Further reading:

The Times, London

http://www.timesonline.co.uk/tol/news/uk/health/article5295794.ece

Journal of Pathology
http://www3.interscience.wiley.com/journal/121411445/abstract

The Lancet
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(96)10149-5/abstract


I would gladly email any further information.