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Category: neuroscience

In order to find a way to trick the body into making new B cells, the researchers probed one of the ways that the body naturally replenishes its supply. Patients undergoing treatment for multiple sclerosis had their MBC stock depleted, at which point their body rapidly started to produce new B cells.

The team identified the specific hormones that shut B cell production down again once stores were replenished, and realized that deactivating the hormone results in the body producing extra B cells left and right. And going forward, they hope to turn that hormonal trick into a new rejuvenating treatment for the elderly and immunocompromised.

“We found specific hormonal signals produced by the old B cells, the memory cells, that inhibit the bone marrow from producing new B cells,” Melamed told The Jerusalem Post. “This is a huge discovery. It is like finding a needle in a haystack.”

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Recent advances have put some interesting possibilities on the table when it comes to tackling hair loss, from topical solutions packed with stem cells, to 3D-printed hair farms, to growing hair with a patient’s own cells. Scientists in China are now throwing another one into the mix that uses a dissolvable microneedle patch to stimulate hair growth, with the technology proving high effective in mouse models of hereditary pattern baldness.

Led by scientists at China’s Zhejiang University, the researchers set out to develop new treatments for the most common of hair loss conditions: male-and female-pattern baldness, also known as androgenic alopecia. The scientists sought to tackle the issue by focusing on what they say are the primary mechanisms behind this, namely oxidative stress and poor circulation.

This relates to the combination of accumulating reactive oxygen species in the scalp that kill off the cells behind new hair growth, and a lack of blood vessels around the follicles to provide them with nutrients and essential molecules. In this way, the team hoped to come up with a two-pronged approach to androgenic alopecia, and their solution starts with previous research carried out on liver injuries and Alzheimer’s.

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Summary: Researchers have discovered a new molecule that could increase the ultra-fast decision-making capabilities of computers. The simple molecule provides a new electronic circuit element in which complex logic is encoded in nanoscale material properties.

Source: University of Limerick.

An international team of scientists including researchers at University of Limerick in Ireland has discovered a new molecule that could further increase ultra-fast decision making in computers.

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Mushrooms and other kinds of fungi are often associated with witchcraft and are the subjects of longstanding superstitions. Witches dance inside fairy rings of mushrooms according to German folklore, while a French fable warns that anyone foolish enough to step inside these ‘sorcerer’s rings’ will be cursed by enormous toads with bulging eyes. These impressions come from the poisonous and psychoactive peculiarities of some species, as well as the overnight appearance of toadstool ring-formations.

Given the magical reputation of the fungi, claiming that they might be conscious is dangerous territory for a credentialled scientist. But in recent years, a body of remarkable experiments have shown that fungi operate as individuals, engage in decision-making, are capable of learning, and possess short-term memory. These findings highlight the spectacular sensitivity of such ‘simple’ organisms, and situate the human version of the mind within a spectrum of consciousness that might well span the entire natural world.

Before we explore the evidence for fungal intelligence, we need to consider the slippery vocabulary of cognitive science. Consciousness implies awareness, evidence of which might be expressed in an organism’s responsiveness or sensitivity to its surroundings. There is an implicit hierarchy here, with consciousness present in a smaller subset of species, while sensitivity applies to every living thing. Until recently, most philosophers and scientists awarded consciousness to big-brained animals and excluded other forms of life from this honour. The problem with this favouritism, as the cognitive psychologist Arthur Reber has pointed out, is that it’s impossible to identify a threshold level of awareness or responsiveness that separates conscious animals from the unconscious. We can escape this dilemma, however, once we allow ourselves to identify different versions of consciousness across a continuum of species, from apes to amoebas. That’s not to imply that all organisms possess rich emotional lives and are capable of thinking, although fungi do appear to express the biological rudiments of these faculties.

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Integrated Information Theory is one of the leading models of consciousness. It aims to describe both the quality and quantity of the conscious experience of a physical system, such as the brain, in a particular state. In this contribution, we propound the mathematical structure of the theory, separating the essentials from auxiliary formal tools. We provide a definition of a generalized IIT which has IIT 3.0 of Tononi et al., as well as the Quantum IIT introduced by Zanardi et al. as special cases. This provides an axiomatic definition of the theory which may serve as the starting point for future formal investigations and as an introduction suitable for researchers with a formal background.

Integrated Information Theory (IIT), developed by Giulio Tononi and collaborators [5, 45–47], has emerged as one of the leading scientific theories of consciousness. At the heart of the latest version of the theory [19, 25 26, 31 40] is an algorithm which, based on the level of integration of the internal functional relationships of a physical system in a given state, aims to determine both the quality and quantity (‘Φ value’) of its conscious experience.

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The most powerful way to combat anxiety is to consistently work on building your resilience and mental strength. “Along the way, you’ll learn to appreciate or even welcome certain kinds of mistakes for all the new information they bring you,” says neuroscientist Wendi Suzuki.

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Summary: Researchers find a region of the brain stem called the periaqueductal gray may mediate religiosity and spirituality in humans.

Source: Elsevier.

Scientists have long suspected that religiosity and spirituality could be mapped to specific brain circuits, but the location of those circuits remains unknown. Now, a new study using novel technology and the human connectome, a map of neural connections, has identified a brain circuit that seems to mediate that aspect of our personality.

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I believe the transduction theory has a great deal to offer in our scientific study of the mind–brain relationship. It is, of course, a dualist theory. It provides a framework for understanding the close link between brain states and mental states, yet at the same time, it explains mental states in a way that does not invoke nonsensical materialist metaphysics.

A successful understanding of the mind–brain relationship will necessarily involve understanding the brain as a transduction device in one way or another. Such an understanding could prove enormously fruitful and can help us move beyond the current materialist framework in which neuroscience is practiced, which has has held us so far back in our understanding of the mind and the brain. The brain is obviously material but it is just as obvious that the mind has immaterial abilities.

We accept that the ear is a transducer for sound to hearing and the eye is a transducer for light to vision. It is reasonable to infer that the brain is a transducer for thought to body. Transduction theory is a plausible approach to understanding the connection between the mind and the brain. It should be taken seriously by neuroscientists and philosophers of the mind.

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Quantum mechanics generally refers to the wave-like properties of things that are commonly considered to be particles, such as electrons. This article discusses evidence of a quantum mechanical switching function that is performed by strictly biological structures—ferritin protein layers that are found in cells including neural tissue.

Many scientists are investigating quantum biology, which is the application of quantum mechanics to investigate biological functions. It has recently been used to answer a number of previously unanswered questions, such as the mechanisms behind photosynthesis and the way birds can perceive magnetic fields. These quantum biological effects generally involve electrons hopping or tunneling over distances of several nanometers, behavior that is incompatible with particles but which makes sense with waves.

Ferritin is a spherical iron storage protein that is found in plants and animals. Early studies of ferritin to look for quantum mechanical effects were conducted at cryogenic temperatures, because it was thought that biological structures were too “warm and wet” to exhibit such effects. Those studies were somewhat inconclusive. But when ferritin was subsequently electrically tested at room temperature, it was discovered that electron tunneling was occurring.

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