Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: neuroscience

A scrupulous gatekeeper stands between the brain and its circulatory system to let in the good and keep out the bad, but this porter, called the blood-brain barrier, also blocks trial drugs to treat diseases like Alzheimer’s or cancer from getting into the brain.

Now a team led by researchers at the Georgia Institute of Technology has engineered a way of studying the barrier more closely with the intent of helping drug developers do the same. In a new study, the researchers cultured the human on a , recreating its physiology more realistically than predecessor chips.

The new chip devised a healthy environment for the barrier’s central component, a brain cell called the , which is not a neuron, but which acts as neurons’ intercessors with the circulatory system. Astrocytes interface in with cells in the vasculature called endothelial cells to collaborate with them as the blood-brain barrier.

Read more | >

Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N = 798), Lothian Birth Cohort 1921 (LBC1921, N = 165), and the INTERVAL BioResource (N = 4451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between −0.11 and −0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.

Read more | >

Neuroscientists-can-now-design-false-memories-and-plant-them-into-animal-brains.

Jake Anderson, The Mind Unleashed Waking Times

Scientists have known for some time that specific circuits in the brain react to experiences and encode those same experiences into our minds as memories. These memories are central to our identity and the narrative we construct about ourselves and the world around us.

In past experiments, neuroscientists have been able to partially transfer memories between rodents but they have never wholesale manufactured false memories—until now.

Read more | >

A research team has shown that a key difference between neurogenic and non-neurogenic tissues is cross-linking proteins causing stiffness, a discovery that could be used to create new brain injury therapies.

Researchers compared the proteomes of regions in the brain that are neurogenic (neural stem cell niches) and those that are not (cerebral cortex). The scientists hope that by establishing how these tissues are different, future therapies for brain injury may be able to activate tissues to produce new neurons to repair the brain.

Read more | >

Antidepressant-soil.

Soil microbes have been found to have similar effects on the brain as prozac, without the negative side effects and potential for chemical dependency and withdrawal.

It turns out getting in the garden and getting dirty is a natural antidepressant due to unique microbes in healthy organic soil. Working and playing in soil can actually make you happier and healthier.

What gardeners and farmers have talked about for millennia is now verifiable by science. Feeling like your garden or farm is your happy place is no coincidence!

Read more | >

Bernardeta Gómez has been blind for 16 years. But using a bionic eye developed by Spanish neuroengineer Eduardo Fernandez, she was able to see again — without using her biological eyes at all.

The system, which Fernandez is honing at his University of Miguel Hernandez lab, comprises a few different parts, as detailed in a newly-published story in MIT Technology Review.

First, there’s a pair of glasses fitted with a camera that connects to a computer. The computer translates the camera’s live video feed into electronic signals. Those signals are then sent via a cable to a port that Fernandez surgically embedded in the back of Gómez’s skull. That port connects to an implant in the visual cortex of Gómez’s brain.

Read more | >