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Dr. Theodore Ho talks about the rapidly expanding possibilities of stem cells to be used in reversing or slowing the aging process. He discusses his previous and current work with the brain, including such methods as tissue clearing, multifiber photometry and optogenetics, and single resolution calcium imaging and control. Dr. Ho is a neuroscientist and stem cell biologist studying the mechanisms and causes of biological aging and potential strategies to slow or reverse them, in order to prevent the onset of age

Associated diseases to help us live healthier and longer lives.

He completed a four-year joint bachelor’s/master’s degree program in.

Human developmental and regenerative biology/bioengineering at.

Harvard University, and he received his PhD in Biophysics from the.

University of California San Francisco, studying stem cell aging in the lab of Dr. Emmanuelle Passegue. In college he developed a nanoparticle drug delivery system, in graduate school he discovered previously unknown mechanisms of cellular and molecular aging of stem cells, and now in the Deisseroth lab he is using optical recording and perturbation of neuronal activity to study neural circuit dynamics that control behavior. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

The FDA has cleared the world’s first portable MRI system, designed to be wheeled to a hospital bedside for scanning a patient’s head and brain.

Developed by Hyperfine Research for people age two and older, the point-of-care imaging system weighs about one-tenth that of a conventional, fixed MRI system. About three feet wide and five feet tall, the device fits in an elevator and runs off an everyday power outlet to create both clinical contrast images and 3D renders.

“More than 40 years after its first use, MRI remains a marvel. Unfortunately, it also remains inaccessible,” Hyperfine Chief Medical Officer Khan Siddiqui said in a statement. “It’s time that MRI made the jump to point of need just like X-ray and ultrasound have before it.”

Glioblastomas are relentless, hard-to-treat, and often lethal brain tumors. Yale scientists have enlisted a most unlikely ally in efforts to treat this form of cancer — elements of the Ebola virus.

“The irony is that one of the world’s deadliest viruses may be useful in treating one of the deadliest of brain cancers,” said Yale’s Anthony van den Pol, professor of neurosurgery, who describes the Yale efforts Feb. 12 in the Journal of Virology.

The approach takes advantage of a weakness in most cancer tumors and also of an Ebola defense against the immune system response to pathogens.

Hart’s demonstrations are entertainment for sure. But his message runs deeper: rhythm and vibration heal the brain. Dementia, he says, is the “loss of rhythm.” And he, along with notables who collaborated on the event — University of California at San Francisco neuroscientist Adam Gazzaley and opera singer Renée Fleming (who lent her soprano to the event’s musical track) — are all at work searching for pathways that can bypass obstacles to function and cognition. Hart has also worked with Dr. Connie Tomaino, who runs the Institute for Music and Neurologic Function, on music as a therapeutic tool for brain function.

Gazzaley is currently conducting clinical trials with healthy older adults to show how a regular regimen of digital rhythm can enhance attention and memory in people with cognitive impairment. Hart has been working with Gazzaley on what will be a downloadable app, their goal to develop a game that challenges one’s rhythmic ability, with the hope of building new neuropathways in the brain. “What we’re talking about here is a deeper and longer immersive experience which can actually harness the brain’s plasticity to change the way it functions,” says Gazzaley.

Taking up an instrument as a child, and playing through adulthood is one proven way to protect one’s brain. But learning later in life is helpful, too. Hart shares the story of his unlikely best friend, Walter Cronkite, who was 73 when he became a Deadhead, and also started playing the drums. In July of 2009, as Cronkite lay dying from complications of cerebrovascular disease, Hart handed him a hand drum. “He could no longer speak, but he could play,” Hart says, tears in his eyes. “He used to ask, ‘When we do we know we have found our groove?’ Well, he found it.”

Yes! In this video with my dear friend, artist Nicholas Wilton, I review the scientific data linking creativity and disease remission from Mind Over Medicine. Plus, Nick reads the quote he wrote in Brene Brown’s Daring Greatly about art-making as treatment for perfectionism. If you or someone you love has been hoping to become a “health outlier” who experiences a better than usual outcome from a health struggle, or if you just love art and want to improve your art-making as part of your prescription for optimal health and a vital, fully expressed life, we hope this will offer you inspiration—and a few medicinal laughs! (As an OB/GYN, I couldn’t resist drawing the female reproductive systems when we got to the art-making part.)

Nick will be teaching a wonderful free online art class ART 2 LIFE that starts on Valentine’s Day, so give yourself this gift of your love of art-making. You can sign up for the free course here. https://share.tellafrienda2l.com/a/a2lworkshop/LissaR

“” This cancer seems simple. Basically, it has been known for many years it is just one type of cells that proliferate out of control,” Zong said. “However, we noticed an interesting paradox. While tumor cells grow really fast in the body, they grow poorly and only for a limited time when we take them out and put them in a [lab] dish. So we suspected some other cells may be in play.”

His investigation of that suspicion turned science’s understanding of medulloblastoma on its head. Using an innovative model of the disease, Zong and his team marked tumor cells so that they would appear green. That led to the first surprise: While all other cell types outside the tumor are colorless, a cell type called astrocyte appeared green, which never happens in normal brain regions.

“Astrocyte actually has been linked to poor prognosis of medulloblastoma, but nobody has ever suspected its origin, since the cell of origin for medulloblastoma normally never gives rise to astrocytes. The fact that tumor-associated astrocytes share the same color with tumor cells suggests that they actually come from tumor cells,” he said. “So some tumor cells basically completely change their identity to make a separate cell type.”

That was a shocker on its own. But it proved to be just the beginning of a complex process that nurtures the growth of this “simple” cancer.”


A surprising discovery about a rare form of childhood brain cancer suggests a new treatment approach for that cancer—and potentially many others.

Researchers at the University of Virginia School of Medicine have determined that the supposedly simple , called medulloblastoma, forms an unexpectedly intricate network to drive its growth. Some cells actually turn into another type of cell altogether. The discovery raises the exciting possibility that doctors may be able to intervene to stop the disease—and possibly other cancers as well.

Lead researcher Hui Zong of UVA’s Department of Microbiology, Immunology and Cancer Biology and the UVA Cancer Center suspects this network formation is common in cancer.

A molecular switch has been identified by scientists at the University of California that controls the immune machinery which is responsible for chronic inflammation within the body; findings published in the journal Cell Metabolism may lead to new ways to halt and/or reverse age related conditions such as cancer, diabetes, Alzheimer’s and Parkinson’s disease.

“My lab is very interested in understanding the reversibility of aging,” said senior author Danica Chen, associate professor of metabolic biology, nutritional sciences and toxicology at UC Berkeley. “In the past, we showed that aged stem cells can be rejuvenated. Now, we are asking: to what extent can aging be reversed? And we are doing that by looking at physiological conditions, like inflammation and insulin resistance, that have been associated with aging-related degeneration and diseases.”

A bulky collection of NLRP3 inflammasome immune proteins which are responsible for sensing potential threats to the body and launching an inflammatory response were shown to be essentially switched off by removing some molecular matter in a deacetylation process. Overactivation of NLRP3 inflammasomes is linked to a range of chronic conditions such as cancer, dementia, diabetes, and multiple sclerosis; this study suggests that drugs targeted towards deacetylation these NLRP3 inflammasomes may help to prevent and/or treat many age related conditions and even possibly age related degeneration itself in general.