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Category: neuroscience

Neuroplasticity is the brain’s ability to change under the influence of experience and activities. Several aspects of neuroplasticity are noteworthy: neurogenesis (development of new nerve cells) and synaptogenesis (development of new contacts between nerve cells) among them. Neuroplasticity used to be thought of as a limited phenomenon, mostly restricted to the early years of life. More recently it has been demonstrated that neuroplasticity continues throughout life, even in advanced age. This provides the conceptual basis for a wide range of therapeutic efforts aiming to slow the detrimental effects of aging on the brain and to treat various brain disorders.

What are the factors influencing neuroplasticity? The question is compelling both as a scientific challenge and because of the therapeutic promise of neuroplasticity once we know how to control and harness it. Among such factors, the environmental factors influencing neuroplasticity are particularly intriguing. It turns out that a strong relationship exists between what people do with their brains and how their brains age.

Both anecdotal observations and formal research suggest that education confers a protective effect against dementia. Highly educated people are less likely to succumb to its effects. Robert Katzman was the first to note that the prevalence of dementia, including Alzheimer’s disease, is lower in people with advanced education. The MacArthur Foundation Research Network on Successful Aging sponsored a study of the predictors of cognitive change in older persons. Education emerged as by far the most powerful predictor of cognitive vigor in old age.

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(CNN) — Scientists have long known our brains need sleep to review the day’s events and transfer them into longer-term memories. Students are often told to study just before turning in to maximize their recall of material for a test the next day.

But the exact way in which the brain stores our memories is poorly understood.

Now for the first time, tiny microelectrodes planted inside the brains of two people show just how the brain’s neurons fire during sleep to “replay” our short-term memories in order to move them into more permanent storage. The study was published Tuesday in the journal Cell Reports.

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We repurposed some tools from the Stem Cell Therapy for Cancer/Brain Tumor. Those tools are T-Cells, B-Cells, and Natural Killer Cells. Instead of programming those cancer killing cells to attack cancer cells, we have programmed them to seek out, identify, attack, and destroy all the Coronavirus cells in the entire body.

Stem Cell Neurotherapy sends therapeutic messages, e.g., “your stem cells are transforming into new cells for the lungs, liver, and kidneys” to the DNA inside the nucleus of stem cells. Inside the nucleus, the DNA receives the message and transmits it to the RNA, which translates the message into genetic code.

The genes inside the stem cells transmit the coded message to the proteins, which are converted by the mitochondria into ATP, which provides the energy for the coded message to transform the stem cells into a new set of lung cells, as well as new cells for the kidneys and liver.

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Scientists in Hong Kong recently completed a clinical study in which they found that administering a cocktail of three different anti-viral medications to patients enduring mild coronavirus symptoms “may rapidly suppress the amount of virus in a patient’s body.”

The three-drug anti-viral cocktail is made up of the HIV medication lopinavir-ritonavir, the hepatitis therapy drug ribavirin and the multiple sclerosis treatment interferon-beta.

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If you really have the need for speed, you could get it on the ground. But if you’re looking more for stuff that can break the sound barrier many times over, you should consider looking up. That’s the hint casually dropped by aeronautic manufacturer Lockheed Martin, which has mulled over revisiting the idea of a hypersonic revamp. In this case, they’re reportedly looking at an upgrade of the old SR-71 “Blackbird” that first took to the air nearly 60 years ago.

Lockheed Martin’s Skunk Works department has been making noises about a revival of the legendary bomber, a jet that was capable of flying up to Mach 3. That’s slightly more than 3,700 mph, about one and a half times speedier than the .220 Swift, reportedly the fastest bullet ever produced.

But the Skunk Work’s brain trust claims the SR-72 might even double the speed of its predecessor. That’s a tricky proposition considering the plane’s air intake would be brutal at those speeds, like trying to start a campfire in gale-force winds.

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Young blood plasma is known to confer beneficial effects on various organs in mice. However, it was not known whether young plasma rejuvenates cells and tissues at the epigenetic level; whether it alters the epigenetic clock, which is a highly-accurate molecular biomarker of aging. To address this question, we developed and validated six different epigenetic clocks for rat tissues that are based on DNA methylation values derived from n=593 tissue samples. As indicated by their respective names, the rat pan-tissue clock can be applied to DNA methylation profiles from all rat tissues, while the rat brain-, liver-, and blood clocks apply to the corresponding tissue types. We also developed two epigenetic clocks that apply to both human and rat tissues by adding n=850 human tissue samples to the training data. We employed these six clocks to investigate the rejuvenation effects of a plasma fraction treatment in different rat tissues. The treatment more than halved the epigenetic ages of blood, heart, and liver tissue. A less pronounced, but statistically significant, rejuvenation effect could be observed in the hypothalamus. The treatment was accompanied by progressive improvement in the function of these organs as ascertained through numerous biochemical/physiological biomarkers and behavioral responses to assess cognitive functions. Cellular senescence, which is not associated with epigenetic aging, was also considerably reduced in vital organs. Overall, this study demonstrates that a plasma-derived treatment markedly reverses aging according to epigenetic clocks and benchmark biomarkers of aging.

Several authors are founders, owners, employees (Harold Katcher and Akshay Sanghavi) or consultants of Nugenics Research (Steve Horvath and Agnivesh Shrivastava) which plans to commercialize the “Elixir” treatment. Other authors (Kavita Singh, Shraddha Khairnar) received financial support from Nugenics Research. The other authors do not have conflict of interest.

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O,.o…

Organoids have become an important tool for studying many disease processes and testing potential drugs. Now, they are being used in a surprising and unexpected way: for the production of snake venom. On January 23 in the journal Cell, researchers are reporting that they have created organoids of the venom glands of the Cape coral snake (Aspidelaps lubricus cowlesi) and that these glands are capable of producing venom.

“More than 100,000 people die from snake bites every year, mostly in developing countries. Yet the methods for manufacturing antivenom haven’t changed since the 19th century,” says senior author Hans Clevers of the Hubrecht Institute for Developmental Biology and Stem Cell Research at Utrecht University in the Netherlands. “It’s clear there is a huge unmet medical need for new treatments.”

He adds: “Every snake has dozens of different components in their venom. These are extremely potent molecules that are designed to stop prey from running away. They affect systems as varied as the brain, neuromuscular junctions, blood coagulation, and more. Many of them have potential bioprospecting applications for new drugs.”

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Education Saturday with Space Time.

Why is it that we can see these multiple histories play out on the quantum scale, and why do lose sight of them on our macroscopic scale? Many physicists believe that the answer lies in a process known as quantum decoherence.

Does conscious observation of a quantum system cause thefunction to collapse? The upshot is that more and more physicists think that consciousness – and even measurement – doesn’t directly causefunction collapse. In fact probably there IS no clear Heisenberg cut. The collapse itself may be an illusion, and the alternate histories that thefunction represents may continue forever. The question then becomes: why is it that we can see these multiple histories play out on the quantum scale, and why do lose sight of them on our macroscopic scale? Many physicists believe that the answer lies in a process known as quantum decoherence.

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