Tapping into both AlphaFold and RoseTTAFold, they tweaked the programs to predict which proteins are likely to tag-team and sketched up the resulting complexes into a 3D models.
Using AI, the team predicted hundreds of complexes—many of which are entirely new—that regulate DNA repair, govern the cell’s digestive system, and perform other critical biological functions. These under-the-hood insights could impact the next generation of DNA editors and spur new treatments for neurodegenerative disorders or anti-aging therapies.
Nanoscale machinery has many uses, including drug delivery, single-atom transistor technology, or memory storage. However, the machinery must be assembled at the nanoscale, which is a considerable challenge for researchers.
For nanotechnology engineers the ultimate goal is to be able to assemble functional machinery part-by-part at the nanoscale. In the macroscopic world, we can simply grab items to assemble them. It is not impossible to “grab” single molecules anymore, but their quantum nature makes their response to manipulation unpredictable, limiting the ability to assemble molecules one by one. This prospect is now a step closer to reality, thanks to an international effort led by the Research Centre Jülich of the Helmholtz society in Germany, including researchers from the Department of Chemistry at the University of Warwick.
In the paper, “The stabilization potential of a standing molecule,” published today, 10 November 2021 in the journal Science Advances, an international team of researchers has been able to reveal the generic stabilization mechanism of a single standing molecule, which can be used in the rational design and construction of three-dimensional molecular devices at surfaces.
From super-strength concrete to fortified infrastructure, this is what the ‘wonder material for the 21st century’ is now bringing to construction. For more by Tomorrow’s Build subscribe now — https://bit.ly/3vOOJ98
Executive Producer and Narrator — Fred Mills. Producer — Adam Savage. Video Editing and Graphics — Thomas Canton.
Special thanks to Dr Lisa Scullion and University of Manchester. Additional footage and images courtesy of University of Manchester, Absolute Photography, Gerdau Graphene, Graphene Flagship, HS2 Ltd, ICON Technology, Kansas State University, NASA/Pat Rawlings, Nanotech Energy and Skanska.
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Forget all the nanotechnology devoted to fighting cancer, and just consider that nanoparticles have invaded makeup, anti-odor socks, sunscreen, plastic beer bottles and home pregnancy tests. Now scientists have developed a way to assess the health and environmental impact of such nanoparticles: a tiny microresonator that can detect and measure individual particles smaller than a single virus.
The microresonator is a lab-on-a-chip that harnesses the “whispering gallery” concept that’s displayed by buildings such as St. Paul’s Cathedral in London. The cathedral’s domed gallery can carry whispers easily across to the other side, but normal-volume voices end up garbled after bouncing around the dome multiple times.
Similarly, microresonators can bounce laser light many times around a circular “waveguide,” such as a glass ring. A laser frequency must perfectly fit the circumference of a ring to achieve this whispering-gallery mode.
Elon Musk’s revolutionary company Neuralink plans to insert Computer Chips into peoples brains but what if there’s a safer and even more performant way of merging humans and machines in the future? Enter DARPAs plan to help the emergence of non-invasive brain computer interfaces which led to the organization Battelle to create a kind of Neural Dust to interface with our brains that might be the first step to having Nanobots inside of the human body in the future.
How will Neuralink deal with that potential rival with this cutting edge technology? Its possibilities in Fulldive Virtual Reality Games, Medical Applications, merging humans with artificial intelligence and its potential to scale all around the world are enormous.
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Researchers in Korea succeeded in developing a core material for the next-generation neuromorphic (neural network imitation) semiconductor for the first time in the country. This is a result of a research team led by Dr. Jung-dae Kwon and Yong-hun Kim of the Department of Energy and Electronic Materials of the Korea Institute of Materials Science, together with Professor Byungjin Cho’s research team at Chungbuk National University. KIMS is a government-funded research institute under the Ministry of Science and ICT.
This new concept memtransistor uses a two-dimensional nanomaterial with a thickness of several nanometers. By reproducibly imitating the electrical plasticity of nerve synapses with more than 1,000 electrical stimulations, the researchers succeeded in obtaining a high pattern recognition rate of about 94.2% (98% of simulation-based pattern recognition rate).
Molybdenum sulfur (MoS2), widely used as a semiconductor material, works on the principle that defects in a single crystal are moved by an external electric field, which makes it difficult to precisely control the concentration or shape of the defect. To solve the problem, the research team sequentially stacked an oxidic layer of niobium oxide (Nb2O5) and a molybdenum sulfur material and succeeded in developing an artificial synaptic device having a memtransistor structure with high electrical reliability by an external electric field. In addition, they have demonstrated that the resistance switching characteristics can be freely controlled by changing the thickness of the niobium oxidic layer, and that brain information related to memory and forgetting can be processed with a very low energy of 10 PJ (picojoule).
Micro-electro-mechanical devices (MEMS) are based on the integration of mechanical and electrical components on a micrometer scale. We all use them continuously in our everyday life: For example, in our mobile phones there are at least a dozen MEMS that regulate different activities ranging from motion, position, and inclination monitoring of the phone; active filters for the different transmission bands, and the microphone itself.
Even more interesting is the extreme nanoscale miniaturization of these devices (NEMS), because it offers the possibility of creating inertial, mass and force sensors with such sensitivity that they can interact with single molecules.
However, the diffusion of NEMS sensors is still limited by the high manufacturing cost of traditional silicon-based technologies. Conversely, new technologies such as 3D printing have shown that similar structures can be created at low cost and with interesting intrinsic functionalities, but to date the performance as mass sensors are poor.
Scientists at the University of Southampton have achieved a data storage breakthrough, offering intense density and long-term archiving capabilities. With this new data storage, you can easily store up to 500 terabytes on a single CD-sized disc. Whether the data is information from museums and libraries to a person’s DNA records, it can store it all and much more!
This technology is known as five-dimensional (5D) optical storage and was first demonstrated back in 2013 when scientists were successful in using it to record and retrieve a 300-kb text file. It might not seem like much, but at that time, it was a breakthrough in data storing technologies just like how floppy discs played the same part some thousand years ago.
The data is written using a femtosecond laser which emits short but powerful pulses of light, forging tiny structures in glass that are measured in nanoscale. These structures contain information on the intensity and polarization of the laser beam in addition to the 3D space, hence it is referred as 5D data storage.
Gallium arsenide (GaAs) has long been touted as the best material for making high-efficiency solar cells because of its extraordinary light absorption and electrical characteristics. It has most notably been put to use in space solar panels.
These GaAs solar cells, however, are extremely pricey to produce resulting in a demand for methods that cut down on the material usage. That’s where nanowire structures come in. These elements can potentially enhance solar cell efficiency compared to standard planar solar cells while utilizing less material.
By using GaAs in the nanowire structures, the team of researchers has found a new way to make an ultrahigh power-per-weight ratio solar cell that is more than 10 times more efficient than any other solar cell.
According to Klaus Schwab, the founder and executive chair of the World Economic Forum (WEF), the 4-IR follows the first, second, and third Industrial Revolutions—the mechanical, electrical, and digital, respectively. The 4-IR builds on the digital revolution, but Schwab sees the 4-IR as an exponential takeoff and convergence of existing and emerging fields, including Big Data; artificial intelligence; machine learning; quantum computing; and genetics, nanotechnology, and robotics. The consequence is the merging of the physical, digital, and biological worlds. The blurring of these categories ultimately challenges the very ontologies by which we understand ourselves and the world, including “what it means to be human.”
The specific applications that make up the 4-R are too numerous and sundry to treat in full, but they include a ubiquitous internet, the internet of things, the internet of bodies, autonomous vehicles, smart cities, 3D printing, nanotechnology, biotechnology, materials science, energy storage, and more.
While Schwab and the WEF promote a particular vision for the 4-IR, the developments he announces are not his brainchildren, and there is nothing original about his formulations. Transhumanists and Singularitarians (or prophets of the technological singularity), such as Ray Kurzweil and many others, forecasted these and more revolutionary developments,. long before Schwab heralded them.The significance of Schwab and the WEF’s take on the new technological revolution is the attempt to harness it to a particular end, presumably “a fairer, greener future.”