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A quick look at synthetic biology and its potential for health and treating age-related diseases.


All living organisms contain an instruction set that determines what they look like and what they do. These instructions are encoded in the organism’s DNA within every cell, this is an organism’s genetic code (or “genome”).

Mankind has been altering the genetic code of plants and animals for thousands of years, by selectively breeding individuals with desired features. Over time we have become experts at viewing and manipulating this code, and we can now take genetic information associated with the desired features from one organism, and add it into another one. This is the basis of genetic engineering, which has allowed us to speed up the process of developing new breeds of plants and animals.

More recent advances however have enabled scientists to create new sequences of DNA from scratch. By combining these advances in biology with modern engineering, chemistry and computer science, researchers can now design and construct new organisms with cells that perform new useful functions. This “customised” cell biology is the essence of synthetic biology.

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Treatment for certain diabetes cases involves constant monitoring of blood-glucose levels and daily insulin shots. But scientists are now developing a painless “smart” patch that monitors blood glucose and releases insulin when levels climb too high. The report on the device, which has been tested on mice, appears in the journal ACS Nano.

People with Type 1 diabetes don’t make insulin—a hormone that regulates , or sugar. Those with Type 2 diabetes can’t use insulin effectively. Either way, glucose builds up in the blood, which can lead to a host of health problems, including heart disease, stroke, blindness and amputation of toes, feet or legs. To avoid these outcomes, people with Type 1 or advanced Type 2 diabetes regularly prick their fingers to measure blood-sugar levels, and some patients must inject themselves with insulin when needed. But sometimes, despite a person’s vigilance, can still get out of whack. Zhen Gu and colleagues wanted to come up with a simpler, more effective, shot-free way to manage diabetes.

The researchers developed a skin patch covered in painless microneedles that are loaded with tiny insulin-carrying pouches. The pouches are engineered to break apart rapidly and release the insulin in response to rising glucose levels. Diabetic mice wearing the patch maintained consistent concentrations of insulin in their blood. When these mice received a shot of glucose, their spiked initially, but then fell to normal levels within two hours.

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It seems more likely what you remove is more important than what you add with old blood.


The evidence is increasingly suggesting that dilution of pro-aging signals is why we are seeing rejuvenation when blood is exchanged between young and old animals. Forget transfusions the next step is to filter our own blood to promote health as we age.

#aging #crowdfundthecure

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We are at the cusp of a stem cell revolution.

Understanding and harnessing these unique cells may unlock breakthroughs in longevity and therapeutic solutions to all kinds of chronic diseases and regenerative opportunities.

Last month, I took a trip down to the Stem Cell Institute in Panama City with Dr. Bob Hariri (co-Founder of Human Longevity Inc.) to get stem cell injections in my knee and shoulder as an alternative to reconstructive surgery.

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Interesting.


TUESDAY, Jan. 17, 2017 (HealthDay News) — Just a half hour a day of moderate physical activity could be potent medicine for patients with advanced colon cancer, preliminary research suggests.

Study authors who tracked more than 1,200 colon cancer patients found a 19 percent decline in risk for early death among those who got 30 minutes or more of moderate exercise daily.

And, five or more hours of moderate — but non-vigorous — activity a week pushed that survival benefit to 25 percent, researchers said.

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Antibiotic-resistant superbugs are now killing more people than breast cancer, according to a new data analysis by the UK Sepsis Trust.

According to the British Department of Health, about 5,000 people die each year from drug-resistant infections. But the UK Sepsis Trust and others have criticized these figures for being based on studies conducted in other countries, many of them with flawed methodology.

For the new analysis, the UK Sepsis Trust looked at the Department of Health’s own data to come up with an estimate of 12,000 killed per year by superbugs — more than twice as high as the current estimate.

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Pretty soon, your smart watch may know you’re sick before you do, according to US scientists. The researchers made an app which tracked health data — such as heart rate and skin temperature — collected by 60 people’s smart watches for up to two years, and found that people’s stats changed when they were getting sick.

The authors say smart watches could also help detect the risk of type 2 diabetes and low oxygen on planes, and that they even helped detect Lyme disease in one of the scientists behind the study.

Smart watches and similar portable devices are commonly used for measuring steps and physiological parameters, but have not generally been used to detect illness.

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Exercise is one of the best ways to slow down aging and its free too!


(Boston) — Older adults who experience good cardiac fitness may be also keeping their brains in good shape as well.

In what is believed to be the first study of its kind, older adults who scored high on cardiorespiratory fitness (CRF) tests performed better on memory tasks than those who had low CRF. Further, the more fit older adults were, the more active their brain was during learning. These findings appear in the journal Cortex. Difficulty remembering new information represents one of the most common complaints in aging and decreased memory performance is one of the hallmark impairments in Alzheimer’s disease.

Healthy young (18−31 years) and older adults (55−74 years) with a wide range of fitness levels walked and jogged on a treadmill while researchers assessed their cardiorespiratory fitness by measuring the ratio of inhaled and exhaled oxygen and carbon dioxide. These participants also underwent MRI scans which collected images of their brain while they learned and remembered names that were associated with pictures of unfamiliar faces.

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Last year, doctors in the United States were unable to treat a patient infected with a bacterial strain that was resistant to 26 different antibiotics. After subjecting the bacteria to multiple tests, the doctors found it to be “resistant to all available antimicrobial drugs”, and the 70-year-old patient unfortunately died from the infection.

Detailed in a newly released Centers for Disease Control and Prevention report, the case highlights the significant threat that the emergence of highly resistant bacteria is becoming to global public health. The woman in the report was initially admitted to a hospital in Reno, Nevada, after she had returned from an extended trip to India with an infected swelling in her right hip.

After doctors conducted tests, they found she was infected with a form of carbapenem-resistant Enterobacteriaceae known as Klebsiella pneumoniae. Normally living in the gut without causing any issues, K. pneumoniae is opportunistic in its infection. It seems that in the case of the woman in this latest report, the infection entered the bone after a femur fracture in India, and then subsequently spread to her hip.

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Bigger question is what happens when it begins to impact it’s other neighbors including Japan and Tiawan?

Bigger question is what happens when it begins to impact it’s other neighbors including Japan and Taiwan?


Hongkongers were forced to breathe China’s airpocalypse smog over the weekend when monsoon winds from the northeast pushed the poisonous air from the mainland down to the city.

According to South China Morning Post, Hong Kong’s Environmental Protection Department reported that 11 of 16 stations in different districts recorded Air Quality Health Index readings by Sunday afternoon.

The districts of Tung Chung and Tuen Mun posted a score of 10, the highest mark in the “very high” health risk category.

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