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Nice. My friend Alex Zhavoronkov will appreciate this article.


Feb. 16 (UPI) — Researchers at McGill University in Montreal have found that targeting the internal circadian or biological clock of cancer cells can affect growth.

Most cells in the human body have an internal clock that sets a rhythm for activities of organs depending on the time of day. However, this internal clock in cancer cells does not function at all or malfunctions.

“There were indications suggesting that the malfunctioning clock contributed to rapid tumor growth, but this had never been demonstrated,” Nicolas Cermakian, a professor in the department of psychiatry at McGill University, director of the Laboratory of Molecular Chronobiology at the Douglas Mental Health University Institute and author of the study, said in a press release. “Thanks to the use of a chemical or a thermic treatment, we succeeded in ‘repairing’ these cells’ clock and restoring it to its normal functioning. In these conditions, tumor growth drops nearly in half.”

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Nice.


A suite of flexible and biocompatible threads, embedded with sensors and electronics, can be sutured/woven into tissue for in situ measurements of physical and chemical biomarkers.

Real-time monitoring of chronic or surgical wounds for signs of infection or inflammation can drastically improve the health outcomes from these issues. Such monitoring requires that sensors be embedded deep within the tissue. In addition, the acquired information needs to be communicated to the doctor/caregiver so that patient-specific treatments can be optimized. Although recent miniaturization of sensors, as well as the fabrication of smart materials, has allowed the development of the necessary devices (e.g., electrocardiogram electrodes, temperature sensors, pH sensors, and flexible batteries) to continuously monitor a patient’s health status,1–5 there are still several challenges that need to be overcome. Such problems include the mismatch between mechanical and topographical properties of semiconductor-based electronics and biological tissues, as well as flexibility and biocompatibility issues.

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When and if that hurdle is overcome, the researchers say that the easily-fabricated stretchy technology could begin to find commercial applications, in devices like rubbery wrist-worn health trackers, deformable tablets and electronic wallpaper that can make huge screens out of entire walls.

“We have created a new technology that is not yet available,” says Wang. “And we have taken it one big step beyond the flexible screens that are about to become commercially available.”

The research was published in the journal ACS Nano.

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While the recent cases of Ebola and Zika contributed to an emphasis on research, response, and policy related to EIDs, the meeting also had presentations on emerging biotechnologies. Of particular note was the Synthetic Biology panel, which focused on the current state of synthetic biology, its use in the health security defense enterprise, and the policy conundrums that need to be addressed.

Synthetic Biology – Complexity through Simplification

The first presenter, Dr. Christopher Voigt of the Synthetic Biology Center at MIT, noted that synthetic biology was the application of engineering principles to biological systems. The end goal of this bioengineering framework is to leverage ever-increasing computer capabilities to simplify both the designing and writing of genomic sequences. Further simplification would then allow for the creation of more complex systems.

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By Drs. David Niesel and Norbert Herzog, Medical Discovery News

H.G. Wells was a writer of fantastic science fiction during the 1890s. He is considered one of the fathers of science fiction and wrote novels whose stories remain popular today. He wrote about time travel in “The Time Machine”, about interplanetary conflict originally made popular by the Orson Wells’ “The War of the Worlds” and in “The Island of Dr. Moreau” he described beings that were part human and part animal. Two of the three remain pure science fiction but one is on the verge of becoming a reality. Do you know which one?

In August, 2016, the National Institutes of Health announced that it was lifting its ban on research that introduces stem cells from humans into animal embryos. Stem cells have the ability to evolve into any human cell and can grow into any human tissue. The goal of this type of research is to grow human tissues and eventually human replacement organs in animals. What an innovative way to improve upon transplantation medicine! But to realize this potential, we would create an organism that is part animal and part human! These hybrids are the stuff of ancient mythology. These mixtures of different animals are called chimeras after the mythical ancient Greek creature that was part lion, snake and goat. One goal of today’s research is to produce tissues and organs for experimentation that will improve our understanding of human disease. An alternative and longer term goal would be to produce organs directly for human transplantation.

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Synergy is very important in medicine and sometimes old drugs have unexpected results when combined with others. Here we have a quad therapy that has had great results with hypertension.


A small but clinically important trial of a new ultra-low dose four-in-one pill to treat high blood pressure has produced remarkable results.

Every patient on the pilot trial conducted by The George Institute for Global Health saw their blood pressure levels drop to normal levels in just four weeks.

Professor Clara Chow, of The George Institute, said the results published in The Lancet were exciting but larger trials were needed to see if these high rates could be maintained and repeated.

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How rejuvenation could help solve the problem of pensions.


I’m sure the pension argument may seem the secret weapon of the opponents of rejuvenation, probably together with the dreaded spectre of overpopulation. However, that of pensions is an argument for of rejuvention, not against.

Let’s recap what’s the deal with pensions as things stand. When people reach the age of 65 or so, they retire (that is, they stop working and produce zero wealth) and receive a pension (aka free money) from the State. In theory, a pension is something you’ve already earned when you were young and working, and the State only gives you back the money it has kept on a side for you all your life; in practice, it seems the pension system may run out of money fairly soon both in US and possibly in Europe, and it may face a serious crisis around 2050, when the number of 80-year-old people and older is expected to be around five times as high as it is now. We’re gonna have one hell of a hard time paying all those pensions.

As a matter of fact, we are already having problems paying pensions. Retirement age is slowly getting higher all around the world, both for men and women, and not just because people in their sixties these days are a bit better than they used to be when my grandfather was young. Obviously, the later they retire the longer they will produce wealth for, and the later the State will have to start paying them money for the rest of their lives. Since human healthspan is not going to increase much at all until we implement rejuvenation therapies, the deal boils down to this: You work for longer in an increasingly crappy health condition, and retire and start receiving your pension later than people from previous generations did. Now that is one pretty bad deal.

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Posthumanists and perhaps especially transhumanists tend to downplay the value conflicts that are likely to emerge in the wake of a rapidly changing technoscientific landscape. What follows are six questions and scenarios that are designed to focus thinking by drawing together several tendencies that are not normally related to each other but which nevertheless provide the basis for future value conflicts.

  1. Will ecological thinking eventuate in an instrumentalization of life? Generally speaking, biology – especially when a nervous system is involved — is more energy efficient when it comes to storing, accessing and processing information than even the best silicon-based computers. While we still don’t quite know why this is the case, we are nevertheless acquiring greater powers of ‘informing’ biological processes through strategic interventions, ranging from correcting ‘genetic errors’ to growing purpose-made organs, including neurons, from stem-cells. In that case, might we not ‘grow’ some organs to function in largely the same capacity as silicon-based computers – especially if it helps to reduce the overall burden that human activity places on the planet? (E.g. the brains in the vats in the film The Minority Report which engage in the precognition of crime.) In other words, this new ‘instrumentalization of life’ may be the most environmentally friendly way to prolong our own survival. But is this a good enough reason? Would these specially created organic thought-beings require legal protection or even rights? The environmental movement has been, generally speaking, against the multiplication of artificial life forms (e.g. the controversies surrounding genetically modified organisms), but in this scenario these life forms would potentially provide a means to achieve ecologically friendly goals.

  1. Will concerns for social justice force us to enhance animals? We are becoming more capable of recognizing and decoding animal thoughts and feelings, a fact which has helped to bolster those concerned with animal welfare, not to mention ‘animal rights’. At the same time, we are also developing prosthetic devices (of the sort already worn by Steven Hawking) which can enhance the powers of disabled humans so their thoughts and feelings are can be communicated to a wider audience and hence enable them to participate in society more effectively. Might we not wish to apply similar prosthetics to animals – and perhaps even ourselves — in order to facilitate the transaction of thoughts and feelings between humans and animals? This proposal might aim ultimately to secure some mutually agreeable ‘social contract’, whereby animals are incorporated more explicitly in the human life-world — not as merely wards but as something closer to citizens. (See, e.g., Donaldson and Kymlicka’s Zoopolis.) However, would this set of policy initiatives constitute a violation of the animals’ species integrity and simply be a more insidious form of human domination?

  1. Will human longevity stifle the prospects for social renewal? For the past 150 years, medicine has been preoccupied with the defeat of death, starting from reducing infant mortality to extending the human lifespan indefinitely. However, we also see that as people live longer, healthier lives, they also tend to have fewer children. This has already created a pensions crisis in welfare states, in which the diminishing ranks of the next generation work to sustain people who live long beyond the retirement age. How do we prevent this impending intergenerational conflict? Moreover, precisely because each successive generation enters the world without the burden of the previous generations’ memories, it is better disposed to strike in new directions. All told then, then, should death become discretionary in the future, with a positive revaluation of suicide and euthanasia? Moreover, should people be incentivized to have children as part of a societal innovation strategy?

  1. Will the end of death trivialize life? A set of trends taken together call into question the finality of death, which is significant because strong normative attitudes against murder and extinction are due largely to the putative irreversibility of these states. Indeed, some have argued that the sanctity – if not the very meaning — of human life itself is intimately related to the finality of death. However, there is a concerted effort to change all this – including cryonics, digital emulations of the brain, DNA-driven ‘de-extinction’ of past species, etc. Should these technologies be allowed to flourish, in effect, to ‘resurrect’ the deceased? As it happens, ‘rights of the dead’ are not recognized in human rights legislation and environmentalists generally oppose introducing new species to the ecology, which would seem to include not only brand new organisms but also those which once roamed the earth.

  1. Will political systems be capable of delivering on visions of future human income? There are two general visions of how humans will earn their keep in the future, especially in light of what is projected to be mass technologically induced unemployment, which will include many ordinary professional jobs. One would be to provide humans with a ‘universal basic income’ funded by some tax on the producers of labour redundancy in both the industrial and the professional classes. The other vision is that people would be provided regular ‘micropayments’ based on the information they routinely provide over the internet, which is becoming the universal interface for human expression. The first vision cuts against the general ‘lower tax’ and ‘anti-redistributive’ mindset of the post-Cold War era, whereas the latter vision cuts against perceived public preference for the maintenance of privacy in the face of government surveillance. In effect, both visions of future human income demand that the state reinvents its modern role as guarantor of, respectively, welfare and security – yet now against the backdrop of rapid technological change and laissez faire cultural tendencies.

  1. Will greater information access turn ‘poverty’ into a lifestyle prejudice? Mobile phone penetration is greater in some impoverished parts of Africa and Asia than in the United States and some other developed countries. While this has made the developed world more informationally available to the developing world, the impact of this technology on the latter’s living conditions has been decidedly mixed. Meanwhile as we come to a greater understanding of the physiology of impoverished people, we realize that their nervous systems are well adapted to conditions of extreme stress, as are their cultures more generally. (See e.g. Banerjee and Duflo’s Poor Economics.) In that case, there may come a point when the rationale for ‘development aid’ might disappear, and ‘poverty’ itself may be seen as a prejudicial term. Of course, the developing world may continue to require external assistance in dealing with wars and other (by their standards) extreme conditions, just as any other society might. But otherwise, we might decide in an anti-paternalistic spirit that they should be seen as sufficiently knowledgeable of their own interests to be able to lead what people in the developed world might generally regard as a suboptimal existence – one in which, say, the life expectancies between those in the developing and developed worlds remain significant and quite possibly increase over time.

Expensive EpiPen auto-injectors dominate the market for emergency allergy treatment, but a cheaper alternative is now being developed: an epinephrine tablet that dissolves under the tongue.

Last month a congressional committee tore into Mylan CEO Heather Bresch. The charge: jacking up the price of EpiPens, her company’s signature product. Those price hikes left some allergy sufferers without access to emergency epinephrine, the drug that saves people who go into anaphylactic shock.

Mylan has control of the marketplace because other companies have a hard time competing with the EpiPen’s patented design. Those who have tried have mostly offered up alternative types of auto-injectors, which generally flop.

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