Lifeboat Foundation: Safeguarding Humanity
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Category: evolution

Researchers from University of Copenhagen have investigated what happened to a specific kind of plasma—the first matter ever to be present—during the first microsecond of Big Bang. Their findings provide a piece of the puzzle to the evolution of the universe, as we know it today.

About 14 billion years ago, our changed from being a lot hotter and denser to expanding radically—a process that scientists have named the Big Bang.

And even though we know that this fast expansion created particles, atoms, stars, galaxies and life as we know it today, the details of how it all happened are still unknown.

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To answer this question, an internal team of scientists, consisting of researchers affiliated with the Buck Institute for Research on Ageing, and researchers from Nanjing University decided to modify both the Insulin and the rapamycin pathways of a group of C.elegans worms, expecting to see a cumulative result of a 130% increase in lifespan. However, instead of seeing a cumulative effect in lifespan, the worms lived five times longer than they normally would.

“The synergistic extension is really wild. The effect isn’t one plus one equals two, it’s one plus one equals five. Our findings demonstrate that nothing in nature exists in a vacuum; in order to develop the most effective anti-aging treatments we have to look at longevity networks rather than individual pathways.” – Jarad Rollins of Nanjing University.

What could this mean for human regenerative medicine? Humans are not worms, however on a cellular level they do possess very similar biology. Both the insulin pathway and the rapamycin pathway are what is known as ‘conserved’ between humans and C.elegans, meaning that these pathways have been maintained in both organisms. In the distant past, both humans and C.elegans had a common ancestor, in exactly the same way as humans and Chimpanzees have a common ancestor. Evolution has changed our bodies significantly over the millions of years that humans and C.elegans have diverged from one another, but a lot of our fundamental biological functions remain largely unchanged.

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Archaea are more than just oddball lifeforms that thrive in unusual places — they turn out to be quite widespread. Moreover, they might hold the key to understanding how complex life evolved on Earth. Many scientists suspect that an ancient archaeon gave rise to the group of organisms known as eukaryotes, which include amoebae, mushrooms, plants and people — although it’s also possible that both eukaryotes and archaea arose from some more distant common ancestor.

As scientists learn more about enigmatic archaea, they’re finding clues about the evolution of the complex cells that make up people, plants and more.

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www.iBiology.org.

Dr. Kate Adamala describes what synthetic cells are and how they can teach us the fundamental principles of life.

Life on Earth evolved once — this means that all biological systems on our planet are rooted in the same fundamental framework. This framework is extremely complex and we have yet to fully understand the processes inside each living cell. One way of understanding complex systems is to break them down into simpler parts. This is the principle of engineering the synthetic cell: to use our current knowledge of biology for building a living cell with the least amount of parts and complexity. Synthetic cells can be used to teach us about the basic principles of life and evolution, and they hold promise for a range of applications including biomaterials and drug development. Dr. Kate Adamala narrates an introduction to this exciting field.

0:00 Introduction.
2:22 How do we build a synthetic cell?
7:12 How can we use synthetic cells?

Speaker Biography:
Dr. Kate Adamala is a synthetic biologist and a McKnight Land-Grant Assistant Professor in the Department of Genetics, Cell Biology and Development at the University of Minnesota. Her research interests include astrobiology, synthetic cell engineering and biocomputing. Adamala is a co-founder and steering group member of the international Build-a-Cell Initiative, which seeks to broaden the impact of synthetic cell engineering. Find more information on Adamala’s lab at:
http://www.protobiology.org.

Credits:
Brittany Anderton (iBiology): Producer.
Eric Kornblum (iBiology): Videographer and Editor.
Kate Adamala (UMN): Graphics and Narration.

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Humans are distinguished from other species by several aspects of cognition. While much comparative evolutionary neuroscience has focused on the neocortex, increasing recognition of the cerebellum’s role in cognition and motor processing has inspired considerable new research. Comparative molecular studies, however, generally continue to focus on the neocortex. We sought to characterize potential genetic regulatory traits distinguishing the human cerebellum by undertaking genome-wide epigenetic profiling of the lateral cerebellum, and compared this to the prefrontal cortex of humans, chimpanzees, and rhesus macaque monkeys. We found that humans showed greater differential CpG methylation–an epigenetic modification of DNA that can reflect past or present gene expression–in the cerebellum than the prefrontal cortex, highlighting the importance of this structure in human brain evolution. Humans also specifically show methylation differences at genes involved in neurodevelopment, neuroinflammation, synaptic plasticity, and lipid metabolism. These differences are relevant for understanding processes specific to humans, such as extensive plasticity, as well as pronounced and prevalent neurodegenerative conditions associated with aging.

Citation: Guevara EE, Hopkins WD, Hof PR, Ely JJ, Bradley BJ, Sherwood CC (2021) Comparative analysis reveals distinctive epigenetic features of the human cerebellum. PLoS Genet 17: e1009506. https://doi.org/10.1371/journal.pgen.

Editor: Takashi Gojobori, National Institute of Genetics, JAPAN.

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0:00 — Title.
0:35 — Into.
1:15 — Super People of The Future.
1:46 — Neal VanDeree ‘Living Long Healthy Lives Will be Possible’ — https://www.churchofperpetuallife.org/ — https://www.youtube.com/user/COPL18
3:24 — Dr. Bill Andrews ‘Super Wonderful Future’ — https://www.sierrasci.com/
6:27 — Selim Bakırcı ‘1000 years long life’
6:58 — Rodrigo Guinea ‘Great Responsibility’ — https://www.linkedin.com/in/rodguinea/
9:22 — Significant Research.
9:40 — Significant Research — Liz Parrish — https://bioviva-science.com/
10:44 — Significant Research — Brent Nally — https://longevityplan.net/ — https://www.linkedin.com/in/brentnally/ — https://www.youtube.com/user/BrentAltonNally.
13:10 — Significant Research — Cain Hillier — https://www.linkedin.com/in/cain-hillier-50571a18a/
14:43 — Significant Research — Chris Curwen — https://www.linkedin.com/in/chris-curwen-67144b169/
17:16 — The Threshold Times.
18:41 — The Threshold Times — Brent Nally.
21:35 — The Threshold Times — Chris Curwen
24:25 — The Threshold Times — Liz Parrish.
26:21 — The Threshold Times — Nicolas Chernavsky
https://www.linkedin.com/in/nicolas-chernavsky-25265835/ — https://www.youtube.com/channel/UCUASjdn96BRlGVytmbDgRRA
27:00 — The Threshold Times — Josh Martin.
27:42 — The Threshold Times — Cain Hillier.
28:50 — The Threshold Times — Vikram Pandya — https://www.linkedin.com/in/vikrampandya/
31:24 — Ageing Is a Disease.
32:49 — Ageing Is a Disease — Neal VanDeree.
34:09 — Ageing Is a Disease — Dr. Bill Andrews.
37:48 — Ageing Is a Disease — Liz Parrish.
39:28 — Ageing Is a Disease — Brent Nally.
42:10 — Ageing Is a Disease — Aaron King.
44:44 — Ageing Is a Disease — Lukas Vismantas — https://www.linkedin.com/in/lukas-vismantas/?originalSubdomain=dk.
46:07 — Ageing Is a Disease — Cain Hillier.
48:02 — Ageing Is a Disease — Chris Curwen.
50:23 — Ageing Is a Disease — Nicolas Chernavsky.
52:49 — The Big Times.
54:40 — The Big Times — Dr. Bill Andrews.
56:52 — The Big Times — Liz Parrish.
59:16 — The Big Times — Brent Nally.
01:03:50 — The Big Times — Nicholas Mohnacky — https://www.bundleiq.com/ — https://www.linkedin.com/in/mohnacky/
01:05:00 — The Big Times — Bolek Kerous — https://www.linkedin.com/in/bolekkerous/ — https://www.youtube.com/channel/UCSpv8MA3xPskco9qdIBeNuQ
01:08:24 — The Big Times — Nicolas Chernavsky.
01:08:58 — The Big Times — Chris Curwen.
01:09:48 — The Big Times — Nicolas Chernavsky.
01:11:19 — The Big Times — Jeremy Rumble — https://www.linkedin.com/in/jeremy-rumble-42910b38/
01:12:22 — The Big Times — Jakub Czubak — https://www.linkedin.com/in/jakub-czubak-603624a9/
01:14:20 — The Big Times — Josh Martin.
01:14:50 — The Big Times — Nicolas Chernavsky.
01:20:15 — The Big Times — Brent Nally.
01:22:09 — Ending.

Omitting natural disasters like an asteroid smashing Earth or a volcano eruption we can say that improving human health and condition is the most important safety case/concern and the fundamental thing to consider and accomplish on our way to be super cosmic humanity. Significant health improvements will free us from all diseases, allow us to develop superhuman intelligence, let us totally self-realize, and consequently, help realize the infinity in the matter for the common good. However intensively we focus on intelligence, it is not possible to experience its natural consequence or the next level of its advancement/evolution if there is no good health. Coherent and consistent collective mind continuum experience is not possible without super health (Healthy life that is free from the danger of uncontrollable death). Our bodies are short-timed and not strong enough to hold up the Earth-Gravity-Geometry sized/adjusted thoughts that are necessary to naturally manage and effectively inhabit our planet.

Our lives often seem to be episodic where the memories and thoughts get lost — one might say that this is the matter of learning and perfecting the mind but this is as far from the truth as big is the number of people who struggle with having a comprehensive perspective, not because of the lack of will to do so but because of the lack of comfort of having good health and life conditions. The comfort of the living space we got ourselves on the planet after the ages of technological developments and evolution is not a direct effect of our intelligence — The main factor for human intelligence is common health. Weak wiring of the nervous system makes it difficult to communicate progress, and therefore, build with the big human intelligence. We need to constructively adjust our metabolic paths, understand and fix our cells, learn to touch and manipulate our DNA, improve internal signaling, and get super healthy if we want to use real great human intelligence to build a wonderful future. The house we can create on the fundaments of super long healthspans will be the first of its kind and magnitude — I hope to give a good vision of the new world in order to get the good motivation to proceed in life and actually get there.

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Rees explained how his astronomy background meshes with his concern for humanity’s fate:

People often ask does being an astronomer have any effect on one’s attitude toward these things. I think it does in a way, because it makes us aware of the long-range future. We’re aware that it’s taken about 4 billion years for life to evolve from simple beginnings to our biosphere of which we are a part, but we also know that the sun is less than halfway through its life and the universe may go on forever. So we are not the culmination of evolution. Post-humans are going to have far longer to evolve. We can’t conceive what they’d be like, but if life is a rarity in the universe, then, of course, the stakes are very high if we snuff things out this century.

Bottom line: From nuclear weapons to biowarfare to cyberattacks, humanity has much to overcome. Martin Rees and Frederick Lamb discuss the obstacles we face as we look forward to humanity’s future on Earth.

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As the Times reports, researchers have been puzzling over the age of the Shigir sculpture for decades. The debate has major implications for the study of prehistory, which tends to emphasize a Western-centric view of human development.

In 1997, Russian scientists carbon-dated the totem pole to about 9500 years ago. Many in the scientific community rejected these findings as implausible: Reluctant to believe that hunter-gatherer communities in the Urals and Siberia had created art or formed cultures of their own, says Terberger to the Times, researchers instead presented a narrative of human evolution that centered European history, with ancient farming societies in the Fertile Crescent eventually sowing the seeds of Western civilization.

Prevailing views over the past century, adds Terberger, regarded hunter-gatherers as “inferior to early agrarian communities emerging at that time in the Levant. At the same time, the archaeological evidence from the Urals and Siberia was underestimated and neglected.”

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The Syntellect Emergence seems to be a cosmic necessity, and in the long run, any voices calling to resist the cybernetic fusion of the mind will be no more influential than the voices calling, right now, to eradicate civilization and return to the jungle. Nature’s tendency to build up hierarchies of emergent patterns, the heuristic law of evolution, supersedes the human race itself. We see it time and again, Nature is constantly trying to combine seemingly opposing forces, to assemble existing parts into the new wholes through the universal process of radical emergence. We are bound to transcend our biology, our human condition, our limited dimensionality, we are bound to transcend ourselves.

#TranscendentalCybernetics #CyberneticSingularity #SyntellectEmergence

Syntellect Emergence is hypothesized to be the next meta-system transition, becoming one Global Mind — that constitutes the Cybernetic Singularity.

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