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Category: electronics

Awesome!

Even the simplest networks of neurons in the brain are composed of millions of connections, and examining these vast networks is critical to understanding how the brain works. An international team of researchers, led by R. Clay Reid, Wei Chung Allen Lee and Vincent Bonin from the Allen Institute for Brain Science, Harvard Medical School and Neuro-Electronics Research Flanders (NERF), respectively, has published the largest network to date of connections between neurons in the cortex, where high-level processing occurs, and have revealed several crucial elements of how networks in the brain are organized. The results are published in the journal Nature.

“This is a culmination of a research program that began almost ten years ago. Brain networks are too large and complex to understand piecemeal, so we used high-throughput techniques to collect huge data sets of brain activity and brain wiring,” says R. Clay Reid, M.D., Ph.D., Senior Investigator at the Allen Institute for Brain Science. “But we are finding that the effort is absolutely worthwhile and that we are learning a tremendous amount about the structure of networks in the brain, and ultimately how the brain’s structure is linked to its function.”

“Although this study is a landmark moment in a substantial chapter of work, it is just the beginning,” says Wei-Chung Lee, Ph.D., Instructor in Neurobiology at Harvard Medicine School and lead author on the paper. “We now have the tools to embark on reverse engineering the brain by discovering relationships between circuit wiring and neuronal and network computations.”

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HOUSTON, March 23, 2016 /PRNewswire/ — Heath Consultants Incorporated (Heath) in collaboration with Physical Sciences Inc. (PSI), is adapting the industry-leading laser-based Remote Methane Leak Detector (RMLD®) for mounting on the InstantEye®, PSI’s two-foot-wide quadrotor Unmanned Aerial Vehicle featuring highly advanced autonomy and all-weather operation. This technology combination, known as the RMLD® Sentry, will implement self-directed flight patterns to continuously monitor, locate, and quantify volumetric leak rates of methane, a potent greenhouse gas, from natural gas production sites.

Photo — http://photos.prnewswire.com/prnh/20160323/347391

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Last summer, the team reported another achievement: the development of a DNA nanosensor that can measure the physiological concentration of chloride with a high degree of accuracy.

“Yamuna Krishnan is one of the leading practitioners of biologically oriented DNA nanotechnology,” said Nadrian Seeman, the father of the field and the Margaret and Herman Sokol Professor of Chemistry at New York University. “These types of intracellular sensors are unique to my knowledge, and represent a major advance for the field of DNA nanotechnology.”

Chloride sensor

Chloride is the single most abundant, soluble, negatively charged molecule in the body. And yet until the Krishnan group introduced its chloride sensor—called Clensor—there was no effective and practical way to measure intracellular stores of chloride.

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The EU-funded COLUMNARCODECRACKING project has successfully used ultra-high fMRI scanners to map cortical columns, a process that opens the door to exciting new applications, such as brain-computer interfaces.

Cortical columnar-level fMRI has already contributed and will further contribute to a deeper understanding of how the brain and mind work by zooming into the fine-grained functional organization within specialized brain areas.

By focussing on this, the project has stimulated a new research line of ‘mesoscopic’ brain imaging that is gaining increasing momentum in the field of human cognitive and computational neuroscience. This new field complements conventional macroscopic brain imaging that measures activity in brain areas and large-scale networks.

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Scientists at Tel Aviv University in Israel have developed a “cyborg heart patch” for replacing injured cardiac tissue. There has been considerable research on creating scaffolds seeded with cardiac cells, but simply delivering a bunch of cells in a neat package produces underwhelming results. The new patch developed at TAU integrates electronics alongside the cellular scaffold to both monitor and influence the activity of the cells.

The device can record intercellular electrical activity and deliver pulses to make the cardiomyocytes contract to a defined beat. Additionally, the researchers demonstrated that the electrodes within the patch can be covered with drugs to provide controlled release of medication right to the nearby heart cells.

This is certainly an impressive achievement that may herald a truly therapeutic approach for treating cardiac infarcts and other conditions of the heart.

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Making the most of the low light in the muddy rivers where it swims, the elephant nose fish survives by being able to spot predators amongst the muck with a uniquely shaped retina, the part of the eye that captures light. In a new study, researchers looked to the fish’s retinal structure to inform the design of a contact lens that can adjust its focus.

Imagine a that autofocuses within milliseconds. That could be life-changing for people with presbyopia, a stiffening of the eye’s that makes it difficult to focus on close objects. Presbyopia affects more than 1 billion people worldwide, half of whom do not have adequate correction, said the project’s leader, Hongrui Jiang, Ph.D., of the University of Wisconsin, Madison. And while glasses, conventional contact lenses and surgery provide some improvement, these options all involve the loss of contrast and sensitivity, as well as difficulty with night vision. Jiang’s idea is to design contacts that continuously adjust in concert with one’s own cornea and lens to recapture a person’s youthful vision.

The project, for which Jiang received a 2011 NIH Director’s New Innovator Award (an initiative of the NIH Common Fund) funded by the National Eye Institute, requires overcoming several engineering challenges. They include designing the lens, algorithm-driven sensors, and miniature electronic circuits that adjust the shape of the lens, plus creating a power source — all embedded within a soft, flexible material that fits over the eye.

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