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Proteins can communicate through DNA, conducting a long-distance dialogue that serves as a kind of genetic “switch,” according to Weizmann Institute of Science researchers. They found that the binding of proteins to one site of a DNA molecule can physically affect another binding site at a distant location, and that this “peer effect” activates certain genes. This effect had previously been observed in artificial systems, but the Weizmann study is the first to show it takes place in the DNA of living organisms.

A team headed by Dr. Hagen Hofmann of the Chemical and Structural Biology Department made this discovery while studying a peculiar phenomenon in the soil bacteria Bacillus subtilis. A small minority of these bacteria demonstrate a unique skill: an ability to enrich their genomes by taking up bacterial gene segments scattered in the soil around them. This ability depends on a protein called ComK, a transcription factor, which binds to the DNA to activate the genes that make the scavenging possible. However, it was unknown how exactly this activation works.

Devices in the submillimetre range – so-called “nano-supercapacitors” – allow the shrinkage of electronic components to tiny dimensions. However, they are difficult to produce and do not usually incorporate biocompatible materials. Corrosive electrolytes, for example, can quickly discharge themselves in the event of defects and contamination.

So-called “biosupercapacitors” (BSCs) offer a solution. These have two outstanding properties: full biocompatibility, which means they can be used in body fluids such as blood, and compensation for self-discharge behaviours through bio-electrochemical reactions. In other words, they can actually benefit from the body’s own reactions. This is because, in addition to typical charge storage reactions of a supercapacitor, redox enzymatic reactions and living cells naturally present in the blood can increase the performance of a device by 40%.

Shrinking these devices down to submillimetre sizes, while maintaining full biocompatibility, has been enormously challenging. Now, scientists have created a prototype that combines both essential properties.

Studying Novel Plasma Fractions For Age-Related Diseases And Systemic Rejuvenation — Dr. Harold Katcher Ph.D., Chief Scientific Officer, Yuvan Research Inc.


Dr. Harold Katcher is the Chief Scientific Officer at Yuvan Research Inc., a biotech company exploring the development of novel, young plasma fraction rejuvenation treatments in mammals.

Most recently Dr. Katcher was the Academic Director for Natural Sciences for the Asian Division of the University of Maryland Global Campus and throughout his career, Dr. Katcher has been a pioneer in the field of cancer research, and in the development of modern aspects of gene hunting and sequencing (including as one of the discoverers of the breast cancer gene BRCA1) as part of Myriad Genetics, and carries expertise in bioinformatics, chronobiology, and biotechnology.

Dr. Katcher has thousands of citations in the scientific literature, with publications ranging from protein structure to bacteriology, biotechnology, bioinformatics and biochemistry.

Dr. Katcher is launching his new book “The Illusion of Knowledge” on September 4th, 2021.

Secretome Derived Regenerative Therapeutics — Dr. Hanadie Yousef Ph.D., Co-Founder & CEO, Juvena Therapeutics


Dr. Hanadie Yousef, Ph.D. is a Scientist, Co-Founder and CEO of Juvena Therapeutics (https://www.juvenatherapeutics.com/), a regenerative medicine company developing protein therapeutics to promote tissue regeneration and increase healthspan, to prevent, reverse, and cure degenerative diseases.

For over 17 years, Dr. Yousef elucidated mechanisms of aging and developed methods for tissue regeneration supported by multiple awards, fellowships and grants. Her discoveries were published in top publications that include Nature Medicine and led to several issued patents which laid the foundation of Juvena Therapeutics’ venture-backed, drug discovery and pre-clinical development platform.

Dr. Yousef earned a BS in Chemistry, summa cum laude, from Carnegie Mellon University, a PhD in Molecular and Cell Biology from UC Berkeley as an NSF graduate research fellow, pursued a 5-year postdoctoral fellowship in Neurology at Stanford School of Medicine, and conducted R&D at Regeneron and Genentech.

Water is the most abundant yet least understood liquid in nature. It exhibits many strange behaviors that scientists still struggle to explain. While most liquids get denser as they get colder, water is most dense at 39 degrees Fahrenheit, just above its freezing point. This is why ice floats to the top of a drinking glass and lakes freeze from the surface down, allowing marine life to survive cold winters. Water also has an unusually high surface tension, allowing insects to walk on its surface, and a large capacity to store heat, keeping ocean temperatures stable.

Now, a team that includes researchers from the Department of Energy’s SLAC National Accelerator Laboratory, Stanford University and Stockholm University in Sweden have made the first direct observation of how in water tug and push neighboring water molecules when they are excited with laser light. Their results, published in Nature today, reveal effects that could underpin key aspects of the microscopic origin of water’s strange properties and could lead to a better understanding of how water helps proteins function in living organisms.

“Although this so-called nuclear quantum effect has been hypothesized to be at the heart of many of water’s strange properties, this experiment marks the first time it was ever observed directly,” said study collaborator Anders Nilsson, a professor of chemical physics at Stockholm University. “The question is if this quantum effect could be the missing link in theoretical models describing the anomalous properties of water.”

Pico technology is hypothetical future level of technology which will revolutionized the scientist world. This technology is combination of pico and meter with scale of trillionths of a meter (10−12). This atomic and subatomic range particles reveals extraordinary properties and pave the way for tremendous applications [1].

The way lengths and angles attach together is the main determine of the materials properties. Alterable or reversible bonds distortions at pico-meter scale which changes the electronic conformation causes multiple properties for materials.

On the other hand, pico-scale particles changes the material properties by converting energy state of electrons within an atom. Physical and chemical properties of systems such as melting point, fluorescence, electrical conductivity, magnetic permeability, and chemical reactivity changes basically at pico-scale due to quantum effects of materials [2]. Moreover, surface energy of atoms increases by alternation of electron distribution and therefore, enhances protein and molecules adsorption on to materials. This privileges will resulting in tracing proteins, DNA and molecules and labeling them for various purpose.

Lipids are abundant in the brain, where they are found not just in the cell membranes of neurons, whose properties they modulate, but also in the so-called myelin sheaths insulating axons — the brain’s ‘wiring.’ The brain is therefore a surprisingly ‘fat’ organ — in fact, it is nearly 60% fat, the study’s first author, Anna Tkachev from Skoltech, said.


Summary: Prozac reduced polyunsaturated fatty acid lipid concentrations in the brains of juvenile macaque monkeys.

Source: Skoltech

Skoltech researchers and their colleagues from Russia, Germany, and the U.S. have found Prozac to reduce lipid concentrations in juvenile macaques who received the antidepressant for two years, compared to a control group of untreated animals.

While none of the monkeys in the study were depressed, the findings still offer a plausible biochemical explanation for the drug’s side effects, particularly in young patients. The paper was published in the International Journal of Molecular Sciences.

#Biology #biochemistry #Biochemist #biotech #bio


This video explains introduction to biochemistry.

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Circa 2014


Scientists in a lab used a powerful laser to re-create what might have been the original spark of life on Earth.

The researchers zapped clay and a chemical soup with the laser to simulate the energy of a speeding asteroid smashing into the planet. They ended up creating what can be considered crucial pieces of the building blocks of .

The findings do not prove that this is how life started on Earth about 4 billion years ago, and some scientists were unimpressed with the results. But the experiment does bolster the long-held theory.

If you think at all about liquid crystals, you probably think of display technology. However, researchers have worked out a way to use an ink-jet-like process to 3D print iridescent colors using a liquid crystal elastomer. The process can mimic iridescent coloring found in nature and may have applications in things as diverse as antitheft tags, art objects, or materials with very special optical properties.

For example, one item created by the team is an arrow that only appears totally green when viewed from a certain angle. The optical properties depend on the thickness of the material which, being crystalline, self-organizes. Controlling the speed of deposition changes the thickness of the material which allows the printer to tune its optical properties.

The ink doesn’t sound too exotic to create, although the chemicals in it are an alphabet soup of unpronounceable organic compounds. At least they appeared available if you know where to shop for exotic chemicals.