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Category: chemistry

Advancing the well-being of animals, people and the planet — aaron schacht — executive vice president, innovation, regulatory & business development, elanco.

Aaron Schacht is Executive Vice President: Innovation, Regulatory + Business Development at Elanco (https://www.elanco.com/), an American pharmaceutical company which produces medicines and vaccinations for pets and livestock, and which until 2,019 was a subsidiary of Eli Lilly and Company.

Prior to this, Mr. Schacht held a role of Global Brand Development Leader – Pain in Lilly Biomedicines. He was the global leader for product development and commercialization activities for Lilly’s novel CGRP neutralizing antibody – a new potential treatment for prevention of Migraine and Cluster Headache.

In 2,012 Mr. Schacht joined Lilly Biomedicines as Senior Advisor – Strategy & Business Development for Lilly BioMedicines. His responsibilities included oversight of Therapeutic Strategy development, R&D Portfolio Management, and Business Development for Lilly BioMedicines – Lilly’s largest business unit. Past roles included serving as Executive Director, Global External R&D, at Eli Lilly and Company, where he was responsible for implementation of strategies which aim to leverage novel approaches to external partnerships to augment Lilly’s access to pharmaceutical innovation as well as Executive Director of LRL (Lilly Research Labs) Strategy, Portfolio Management and Project Management where he was responsible for strategic planning, R&D portfolio and project management. Prior to these roles, he was Director, Innovation Center in the eLilly organization where he focused on the exploration, incubation and implementation of new business models and capabilities relevant to the strategic evolution of the pharmaceutical industry.

In 2,002 during a short leave from Lilly, Mr. Schacht was co-founder, President and CEO of Artesian Therapeutics, a Gaithersburg, MD cardiovascular drug discovery start-up.

Previously, Mr. Schacht held roles as Managing Director of Lilly University, Director of Knowledge Management, and Manager of Strategy and Productivity for Discovery Research.

Mr. Schacht began his career at Lilly in1990as a medicinal chemist, and spent 5 years in the laboratory working to discover pharmaceuticals to treat cardiovascular disorders.

Mr. Schacht studied Organic Chemistry at the University of Illinois, receiving his Bachelors of Science degree in 1990.

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Since the early days of the COVID pandemic, scientists have aggressively pursued the secrets of the mechanisms that allow severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter and infect healthy human cells.

Early in the pandemic, University of California San Diego’s Rommie Amaro, a computational biophysical chemist, helped develop a detailed visualization of the SARS-CoV-2 spike protein that efficiently latches onto our cell receptors.

Now, Amaro and her research colleagues from UC San Diego, University of Pittsburgh, University of Texas at Austin, Columbia University and University of Wisconsin-Milwaukee have discovered how glycans–molecules that make up a sugary residue around the edges of the spike protein–act as infection gateways.

Published August 19 in the journal Nature Chemistry, a research study led by Amaro, co-senior author Lillian Chong at the University of Pittsburgh, first author and UC San Diego graduate student Terra Sztain and co-first author and UC San Diego postdoctoral scholar Surl-Hee Ahn, describes the discovery of glycan “gates” that open to allow SARS-CoV-2 entry.

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I am pleased to announce that my lead-author review paper has been published in ACS Nano! If you are interested in learning about the convergence of synthetic biology and adenoviral gene therapy, I encourage you to check out my paper.

If you cannot access the full text, I have also posted a local copy at the following link: https://logancollinsblog.files.wordpress.com/2021/08/synthetic-biology-approaches-for-engineering-next-generation-adenoviral-gene-therapies-2021.pdf.

#ACS #ACSNano #SyntheticBiology #GeneTherapy #Biology #Biotech #Science #Biotechnology #Nanotechnology #Adenovirus #Engineering #Virology

Synthetic biology centers on the design and modular assembly of biological parts so as to construct artificial biological systems. Over the past decade, synthetic biology has blossomed into a highly productive field, yielding advances in diverse areas such as neuroscience, cell-based therapies, and chemical manufacturing. Similarly, the field of gene therapy has made enormous strides both in proof-of-concept studies and in the clinical setting. One viral vector of increasing interest for gene therapy is the adenovirus (Ad). A major part of the Ad’s increasing momentum comes from synthetic biology approaches to Ad engineering. Convergence of gene therapy and synthetic biology has enhanced Ad vectors by mitigating Ad toxicity in vivo, providing precise Ad tropisms, and incorporating genetic circuits to make smart therapies which adapt to environmental stimuli. Synthetic biology engineering of Ad vectors may lead to superior gene delivery and editing platforms which could find applications in a wide range of therapeutic contexts.

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Investigators who previously developed a recipe for turning skin cells into primitive muscle-like cells that can be maintained indefinitely in the lab without losing the potential to become mature muscle have now uncovered how this recipe works and what molecular changes it triggers within cells. The research, which was led by scientists at Massachusetts General Hospital (MGH) and is published in Genes & Development, could allow clinicians to generate patient-matched muscle cells to help treat muscle injuries, aging-related muscle degeneration, or conditions such as muscular dystrophy.

It’s known that expression of a regulatory gene called MyoD is sufficient to directly convert into mature ; however, mature muscle do not divide and self-renew, and therefore they cannot be propagated for clinical purposes. “To address this shortcoming, we developed a system several years ago to convert skin cells into self-renewing muscle stem-like cells we coined induced myogenic progenitor cells, or iMPCs. Our system uses MyoD in combination with three chemicals we previously identified as facilitators of cell plasticity in other contexts,” explains senior author Konrad Hochedlinger, Ph.D., a principal investigator at the Center for Regenerative Medicine at MGH and a professor of medicine at Harvard Medical School.

In this latest study, Hochedlinger and his colleagues uncovered the details behind how this combination converts skin cells into iMPCs. They found that while MyoD expression alone causes skin cells to take on the identity of mature muscle cells, adding the three chemicals causes the skin cells to instead acquire a more primitive stem cell–like state. Importantly, iMPCs are molecularly highly similar to muscle tissue stem cells, and muscle cells derived from iMPCs are more stable and mature than muscle cells produced with MyoD expression alone.

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Researchers from Skoltech, KTH Royal Institute of Technology, and Uppsala University have predicted the existence of antichiral ferromagnetism, a nontrivial property of some magnetic crystals that opens the door to a variety of new magnetic phenomena. The paper was published in the journal Physical Review B.

Chirality, or handedness, is an extremely important fundamental property of objects in many fields of physics, mathematics, chemistry and biology; a chiral object cannot be superimposed on its in any way. The simplest chiral objects are human hands, hence the term itself. The opposite of chiral is achiral: a circle or a square are simple achiral objects.

Chirality can be applied to much more complex entities; for instance, competing internal interactions in a can lead to the appearance of periodic magnetic textures in the structure that differ from their mirror images—this is called chiral ferromagnetic ordering. Chiral crystals are widely considered promising candidates for and processing device realization as information can be encoded via their nontrivial magnetic textures.

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Battery-and carmakers are already spending billions of dollars on reducing the costs of manufacturing and recycling electric-vehicle (EV) batteries — spurred in part by government incentives and the expectation of forthcoming regulations. National research funders have also founded centres to study better ways to make and recycle batteries. Because it is still less expensive, in most instances, to mine metals than to recycle them, a key goal is to develop processes to recover valuable metals cheaply enough to compete with freshly mined ones. “The biggest talker is money,” says Jeffrey Spangenberger, a chemical engineer at Argonne National Laboratory in Lemont, Illinois, who manages a US federally funded lithium-ion battery-recycling initiative, called ReCell.

Reducing the use of scarce metals — and recycling them — will be key to the world’s transition to electric vehicles.

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Deep below the ground, radioactive elements disintegrate water molecules, producing ingredients that can fuel subterranean life. This process, known as radiolysis, has sustained bacteria in isolated, water-filled cracks and rock pores on Earth for millions to billions of years. Now a study published in Astrobiology contends that radiolysis could have powered microbial life in the Martian subsurface.

Dust storms, cosmic rays and solar winds ravage the Red Planet’s surface. But belowground, some life might find refuge. “The environment with the best chance of habitability on Mars is the subsurface,” says Jesse Tarnas, a planetary scientist at NASA’s Jet Propulsion Laboratory and the new study’s lead author. Examining the Martian underground could help scientists learn whether life could have survived there—and the best subsurface samples available today are Martian meteorites that have crash-landed on Earth.

Tarnas and his colleagues evaluated the grain sizes, mineral makeup and radioactive element abundance in Martian meteorites and estimated the Martian crust’s porosity using satellite and rover data. They plugged these attributes into a computer model that simulated radiolysis to see how efficiently the process would have generated hydrogen gas and sulfates: chemical ingredients that can power the metabolism of underground bacteria. The researchers report that if water was present, radiolysis in the Martian subsurface could have sustained microbial communities for billions of years—and perhaps still could today.

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NASA has selected two missions, dubbed DAVINCI+ and VERITAS, to study the “lost habitable” world of Venus. Each mission will receive approximately $500 million for development and both are expected to launch between 2,028 and 2030.

It had long been thought there was no life on Venus, due to its extremely high temperatures. But late last year, scientists studying the planet’s atmosphere announced the surprising (and somewhat controversial) discovery of phosphine. On Earth, this chemical is produced primarily by living organisms.

The news sparked renewed interest in Earth’s “twin,” prompting NASA to plan state-of-the-art missions to look more closely at the planetary environment of Venus—which could hint at life-bearing conditions.

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This work proves that stability of C60 is a geometrical property of the thermodynamics of the system: a significant methodological advance since a detailed treatment of the energetics may be avoidable. This approach may be fruitful, not only for fullerenes but also for general problems of molecular stability and in other applications of conformational chemistry. For the non-chiral C60, C384, and the weakly-chiral C28, C76 and C380 (of these, C380 and C384 are classed as “unspirallable”), Schlegel projections are used to show that these fullerenes can all be represented by pairs of spirals counter-propagating in anti-parallel (C2) symmetry. For C60, the high symmetry is used to construct an analytical approximation for the spherical double-spirals, shown mathematically to be Maximum Entropy (MaxEnt) using the formalism of Quantitative Geometrical Thermodynamics (QGT). Therefore C60 is necessarily stable. This MaxEnt stability criterion is general, depending only on the geometry and not the kinematics of the system. The sense and degree of chirality for C76 and C380 is also quantified using a Shannon entropy-based fragmentation metric.

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