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A team of researchers at Columbia University has developed a way to allow DNA strands to store more data. In their study, published in the journal Science, the group applied a small amount of electricity to DNA strands to allow for encoding more information than was possible with other methods.

For several years, researchers have been looking for ways to increase data storage capacity—storage requirements are expected to exceed capacity in the near future as demand skyrockets. One such approach has involved encoding data into strands of DNA—prior research has shown that it is possible. In the early stages of such research, scientists manually edited strands to add characteristics to represent zeroes or ones. More recently, researchers have used the CRISPR gene editing tool. Most such studies used DNA extracted from the tissue of deceased animals. More recently, researchers have begun efforts to move the research to living animals because it will last longer. And not just in the edited strands—the information they contain could conceivably be passed on to offspring, allowing data to be stored for very long periods of time.

Back in 2017, another team at Columbia University used CRISPR to detect a certain signal—in their case, it was the presence of sugar molecules. Adding such molecules resulted in gene expressions of plasmid DNA. Over time, the editing process was improved as genetic bits were added to represent ones and zeroes. Unfortunately, the system only allowed for storing a few bits of data.

Researchers at Columbia Engineering report today that they have developed the first nanomaterial that demonstrates “photon avalanching,” a process that is unrivaled in its combination of extreme nonlinear optical behavior and efficiency. The realization of photon avalanching in nanoparticle form opens up a host of sought-after applications, from real-time super-resolution optical microscopy, precise temperature and environmental sensing, and infrared light detection, to optical analog-to-digital conversion and quantum sensing.

“Nobody has seen avalanching behavior like this in nanomaterials before,” said James Schuck, associate professor of mechanical engineering, who led the study published today by Nature. “We studied these new nanoparticles at the single-nanoparticle level, allowing us to prove that avalanching behavior can occur in nanomaterials. This exquisite sensitivity could be incredibly transformative. For instance, imagine if we could sense changes in our chemical surroundings, like variations in or the actual presence of molecular species. We might even be able to detect coronavirus and other diseases.”

Avalanching processes—where a cascade of events is triggered by series of small perturbations—are found in a wide range of phenomena beyond snow slides, including the popping of champagne bubbles, nuclear explosions, lasing, neuronal networking, and even financial crises. Avalanching is an extreme example of a nonlinear process, in which a change in input or excitation leads to a disproportionate—often disproportionately large—change in output signal. Large volumes of material are usually required for the efficient generation of nonlinear optical signals, and this had also been the case for avalanching, until now.

“This is perhaps the hardest part of all DNA storage approaches. If you can get the cells to directly talk to a computer, and interface its DNA-based memory system with a silicon-based memory system, then there are lots of possibilities in the future.”

The work builds on a CRISPR-based cellular recorder Wang had previously designed for E. coli bacteria, which detects the presence of certain DNA sequences inside the cell and records this signal into the organism’s genome.

The system includes a DNA-based “sensing module” that produces elevated levels of a “trigger sequence” in response to specific biological signals. These sequences are incorporated into the recorder’s “DNA ticker tape” to document the signal.

A keen sense of smell is a powerful ability shared by many organisms. However, it has proven difficult to replicate by artificial means. Researchers combined biological and engineered elements to create what is known as a biohybrid component. Their volatile organic compound sensor can effectively detect odors in gaseous form. They hope to refine the concept for use in medical diagnosis and the detection of hazardous materials.

Electronic devices such as cameras, microphones and pressure sensors enable machines to sense and quantify their environments optically, acoustically and physically. Our sense of smell however, despite being one of nature’s most primal senses, has proven very difficult to replicate artificially. Evolution has refined this sense over millions of years and researchers are working hard to catch up.

“Odors, airborne chemical signatures, can carry useful information about environments or samples under investigation. However, this information is not harnessed well due to a lack of sensors with sufficient sensitivity and selectivity,” said Professor Shoji Takeuchi from the Biohybrid Systems Laboratory at the University of Tokyo. “On the other hand, biological organisms use information extremely efficiently. So we decided to combine existing biological sensors directly with artificial systems to create highly sensitive volatile organic compound (VOC) sensors. We call these biohybrid sensors.”

Summary: Scientists have long marveled at the rejuvenating effects of heterochronic parabiosis. When you mix the blood of a young mouse and an old mouse by joining their circulatory systems, the older animal recovers some features of youth, while the young animal becomes functionally older. While many have assumed that these effects were driven by the infusion of pro-youth factors from the young parabiont into the older one, an alternative “Dilution Solution” hypothesis is possible: that the young blood is instead diluting pro-aging factors from the old animal’s blood, as well as allowing the young animal’s livers and kidneys to filter out metabolic toxins through the young animals’ livers and kidneys.


In heterochronic parabiosis, joining the circulatory systems of young and old mice causes the older animal to recover some features of youth. The effect has been widely assumed to be driven by pro-youth factors in younger blood, but an alternative hypothesis is possible: that the procedure is instead diluting pro-aging factors in the older partner.

Aging research fans might like.

“In their work, Hamiliton’s team found that the Dunkin Hartley guinea pig was a good candidate for a muscle aging model due to the animal’s tendency to develop osteoarthritis (OA) at a young age.”


There are many components to aging, both mental and physical. When it comes to the infrastructure of the human body—the musculoskeletal system that includes muscles, bones, tendons and cartilage—age-associated decline is inevitable, and the rate of that decline increases the older we get. The loss of muscle function—and often muscle mass—is scientifically known as sarcopenia or dynapenia.

For adults in their 40s, sarcopenia is hardly noticeable—about 3% is lost each decade. For those aged 65 years and older, however, can become much more rapid, with an average loss of 1% muscle mass each year. More importantly, sarcopenia is also marked by a decrease in strength, impaired gait, reduced physical activity, or difficulty completing everyday tasks.

The proportion of older adults aged 65+ is projected to more than double by the year 2060, driving research into the process of musculoskeletal decline. Researchers at Colorado State University’s Columbine Health Systems Center for Healthy Aging believe they have found an that will help them better understand it and find ways to curtail the symptoms.

Review: Meat Planet (2019) by Benjamin Aldes Wurgaft

In the words of the book’s author, Benjamin Aldes Wurgaft, Meat Planet: Artificial Flesh and the Future of Food (2019) is “not an attempt at prediction but rather a study of cultured meat as a special case of speculation on the future of food, and as a lens through which to view the predictions we make about how technology changes the world.” While not serving as some crystal ball to tell us the future of food, Wurgaft’s book certainly does serve as a kind of lens.

Our very appetites are questioned quite a bit in the book. Wondering about the ever-changing history of food, the author asks, “Will it be an effort to reproduce the industrial meat forms we know, albeit on a novel, and more ethical and sustainable, foundation?” Questioning why hamburgers are automatically the default goal, he points out cultured meat advocates should carefully consider “the question of which human appetite for meat, in historical terms, they wish to satisfy.”

Wurgaft’s question of “which human appetite” – past, present, or future – is an excellent one. If we use his book as a lens to observe other emerging technologies, the question extends well beyond our choices of food. It could even have direct implications for such endeavours as radical life extension. Will we, if we extend our lifetimes, be satisfactory to future people? We already know the kind of clash that persists between different generations, and the blame we often place on previous generations for current social ills, without there also being a group of people who simply refuse to die. We should be wary of basing our future on the present – of attempting to preserve present tastes as somehow immutable and deserving immortality. This may be a problem such futurists as Ray Kurzweil, author of The Singularity is Near (2005) need to respond to.

If we are to justify the singularity at which we or our appetites are immortalized, we should remember technology changes “morality’s horizon”, as Wurgaft observes. If, for example, a new technology arises that can entirely eliminate suffering, our choice to allow suffering is an immoral one. If further technologies then emerge that can eliminate not just suffering but death, it will become immoral on that day to permit someone’s natural death – at least to the extent it is like the crime of manslaughter. I argued in my own book that it will be immoral to withhold novel biotechnologies from impoverished countries, if we know such direct action will increase their economic independence or improve their health. Put simply, our inaction in a situation can become an immoral deed if we have the necessary tools to stop suffering.

Beyond the way they alter our moral structures and expectations, Wurgaft notes that much fear over emerging technologies stems from the belief “technology might introduce a new plasticity into our concept of what it is to be human.” This is already expected to be the case with potential transhuman technologies, which critics of transhumanism find greatly troubling. Fully respecting the sanctity of animal life may ultimately coincide with respecting the same for all sentient beings, such as artificial and posthuman beings. Alternatively, the plasticity being described may ultimately undermine all our rights, leaving sentient life open to a whole new range of abuses, which certainly is the outcome critics of transhumanism fear. The fear of human rights being only more easily degraded and devalued by technology, or the notion technology will broaden the scope of all things morally wrong, is frequently expressed in the British dystopian Netflix series Black Mirror.

The moral appetite of the advocates of cultured meat is clear. They seek increased animal protection primarily, followed by environmental protection, but much rarer are their appeals to food security and human health. Wurgaft points out there is no apparent compelling philosophical defence or apologetic for the eating of animals. Perhaps the aforementioned plasticity of our morals to align with our species’ technological abilities, however, means most of us will remain unable to develop an acceptance of the sanctity of animal life until it becomes more broadly convenient to do so.

A chapter of Meat Planet addresses promises, noting how hopeful expectations often reinforce each other. The author also discusses “hype”, noting it is both necessary to the success of, and yet also a component leading to eventual (in Wurgaft’s view inevitable) disillusionment with any emerging technology. Such lessons may seem dissatisfying to those of us who are more enthusiastic about the future, but they seem necessary. Those of us who write science fiction know it is still fiction, and at best can only inspire some small part of the real future.

Wurgaft acknowledges “physical technologies (in energy, in transport, in medicine, in manufacturing) have lagged behind our digital ones”. This is regrettably true. Far too much effort in the tech sectors goes into software and smarter approaches to old problems rather than achieving real breakthroughs or actually inventing something. This only adds to the disappointment many feel. Rather than entering a sci-fi world filled with new domains of advanced technology, we are striding into a world only filled with new gimmicky apps and ever more efficient ways of doing whatever we already did.

Staying on the issue of technological disappointment, many problems are especially frustrating because they are the result of our culture rather than hurdles in engineering itself. Wurgaft makes a good point that privately funded labs don’t share their research and are “at risk of reinventing the wheel”. If we are to imagine a solution, it may be that governments should purchase the research of failed biotech start-ups, then hand it out freely with a goal to reduce any duplicated work and accelerate research.

It is my own observation that states are often capable of a significant amount of heavy lifting on the way to new technologies where private companies were not willing to take risks. Companies focused on new experimental technologies often leave it to engineers to solve the problem of scaling – work that too often simply doesn’t get done, as was the case with a lab-tested fuel production method using bacteria. It is possible that a state could learn best when to step in and could compensate both for the poor communication between innovators and the lack of engineering expertise and funding necessary for scaling.

On the topic of cultured meat specifically, maybe the focus should not currently be on replacing the most desired forms of meat (e.g., burgers and steaks) with cultured meat but in replacing at least a substantial percentage of lower-quality meat products with cultured meat. This, of course, depends on government adopting an agenda of phasing out industrial animal slaughter in much the same way carbon reduction targets were adopted.

A final consideration, for me, is that there may be alternative ways of achieving the same goals as cultured meat proponents. If genetic engineering could produce animals that efficiently yield greater quantities of meat, and of better quality, this may result in fewer individual animals suffering. Better yet, if synthetic biology is what it claims to be, it may eventually be possible to remake our favourite meats using the body of some wholly engineered or cognitively suppressed animal that does not experience suffering and exists its whole life as a steak.

To conclude, Wurgaft’s Meat Planet is quite nutritious food for thought. Beyond directly addressing and critically examining the hopes behind cultured meat, it raises a number of questions that should be asked of the advocates of other emerging technologies. The most important lesson is that we should not view new technology as morally neutral. It is almost certain to reconfigure our morality, whether it is for better or worse. I like to think technology only better supports us to make good moral choices in the long-term, even if there are short-term instances of abuse, as can be seen by looking at the overall course of human history.

More from me: Catalyst: A Techno-Liberation Thesis

Dr. Halima Benbouza is an Algerian scientist in the field of agronomic sciences and biological engineering.

She received her doctorate in 2004 from the University Agro BioTech Gembloux, Belgium studying Plant Breeding and Genetics and was offered a postdoctoral position to work on a collaborative project with the Agricultural Research Service, United States Department of Agriculture in Stoneville, Mississippi.

Subsequently, Dr. Benbouza was funded by Dow Agro Science to study Fusarium wilt resistance in cotton. In 2009 she was awarded the Special Prize Eric Daugimont et Dominique Van der Rest by the University Agro BioTech Gembloux, Belgium.

Dr. Benbouza is Professor at Batna 1 University where she teaches graduate and postgraduate students in the Institute of Veterinary Medicine and Agronomy. She also supervises Master’s and PhD students.

From 2010–2016, Dr. Benbouza served as inaugural Director of the Biotechnology Research Center (CRBt) in Constantine, appointed by the Ministry of Higher Education and Scientific Research. In 2011, she was appointed by the Algerian government as President of the Intersectoral Commission of Health and Life Sciences. Dr. Benbouza is a member of the Algerian National Council for Research Evaluation and a past member of the Sectorial Permanent Board of the Ministry of Higher Education and Scientific Research.

In 2013, Dr. Benbouza was appointed by the Prime Minister as President of the steering committee of Algeria’s Biotech Pharma project. In 2014 she was honored by the US Embassy in Algiers as one of the “Women in Science Hall of Fame” for her research achievements and her outstanding contribution to promote research activities and advance science in her country.

Annotated!


Aubrey David Nicholas Jasper de Grey is an English author and biomedical gerontologist. He is the Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics.
Feel free to ask any related questions that you want Aubrey to try and answer!

Futurist Foundation is a non-profit organization with the goal to connect futurists and promote crowd-sourced projects in science, technology, engineering, mathematics & design.

Donate to Futurist Foundation — https://opencollective.com/future.
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Discord: https://discord.gg/u3JM2cu.
Website: http://thefuturistfoundation.com.
Our Other Links: https://linktr.ee/futuristfoundation.

0:00 Introduction.
2:30 Aubreys last 25 years & Starting at SENS
14:35 SENS in 2020
21:27 Will there be a cut off age when its too late to repair aging?
24:36 Elasticity & Glycation.
30:13 As a medical student how can I get involved in longevity research?
33:07 SENS projects Underdog & Oisin.
38:51 mRNA Gene Therapy.
42:10 Effect of Aging on the Neural System.
49:41 Aubreys thoughts on Hyberbaric Oxygen Therapy.
51:21 SENS experience with regulators.
53:42 How do we make life extension treatments affordable?
58:28 Longevity Escape Velocity & Aubreys Timeline.
1:02:57 Is cryonics the backup plan?
1:08:28 Donate to SENS & Futurist Foundation.