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One of the first people in the UK to have a double hand transplant has said her progress has been “phenomenal”, as she continues to pick up new skills two years on.

Cor Hutton, from Lochwinnoch in Renfrewshire, was the first patient in Scotland and the third in the UK to successfully have the procedure, having had her hands and feet amputated in 2013 after suffering acute pneumonia and sepsis which nearly killed her.

On the second anniversary of coming round from the 12-hour operation on January 9 2019, Ms Hutton paid tribute to the donor and the medical team as she said she is “very lucky”.

The men are reportedly doing well one year on, but there is no way to confirm that the unpublished treatment using ‘reprogrammed’ stem cells works. The two men are reportedly doing well one year on, but there is no way to confirm that the unpublished treatment using ‘reprogrammed’ stem cells works.

Biotechnologists at Delft University of Technology have built an artificial chromosome in yeast. The chromosome can exist alongside natural yeast chromosomes, and serves as a platform to safely and easily add new functions to the micro-organism. Researchers can use the artificial chromosome to convert yeast cells into living factories capable of producing useful chemicals and even medicines.

Biotechnologists from all over the world are trying to engineer and other micro-organisms such that they can produce useful substances. To do this, they have to make adjustments to the existing genetic material of the cell. For example, they insert a number of genes into the genome using CRISPR-Cas9, or switch off existing genes, thereby gradually transforming yeast into ‘cell factories’ that produce useful substances.

The disadvantage of this method is that it is not possible to make all the necessary changes at once, but that several rounds of genetic manipulation are needed. This is time-consuming. Additionally, multiple sessions of DNA-tinkering using CRISPR-Cas9 can lead to mutations that disrupt (essential) functions. The result of this could be, for instance, that the metabolism of the cell is disrupted, causing problems with growth and division.

Alzheimer’s Disease (AD) is probably more diverse than our traditional models suggest.

Postmortem, RNA sequencing has revealed three major molecular subtypes of the disease, each of which presents differently in the brain and which holds a unique genetic risk.

Such knowledge could help us predict who is most vulnerable to each subtype, how their disease might progress and what treatments might suit them best, potentially leading to better outcomes.

A team led by University of Minnesota Twin Cities researchers has discovered a groundbreaking one-step process for creating materials with unique properties, called metamaterials. Their results show the realistic possibility of designing similar self-assembled structures with the potential of creating “built-to-order” nanostructures for wide application in electronics and optical devices.

The research was published and featured on the cover of Nano Letters, a peer-reviewed scientific journal published by the American Chemical Society.

In general, metamaterials are made in the lab so as to provide specific physical, chemical, electrical, and optical properties otherwise impossible to find in naturally occurring materials. These materials can have which make them ideal for a variety of applications from optical filters and medical devices to aircraft soundproofing and infrastructure monitoring. Usually these nano-scale materials are painstakingly produced in a specialized clean room environment over days and weeks in a multi-step fabrication process.

Moonshot Thinking For Aging, Mental Health, And Drug Re-Purposing — Dr. Tim R. Peterson.

Washington University in St. Louis.


Dr. Tim R. Peterson PhD. is Assistant Professor, in the Department of Medicine, at Washington University in St. Louis.

Dr. Peterson went to the Massachusetts Institutes of Technology (MIT) where he received his doctorate in biology.

Dr. Peterson’s lab is interested in quality of life issues that affect all people, indirectly or directly, and two critical conditions that his lab is especially interested in are aging (specifically research on health span – the healthy period of one’s life) and mental health / mental health equality for all people.

Dr. Peterson’s lab takes both molecular and population-level approaches to identify causal factors underlying these global public health issues. In particular, his lab is uses computational approaches, such as natural language processing and machine learning for co-expression analysis, as well as “wet-lab” approaches, such as high-throughput sequencing, CRISPR screening, and metabolomics.

Very interesting.


Patients with severe COVID-19 disease have significantly shorter telomeres, according to a study conducted by researchers at the Spanish National Cancer Research Centre (CNIO) in collaboration with the COVID-IFEMA Field Hospital, published in the journal Aging. The study, led by Maria A. Blasco and whose first authors are Raúl Sánchez and Ana Guío-Carrión, postulates that telomere shortening as a consequence of the viral infection impedes tissue regeneration and that this is why a significant number of patients suffer prolonged sequelae.

Blasco was already developing a therapy to regenerate lung tissue in pulmonary fibrosis patients; she now believes that this treatment — which should still take at least a year and a half to become available — could also help those who have lung lesions remaining after overcoming COVID-19.

Telomeres and tissue regeneration

The Telomeres and Telomerase Group, led by Blasco at the CNIO, has been researching the role of telomeres in tissue regeneration for decades. Telomeres are structures that protect the chromosomes within each cell of the organism. It is known that telomere length is an indicator of ageing: each time a cell divides, its telomeres shorten until they can no longer perform their protective function and the cell, which now becomes damaged, stops dividing. Throughout life, cells are constantly dividing to regenerate tissues, and when they stop doing so because the telomeres are too short, the body ages.