Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical

Astronauts face many challenges to their health, due to the exceptional conditions of spaceflight. Among these are a variety of infectious microbes that can attack their suppressed immune systems.

Now, in the first study of its kind, Cheryl Nickerson, lead author Jennifer Barrila and their colleagues describe the infection of by the intestinal pathogen Salmonella Typhimurium during . They show how the microgravity environment of spaceflight changes the molecular profile of human intestinal and how these expression patterns are further changed in response to infection. In another first, the researchers were also able to detect in the bacterial pathogen while inside the infected host cells.

The results offer fresh insights into the infection process and may lead to novel methods for combatting invasive pathogens during spaceflight and under less exotic conditions here on earth.

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Materials capable of performing complex functions in response to changes in the environment could form the basis for exciting new technologies. Think of a capsule implanted in your body that automatically releases antibodies in response to a virus, a surface that releases an antibacterial agent when exposed to dangerous bacteria, a material that adapts its shape when it needs to sustain a particular weight, or clothing that senses and captures toxic contaminants from the air.

Scientists and engineers have already taken the first step toward these types of autonomous materials by developing “active” materials that have the ability to move on their own. Now, researchers at the University of Chicago have taken the next step by showing that the movement in one such active material—liquid crystals—can be harnessed and directed.

This proof-of-concept research, published on February 182021, in the journal Nature Materials, is the result of three years of collaborative work by the groups of Juan de Pablo, Liew Family Professor of Molecular Engineering, and Margaret Gardel, Horace B. Horton Professor of Physics and Molecular Engineering, along with Vincenzo Vitelli, professor of physics, and Aaron Dinner, professor of chemistry.

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Envisioning an animal-free drug supply, scientists have — for the first time — reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published on March 22021, in Nature Communications, the researchers modified E. coli to produce chondroitin sulfate, a drug best known as a dietary supplement to treat arthritis that is currently sourced from cow trachea.

Genetically engineered E. coli is used to make a long list of medicinal proteins, but it took years to coax the bacteria into producing even the simplest in this class of linked sugar molecules — called sulfated glycosaminoglycans — that are often used as drugs and nutraceuticals…

“It’s a challenge to engineer E. coli to produce these molecules, and we had to make many changes and balance those changes so that the bacteria will grow well,” said Mattheos Koffas, lead researcher and a professor of chemical and biological engineering at Rensselaer Polytechnic Institute. “But this work shows that it is possible to produce these polysaccharides using E. coli in animal-free fashion, and the procedure can be extended to produce other sulfated glycosaminoglycans.”

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Columbia researchers engineer first technique to exploit the tunable symmetry of 2D materials for nonlinear optical applications, including laser, optical spectroscopy, imaging, and metrology systems, as well as next-generation optical quantum information processing and computing.

Nonlinear optics, a study of how light interacts with matter, is critical to many photonic applications, from the green laser pointers we’re all familiar with to intense broadband (white) light sources for quantum photonics that enable optical quantum computing, super-resolution imaging, optical sensing and ranging, and more. Through nonlinear optics, researchers are discovering new ways to use light, from getting a closer look at ultrafast processes in physics, biology, and chemistry to enhancing communication and navigation, solar energy harvesting, medical testing, and cybersecurity.

Columbia Engineering researchers report that they developed a new, efficient way to modulate and enhance an important type of nonlinear optical process: optical second harmonic generation — where two input photons are combined in the material to produce one photon with twice the energy — from hexagonal boron nitride through micromechanical rotation and multilayer stacking. The study was published online on March 32021, by Science Advances.

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While these tools will enable our society to reopen (and stay open) by improving detection of the virus, CRISPR will also have an important effect on the way we treat other diseases. In 2021, we will see increased use of CRISPR-Cas enzymes to underpin a new generation of cost-effective, individualised therapies. With CRISPR enzymes, we can cut DNA at precise locations, using specifically designed proteins, and insert or delete pieces of DNA to correct mutations.

As we deepen our understanding of the human genome and genetic disorders, patients with previously intractable diseases, such as sickle-cell disease and cancer, will benefit more widely from CRISPR-based therapies that are rapidly moving from the lab to the clinic. In 2019, sickle-cell patient Victoria Gray, for example, became one of the first patients in the world to receive CRISPR therapy for her genetic disease. She has already seen significant improvements to her health, including reduced pain and less frequent need for blood transfusions.

CRISPR will also allow us to act more boldly in the face of other important, interconnected issues such as food security, environmental sustainability and social inequality. The technology will help us grow more nutritious and robust crops, establish “gene drives” to control the spread of other infectious diseases such as Zika, and develop cleaner energy sources such as algae-based biofuels.

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Researchers affiliated with Nvidia and Harvard today detailed AtacWorks, a machine learning toolkit designed to bring down the cost and time needed for rare and single-cell experiments. In a study published in the journal Nature Communications, the coauthors showed that AtacWorks can run analyses on a whole genome in just half an hour compared with the multiple hours traditional methods take.

Most cells in the body carry around a complete copy of a person’s DNA, with billions of base pairs crammed into the nucleus. But an individual cell pulls out only the subsection of genetic components that it needs to function, with cell types like liver, blood, or skin cells using different genes. The regions of DNA that determine a cell’s function are easily accessible, more or less, while the rest are shielded around proteins.

AtacWorks, which is available from Nvidia’s NGC hub of GPU-optimized software, works with ATAC-seq, a method for finding open areas in the genome in cells pioneered by Harvard professor Jason Buenrostro, one of the paper’s coauthors. ATAC-seq measures the intensity of a signal at every spot on the genome. Peaks in the signal correspond to regions with DNA such that the fewer cells available, the noisier the data appears, making it difficult to identify which areas of the DNA are accessible.

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Advocates contend central bank digital currencies can make cross-border transactions easier, promote financial inclusion and provide payment system stability. There are also privacy and surveillance risks with government-issued digital currencies. And in times of economic uncertainty, people may be more likely to pull their funds from commercial banks, accelerating a bank run.

Intense interest in cryptocurrencies and the Covid-19 pandemic have sparked debate among central banks on whether they should issue digital currencies of their own.

China has been in the lead in developing its own digital currency. It’s been working on the initiative since 2014. Chinese central bank officials have already conducted massive trials in major cities including Shenzhen, Chengdu and Hangzhou.

“China’s experiment is very large scale,” said J. Christopher Giancarlo, former chairman of the U.S. Commodity Futures Trading Commission. “When the world arrives in Beijing next winter for the Winter Olympics, they are going to be using the new digital renminbi to shop and to stay in hotels and to buy meals in restaurants. The world is going to see a functioning [central bank digital currency] very soon, within the coming year.”

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Researchers at the University of California San Diego School of Medicine have shown that they can block inflammation in mice, thereby protecting them from liver disease and hardening of the arteries while increasing their healthy lifespan.

Researchers have succeeded in making an AI understand our subjective notions of what makes faces attractive. The device demonstrated this knowledge by its ability to create new portraits that were tailored to be found personally attractive to individuals. The results can be used, for example, in modeling preferences and decision-making as well as potentially identifying unconscious attitudes.

Researchers at the University of Helsinki and University of Copenhagen investigated whether a computer would be able to identify the facial features we consider attractive and, based on this, create new images matching our criteria. The researchers used to interpret and combined the resulting brain-computer interface with a generative model of artificial faces. This enabled the computer to create facial images that appealed to individual preferences.

“In our previous studies, we designed models that could identify and control simple portrait features, such as hair color and emotion. However, people largely agree on who is blond and who smiles. Attractiveness is a more challenging subject of study, as it is associated with cultural and that likely play unconscious roles in our individual preferences. Indeed, we often find it very hard to explain what it is exactly that makes something, or someone, beautiful: Beauty is in the eye of the beholder,” says Senior Researcher and Docent Michiel Spapé from the Department of Psychology and Logopedics, University of Helsinki.

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Researchers at the University of California San Diego (UCSD) have developed a wearable health monitor that may bring us one step closer to the dream of Star Trek’s famous tricorder.

The monitor, a stretchy skin patch, can do it all: measuring blood pressure and heart rate, your glucose levels, as well as one of alcohol, caffeine, or lactate levels.

According to UCSD’s press release, the patch is the first device to demonstrate measuring multiple biochemical and cardiovascular signals at the same time.

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