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Category: biotech/medical

Researchers in Australia have developed a patch lined with microscopic needles that can quickly and painlessly detect disease-carrying proteins in the blood, potentially replacing the need for needle-based blood samples, and time spent waiting for lab analysis.

Based on a similar patch that could one day deliver injection-free vaccines through the skin, the diagnostic nanopatch has been designed to identify diseases such as malaria and dengue fever, which are prevalent in remote areas and developing regions where people might not have the resources to routinely draw blood and analyse it.

“The concept here is that we could just put a patch on the skin and this could give a result based on what it can find in your blood,” one of the researchers, Simon Corrie from the University of Queensland, told Fairfax Media. “The microneedle arrays can capture proteins that circulate around the body that are normally tested for in blood samples.”

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DNA has garnered attention for its potential as a programmable material platform that could spawn entire new and revolutionary nanodevices in computer science, microscopy, biology, and more. Researchers have been working to master the ability to coax DNA molecules to self assemble into the precise shapes and sizes needed in order to fully realize these nanotechnology dreams.

For the last 20 years, scientists have tried to design large DNA crystals with precisely prescribed depth and complex features – a design quest just fulfilled by a team at Harvard’s Wyss Institute for Biologically Inspired Engineering. The team built 32 DNA crystals with precisely-defined depth and an assortment of sophisticated three-dimensional (3D) features, an advance reported in Nature Chemistry.

The team used their “DNA-brick self-assembly” method, which was first unveiled in a 2012 Science publication when they created more than 100 3D complex nanostructures about the size of viruses. The newly-achieved periodic crystal structures are more than 1000 times larger than those discrete DNA brick structures, sizing up closer to a speck of dust, which is actually quite large in the world of DNA nanotechnology.

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(Phys.org) —Scientists at the University of Bristol have developed a process where reagents are added to a growing carbon chain with extraordinary high fidelity and precise orientation, thereby controlling the conformation of the molecule so that it adopts a helical or linear shape. The process can be likened to a molecular assembly line.

Nature has evolved highly sophisticated machinery for . One of the most beautiful examples is its machinery for the synthesis of polyketides, a very important class of molecules due to their broad spectrum of biological activities (for example antibiotic, antitumor, antifungal, antiparasitic).

In this process, a simple thioester (small building block) is passed from one enzyme domain to another, growing as it does so until the is formed. The process resembles a molecular assembly line.

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Called a shape-memory polymer (SMP) and developed by a team at Texas A&M University in the US, this biodegradable material can be used to fill in gaps in a damaged face and act as a scaffold to guide the growth of existing bones.

The researchers made their shape-memory polymer by linking molecules of another material — polycaprolactone, or PCL — and whipping it into a foam. According to Jackie Hong at Motherboard, the material is soft and easy to mould when heated to 60°C (140°F), and sets when it’s cooled to body temperature without becoming brittle. It can be used in 3D printing and moulding, which means it can be shaped into extremely precise models and bone scaffolds, and it’s full of tiny holes like a sponge, which allows bone-producing cells called osteoblasts to collect inside and grow.

According to Hong, the researchers enhanced this osteoblast-growing effect by coating their SMP material in polydopamine — a different kind of polymer substance that helps bind existing bones to the SMP scaffold, and has been shown in previous studies to encourage the growth of osteoblasts. Over a three-day trial, their coated SMP scaffold grew five times more osteoblasts than their uncoated scaffold.

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We believe in harnessing the power of biology to make transformative products that are good for business, people and the environment. By applying the latest in automation, data architecture and machine learning, we’re making better microbes for use in industrial fermentation.

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