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Category: biotech/medical

New research from Brown University details a relatively accessible method for making a working (though not thinking) sphere of central nervous system tissue.

If you need a working miniature brain — say for drug testing, to test neural tissue transplants, or to experiment with how stem cells work — a new paper describes how to build one with what the Brown University authors say is relative ease and low expense. The little balls of brain aren’t performing any cogitation, but they produce electrical signals and form their own neural connections — synapses — making them readily producible testbeds for neuroscience research, the authors said.

“We think of this as a way to have a better in vitro [lab] model that can maybe reduce animal use,” said graduate student Molly Boutin, co-lead author of the new paper in the journal Tissue Engineering: Part C. “A lot of the work that’s done right now is in two-dimensional culture, but this is an alternative that is much more relevant to the in vivo [living] scenario.”

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A Nobel prize winning scientist who shared the 2008 prize for medicine for his role in establishing the link between HIV and AIDS has stirred up a good deal of both interest and skepticism with his latest experimental results, which more or less show that DNA can teleport itself to distant cells via electromagnetic signals. If his results prove correct, they would shake up the foundations upon which modern chemistry rests. But plenty of Montagnier’s peers are far from convinced.

The full details of Montagnier’s experiments are not yet known, as his paper has not yet been accepted for publication. But he and his research partners have made a summary of his findings available. Essentially, they took two test tubes – one containing a fragment of DNA about 100 bases long, another containing pure water – and isolated them in a chamber that muted the earth’s natural electromagnetic field to keep it from muddying the results. The test tubes were housed within a copper coil emanating a weak electromagnetic field.

Several hours later, the contents of both test tubes were put through polymerase chain reactions to identify any remnants of DNA – a process that subjected the contents to enzymes that would make copies of any DNA fragments they found. According to Montagnier, the DNA was recovered from both tubes even though the second should have only contained water.

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While scientists have had success in the past printing structures like “bionic ears,” a clear path to making functional internal organs and tissue hasn’t really emerged. However, researchers at the University of Florida in Gainesville have developed a way of printing complex objects in gel, a method that could help pave the way to 3D-printed organs in the future.

The hard thing about printing intricate organic structures like blood vessels and complicated organs is that they collapse under their own weight before they solidify. The gel here, which is made of an acrylic acid polymer, acts as a scaffold to hold the structure in place during the printing process. That approach has already allowed the team to print with organic materials — and even make a replica of a human brain.

Printing in gel isn’t an entirely new idea. And, of course, the method isn’t perfect. For one thing, using inorganic gel as a scaffold can’t keep organic tissue alive. For another, printing very small objects could lead to some particles slipping through the material. However, it’s certainly a solid step forward on the way to printing organs for patients in need someday.

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Researchers have developed a new technique to produce a 3D ‘micro-printed’ array of needles capable of drug delivery. The technique would offer a pain-free drug delivery device that would allow drugs to diffuse within the body as the biomaterial device degrades in the body. This offers treatments for a wide range of diseases, including melanoma cancers.

The results are published today, Wednesday 30th September, in the journal Biofabrication .

The researchers, based at the University of Akron and the University of Texas, report producing a drug-loaded array for transdermal delivery of a , fabricated using microstereolithography. The arrays consisted of 25 poly(propylene fumarate) microneedles, each needle having a tip and base diameter of 20 µm and 200 µm, respectively, and a height of 1 mm.

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Visionary Liz Parrish shares some of the remarkable ways that genetic therapies are helping humanity transcend disease, aging and physical limitations. We discuss some of the current applications of gene therapy, what we can reasonably expect given the rate of progress and some of the moral implications of this science. If you’re anything like us, you’ll be astounded to hear about this work; it can already make you stronger and faster, and it may help future generations live upwards of 400 years!

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“Known as “the woman who wants to genetically engineer you,” Elizabeth Parrish is the CEO of BioViva USA Inc ™ she is a humanitarian, entrepreneur and innovator and a leading voice for genetic cures. As a strong proponent of progress and education for the advancement of gene therapy, she serves as a motivational speaker to the public at large for the life sciences. She is actively involved in international educational media outreach and sits on the board of the International Longevity Alliance (ILA). She is an affiliated member of the Complex Biological Systems Alliance (CBSA) whose mission is to further scientific understanding of biological complexity and the nature and origins of human disease. She is the founder of BioTrove Investments LLC and the BioTrove Podcasts which is committed to offering a meaningful way for people to learn about and fund research in regenerative medicine. She is also the Secretary of the American Longevity Alliance (ALA) a 501©(3) nonprofit trade association that brings together individuals, companies, and organizations who work in advancing the emerging field of cellular & regenerative medicine with the aim to get governments to consider aging a disease.” –Blurb taken from Liz’ LinkedIn Profile.

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