Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical

By Julianna Photopoulos

A laser device can monitor vital signs such as your heartbeat, breathing rate, and muscle activity from up to a metre away. The device is intended for hospital patients or those with chronic diseases who need close monitoring at home. What’s more, it works through your clothes.

“No wires — everything is non-contact — continuously measuring different biomedical parameters with a single sensor,” says Zeev Zalevsky who developed the SmartHealth Mod with his team at ContinUse Biometrics, based …

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The first conference on ageing research organised by the Life Extension Advocacy Foundation is coming to New York on July 12th!

We’re extremely excited to announce “Ending Age-Related Diseases: Investment Prospects & Advances in Research”, the very first rejuvenation biotechnology conference that LEAF has organized.

Respected speakers from around the globe

The event, which will take place on July 12, 2018 from 10:30 AM to 6:00 PM EDT in New York City, is one of the many LEAF initiatives made possible by the support of our Heroes; it will feature a superb series of speakers—researchers, investors, advocates—including gerontologist and stem cell pioneer Dr. Michael West from AgeX Therapeutics; Bioage Labs Vice President and regenerative medicine specialist Dr. Alexandra Stolzing; SENS Research Foundation CSO Dr. Aubrey de Grey, pioneer of the maintenance approach to aging; “Fight Aging!” blog editor and co-founder of the recently launched Repair Biotechnologies; and, of course, LEAF President Keith Comito and LEAF Vice President Dr. Oliver Medvedik.

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Recently, roughly 200 eminent scientists assembled in Boston. Their agenda? Creating “superhero” human cells impervious to all viral attacks and possibly other killers—radiation, freezing, aging, or even cancer.

The trick isn’t super-soldier serum. Instead, the team is relying on tools from synthetic biology to read the cell’s genetic blueprint and rewrite large chunks of the genome to unlock these superpowers.

“There is very strong reason to believe that we can produce cells that would be completely resistant to all known viruses,” said Dr. Jef Boeke, a geneticist at New York University and a co-leader of the project. “It should also be possible to engineer other traits, including resistance to prions and cancer.”

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Today, we wanted to bring your attention to a new review that takes an in-depth look at genomic instability, senescent cell accumulation, and its role in aging.

DNA damage as a driver of aging

Genomic instability, otherwise known as DNA damage, is thought by many researchers to be a primary reason why we age. Damage to, and imperfect repair of, the genomes of stem and progenitor cells causes mutations, which are then passed to the somatic cells they create [1].

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May 15 (UPI) — Until now, scientists weren’t sure how gene activation mechanisms avoided nucleosomes, the bodyguards tasked with keeping DNA turned off.

Researchers at the University of California, San Diego, however, have pinpointed a key factor responsible for unraveling nucleosome structures and allowing genes to be activated.

Geneticists described the newly identified nucleosome destabilizing factor, or NDF, this week in the journal Genes and Development.

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The University of Southern California is developing the means to control and direct radio frequency energy to destroy cancer tumors…

A new technique from the University of Southern California uses radio-frequency waves to burn away tumors as doctor’s monitor the procedure in real-time.

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Cancer cells, by definition, are abnormal cells that divide with abandon and have the potential to spread throughout and wreak havoc on your vital organs and tissues. But what if you could tell those same troublesome cells to stop misbehaving? Israeli scientists think they’ve found a way to do just that.

A group of researchers at Ben-Gurion University of the Negev, led by Professor Varda Shoshan-Barmatz, PhD, have developed a molecule that prevents cancer cells from growing and turns them into normal, non-cancerous cells. This unique approach is based on siRNA (small interfering ribonucleic acid), a molecule that turns off a protein, VDAC1, that helps get energy to malignant cells. By targeting VDAC1, Shoshan-Barmatz and her team have essentially figured out how to make cancer cells start acting like regular ones.

So far, in vitro and mice models have suggested that this treatment might be effective for lung cancer, triple negative breast cancer, and glioblastoma (the type of brain tumor that John McCain is currently battling). But the applications might be even broader, and similar treatments might be one day used to combat an even wider variety of cancers.

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If someone tells you to go suck an egg, you might want to think twice about it if you live on the east coast. The United States Centers for Disease Control and Prevention announced last month that a Salmonella outbreak affecting hundreds of millions of eggs had been traced back to a farm in Hyde County, North Carolina. Public health officials have traced consumers’ illnesses in nine different states to the outbreak. Last week, the CDC released a map showing the outbreak’s spread.

Rose Acre Farms, the company responsible for the outbreak, distributes eggs all over the US, to both grocery stores and restaurants. As a result of contamination on the North Carolina farm, over 206 million eggs were exposed to Salmonella braenderup, a bacteria that causes severe diarrhea. The outbreak began in mid-April and appears to be slowing down, but in a multi-state outbreak like this, officials at the CDC may not hear about people getting sick right away. Therefore, the data on the case continues to evolve as reports roll in. The most recent numbers count 35 illnesses, 11 hospitalizations, and no deaths. Here’s a map of the outbreak’s current extent:

Article continues below.

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Learning new things would be so much easier if we could just download them into our brains, like in The Matrix. Now, biologists at the University of California, Los Angeles (UCLA) have pulled off something similar – at least on a gastropod level – by effectively transferring a memory from a trained snail into the mind of an untrained one. The experiment could eventually lead to new treatments for restoring memory in Alzheimer’s patients or to reduce traumatic memories.

The researchers studied a species of marine snail known as Aplysia. These are commonly used as animal models for neuroscience because the cellular and molecular processes at work are relatively similar to humans, but they have a far more manageable number of neurons – about 20,000, compared to our 100 billion.

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When Google DeepMind researchers trained a neural network to tackle a virtual maze, it spontaneously developed digital equivalents to the specialized neurons called grid cells that mammals use to navigate. Not only did the resulting AI system have superhuman navigation capabilities, the research could provide insight into how our brains work.

Grid cells were the subject of the 2014 Nobel Prize in Physiology or Medicine, alongside other navigation-related neurons. These cells are arranged in a lattice of hexagons, and the brain effectively overlays this pattern onto its environment. Whenever the animal crosses a point in space represented by one of the corners these hexagons, a neuron fires, allowing the animal to track its movement.

Mammalian brains actually have multiple arrays of these cells. These arrays create overlapping grids of different sizes and orientations that together act like an in-built GPS. The system even works in the dark and independently of the animal’s speed or direction.

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